| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andréa Dias Elpo Zomkowski, Angelo Oscar Rosa, Jaime Lin, Adair R S Santos, João Batista Calixto, Ana Lúcia Severo Rodrigue. Evidence for serotonin receptor subtypes involvement in agmatine antidepressant like-effect in the mouse forced swimming test. Brain research. vol 1023. issue 2. 2005-01-24. PMID:15374751. |
), an inhibitor of serotonin synthesis, for 4 consecutive days), methysergide (5 mg/kg, i.p., a serotonin (5-ht) antagonist), pindolol (32 mg/kg, i.p., a 5-ht(1a/1b) receptor/beta-adrenoceptor antagonist), n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-n-(2-pyridynyl)cyclohexanecarboxamide (way 100635; 0.3 mg/kg, subcutaneously (s.c.), a selective 5-ht(1a) receptor antagonist), 1-(2-methoxyphenyl)-4[-(2-phthalimido)butyl]piperazine) (nan-190; 0.5 mg/kg, i.p., a 5-ht(1a) receptor antagonist), 1-(2-(1-pyrrolyl)-phenoxy)-3-isopropylamino-2-propanol (isamoltane; 2.5 mg/kg, i.p., a 5-ht(1b) receptor antagonist), cyproheptadine (3 mg/kg, i.p., a 5-ht(2) antagonist) or ketanserin (5 mg/kg, i.p., a 5-ht(2a/2c) receptor antagonist), but not with propranolol (2 mg/kg, i.p., a beta-adrenoceptor antagonist), prevented the effect of agmatine (10 mg/kg, i.p.) |
2005-01-24 |
2023-08-12 |
mouse |
| Simonetta Lorenzon, Sara Brezovec, Enrico A Ferrer. Species-specific effects on hemolymph glucose control by serotonin, dopamine, and L-enkephalin and their inhibitors in Squilla mantis and Astacus leptodactylus (crustacea). Journal of experimental zoology. Part A, Comparative experimental biology. vol 301. issue 9. 2005-01-18. PMID:15559934. |
5-ht1-like receptors are more involved in mediating serotonin action as co-injected cyproheptadine was a more effective antagonist than ketanserin (5-ht2-like receptor inhibitor). |
2005-01-18 |
2023-08-12 |
Not clear |
| Salim Yalcin Inan, Ipek Yalcin, Fazilet Aks. Dual effects of nitric oxide in the mouse forced swimming test: possible contribution of nitric oxide-mediated serotonin release and potassium channel modulation. Pharmacology, biochemistry, and behavior. vol 77. issue 3. 2004-10-22. PMID:15006455. |
in addition, we used sertraline as a serotonin reuptake inhibitor and cyproheptadine as a serotonin antagonist. |
2004-10-22 |
2023-08-12 |
mouse |
| Suzana Ljubojević, Jasna Lipozencić, Nives Pustise. Erythromelalgia. Acta dermatovenerologica Croatica : ADC. vol 12. issue 2. 2004-09-24. PMID:15075045. |
the most useful oral medications for erythromelalgia seem to be aspirin, propranolol, clonazepam, cyproheptadine, drugs inhibiting serotonin re-uptake (venlafaxine and sertraline), tricyclic antidepressants (amitriptyline, imipramine), anticonvulsants (gabapentin), calcium antagonists (nifedipine, diltiazem), and prostaglandins (micoprostol). |
2004-09-24 |
2023-08-12 |
Not clear |
| Abegale W Hartfield, Nicholas A Moore, Peter G Clifto. Serotonergic and histaminergic mechanisms involved in intralipid drinking? Pharmacology, biochemistry, and behavior. vol 76. issue 2. 2004-06-18. PMID:14592676. |
to examine the possible contribution of serotonin (5-ht) and histamine (h) receptor blockade in antipsychotic-associated hyperphagia, rats were trained to drink a palatable, high-calorie fat emulsion (10% intralipid) during 30-min sessions and were tested following pretreatment with mepyramine (h1 receptor antagonist), metergoline (5-ht(1/2) receptor antagonist), cyproheptadine (h1 and 5-ht(2a/2b/2c) and muscarinic receptor antagonist), sb 242084 (5-ht2c receptor antagonist) and an sb 242084-mepyramine combination. |
2004-06-18 |
2023-08-12 |
rat |
| Abegale W Hartfield, Nicholas A Moore, Peter G Clifto. Serotonergic and histaminergic mechanisms involved in intralipid drinking? Pharmacology, biochemistry, and behavior. vol 76. issue 2. 2004-06-18. PMID:14592676. |
conversely, simultaneous blockade of h1, 5-ht(2a/2c) and muscarinic receptors (cyproheptadine) led to a substantial hyperphagia and pattern of ingestive behaviour that was similar to that previously observed with some newer antipsychotic agents. |
2004-06-18 |
2023-08-12 |
rat |
| Narendra Gunja, Michael Collins, Andis Graudin. A comparison of the pharmacokinetics of oral and sublingual cyproheptadine. Journal of toxicology. Clinical toxicology. vol 42. issue 1. 2004-04-27. PMID:15083941. |
cyproheptadine is reported to be effective in treating serotonin syndrome. |
2004-04-27 |
2023-08-12 |
Not clear |
| J M Mancilla-Díaz, R E Escartín-Pérez, V E López-Alons. The effects of 5-HT on feeding behaviour in mianserin- or cyproheptadine-pretreated rats. Eating and weight disorders : EWD. vol 8. issue 4. 2004-04-21. PMID:15018375. |
we examined the effects of 5-ht on the feeding behaviour patterns of rats pretreated with mianserin (5-ht(1b/2a/1d receptor antagonist) or cyproheptadine (a 5-ht(2c) receptor antagonist), injected into the pariventricular hypothalamus nucleus (pvn). |
2004-04-21 |
2023-08-12 |
rat |
| J M Mancilla-Díaz, R E Escartín-Pérez, V E López-Alons. The effects of 5-HT on feeding behaviour in mianserin- or cyproheptadine-pretreated rats. Eating and weight disorders : EWD. vol 8. issue 4. 2004-04-21. PMID:15018375. |
the results indicate that the suppressive effect of 5-ht on carbohydrate intake can be blocked by mianserin and cyproheptadine even at the onset of the natural (dark) feeding period; however, this is a distinct blockade in the paradigm of feeding behavior. |
2004-04-21 |
2023-08-12 |
rat |
| Mamunur Rashid, Habib Abul Muntasir, Masatomo Watanabe, Mikio Nakazawa, Masanobu Ozaki, Takafumi Nagatom. Assessment of affinities and dissociation potencies of several 5-HT2 antagonists to and from M2 muscarinic receptor in rat heart membranes. Biological & pharmaceutical bulletin. vol 26. issue 8. 2004-04-07. PMID:12913274. |
the 5-ht(2) antagonists used in this study were sarpogrelate, ketanserin and cyproheptadine. |
2004-04-07 |
2023-08-12 |
rat |
| Yu-Ming Kang, Jian-Yong Chen, Wei Ouyang, Jian-Tian Qiao, Cruz Reyes-Vazquez, Nachum Dafn. Serotonin modulates hypothalamic neuronal activity. The International journal of neuroscience. vol 114. issue 3. 2004-03-22. PMID:14754657. |
the results showed that (1) of 385 arcuate neurons observed, the patterns of spontaneous firing were divided into 3 categories: "slow irregular" (46.0%), "fast continuous" (22.6%), and "bursting" firing (31.4%); (2) of 149 neurons tested for 5-ht, most (55.0%) responded to the drug by decreasing firing rate, 22.2% by increasing firing rate, 11.4% exhibit biphasic pattern, and 11.4% did not respond to 5-ht application; (3) substitution of low ca2-high mg2+ artificial cerebrospinal fluid (acsf) for normal acsf did not abolish the 5-ht-induced excitatory effect while it did abolish the 5-ht-induced inhibitory effect, suggesting the effect in latter cases was elicited by a ca2+-dependent release of neuroactive substances; (4) cyproheptadine, a non-selective 5-ht receptor antagonist, antagonized the 5-ht-induced excitatory effect in all neurons tested, while pindolol, a 5-ht1a/1b receptor antagonist, antagonized the 5-ht-induced excitatory effect in 50% of neurons tested; (5) both cyproheptadine and pindolol antagonized the 5-ht-induced inhibitory effect; and (6) bicuculline, a gabaa receptor antagonist, antagonized the 5-ht-induced inhibitory effect. |
2004-03-22 |
2023-08-12 |
rat |
| Ana M Barbosa, Renata O do Amaral, Catarina F P Teixeira, Stephen Hyslop, José C Cog. Pharmacological characterization of mouse hind paw oedema induced by Bothrops insularis (jararaca ilhoa) snake venom. Toxicon : official journal of the International Society on Toxinology. vol 42. issue 5. 2004-03-04. PMID:14529733. |
the peak oedematogenic response occurred 3 h after venom injection with all doses and decreased gradually thereafter, but was still elevated with high doses after 24 h. pretreating the mice with cyproheptadine (histamine h(1) and serotonin 5-ht(2) receptor antagonist), mepyramine (histamine h(1) receptor antagonist), l-name (inhibitor of nitric oxide synthase), indomethacin and rofecoxib (inhibitors of cyclooxygenases), and dexamethasone (indirect inhibitor of pla(2)) significantly attenuated venom-induced oedema, whereas methysergide, a serotonin 5-ht(1)/5-ht(2) receptor antagonist, had no effect. |
2004-03-04 |
2023-08-12 |
mouse |
| Goudarz Molaei, Angela B Lang. The association of serotonin with the alimentary canal of the African migratory locust, Locusta migratoria: distribution, physiology and pharmacological profile. Journal of insect physiology. vol 49. issue 11. 2004-02-26. PMID:14568585. |
the serotonin antagonist cyproheptadine was less effective leading to a 39% reduction of the 5x10(-6) m serotonin-induced relaxation. |
2004-02-26 |
2023-08-12 |
Not clear |
| G D Baige. Cyproheptadine and the treatment of an unconscious patient with the serotonin syndrome. European journal of anaesthesiology. vol 20. issue 7. 2003-11-05. PMID:12884999. |
cyproheptadine and the treatment of an unconscious patient with the serotonin syndrome. |
2003-11-05 |
2023-08-12 |
Not clear |
| Michael Poyurovsky, Svetlana Epshtein, Camil Fuchs, Michael Schneidman, Ronit Weizman, Abraham Weizma. Efficacy of low-dose mirtazapine in neuroleptic-induced akathisia: a double-blind randomized placebo-controlled pilot study. Journal of clinical psychopharmacology. vol 23. issue 3. 2003-10-23. PMID:12826992. |
the nonselective serotonin (5-ht)-2a antagonists ritanserin, mianserin, and cyproheptadine were found efficacious in neuroleptic-induced akathisia (nia). |
2003-10-23 |
2023-08-12 |
Not clear |
| Gennady A Buznikov, Lyudmila A Nikitina, Elena E Voronezhskaya, Vladimir V Bezuglov, A O Dennis Willows, Leonid P Nezli. Localization of serotonin and its possible role in early embryos of Tritonia diomedea(Mollusca: Nudibranchia). Cell and tissue research. vol 311. issue 2. 2003-10-15. PMID:12596045. |
antagonists of 5-ht(2) receptors, ritanserin and cyproheptadine, as well as lipophilic derivatives of dopamine blocked cleavage divisions or distorted their normal pattern. |
2003-10-15 |
2023-08-12 |
Not clear |
| Louis F Gainey, James C Walton, Michael J Greenber. Branchial musculature of a venerid clam: pharmacology, distribution, and innervation. The Biological bulletin. vol 204. issue 1. 2003-10-14. PMID:12588747. |
the 5ht antagonists cyproheptadine and mianserin blocked the contractile effects of all of the agonists. |
2003-10-14 |
2023-08-12 |
Not clear |
| Peter P Fong, Caroline M Philbert, Brian J Robert. Putative serotonin reuptake inhibitor-induced spawning and parturition in freshwater bivalves is inhibited by mammalian 5-HT2 receptor antagonists. Journal of experimental zoology. Part A, Comparative experimental biology. vol 298. issue 1. 2003-10-07. PMID:12840841. |
we have elucidated further the pharmacology of ssri-induced spawning and part-urition by blocking these reproductive processes with two mammalian 5-ht(2) receptor antagonists, cyproheptadine and mianserin. |
2003-10-07 |
2023-08-12 |
Not clear |
| S Krishnakumar, E P Holmes, R M Moore, L Kappel, C S Venugopa. Non-adrenergic non-cholinergic excitatory innervation in the airways: role of neurokinin-2 receptors. Autonomic & autacoid pharmacology. vol 22. issue 4. 2003-09-23. PMID:12656947. |
5 the involvement of the putative neurotransmitters such as neurokinin-a (nk-a), histamine, serotonin and endothelin (et) was investigated by using the respective antagonists, men-10376, pyrilamine maleate, cyproheptadine hydrochloride, and two et receptor antagonists (bq-123 and irl-1038), respectively. |
2003-09-23 |
2023-08-12 |
Not clear |
| S Krishnakumar, E P Holmes, R M Moore, L Kappel, C S Venugopa. Non-adrenergic non-cholinergic excitatory innervation in the airways: role of neurokinin-2 receptors. Autonomic & autacoid pharmacology. vol 22. issue 4. 2003-09-23. PMID:12656947. |
the 5-ht antagonist, cyproheptadine, significantly enhanced the nanc-e response. |
2003-09-23 |
2023-08-12 |
Not clear |