| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Motoko Honda, Takashi Nishida, Hideki On. Tricyclic analogs cyclobenzaprine, amitriptyline and cyproheptadine inhibit the spinal reflex transmission through 5-HT(2) receptors. European journal of pharmacology. vol 458. issue 1-2. 2003-05-16. PMID:12498911. |
tricyclic analogs cyclobenzaprine, amitriptyline and cyproheptadine inhibit the spinal reflex transmission through 5-ht(2) receptors. |
2003-05-16 |
2023-08-12 |
rat |
| Motoko Honda, Takashi Nishida, Hideki On. Tricyclic analogs cyclobenzaprine, amitriptyline and cyproheptadine inhibit the spinal reflex transmission through 5-HT(2) receptors. European journal of pharmacology. vol 458. issue 1-2. 2003-05-16. PMID:12498911. |
in the present study, we attempted to elucidate the relationship between 5-ht(2) receptor antagonistic and inhibitory effects of cyclobenzaprine, amitriptyline, cyproheptadine and ketanserin on the spinal reflexes. |
2003-05-16 |
2023-08-12 |
rat |
| Motoko Honda, Takashi Nishida, Hideki On. Tricyclic analogs cyclobenzaprine, amitriptyline and cyproheptadine inhibit the spinal reflex transmission through 5-HT(2) receptors. European journal of pharmacology. vol 458. issue 1-2. 2003-05-16. PMID:12498911. |
these results suggest that the inhibitory effects of cyclobenzaprine, amitriptyline, and cyproheptadine on mono- and polysynaptic reflex potentials are due to the inhibition of descending serotonergic systems through 5-ht(2) receptors in the spinal cord. |
2003-05-16 |
2023-08-12 |
rat |
| Jonathan E Cohen, Chiadi U Onyike, Virginia L McElroy, Allison H Lin, Thomas W Abram. Pharmacological characterization of an adenylyl cyclase-coupled 5-HT receptor in aplysia: comparison with mammalian 5-HT receptors. Journal of neurophysiology. vol 89. issue 3. 2003-05-09. PMID:12611939. |
eight of the 14 antagonists tested were effective against 5-ht(apac) in cns membranes with the following rank order of potency: methiothepin > metergoline approximately fluphenazine > clozapine > cyproheptadine approximately risperidone approximately ritanserin > nan-190. |
2003-05-09 |
2023-08-12 |
aplysia |
| Jonathan E Cohen, Chiadi U Onyike, Virginia L McElroy, Allison H Lin, Thomas W Abram. Pharmacological characterization of an adenylyl cyclase-coupled 5-HT receptor in aplysia: comparison with mammalian 5-HT receptors. Journal of neurophysiology. vol 89. issue 3. 2003-05-09. PMID:12611939. |
consistent with cyproheptadine blocking 5-ht stimulation of ac, cyproheptadine also blocked the 5-ht-induced increase in sn excitability. |
2003-05-09 |
2023-08-12 |
aplysia |
| V V Nefedova, E V Inzhevatkin, V P Nefedo. Role of S2 receptors in the stimulatory effect of serotonin on hemopoietic bone marrow stem cells. Bulletin of experimental biology and medicine. vol 133. issue 5. 2003-03-20. PMID:12420048. |
studies by the method of splenic exocolonies with serotonin receptor blockers methysergide and cyproheptadine showed that s2 receptors are involved in the stimulatory effect of serotonin on hemopoietic bone marrow stem cells. |
2003-03-20 |
2023-08-12 |
Not clear |
| Nicoletta Sonino, Giovanni A Fav. Residual symptoms in depression an emerging therapeutic concept. Progress in neuro-psychopharmacology & biological psychiatry. vol 26. issue 4. 2003-03-12. PMID:12188108. |
since central serotonergic regulation could have a role in the course of cushing's disease, serotonin antagonists (e.g., cyproheptadine, ritanserin and ketanserin) have been employed. |
2003-03-12 |
2023-08-12 |
Not clear |
| Karl-Erik Eilertsen, Bjarne Østeru. The central role of thromboxane and platelet activating factor receptors in ex vivo regulation of endotoxin-induced monocyte tissue factor activity in human whole blood. Journal of endotoxin research. vol 8. issue 4. 2003-02-11. PMID:12230918. |
in this study, steps in the regulatory pathways of lipopolysaccharide (lps)-induced monocyte tf activity and released tnf-alpha in human whole blood were probed for using an array of inhibitors, comprising specific inhibitors of cytosolic phospholipase a(2) (pla(2)) (aacocf(3)), secretory pla(2) (sb-203347), protein kinase (pk) (staurosporine), pkc (gf-109203; bim), and serine protease (pefabloc sc), antagonists of thromboxane prostanoid (tp) receptor (r) (sq-29548), platelet activating factor (paf) r (bn-52021), leukotriene b(4) r (sc-41930), serotonin r (cyproheptadine), fibronectin/fibrinogen r (rgds), and finally, creatine phosphate/creatine phosphokinase (cp/cpk) which removes adp. |
2003-02-11 |
2023-08-12 |
human |
| Nicoletta Sonino, Giovanni A Fav. Erratum to "CNS drugs in Cushing's disease: pathophysiological and therapeutic implications for mood disorders" [Prog. Neuro-Psycol. Biol. Psychiatry, 26, 763 (2002)]. Progress in neuro-psychopharmacology & biological psychiatry. vol 26. issue 5. 2003-02-11. PMID:12369251. |
since central serotonergic regulation could have a role in the course of cushing's disease, serotonin antagonists (e.g., cyproheptadine, ritanserin and ketanserin) have been employed. |
2003-02-11 |
2023-08-12 |
Not clear |
| Yu-Ming Kang, Jian-Yong Chen, Wei Ouyang, Jian-Tian Qia. Serotonin excites arcuate neurons directly but inhibits them through intercalated GABAergic neurons. Sheng li xue bao : [Acta physiologica Sinica]. vol 54. issue 3. 2002-11-22. PMID:12075463. |
the results showed that (1) of 149 neurons selected randomly and tested for 5-ht application, 33 (22.2%) were excited, 82 (55.0%) were inhibited, and 34 (22.8%) showed biphasic responses or failed to respond; (2) substitution of low ca(2+)-high mg(2+) artificial cerebrospinal fluid (acsf) for normal acsf abolished the 5-ht-induced inhibitory effect but failed to affect the 5-ht-induced excitatory effect; (3) cyproheptadine, a non-selective 5-ht receptor antagonist, could block either the 5-ht-induced excitatory or inhibitory effects in all neurons tested; and (4) bicuculline, a gaba(a)-receptor antagonist, blocked the 5-ht-induced inhibitory effect. |
2002-11-22 |
2023-08-12 |
rat |
| María-Angeles Honrubia, Jordi Rodrigo, María-Isabel Cadavid, José María Calleja, Ferran Sanz, María-Isabel Loz. Influence of pH on the binding of diphenylmethylenepiperidines by 5-HT2B receptors in rat stomach fundus. Chemical & pharmaceutical bulletin. vol 50. issue 3. 2002-09-25. PMID:11911205. |
consequently, we studied the protonation influence (by varying the ph of the medium) on the antagonism of serotonin by some cyproheptadine analogues in rat stomach fundus. |
2002-09-25 |
2023-08-12 |
rat |
| C Küçükhüseyin, N Akbaş, D O Yilla. Effect of ondansetron on the contractile responses to positive inotropic agents in electrically driven left atria of rats. Journal of basic and clinical physiology and pharmacology. vol 12. issue 4. 2002-08-06. PMID:11868904. |
the positive inotropic effect of 5-ht was abolished almost completely by cyproheptadine (2 microg/ml) and was reversed only partially by pretreatment with reserpine (1 or 3 mg/kg). |
2002-08-06 |
2023-08-12 |
rat |
| G K Isbiste. Comment: serotonin syndrome, mydriasis, and cyproheptadine. The Annals of pharmacotherapy. vol 35. issue 12. 2002-06-11. PMID:11793643. |
comment: serotonin syndrome, mydriasis, and cyproheptadine. |
2002-06-11 |
2023-08-12 |
Not clear |
| T Fischel, H Hermesh, D Aizenberg, Z Zemishlany, H Munitz, Y Benjamini, A Weizma. Cyproheptadine versus propranolol for the treatment of acute neuroleptic-induced akathisia: a comparative double-blind study. Journal of clinical psychopharmacology. vol 21. issue 6. 2002-05-07. PMID:11763011. |
the antiakathisic effect of cyproheptadine may be mostly attributable to its serotonin antagonistic activity. |
2002-05-07 |
2023-08-12 |
Not clear |
| S D Gleason, V L Lucaites, H E Shannon, D L Nelson, J D Leande. m-CPP hypolocomotion is selectively antagonized by compounds with high affinity for 5-HT(2C) receptors but not 5-HT(2A) or 5-HT(2B) receptors. Behavioural pharmacology. vol 12. issue 8. 2002-04-08. PMID:11856898. |
furthermore, we investigated the effects of the non-selective serotonin antagonists, ritanserin, ly 53857, mianserin and cyproheptadine on m-cpp hypolocomotion. |
2002-04-08 |
2023-08-12 |
mouse |
| I B Chaudhry, S D Soni, J S E Hellewell, J F W Deaki. Effects of the 5HT antagonist cyproheptadine on neuropsychological function in chronic schizophrenia. Schizophrenia research. vol 53. issue 1-2. 2002-02-22. PMID:11728834. |
effects of the 5ht antagonist cyproheptadine on neuropsychological function in chronic schizophrenia. |
2002-02-22 |
2023-08-12 |
Not clear |
| W W McDanie. Serotonin syndrome: early management with cyproheptadine. The Annals of pharmacotherapy. vol 35. issue 7-8. 2001-12-11. PMID:11485136. |
serotonin syndrome: early management with cyproheptadine. |
2001-12-11 |
2023-08-12 |
Not clear |
| W W McDanie. Serotonin syndrome: early management with cyproheptadine. The Annals of pharmacotherapy. vol 35. issue 7-8. 2001-12-11. PMID:11485136. |
to report a psychiatric patient who developed serotonin syndrome after a medication overdose and whose marked mydriasis was quickly reversed by administration of cyproheptadine. |
2001-12-11 |
2023-08-12 |
Not clear |
| J D Connor, H Rasheed, A H Gilani, M Cheema, Z Rizvi, S A Saee. Second messengers in platelet aggregation evoked by serotonin and A23187, a calcium ionophore. Life sciences. vol 69. issue 23. 2001-12-07. PMID:11720080. |
synergism between 5-ht (2-5 microm) and a23187 (0.5-2 microm) was inhibited by 5-ht receptor blockers, methysergide (ic50 = 18 microm) and cyproheptadine (ic50 = 20 microm), and calcium channel blockers (verapamil and diltiazem, ic50 = 20 microm and 40 microm respectively). |
2001-12-07 |
2023-08-12 |
human |
| E B Nelson, V N Shah, J A Welge, P E Kec. A placebo-controlled, crossover trial of granisetron in SRI-induced sexual dysfunction. The Journal of clinical psychiatry. vol 62. issue 6. 2001-08-02. PMID:11465525. |
evidence from open-label reports suggests that cyproheptadine, nefazodone, mirtazapine, and mianserin, which block one or more serotonin receptors, may reverse sexual side effects. |
2001-08-02 |
2023-08-12 |
Not clear |