| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Binod Wagle, Margaret Finn, Naga Prasuna Vanipent. A Rare Overlap of Serotonin Syndrome and Status Epilepticus Confirmed on Electroencephalogram. Cureus. vol 11. issue 5. 2020-10-01. PMID:31328059. |
our patient required aggressive treatment with various anticonvulsant medications to control status epilepticus and was also treated with cyproheptadine for the serotonin syndrome. |
2020-10-01 |
2023-08-13 |
Not clear |
| Jéssica de Araujo Isaias Muller, Márcia Renata Mortari, Iluska Senna Bonfá Moslaves, Mônica Cristina Toffoli-Kadr. Pharmacological Characterization of Mouse Hind Paw Edema Induced by Parachartergus fraternus Venom. Inflammation. vol 42. issue 6. 2020-03-30. PMID:31309372. |
together, these mediators amplify the inflammatory process, with emphasis on histamine and serotonin in triggering the edematogenic response, being more effective the use of cyproheptadine in the therapeutic approach. |
2020-03-30 |
2023-08-13 |
mouse |
| Francisco José Batista-Lima, Felipe Macário Dos Santos Rodrigues, Kalinne Kelly Lima Gadelha, Daniel Maia Nogueira de Oliveira, Emanuella Feitosa Carvalho, Tatyanne Linhares Oliveira, Fernanda Carlos Nóbrega, Teresinha Silva Brito, Pedro Jorge Caldas Magalhãe. Dual excitatory and smooth muscle-relaxant effect of β-phenylethylamine on gastric fundus strips in rats. Clinical and experimental pharmacology & physiology. vol 46. issue 1. 2020-02-13. PMID:30229988. |
the contractile effect of β-pea was inhibited by 5-hydroxytryptamine (5-ht) receptor antagonists (i.e., cyproheptadine and ketanserin) but not by the taar |
2020-02-13 |
2023-08-13 |
rat |
| Aruna Sharma, Rudy J Castellani, Mark A Smith, Dafin Fior Muresanu, Prasanta Kumar Dey, Hari Shanker Sharm. 5-Hydroxytryptophan: A precursor of serotonin influences regional blood-brain barrier breakdown, cerebral blood flow, brain edema formation, and neuropathology. International review of neurobiology. vol 146. 2020-02-03. PMID:31349924. |
in addition, several neurochemical agents such as p-cpa (5-ht synthesis inhibitor) indomethacin (prostaglandin synthase inhibitor), diazepam (ant stress drug), cyproheptadine, ketanserin (5-ht2 receptor antagonists) and vinblastine (inhibitor of microtubule function) were examined on 5-ht neurotoxicity. |
2020-02-03 |
2023-08-13 |
rat |
| J.M. Witkin, L.A. Pere. Comparison of effects of buspirone and gepirone with benzodiazepines and antagonists of dopamine and serotonin receptors on punished behavior of rats. Behavioural pharmacology. vol 1. issue 3. 2019-11-20. PMID:11224036. |
the non-selective serotonin (5ht) antagonists, cyproheptadine and methysergide, consistently increased responding 2-fold, but the 5ht-2 antagonists, ketanserin, pirenperone, ritanserin, r-56 413, and ly 53857 and the 5ht-1a agonist, 8-oh-dpat, were inactive. |
2019-11-20 |
2023-08-12 |
rat |
| A. R. Dehpour, H. R. Sadeghipour, A. Nowroozi, N. Akbarlo. The effect of the serotonergic system on opioid withdrawal-like syndrome in a mouse model of cholestasis. Human psychopharmacology. vol 15. issue 6. 2019-11-20. PMID:12404304. |
administration of serotonin receptors antagonists, cyproheptadine (10 mg/kg), methysergide (6 mg/kg) and ondansetron (10 mg/kg) attenuated withdrawal signs and decreased the antinociception. |
2019-11-20 |
2023-08-12 |
mouse |
| Sameer Hassamal, Karen Miotto, William Dale, Itai Danovitc. Tramadol: Understanding the Risk of Serotonin Syndrome and Seizures. The American journal of medicine. vol 131. issue 11. 2019-09-09. PMID:29752906. |
cyproheptadine should be administered in moderate to severe cases of serotonin syndrome. |
2019-09-09 |
2023-08-13 |
Not clear |
| Youngjae Ryu, Toru Ogata, Motoshi Nagao, Yasuhiro Sawada, Ryohei Nishimura, Naoki Fujit. Effects of Treadmill Training Combined with Serotonergic Interventions on Spasticity after Contusive Spinal Cord Injury. Journal of neurotrauma. vol 35. issue 12. 2019-09-02. PMID:29336209. |
spasticity-strong sci rats were selected 4 weeks after sci and received one of the following interventions for 2 weeks: only tmt, tmt with fluoxetine (a selective serotonin re-uptake inhibitor), tmt with cyproheptadine (a 5-ht |
2019-09-02 |
2023-08-13 |
rat |
| Hien Nguyen, Angel Pan, Craig Smollin, Lee F Cantrell, Tom Kearne. An 11-year retrospective review of cyproheptadine use in serotonin syndrome cases reported to the California Poison Control System. Journal of clinical pharmacy and therapeutics. vol 44. issue 2. 2019-03-20. PMID:30650197. |
an 11-year retrospective review of cyproheptadine use in serotonin syndrome cases reported to the california poison control system. |
2019-03-20 |
2023-08-13 |
Not clear |
| Hien Nguyen, Angel Pan, Craig Smollin, Lee F Cantrell, Tom Kearne. An 11-year retrospective review of cyproheptadine use in serotonin syndrome cases reported to the California Poison Control System. Journal of clinical pharmacy and therapeutics. vol 44. issue 2. 2019-03-20. PMID:30650197. |
cyproheptadine is a serotonin and histamine antagonist that has been suggested as a treatment for serotonin syndrome in case reports. |
2019-03-20 |
2023-08-13 |
Not clear |
| Kimberly Little, Christine M Lin, Paul M Reynold. Delayed Serotonin Syndrome in the Setting of a Mixed Fluoxetine and Serotonin Antagonist Overdose. The American journal of case reports. vol 19. 2018-11-26. PMID:29795058. |
he was diagnosed with delayed-onset serotonin syndrome, which responded well to re-administration of cyproheptadine, leading to resolution of symptoms by day 5 of his stay. |
2018-11-26 |
2023-08-13 |
Not clear |
| Kimberly Little, Christine M Lin, Paul M Reynold. Delayed Serotonin Syndrome in the Setting of a Mixed Fluoxetine and Serotonin Antagonist Overdose. The American journal of case reports. vol 19. 2018-11-26. PMID:29795058. |
this was likely secondary to co-ingestion of long-acting serotonin agonists with protective shorter-acting serotonin antagonists (cyproheptadine and olanzapine). |
2018-11-26 |
2023-08-13 |
Not clear |
| Alex Morris, Michael Green, Hayley Martin, Katie Crossland, William T Swaney, Sally M Williamson, Robbie Ra. A nematode that can manipulate the behaviour of slugs. Behavioural processes. vol 151. 2018-09-10. PMID:29499346. |
to investigate how p. hermaphrodita changes slug behaviour we exposed slugs to fluoxetine (a selective serotonin reuptake inhibitor) and cyproheptadine (a serotonin receptor antagonist). |
2018-09-10 |
2023-08-13 |
Not clear |
| Toshiya Inad. [Drug-Induced Akathisia]. Brain and nerve = Shinkei kenkyu no shinpo. vol 69. issue 12. 2018-06-08. PMID:29282345. |
these include anticholinergic agents (e.g., biperiden and trihexyphenidyl), benzodiazepines, beta-adrenoceptor blockers (e.g., propranolol), and serotonin 2a receptor antagonists (e.g., mianserin, cyproheptadine, and mirtazapine). |
2018-06-08 |
2023-08-13 |
Not clear |
| Amornluck Krasaelap, Shailender Madan. Cyproheptadine: A Potentially Effective Treatment for Functional Gastrointestinal Disorders in Children. Pediatric annals. vol 46. issue 3. 2017-10-03. PMID:28287686. |
cyproheptadine, a serotonin antagonist, has been shown to be a potentially effective and safe treatment option in children who meet the clinical criteria for fgids. |
2017-10-03 |
2023-08-13 |
Not clear |
| Camille Lagard, Lucie Chevillard, Isabelle Malissin, Patricia Risède, Jacques Callebert, Laurence Labat, Jean-Marie Launay, Jean-Louis Laplanche, Bruno Mégarban. Mechanisms of tramadol-related neurotoxicity in the rat: Does diazepam/tramadol combination play a worsening role in overdose? Toxicology and applied pharmacology. vol 310. 2017-05-31. PMID:27641627. |
interestingly neither pretreatment with cyproheptadine (a serotonin-receptor antagonist) nor a benserazide/5-hydroxytryptophane combination (enhancing brain serotonin) reduced tramadol-induced seizures. |
2017-05-31 |
2023-08-13 |
rat |
| Jacek C Szepietowski, Radomir Reszk. Psychogenic Itch Management. Current problems in dermatology. vol 50. 2017-04-18. PMID:27578081. |
as in pruritus of other causes, several drugs are used, with more emphasis on substances that influence central nervous system: h1-antihistamines (hydroxyzine, chlorpheniramine, cyproheptadine, diphenhydramine, promethazine), tricyclic antidepressants (doxepin), tetracyclic antidepressants (mirtazapine), selective serotonin reuptake inhibitors (citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline), antipsychotic drugs (pimozide), anticonvulsants (topiramate), and benzodiazepines (alprazolam), preferably depending on the coexisting symptoms. |
2017-04-18 |
2023-08-13 |
Not clear |
| O Greg Deardorff, Talha Khan, Gaurav Kulkarni, Richard Doisy, Colleen Loeh. Serotonin Syndrome: Prophylactic Treatment With Cyproheptadine. The primary care companion for CNS disorders. vol 18. issue 4. 2017-03-07. PMID:27828700. |
serotonin syndrome: prophylactic treatment with cyproheptadine. |
2017-03-07 |
2023-08-13 |
Not clear |
| O Greg Deardorff, Talha Khan, Gaurav Kulkarni, Richard Doisy, Colleen Loeh. Serotonin Syndrome: Prophylactic Treatment With Cyproheptadine. The primary care companion for CNS disorders. vol 18. issue 4. 2017-03-07. PMID:27828700. |
the severity of the patient's condition in conjunction with increased risk for serotonin syndrome warranted prophylactic treatment with cyproheptadine. |
2017-03-07 |
2023-08-13 |
Not clear |
| O Greg Deardorff, Talha Khan, Gaurav Kulkarni, Richard Doisy, Colleen Loeh. Serotonin Syndrome: Prophylactic Treatment With Cyproheptadine. The primary care companion for CNS disorders. vol 18. issue 4. 2017-03-07. PMID:27828700. |
the complex pathophysiology of prophylactic treatment of serotonin syndrome with cyproheptadine is worthy of discussion. |
2017-03-07 |
2023-08-13 |
Not clear |