| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Masaji Sakaguchi, Weikang Cai, Chih-Hao Wang, Carly T Cederquist, Marcos Damasio, Erica P Homan, Thiago Batista, Alfred K Ramirez, Manoj K Gupta, Martin Steger, Nicolai J Wewer Albrechtsen, Shailendra Kumar Singh, Eiichi Araki, Matthias Mann, Sven Enerbäck, C Ronald Kah. FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism. Nature communications. vol 10. issue 1. 2019-05-09. PMID:30952843. |
a major target of insulin signaling is the foxo family of forkhead transcription factors, which translocate from the nucleus to the cytoplasm following insulin-stimulated phosphorylation. |
2019-05-09 |
2023-08-13 |
Not clear |
| Takayoshi Sasako, Kohjiro Uek. Insulin/IGF-1 signaling and aging. Nihon rinsho. Japanese journal of clinical medicine. vol 74. issue 9. 2019-05-06. PMID:30557473. |
insulin is bound to insulin receptor on cell surface, whereas igf-1 is bound to igf1r, but the molecules to transduce intracellular signals are almost identical, including akt and foxo. |
2019-05-06 |
2023-08-13 |
mouse |
| Abdelfattah El Ouaamari, InSug O-Sullivan, Jun Shirakawa, Giorgio Basile, Wenwei Zhang, Sandra Roger, Thomas Thomou, Shanshan Xu, Guifen Qiang, Chong Wee Liew, Rohit N Kulkarni, Terry G Unterma. Forkhead box protein O1 (FoxO1) regulates hepatic serine protease inhibitor B1 (serpinB1) expression in a non-cell-autonomous fashion. The Journal of biological chemistry. vol 294. issue 3. 2019-04-16. PMID:30459233. |
foxo proteins are major targets of insulin action, and foxo1 mediates the effects of insulin on hepatic glucose metabolism. |
2019-04-16 |
2023-08-13 |
mouse |
| Terry G Unterma. Regulation of Hepatic Glucose Metabolism by FoxO Proteins, an Integrated Approach. Current topics in developmental biology. vol 127. 2019-02-07. PMID:29433735. |
foxo proteins are ancient targets of insulin action and play an important role in mediating effects of insulin on gene expression and metabolism. |
2019-02-07 |
2023-08-13 |
Not clear |
| Terry G Unterma. Regulation of Hepatic Glucose Metabolism by FoxO Proteins, an Integrated Approach. Current topics in developmental biology. vol 127. 2019-02-07. PMID:29433735. |
regulation of foxo function in the liver is critical for the ability of insulin to maintain glucose homeostasis and suppress hepatic glucose production (hgp), and dysregulation of foxo function is thought to contribute to the pathogenesis of diabetes mellitus. |
2019-02-07 |
2023-08-13 |
Not clear |
| Nicholas O Burton, Vivek K Dwivedi, Kirk B Burkhart, Rebecca E W Kaplan, L Ryan Baugh, H Robert Horvit. Neurohormonal signaling via a sulfotransferase antagonizes insulin-like signaling to regulate a Caenorhabditis elegans stress response. Nature communications. vol 9. issue 1. 2019-01-15. PMID:30514845. |
both ssu-1 and the daf-16 foxo transcription factor, which is activated when insulin signaling is low, are needed to drive specific responses to reduced insulin-like signaling. |
2019-01-15 |
2023-08-13 |
caenorhabditis_elegans |
| Shiqiu You, Huifang Li, Zhubing Hu, Wei Zhan. eIF2α kinases PERK and GCN2 act on FOXO to potentiate FOXO activity. Genes to cells : devoted to molecular & cellular mechanisms. vol 23. issue 9. 2018-12-18. PMID:30043468. |
previously, we reported that er stress potentiates insulin resistance through perk-mediated foxo phosphorylation. |
2018-12-18 |
2023-08-13 |
drosophila_melanogaster |
| Shiqiu You, Huifang Li, Zhubing Hu, Wei Zhan. eIF2α kinases PERK and GCN2 act on FOXO to potentiate FOXO activity. Genes to cells : devoted to molecular & cellular mechanisms. vol 23. issue 9. 2018-12-18. PMID:30043468. |
inhibition of perk improves cellular insulin responsiveness at the level of foxo activity. |
2018-12-18 |
2023-08-13 |
drosophila_melanogaster |
| Meghan M Fawcett, Mary C Parks, Alice E Tibbetts, Jane S Swart, Elizabeth M Richards, Juan Camilo Vanegas, Meredith Cenzer, Laura Crowley, William R Simmons, Wenzhen Stacey Hou, David R Angelin. Manipulation of insulin signaling phenocopies evolution of a host-associated polyphenism. Nature communications. vol 9. issue 1. 2018-12-11. PMID:29703888. |
further, the plastic response of ancestral-state bugs can be shifted to resemble the reaction norm of derived bugs by the introduction of exogenous insulin or rna interference targeting the insulin signaling component encoded by foxo. |
2018-12-11 |
2023-08-13 |
Not clear |
| He Chen, Huirong Li, Dayong Wan. Graphene Oxide Dysregulates Neuroligin/NLG-1-Mediated Molecular Signaling in Interneurons in Caenorhabditis elegans. Scientific reports. vol 7. 2018-10-29. PMID:28128356. |
more importantly, intestinal rnai knockdown of daf-16 gene encoding a foxo transcriptional factor in insulin signaling pathway suppressed the resistant property of nematodes overexpressing nlg-1 to go toxicity, suggesting the possible link between neuronal nlg-1 signaling and intestinal insulin signaling in the regulation of response to go exposure. |
2018-10-29 |
2023-08-13 |
caenorhabditis_elegans |
| Parisa Kakanj, Bernard Moussian, Sebastian Grönke, Victor Bustos, Sabine A Eming, Linda Partridge, Maria Lepti. Insulin and TOR signal in parallel through FOXO and S6K to promote epithelial wound healing. Nature communications. vol 7. 2018-09-04. PMID:27713427. |
insulin and tor signal in parallel through foxo and s6k to promote epithelial wound healing. |
2018-09-04 |
2023-08-13 |
drosophila_melanogaster |
| Parisa Kakanj, Bernard Moussian, Sebastian Grönke, Victor Bustos, Sabine A Eming, Linda Partridge, Maria Lepti. Insulin and TOR signal in parallel through FOXO and S6K to promote epithelial wound healing. Nature communications. vol 7. 2018-09-04. PMID:27713427. |
insulin and tor signalling are independently necessary for normal wound healing, with foxo and s6k as their respective effectors. |
2018-09-04 |
2023-08-13 |
drosophila_melanogaster |
| Parisa Kakanj, Bernard Moussian, Sebastian Grönke, Victor Bustos, Sabine A Eming, Linda Partridge, Maria Lepti. Insulin and TOR signal in parallel through FOXO and S6K to promote epithelial wound healing. Nature communications. vol 7. 2018-09-04. PMID:27713427. |
these findings may have implications for the role of insulin signalling and foxo activation in diabetic wound healing. |
2018-09-04 |
2023-08-13 |
drosophila_melanogaster |
| Jingfeng Wang, Jingjing Zhang, Xuefeng Ding, Yanyan Wang, Zhiming Li, Weipeng Zhao, Jianguo Jia, Jingmin Zhou, Junbo G. Differential microRNA expression profiles and bioinformatics analysis between young and aging spontaneously hypertensive rats. International journal of molecular medicine. vol 41. issue 3. 2018-08-03. PMID:29328372. |
the target genes were significantly enriched in 688 go terms and 39 kegg pathways, including regulation of peptidyl‑tyrosine phosphorylation, regulation of protein serine/threonine kinase activity, adrenergic signaling in cardiomyocytes, erbb signaling pathway, mtor signaling pathway, foxo signaling pathway, ras signaling pathway, insulin secretion, adipocytokine signaling pathway, hif‑1 signaling pathway, rap1 signaling pathway, vegf signaling pathway and tnf signaling pathway. |
2018-08-03 |
2023-08-13 |
rat |
| Sujin Kim, Hyongjong Ko. Role of FOXO transcription factors in crosstalk between mitochondria and the nucleus. Journal of bioenergetics and biomembranes. vol 49. issue 4. 2018-07-24. PMID:28417222. |
foxo transcription factors are evolutionally conserved regulators of organismal life span downstream of insulin signaling. |
2018-07-24 |
2023-08-13 |
Not clear |
| Xianyu Lin, Na Yu, Guy Smaggh. FoxO mediates the timing of pupation through regulating ecdysteroid biosynthesis in the red flour beetle, Tribolium castaneum. General and comparative endocrinology. vol 258. 2018-07-17. PMID:28526479. |
in our study with last larval stages of the red flour beetle, tribolium castaneum, dsrna-mediated gene silencing of forkhead box protein o (foxo) resulted in reduced food intake and larval mass and this agreed with a reduction in the expression of insulin signaling-related genes (insulin-like peptides 2, 3, 4, and chico). |
2018-07-17 |
2023-08-13 |
Not clear |
| Xianyu Lin, Na Yu, Guy Smaggh. FoxO mediates the timing of pupation through regulating ecdysteroid biosynthesis in the red flour beetle, Tribolium castaneum. General and comparative endocrinology. vol 258. 2018-07-17. PMID:28526479. |
the observations of this project suggest that foxo is a player in the timing of pupation via the regulating of ecdysteroid biosynthesis, together with the regulation of both insulin signaling and nutrition. |
2018-07-17 |
2023-08-13 |
Not clear |
| Alissa R Armstrong, Daniela Drummond-Barbos. Insulin signaling acts in adult adipocytes via GSK-3β and independently of FOXO to control Drosophila female germline stem cell numbers. Developmental biology. vol 440. issue 1. 2018-06-22. PMID:29729259. |
insulin signaling acts in adult adipocytes via gsk-3β and independently of foxo to control drosophila female germline stem cell numbers. |
2018-06-22 |
2023-08-13 |
drosophila_melanogaster |
| Lin Ling, Vladimir A Kokoza, Changyu Zhang, Emre Aksoy, Alexander S Raikhe. MicroRNA-277 targets Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 38. 2018-06-05. PMID:28874536. |
examination of subcellular localization of foxo protein via crispr-assisted, single-stranded oligodeoxynucleotide-mediated homology-directed repair revealed that insulin signaling is up-regulated in response to mir-277 depletion. |
2018-06-05 |
2023-08-13 |
human |
| Ghulam Murtaza, Abida Kalsoom Khan, Rehana Rashid, Saiqa Muneer, Syed Muhammad Farid Hasan, Jianxin Che. FOXO Transcriptional Factors and Long-Term Living. Oxidative medicine and cellular longevity. vol 2017. 2018-05-09. PMID:28894507. |
foxo transcription factors are involved in the regulation of longevity phenomenon via insulin and insulin-like growth factor signaling. |
2018-05-09 |
2023-08-13 |
human |