| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuexiu Qiu, Yaqi Liu, Yunhui Li, Dayong Wan. Intestinal mir-794 responds to nanopolystyrene by linking insulin and p38 MAPK signaling pathways in nematode Caenorhabditis elegans. Ecotoxicology and environmental safety. vol 201. 2020-08-07. PMID:32534332. |
intestinal overexpression of mir-794 further decreased the expressions of daf-16 encoding a foxo transcriptional factor in insulin signaling pathway, skn-1 encoding a nrf transcriptional factor in p38 mapk signaling pathway, and mdt-15 encoding a lipid metabolic sensor acting downstream of skn-1 in nanopolystyrene exposed nematodes. |
2020-08-07 |
2023-08-13 |
caenorhabditis_elegans |
| Yuexiu Qiu, Yaqi Liu, Yunhui Li, Guojun Li, Dayong Wan. Effect of chronic exposure to nanopolystyrene on nematode Caenorhabditis elegans. Chemosphere. vol 256. 2020-07-27. PMID:32470744. |
rnai knockdown of daf-2 encoding an insulin receptor enhanced the autophagy induction, and rnai knockdown of daf-16 encoding a foxo transcriptional factor in insulin signaling pathway suppressed the autophagy induction in 10 μg/l nanopolystyrene exposed nematodes. |
2020-07-27 |
2023-08-13 |
caenorhabditis_elegans |
| Dan Li, Yujie Yuan, Dayong Wan. Regulation of response to nanopolystyrene by intestinal microRNA mir-35 in nematode Caenorhabditis elegans. The Science of the total environment. vol 736. 2020-07-10. PMID:32473456. |
moreover, intestinal ndk-1 could regulate the response to nanopolystyrene by suppressing the function of foxo transcriptional factor daf-16 in the insulin signaling pathway. |
2020-07-10 |
2023-08-13 |
caenorhabditis_elegans |
| Hannah Crossland, Sarah Skirrow, Zudin A Puthucheary, Dumitru Constantin-Teodosiu, Paul L Greenhaf. The impact of immobilisation and inflammation on the regulation of muscle mass and insulin resistance: different routes to similar end-points. The Journal of physiology. vol 597. issue 5. 2020-07-07. PMID:29968251. |
nevertheless, there is evidence that akt (protein kinase b) signalling and foxo transcription factors form part of a common signalling pathway in this scenario, such that molecular cross-talk between atrophy and insulin signalling during heightened inflammation is believed to be possible. |
2020-07-07 |
2023-08-13 |
human |
| Tingting Bao, Kailin Yang, Zhiyong Long, Liuting Zeng, Yuehua L. Systematic Pharmacological Methodology to Explore the Pharmacological Mechanism of Siwu Decoction for Osteoporosis. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-04-15. PMID:31666500. |
hsp90ab1, fgfr1, hras, grb2, and pgf), clusters, biological processes, and signaling pathways (e.g., pi3k-akt signaling pathway, insulin signaling pathway, mapk signaling pathway and foxo signaling pathway) were found. |
2020-04-15 |
2023-08-13 |
Not clear |
| Jia-Zhen Zhu, Hong-Wei Yi, Wei Huang, Tao Pang, Hui-Ping Zhou, Xu-Dong W. Fatty liver diseases, mechanisms, and potential therapeutic plant medicines. Chinese journal of natural medicines. vol 18. issue 3. 2020-04-08. PMID:32245585. |
we review the current understanding of insulin, thyroid hormone and inflammatory cytokines in regulating hepatic lipid metabolism, focusing on several essential transcription regulators, such as sirtuins (sirts), forkhead box o (foxo), sterol-regulatory element-binding proteins (srebps). |
2020-04-08 |
2023-08-13 |
Not clear |
| Shaohua Wang, Xiaojun Liu, Zhiyong Xia, Guoqiang Xie, Bin Tang, Shigui Wan. Transcriptome analysis of the molecular mechanism underlying immunity- and reproduction trade-off in Locusta migratoria infected by Micrococcus luteus. PloS one. vol 14. issue 8. 2020-03-05. PMID:31412031. |
moreover, kegg analysis indicated that vital pathways related with immunity and reproduction, such as insulin resistance, foxo signaling, lysosome, mtor signaling, and toll-like receptor signaling pathways were up-regulated. |
2020-03-05 |
2023-08-13 |
Not clear |
| Dae Hyun Kim, Bonggi Lee, Jaewon Lee, Mi Eun Kim, Jun Sik Lee, Jae Heun Chung, Byung Pal Yu, H Henry Dong, Hae Young Chun. FoxO6-mediated IL-1β induces hepatic insulin resistance and age-related inflammation via the TF/PAR2 pathway in aging and diabetic mice. Redox biology. vol 24. 2020-02-26. PMID:30974318. |
foxo has been proposed to play a role in the promotion of insulin resistance, and inflammation. |
2020-02-26 |
2023-08-13 |
mouse |
| Huimin Shao, Zhongyu Han, Natalia Krasteva, Dayong Wan. Identification of signaling cascade in the insulin signaling pathway in response to nanopolystyrene particles. Nanotoxicology. vol 13. issue 2. 2020-02-07. PMID:30729873. |
exposure to nanopolystyrene particles (1 μg/l) significantly decreased expressions of daf-2 encoding an insulin receptor, age-1 encoding a pi3k, and akt-1 encoding an akt/pkb, and increased expression of daf-16 encoding a foxo transcriptional factor in insulin signaling pathway. |
2020-02-07 |
2023-08-13 |
caenorhabditis_elegans |
| Solaleh Emamgholipour, Reyhane Ebrahimi, Alireza Bahiraee, Farshad Niazpour, Reza Meshkan. Acetylation and insulin resistance: a focus on metabolic and mitogenic cascades of insulin signaling. Critical reviews in clinical laboratory sciences. 2020-01-02. PMID:31894999. |
there is accumulating evidence for the post-translational modification effects of igfr, insr, irs1/2, pi3k, akt, glut4, foxo, pgc-1α, ppar, ampk and mapks on insulin resistance and glucose homeostasis. |
2020-01-02 |
2023-08-13 |
Not clear |
| Yanyan Sun, Li Fu, Fuguang Xue, Yunlei Li, Hong Xu, Jilan Che. Digital gene expression profiling and validation study highlight Cyclin F as an important regulator for sperm motility of chickens. Poultry science. vol 98. issue 10. 2019-12-18. PMID:31329967. |
the kyoto encyclopedia of genes and genomes (kegg) enrichment analysis indicated that these degs were involved in the foxo signaling pathway and insulin resistance pathway. |
2019-12-18 |
2023-08-13 |
chicken |
| Yanyan Sun, Li Fu, Fuguang Xue, Yunlei Li, Hong Xu, Jilan Che. Digital gene expression profiling and validation study highlight Cyclin F as an important regulator for sperm motility of chickens. Poultry science. vol 98. issue 10. 2019-12-18. PMID:31329967. |
in summary, the present study provides insight into the potential genetic regulation of sperm motility and highlighted the underlying pathways (insulin resistance and foxo signaling pathways) and important candidate genes such as ccnf. |
2019-12-18 |
2023-08-13 |
chicken |
| Austin P Dreyer, Alexander W Shingleto. Insulin-insensitivity of male genitalia maintains reproductive success in Drosophila. Biology letters. vol 15. issue 5. 2019-12-11. PMID:31088279. |
in drosophila melanogaster, reduced nutritional plasticity of the male genitalia is a consequence of low insulin sensitivity through a tissue-specific reduction in the expression of foxo, a negative growth regulator . |
2019-12-11 |
2023-08-13 |
drosophila_melanogaster |
| Nataly E Gruntenko, Natalya V Adonyeva, Elena V Burdina, Evgenia K Karpova, Olga V Andreenkova, Daniil V Gladkikh, Yury Y Ilinsky, Inga Yu Rauschenbac. The impact of FOXO on dopamine and octopamine metabolism in Drosophila under normal and heat stress conditions. Biology open. vol 5. issue 11. 2019-11-20. PMID:27754851. |
the forkhead boxo transcription factor (foxo) is a component of the insulin signalling pathway and plays a role in responding to adverse conditions, such as oxidative stress and starvation. |
2019-11-20 |
2023-08-13 |
drosophila_melanogaster |
| Verónica Muñoz-Soriano, Yaiza Belacortu, Francisco José Sanz, Cristina Solana-Manrique, Luke Dillon, Carmen Suay-Corredera, Marina Ruiz-Romero, Montserrat Corominas, Nuria Parici. Cbt modulates Foxo activation by positively regulating insulin signaling in Drosophila embryos. Biochimica et biophysica acta. Gene regulatory mechanisms. 2019-11-20. PMID:30055320. |
cbt modulates foxo activation by positively regulating insulin signaling in drosophila embryos. |
2019-11-20 |
2023-08-13 |
drosophila_melanogaster |
| Samuel X Lee, Markus Heine, Christian Schlein, Rajasekhar Ramakrishnan, Jing Liu, Gabriella Belnavis, Ido Haimi, Alexander W Fischer, Henry N Ginsberg, Joerg Heeren, Franz Rinninger, Rebecca A Haeusle. FoxO transcription factors are required for hepatic HDL cholesterol clearance. The Journal of clinical investigation. vol 128. issue 4. 2019-09-10. PMID:29408809. |
the insulin-repressible foxo transcription factors are potential mediators of the effect of insulin on hdl-c. foxos mediate a substantial portion of insulin-regulated transcription, and poor foxo repression is thought to contribute to the excessive glucose production in diabetes. |
2019-09-10 |
2023-08-13 |
mouse |
| Fanny Langlet, Marcel Tarbier, Rebecca A Haeusler, Stefania Camastra, Eleuterio Ferrannini, Marc R Friedländer, Domenico Accil. microRNA-205-5p is a modulator of insulin sensitivity that inhibits FOXO function. Molecular metabolism. vol 17. 2019-09-10. PMID:30174230. |
microrna-205-5p is a modulator of insulin sensitivity that inhibits foxo function. |
2019-09-10 |
2023-08-13 |
Not clear |
| Brian T O'Neill, Gourav Bhardwaj, Christie M Penniman, Megan T Krumpoch, Pablo A Suarez Beltran, Katherine Klaus, Kennedy Poro, Mengyao Li, Hui Pan, Jonathan M Dreyfuss, K Sreekumaran Nair, C Ronald Kah. FoxO Transcription Factors Are Critical Regulators of Diabetes-Related Muscle Atrophy. Diabetes. vol 68. issue 3. 2019-08-26. PMID:30523026. |
foxo transcription factors are suppressed by insulin and thus are key mediators of insulin action. |
2019-08-26 |
2023-08-13 |
mouse |
| Wolfgang Lin. Introduction to FOXO Biology. Methods in molecular biology (Clifton, N.J.). vol 1890. 2019-06-05. PMID:30414140. |
foxo factors, originally identified as downstream regulators of the insulin pathway, are known to bind to the promoters of a broad variety of target genes and control several processes of key importance for cellular homeostasis including cellular energy production, oxidative stress resistance, and cell viability and proliferation. |
2019-06-05 |
2023-08-13 |
human |
| Abrar E Al-Shaer, George R Flentke, Mark E Berres, Ana Garic, Susan M Smit. Exon level machine learning analyses elucidate novel candidate miRNA targets in an avian model of fetal alcohol spectrum disorder. PLoS computational biology. vol 15. issue 4. 2019-05-28. PMID:30973878. |
other pathways are crucial to facial morphogenesis and represent both novel (focal adhesion, foxo signaling, insulin signaling) and known (wnt signaling) alcohol targets. |
2019-05-28 |
2023-08-13 |
chicken |