| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C M Olarte-Sánchez, L Valencia Torres, S Body, H J Cassaday, C M Bradshaw, E Szabadi, A J Goudi. A clozapine-like effect of cyproheptadine on progressive ratio schedule performance. Journal of psychopharmacology (Oxford, England). vol 26. issue 6. 2013-01-15. PMID:21890589. |
the atypical antipsychotic drug clozapine has multiple pharmacological actions, some of which, including 5-hydroxytryptamine (5-ht₂) and histamine (h₁) receptor antagonist effects, are shared by the non-selective 5-ht receptor antagonist cyproheptadine. |
2013-01-15 |
2023-08-12 |
rat |
| B Kacsóh, C E Grosveno. Regulation of Basal and nursing-induced secretion of growth hormone in the neonatal rat: the involvement of serotonergic, muscarinic cholinergic, alpha-adrenergic, somatostatin and growth hormone-releasing hormone systems. Journal of neuroendocrinology. vol 3. issue 5. 2012-10-02. PMID:19215503. |
the 5-ht antagonist cyproheptadine decreased serum gh levels in separated 2-day-old pups, and although it reduced the amplitude of the suckling-induced increase in serum gh concentration, it did not alter the increase in serum gh on a percentage basis. |
2012-10-02 |
2023-08-12 |
rat |
| C T Dourish, G A Kennett, G Curzo. The 5-HT1A agonists 8-OH-DPAT, buspirone and ipsapirone attenuate stress-induced anorexia in rats. Journal of psychopharmacology (Oxford, England). vol 1. issue 1. 2012-10-02. PMID:22158750. |
the benzodiazepines chlordiazepoxide and diazepam and the 5-ht antagonist cyproheptadine had no effect on stress-induced anorexia, when given (like the 5-ht(1a) agonists) 2 h after the stress. |
2012-10-02 |
2023-08-12 |
rat |
| R J Rauch, I P Stolerma. Midazolam cue in rats: effects of drugs acting on GABA and 5-hydroxytryptamine systems, anticonvulsants and sedatives. Journal of psychopharmacology (Oxford, England). vol 1. issue 2. 2012-10-02. PMID:22158887. |
there was no generalization to the gaba agonists muscimol and thip, to the 5-ht antagonists cyproheptadine and methergoline, to buspirone, cgs 9896, ethanol, ro 5-4864, promethazine, phenytoin sodium or sodium valproate. |
2012-10-02 |
2023-08-12 |
rat |
| A M Northover, B J Northove. Mast cell amines and inosineinduced vasoconstriction in the rat hind limb. Mediators of inflammation. vol 6. issue 2. 2012-09-10. PMID:18472848. |
the pressor effect of injected 5ht (400 mug) was abolished by pre-treatment with cyproheptadine, but not by pre-treatment with compound 48 80. |
2012-09-10 |
2023-08-12 |
rat |
| Bruno Campos, Benjamín Piña, Carlos Barata . Mechanisms of action of selective serotonin reuptake inhibitors in Daphnia magna. Environmental science & technology. vol 46. issue 5. 2012-05-29. PMID:22324381. |
d. magna reproduction tests, respiration, feeding, and survival-starvation assays and studies of lipids, proteins, and carbohydrate levels of unexposed and exposed females to the ssri fluoxetine and fluvoxamine and the 5-ht serotonin receptor antagonist cyproheptadine were conducted. |
2012-05-29 |
2023-08-12 |
Not clear |
| Bruno Campos, Benjamín Piña, Carlos Barata . Mechanisms of action of selective serotonin reuptake inhibitors in Daphnia magna. Environmental science & technology. vol 46. issue 5. 2012-05-29. PMID:22324381. |
these effects were reversed by the presence of cyproheptadine, indicating that 5-ht function was essential to the ssri effects on daphnia and linking them to the pharmacological effects of ssri in humans. |
2012-05-29 |
2023-08-12 |
Not clear |
| Elias B Nascimento, João Gabriel T Seniuk, Adriana M Godin, Wallace C Ferreira, Marcela B Dutra, Antônio Carlos P Oliveira, Leandro F S Bastos, Bernd L Fiebich, Márcio M Coelh. Peripheral 5-HT1B and 5-HT2A receptors mediate the nociceptive response induced by 5-hydroxytryptamine in mice. Pharmacology, biochemistry, and behavior. vol 99. issue 4. 2011-12-09. PMID:21699915. |
intraplantar injection of 5-ht (10, 20 or 40 μg) into the hind-paw of mice induced paw licking behavior, which was inhibited by previous intraplantar treatment with cyproheptadine (5-ht(1) and 5-ht(2) antagonist; 0.5 or 5 μg), mianserin (5-ht(2) and 5-ht(6) antagonist; 0.1 μg), isamoltane (5-ht(1b) antagonist; 0.5 or 5 μg) and ketanserin (5-ht(2a) antagonist; 0.1 or 1 μg), but not by brl 15572 (5-ht(1d) antagonist; 1 or 10 μg), ondansetron (5-ht(3) antagonist; 1, 5, 10 or 20 μg) and sb 269970 (5-ht(7) antagonist; 2.5 and 25 μg). |
2011-12-09 |
2023-08-12 |
mouse |
| Luis A Zarazaga, Irma Celi, José Luis Guzmán, Benoît Malpau. The role of nutrition in the regulation of luteinizing hormone secretion by the opioidergic, dopaminergic, and serotonergic systems in female Mediterranean goats. Biology of reproduction. vol 84. issue 3. 2011-06-14. PMID:20980689. |
the effects of intravenous injections of naloxone (endogenous opioid receptor antagonist), pimozide (dopaminergic(2) receptor antagonist), and cyproheptadine (serotonin 5-hydroxytryptamine(2) receptor antagonist) on lh secretion were assessed during challenges in three different photoperiodic situations: the onset of lh stimulation by short days (onsetsd), the onset of lh inhibition by long days (onsetld), and during the lh inhibition by long days (lateld). |
2011-06-14 |
2023-08-12 |
Not clear |
| Li-Tao Yi, He-Li Xu, Jing Feng, Xia Zhan, Li-Pan Zhou, Cun-Cang Cu. Involvement of monoaminergic systems in the antidepressant-like effect of nobiletin. Physiology & behavior. vol 102. issue 1. 2011-04-07. PMID:20951716. |
was completely prevented by the pretreatment of mice with way 100635 (0.1mg/kg, s.c., a serotonin 5-ht(1a) receptor antagonist), cyproheptadine (3mg/kg, i.p., a serotonin 5-ht(2) receptor antagonist), prazosin (62.5μg/kg, i.p., an α(1)-adrenoceptor antagonist), sch23390 (0.05mg/kg, s.c., a dopamine d(1) receptor antagonist) or sulpiride (50mg/kg, i.p., a dopamine d(2) receptor antagonist). |
2011-04-07 |
2023-08-12 |
mouse |
| Masaru Tanaka, Gyula Telegd. Involvement of adrenergic and serotonergic receptors in antidepressant-like effect of urocortin 3 in a modified forced swimming test in mice. Brain research bulletin. vol 77. issue 5. 2011-03-03. PMID:18793704. |
mice were pretreated with a non-selective α-adrenergic receptor antagonist, phenoxybenzamine, an α(1)/α(2β)-adrenergic receptor antagonist, prazosin, an α(2)-adrenergic receptor antagonist, yohimbine, a mixed 5-ht(1)/5-ht(2) serotonergic receptor antagonist, methysergide, a non-selective 5-ht(2) serotonergic receptor antagonist, cyproheptadine or a β-adrenergic receptor antagonist, propranolol. |
2011-03-03 |
2023-08-12 |
mouse |
| Maria Verena Cicala, Franco Manter. Hypertension in Cushing's syndrome: from pathogenesis to treatment. Neuroendocrinology. vol 92 Suppl 1. 2010-12-28. PMID:20829617. |
neuromodulatory agents such as the serotonin inhibitors cyproheptadine and ritanserin, valproid acid, dopamine agonists, somatostatin analogs may occasionally be effective, as well as drugs acting directly at the adrenal levels, such as ketoconazole and aminoglutetimide or even opddd. |
2010-12-28 |
2023-08-12 |
Not clear |
| Damanpreet Singh, Rajesh Kumar Goe. Proconvulsant potential of cyproheptadine in experimental animal models. Fundamental & clinical pharmacology. vol 24. issue 4. 2010-11-30. PMID:20002750. |
since, cyproheptadine interferes with these pathways via antagonizing subtypes of 5-ht(1/2) receptors and h(1) receptor, therefore the present study was undertaken to investigate its effect on seizures threshold, so as to substantiate its use in epileptics. |
2010-11-30 |
2023-08-12 |
mouse |
| Güner Ulak, Oguz Mutlu, Pelin Tanyeri, F Ipek Komsuoglu, Füruzan Yildiz Akar, B Faruk Erde. Involvement of serotonin receptor subtypes in the antidepressant-like effect of TRIM in the rat forced swimming test. Pharmacology, biochemistry, and behavior. vol 95. issue 3. 2010-11-01. PMID:20171242. |
pretreatment with methiothepin (0.1mg/kg, i.p, a non-selective 5-ht receptor antagonist), cyproheptadine (3mg/kg i.p, a 5-ht(2) receptor antagonist) or ketanserin (5mg/kg i.p, a 5ht(2a/2c) receptor antagonist) prevented the effect of trim (50mg/kg) in the fst. |
2010-11-01 |
2023-08-12 |
rat |
| Xi-Jian Zhou, Jun Yang, Fu-Lin Yan, Da-Xin Wang, Xiang-Yong Li, Xiao-Qiang Fan, Fang Hao, Xi-Qing Yan, Xue-Ping Li, Hui Li, Wen-Yan Liu, Bao-Cheng Li. Norepinephrine plays an important role in antinociceptive modulation of hypothalamic paraventricular nucleus in the rat. The International journal of neuroscience. vol 120. issue 6. 2010-09-14. PMID:20504214. |
the results showed: (1) pain stimulation increased norepinephrine (ne), but not epinephrine, dopamine (da), 3,4-dihydroxyphenylacetic acid (da metabolic product), homovanilic acid (da metabolic product), serotonin (5-ht), 5-hydroxyindoleacetic acid (5-ht metabolic product), acetycholine (ach), choline (ach metabolic product), gamma-aminobutyric acid (gaba), and l-glutamate acid concentrations in the pvn perfusion liquid; (2) pvn stimulation with l-glutamate sodium, which excited local neurons only, did not influence the concentrations of the studied classical neurotransmitter and metabolic product in the pvn perfusion liquid; (3) microinjection of ne, epinephrine, or l-glutamate sodium into the pvn elevated pain threshold, and local administration of gaba decreased pain threshold in a dose-dependent manner, but pvn administration of ach, da, or 5-ht did not change pain threshold; (4) microinjection of phentolamine (alpha-receptor antagonist) or mk801 [nmda-receptor antagonist] into the pvn reduced pain threshold, and local administration of bicuculline (gaba-receptor antagonist) raised pain threshold, but pvn administration of propranolol (beta-receptor antagonist), atropine (muscarinic cholinergic receptor antagonist), 6-oh gallamine (nicotinic cholinergic receptor antagonist), fluperidol (da-receptor antagonist), or cyproheptadine (5-ht-receptor antagonist) did not alter pain threshold. |
2010-09-14 |
2023-08-12 |
rat |
| Kevin M Crisp, Rebecca E Grupe, Tenzin T Lobsang, Xong Yan. Biogenic amines modulate pulse rate in the dorsal blood vessel of Lumbriculus variegatus. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 151. issue 4. 2010-06-08. PMID:20167287. |
this effect of 5-ht was weakly mimicked by 5-methoxytryptamine, but not by alpha-methylserotonin; it was completely blocked by clozapine and partially blocked by cyproheptadine. |
2010-06-08 |
2023-08-12 |
Not clear |
| Gongliang Zhang, Swapna Krishnamoorthy, Zhiyuan Ma, Nick P Vukovich, Xupei Huang, Rui Ta. Assessment of 5-hydroxytryptamine efflux in rat brain during a mild, moderate and severe serotonin-toxicity syndrome. European journal of pharmacology. vol 615. issue 1-3. 2009-11-10. PMID:19464285. |
in the last series of experiments, the excessive increases in 5-ht were pharmacologically separated into primary and secondary component effluxes with the 5-ht2a receptor antagonists cyproheptadine and ketanserin and nmda receptor antagonist (+)-mk-801. |
2009-11-10 |
2023-08-12 |
rat |
| Ivani A Desouza, Enilton A Camargo, Nadia S Mariano, João B Optiz-Neto, Jorge S Resende, Gláucia C Mello, Soraia K P Costa, Gilberto De Nucci, Edson Antune. Role of sensory innervation in the rat pulmonary neutrophil recruitment induced by staphylococcal enterotoxins type A and B. European journal of pharmacology. vol 613. issue 1-3. 2009-08-28. PMID:19375418. |
cyproheptadine (histamine/5-hydroxytriptamine receptor antagonist) and md 7222 (5-ht(3) receptor antagonist) reduced sea- and seb-induced neutrophil influx. |
2009-08-28 |
2023-08-12 |
rat |
| Steven Droogmans, Bram Roosens, Bernard Cosyns, Céline Degaillier, Sophie Hernot, Caroline Weytjens, Christian Garbar, Vicky Caveliers, Miriam Pipeleers-Marichal, Philippe R Franken, Tony Lahoutte, Danny Schoors, Guy Van Cam. Cyproheptadine prevents pergolide-induced valvulopathy in rats: an echocardiographic and histopathological study. American journal of physiology. Heart and circulatory physiology. vol 296. issue 6. 2009-07-17. PMID:19346455. |
therefore, we sought to determine whether cyproheptadine, a 5-ht(2b)r antagonist, might prevent toxic valvulopathy in an animal model of pergolide-induced valvular heart disease. |
2009-07-17 |
2023-08-12 |
rat |
| Steven Droogmans, Bram Roosens, Bernard Cosyns, Céline Degaillier, Sophie Hernot, Caroline Weytjens, Christian Garbar, Vicky Caveliers, Miriam Pipeleers-Marichal, Philippe R Franken, Tony Lahoutte, Danny Schoors, Guy Van Cam. Cyproheptadine prevents pergolide-induced valvulopathy in rats: an echocardiographic and histopathological study. American journal of physiology. Heart and circulatory physiology. vol 296. issue 6. 2009-07-17. PMID:19346455. |
in conclusion, we found that cyproheptadine prevented pergolide-induced valvulopathy in rats, which was associated with a reduced number of 5-ht(2b)r-positive valvular cells. |
2009-07-17 |
2023-08-12 |
rat |