| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Schenk, S Wir. [Serotonin syndrome and pain medication : What is relevant for practice?]. Schmerz (Berlin, Germany). vol 29. issue 2. 2016-12-14. PMID:25860200. |
patients with a severe serotonin syndrome require symptomatic intensive care and specifically a pharmacological antagonism with cyproheptadine or chlorpromazine. |
2016-12-14 |
2023-08-13 |
Not clear |
| Hsiao-Yen Hsieh, Cheng-Huang Shen, Ru-Inn Lin, Yu-Min Feng, Shih-Yuan Huang, Yuan-Hung Wang, Shu-Fen Wu, Cheng-Da Hsu, Michael W Y Cha. Cyproheptadine exhibits antitumor activity in urothelial carcinoma cells by targeting GSK3β to suppress mTOR and β-catenin signaling pathways. Cancer letters. vol 370. issue 1. 2016-04-27. PMID:26454215. |
cyproheptadine, a serotonin antagonist, has recently been reported to function as a novel therapeutic agent by inhibiting pi3k/akt signaling in several human cancers. |
2016-04-27 |
2023-08-13 |
human |
| Nadia Khan, Ahsana Dar Farooq, Bassem Sade. Investigation of cyclooxygenase and signaling pathways involved in human platelet aggregation mediated by synergistic interaction of various agonists. Drug design, development and therapy. vol 9. 2016-04-18. PMID:26185418. |
interestingly, the synergistic effect observed for aa with 5-ht was, also, blocked by the 5-ht receptor blockers cyproheptadine (ic50=22.0 ± 7 μmol/l), ketanserin (ic50=152 ± 23 μmol/l), phospholipase c (plc) inhibitor (u73122; ic50=6.1 ± 0.8 μmol/l), and mitogen activated protein kinase (mapk) inhibitor (pd98059; ic50=3.8 ± 0.5 μmol/l). |
2016-04-18 |
2023-08-13 |
human |
| Thomaz A A Rocha-E-Silva, Alessandra Linardi, Edson Antunes, Stephen Hyslo. Pharmacological Characterization of the Edema Caused by Vitalius dubius (Theraphosidae, Mygalomorphae) Spider Venom in Rats. The Journal of pharmacology and experimental therapeutics. vol 356. issue 1. 2016-03-15. PMID:26607257. |
this edema was significantly inhibited by ((s)1-{2-[3(3-4-dichlorophenyl)-1-(3-iso-propoxyphenylacetyl)piperidine-3-yl]ethyl}-4-phenyl-1-azoniabicyclo[2.2.2]octone, chloride) (sr140333, a neurokinin nk1 receptor antagonist), indomethacin [a nonselective cyclooxygenase (cox) inhibitor], cyproheptadine (a serotonin 5-hydroxytryptamine1/2 and histamine h1 receptor antagonist), and n(ω)-nitro-l-arginine methyl ester (a nitric oxide synthase inhibitor). |
2016-03-15 |
2023-08-13 |
rat |
| Elen Thegla Sander Inohara, Charles Budazewsky Pinto, Jorge Felipe Argenta Model, Márcia Trapp, Luiz Carlos Kucharski, Roselis Silveira Martins Da Silva, Anapaula Sommer Vinagr. Serotonin effects in the crab Neohelice granulata: Possible involvement of two types of receptors in peripheral tissues. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. vol 185. 2016-02-12. PMID:25810362. |
cyproheptadine blocked the hyperglycemic effect of 5-ht in hp-fed crabs. |
2016-02-12 |
2023-08-13 |
Not clear |
| Sebastian Weiterer, Dagmar Schulte, Sabrina Müller, Thomas Kohlen, Florian Uhle, Markus A Weigand, Michael Henric. Tumor necrosis factor alpha induces a serotonin dependent early increase in ciliary beat frequency and epithelial transport velocity in murine tracheae. PloS one. vol 9. issue 3. 2015-12-14. PMID:24626175. |
the increases in ciliary beat frequency as well as the accelerated particle transport velocity were either inhibited by the unspecific serotonin antagonist methysergide or by cyproheptadine a specific 5-ht2 receptor antagonist. |
2015-12-14 |
2023-08-12 |
mouse |
| Manjeet S Bhatia, Jaswinder Kaur, Priyanka Gauta. A Case of Serotonin Syndrome Following Cyproheptadine Withdrawal. The primary care companion for CNS disorders. vol 17. issue 3. 2015-12-08. PMID:26644949. |
a case of serotonin syndrome following cyproheptadine withdrawal. |
2015-12-08 |
2023-08-13 |
Not clear |
| Tasuku Nakasone, Takumi Sato, Yoshibumi Matsushima, Toshio Inoue, Chiaki Kame. Characteristics of scratching behavior in ADJM mice (atopic dermatitis from Japanese mice). Immunopharmacology and immunotoxicology. vol 37. issue 2. 2015-12-04. PMID:25578901. |
histamine h1 antagonist with serotonin 5-th(5-hydroxytryptamine)2 antagonist, cyproheptadine, also inhibited this behavior. |
2015-12-04 |
2023-08-13 |
mouse |
| Carl L Faingold, Srinivasa P Kommajosyula, X Long, Kristin Plath, Marcus Randal. Serotonin and sudden death: differential effects of serotonergic drugs on seizure-induced respiratory arrest in DBA/1 mice. Epilepsy & behavior : E&B. vol 37. 2015-09-03. PMID:25064738. |
in developing dba/1 mice that had not previously experienced agsz, administration of a nonselective 5-ht antagonist, cyproheptadine, induced a significantly greater incidence of s-ira than that of saline. |
2015-09-03 |
2023-08-13 |
mouse |
| Arash Javanbakh. As-needed use of cyproheptadine for treatment of selective serotonin reuptake inhibitor-related female anorgasmia. Journal of clinical psychopharmacology. vol 35. issue 1. 2015-08-28. PMID:25502486. |
as-needed use of cyproheptadine for treatment of selective serotonin reuptake inhibitor-related female anorgasmia. |
2015-08-28 |
2023-08-13 |
Not clear |
| Jean-Paul V Paluzzi, Garima Bhatt, Chang-Hui J Wang, Meet Zandawala, Angela B Lange, Ian Orchar. Identification, functional characterization, and pharmacological profile of a serotonin type-2b receptor in the medically important insect, Rhodnius prolixus. Frontiers in neuroscience. vol 9. 2015-06-04. PMID:26041983. |
rhopr5htr2b is sensitive to alpha-methyl serotonin and is inhibited by a variety of serotonin receptor antagonists, including propranolol, spiperone, ketanserin, mianserin, and cyproheptadine. |
2015-06-04 |
2023-08-13 |
Not clear |
| Sébastien Beaune, Jacques Callebert, Frédéric J Baud, Patricia Risède, Philippe Juvin, Bruno Mégarban. Mechanisms of high-dose citalopram-induced death in a rat model. Toxicology. vol 302. issue 2-3. 2014-03-28. PMID:22951378. |
neuroprotection with diazepam and cyproheptadine was not associated with decreased serotonin plasma concentrations. |
2014-03-28 |
2023-08-12 |
rat |
| Christopher K Thompson, T George Hornb. Divergent modulation of clinical measures of volitional and reflexive motor behaviors following serotonergic medications in human incomplete spinal cord injury. Journal of neurotrauma. vol 30. issue 6. 2014-01-21. PMID:22994901. |
clinical measures of strength, spasticity/spasms, and walking ability were assessed in 12 individuals with chronic incomplete sci following acute administration of either 8 mg cyproheptadine, a 5-ht antagonist, or 10 mg escitalopram, a selective 5-ht reuptake inhibitor (ssri), in a double-blinded, randomized, crossover fashion. |
2014-01-21 |
2023-08-12 |
human |
| W J Xu, Y Zhao, F Q Huo, J Q Du, J S Tan. Involvement of ventrolateral orbital cortex 5-HT 1-7 receptors in 5-HT induced depression of spared nerve injury allodynia. Neuroscience. vol 238. 2013-10-17. PMID:23485814. |
microinjection of selective 5-ht1a, 5-ht2, 5-ht3, 5-ht4, 5-ht5a, 5-ht6 and 5-ht7 receptor antagonists, 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl] piperazine hydrobromide (nan-190) (10μg), cyproheptadine (50ng), granisetron hydrochloride (granisetron) (10μg), 1-[2-[(methylsulfonyl)-amino]ethyl]-4-piperidinyl]methyl1-methyl-1h-indole-3-carboxylate (gr113808) (5μg), sb699551 dihydrochloride (sb699551) (10μg), sb258585 dihydrochloride (sb258585) (2μg) or sb269970 hydrochloride (sb269970) (10μg) into the vlo 5-min prior to 5-ht (10μg) injection, all antagonized the 5-ht-induced inhibition of allodynia. |
2013-10-17 |
2023-08-12 |
rat |
| Leonel Rodriguez, Juan Diaz, Samuel Nurk. Safety and efficacy of cyproheptadine for treating dyspeptic symptoms in children. The Journal of pediatrics. vol 163. issue 1. 2013-09-03. PMID:23419589. |
to present our experience using cyproheptadine, a potent serotonin antagonist used to stimulate appetite, to treat dyspeptic symptoms in children. |
2013-09-03 |
2023-08-12 |
Not clear |
| Vishal Gupta, Niteen D Karnik, Rushikesh Deshpande, Meenakshi Amit Pati. Linezolid-induced serotonin syndrome. BMJ case reports. vol 2013. 2013-09-03. PMID:23513014. |
serotonin syndrome was suspected and the patient was started on cyproheptadine. |
2013-09-03 |
2023-08-12 |
Not clear |
| L A Kuznetsova, S A Plesneva, T S Sharova, M N Pertseva, A O Shpako. [Regulation of adenylyl cyclase signaling system by insulin, biogenic amines, and glucagon at their separate and combined action in the muscle membranes of the mollusc Anodonta cygnea]. Zhurnal evoliutsionnoi biokhimii i fiziologii. vol 49. issue 2. 2013-07-12. PMID:23789396. |
specific blocking of the ac-stimulatory serotonin effect by cyproheptadine - an antagonist of serotonin receptors - did not affect stimulation of ac by insulin. |
2013-07-12 |
2023-08-12 |
Not clear |
| M Tanaka, K Csabafi, G Telegd. Neurotransmissions of antidepressant-like effects of kisspeptin-13. Regulatory peptides. vol 180. 2013-06-10. PMID:22999921. |
the mice were pretreated with a nonselective α-adrenergic receptor antagonist, phenoxybenzamine, an α(1)/α(2β)-adrenergic receptor antagonist, prazosin, an α(2)-adrenergic receptor antagonist, yohimbine, a β-adrenergic receptor antagonist, propranolol, a mixed 5-ht(1)/5-ht(2) serotonergic receptor antagonist, methysergide, a nonselective 5-ht(2) serotonergic receptor antagonist, cyproheptadine, a nonselective muscarinic acetylcholine receptor antagonist, atropine, a d(2),d(3),d(4) dopamine receptor antagonist, haloperidol, or a γ-aminobutyric acid subunit a receptor antagonist, bicuculline. |
2013-06-10 |
2023-08-12 |
mouse |
| M Mutseura, D Tagwireyi, L L Gadag. Pre-treatment of BALB/c mice with a centrally acting serotonin antagonist (cyproheptadine) reduces mortality from Boophone disticha poisoning. Clinical toxicology (Philadelphia, Pa.). vol 51. issue 1. 2013-03-07. PMID:23194021. |
pre-treatment of balb/c mice with a centrally acting serotonin antagonist (cyproheptadine) reduces mortality from boophone disticha poisoning. |
2013-03-07 |
2023-08-12 |
mouse |
| M Mutseura, D Tagwireyi, L L Gadag. Pre-treatment of BALB/c mice with a centrally acting serotonin antagonist (cyproheptadine) reduces mortality from Boophone disticha poisoning. Clinical toxicology (Philadelphia, Pa.). vol 51. issue 1. 2013-03-07. PMID:23194021. |
the present work sought to test that hypothesis by investigating whether pre-treatment of b. disticha poisoned balb/c mice with the cns acting serotonin antagonist, cyproheptadine, has a dose-dependent protective effect on toxicity and mortality. |
2013-03-07 |
2023-08-12 |
mouse |