| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B Z Horowitz, M E Mullin. Cyproheptadine for serotonin syndrome in an accidental pediatric sertraline ingestion. Pediatric emergency care. vol 15. issue 5. 1999-12-21. PMID:10532660. |
cyproheptadine for serotonin syndrome in an accidental pediatric sertraline ingestion. |
1999-12-21 |
2023-08-12 |
Not clear |
| B Z Paul, J Jin, S P Kunapul. Molecular mechanism of thromboxane A(2)-induced platelet aggregation. Essential role for p2t(ac) and alpha(2a) receptors. The Journal of biological chemistry. vol 274. issue 41. 1999-11-09. PMID:10506165. |
furthermore, u46619-induced intracellular calcium mobilization and shape change were unaffected by a3p5p, a p2y1 receptor-selective antagonist, and/or cyproheptadine, a 5-hydroxytryptamine subtype 2a receptor antagonist. |
1999-11-09 |
2023-08-12 |
human |
| L Wang, S Cai, Z Huang, Q Shao, R Ma, J Zha. Serotonin receptor subtypes that depolarize guinea pig inferior mesenteric ganglion neurons. Brain research. vol 839. issue 1. 1999-10-20. PMID:10482795. |
cyproheptadine, a 5-ht(1/2) receptor antagonist, reversibly inhibited the slow, but not the fast, depolarization and ls-epsp in the 5-ht-sensitive neurons. |
1999-10-20 |
2023-08-12 |
Not clear |
| F Lovren, X F Li, J Lytton, C Triggl. Functional characterization and m-RNA expression of 5-HT receptors mediating contraction in human umbilical artery. British journal of pharmacology. vol 127. issue 5. 1999-10-05. PMID:10455272. |
several 5-ht2 selective receptor antagonists (spiperone, cyproheptadine, pirenperone) competitively inhibited responses to 5-ht. |
1999-10-05 |
2023-08-12 |
human |
| P K Gillma. The serotonin syndrome and its treatment. Journal of psychopharmacology (Oxford, England). vol 13. issue 1. 1999-06-28. PMID:10221364. |
there is some evidence suggesting the efficacy of chlorpromazine and cyproheptadine in the treatment of serotonin syndrome. |
1999-06-28 |
2023-08-12 |
Not clear |
| H S Kim, I S Park, H K Lim, H S Cho. NMDA receptor antagonists enhance 5-HT2 receptor-mediated behavior, head-twitch response, in PCPA-treated mice. Archives of pharmacal research. vol 22. issue 2. 1999-06-28. PMID:10230499. |
in addition, the enhancement of 5-ht-induced htr was inhibited by a dopamine agonist, apomorphine, nmda receptor antagonist, nmda and a serotonin 5-ht2 receptor antagonist, cyproheptadine, in pcpa-treated mice. |
1999-06-28 |
2023-08-12 |
mouse |
| Y Ohta, T Kobayashi, I Ishigur. Role of endogenous serotonin and histamine in the pathogenesis of gastric mucosal lesions in unanaesthetised rats with a single treatment of compound 48/80, a mast cell degranulator. Pharmacological research. vol 39. issue 4. 1999-06-15. PMID:10208755. |
), gastric lesions occurred with increased serum serotonin and histamine levels and reduced gastric mucosal blood flow at 0.5 h after the injection and developed at 3 h. pretreatment with either cyproheptadine (a serotonin and histamine antagonist) or methysergide (a serotonin antagonist) prevented the formation of gastric mucosal lesions with attenuation of reduced gastric mucosal blood flow at 0.5 h after compound 48/80 injection, while pretreatment with either amitriptyline (a selective inhibitor of histamine release from mast cells), tripelennamine (a histamine h1-receptor antagonist), famotidine (a histamine h2-receptor antagonist) or cimetidine (a histamine h2-receptor antagonist) had no effect. |
1999-06-15 |
2023-08-12 |
rat |
| B A Chua, A M Perk. The pulmonary neuroendocrine system and drainage of the fetal lung: effects of serotonin. General and comparative endocrinology. vol 113. issue 3. 1999-05-07. PMID:10068499. |
serotonin receptors were involved, since 10(-6) m cyproheptadine abolished responses (based on 24 preparations). |
1999-05-07 |
2023-08-12 |
Not clear |
| B S Chan, A Graudins, I M Whyte, A H Dawson, G Braitberg, G G Duggi. Serotonin syndrome resulting from drug interactions. The Medical journal of Australia. vol 169. issue 10. 1999-01-07. PMID:9861909. |
management included supportive care and the use of non-specific serotonin antagonists (cyproheptadine, benzodiazepines and chlorpromazine). |
1999-01-07 |
2023-08-12 |
Not clear |
| G D Yu, X P Wei, H Q Zhang, S Xu, Q Z Yin, P L Tang, Z M Qia. [Effect of dorsal raphe nucleus stimulation on unit discharges of light-sensitive neurons of suprachiasmatic nucleus in rats]. Sheng li xue bao : [Acta physiologica Sinica]. vol 49. issue 3. 1998-12-16. PMID:9812817. |
pharmacologically, this inhibition could be enhanced by monoamine oxidase inhibitor pargyline, attenuated by 5-hydroxytryptamine (5-ht) synthesis inhibitor parachlorophenylalanine and blocked by 5-ht receptor antagonist cyproheptadine. |
1998-12-16 |
2023-08-12 |
rat |
| W J HAL. The action of tyramine on the dog isolated atrium. British journal of pharmacology and chemotherapy. vol 20. 1998-11-01. PMID:13952141. |
the use of an antihistamine and an anti-5-hydroxytryptamine agent (cyproheptadine) appeared to exclude the possibility that the effect was due to the release of histamine or 5-hydroxytryptamine from the atrium by tyramine. |
1998-11-01 |
2023-08-12 |
rat |
| A Graudins, A Stearman, B Cha. Treatment of the serotonin syndrome with cyproheptadine. The Journal of emergency medicine. vol 16. issue 4. 1998-10-06. PMID:9696181. |
treatment of the serotonin syndrome with cyproheptadine. |
1998-10-06 |
2023-08-12 |
Not clear |
| A Graudins, A Stearman, B Cha. Treatment of the serotonin syndrome with cyproheptadine. The Journal of emergency medicine. vol 16. issue 4. 1998-10-06. PMID:9696181. |
the role of specific serotonin receptor antagonists such as cyproheptadine in the treatment of the serotonin syndrome remains to be delineated. |
1998-10-06 |
2023-08-12 |
Not clear |
| J M Strayhor. Case study: cyproheptadine and aggression in a five-year-old boy. Journal of the American Academy of Child and Adolescent Psychiatry. vol 37. issue 6. 1998-07-09. PMID:9628088. |
cyproheptadine is an antihistamine and serotonin antagonist given to children for allergies, migraine headaches, and growth problems. |
1998-07-09 |
2023-08-12 |
Not clear |
| J M Strayhor. Case study: cyproheptadine and aggression in a five-year-old boy. Journal of the American Academy of Child and Adolescent Psychiatry. vol 37. issue 6. 1998-07-09. PMID:9628088. |
although there are other causal explanations possible in this case, cyproheptadine seems the most likely cause of the violent behavior, especially in view of the literature on the relation between serotonin and aggression. |
1998-07-09 |
2023-08-12 |
Not clear |
| B Levine, D Green-Johnson, S Hogan, J E Smiale. A cyproheptadine fatality. Journal of analytical toxicology. vol 22. issue 1. 1998-06-25. PMID:9491973. |
comprehensive testing for abused and therapeutic drugs in the blood and urine identified cyproheptadine, a serotonin and histamine antagonist. |
1998-06-25 |
2023-08-12 |
Not clear |
| E C Landucci, R C Castro, M F Pereira, A C Cintra, J R Giglio, S Marangoni, B Oliveira, G Cirino, E Antunes, G De Nucc. Mast cell degranulation induced by two phospholipase A2 homologues: dissociation between enzymatic and biological activities. European journal of pharmacology. vol 343. issue 2-3. 1998-06-09. PMID:9570475. |
these oedematogenic activities were largely reduced in animals pretreated with the histamine/5-hydroxytryptamine (5-ht) receptor antagonist cyproheptadine (2 mg/kg, i.p. |
1998-06-09 |
2023-08-12 |
rat |
| D Balsa, M Merlos, M Giral, R Ferrando, J Garcia-Rafanell, J For. Effect of endotoxin and platelet-activating factor on rat vascular permeability: role of vasoactive mediators. Journal of lipid mediators and cell signalling. vol 17. issue 1. 1998-04-21. PMID:9302653. |
the cyclooxygenase inhibitor indomethacin (5 mg/kg) in trachea (78%) and seminal vesicle (64%), the serotonin and h1 antagonists cyproheptadine (2 mg/kg) in trachea (88%) and stomach (56%) and the dual cyclooxygenase/lipoxygenase inhibitor phenidone (10 mg/kg) in seminal vesicle (87%). |
1998-04-21 |
2023-08-12 |
rat |
| Y Miyazawa, H Tsutsui, H Mizuhara, H Fujiwara, K Kaned. Involvement of intrasinusoidal hemostasis in the development of concanavalin A-induced hepatic injury in mice. Hepatology (Baltimore, Md.). vol 27. issue 2. 1998-03-09. PMID:9462649. |
reduction in the extent of hemostasis by the treatment with heparin (thrombin inhibitor) or cyproheptadine (serotonin inhibitor) decreased hepatic injury. |
1998-03-09 |
2023-08-12 |
mouse |
| A Keller Ashton, R Hamer, R C Rose. Serotonin reuptake inhibitor-induced sexual dysfunction and its treatment: a large-scale retrospective study of 596 psychiatric outpatients. Journal of sex & marital therapy. vol 23. issue 3. 1997-12-02. PMID:9292832. |
in the present study, a large-scale retrospective case review was undertaken to assess the incidence and type of sexual dysfunctions associated with serotonin reuptake inhibitor (sri) therapy, in addition to the effects of three pharmacological antidotes (yohimbine, amantadine, cyproheptadine) on sri-induced sexual dysfunctions. |
1997-12-02 |
2023-08-12 |
Not clear |