| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yury Gerasimenko, Pavel Musienko, Irina Bogacheva, Tatiana Moshonkina, Alexandr Savochin, Igor Lavrov, Roland R Roy, V Reggie Edgerto. Propriospinal bypass of the serotonergic system that can facilitate stepping. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 17. 2009-06-03. PMID:19403834. |
cyproheptadine, a nonselective 5-ht blocker, prevented facilitation of stepping by epidural stimulation. |
2009-06-03 |
2023-08-12 |
Not clear |
| L S Lopes, S S Pereira, L L Silva, K A Figueiredo, B A Moura, F R C Almeida, F C F Sous. Antinociceptive effect of topiramate in models of acute pain and diabetic neuropathy in rodents. Life sciences. vol 84. issue 3-4. 2009-03-10. PMID:19056404. |
the antinociceptive effect caused by tp (80 mg/kg, p.o) in the formalin test was reversed by prior treatment with naloxone (opioid antagonist), but not with glibenclamide (antagonist of the potassium channel), ondansetron (antagonist of the serotonin 5ht3 receptor) or cyproheptadine (antagonist of the serotonin 5ht2a receptor).the data show that tp has an important antinociceptive effect in the models of nociception induced by chemical (formalin) or thermal (hot plate) stimuli, and that the opioid system plays a part in the antinociceptive effect, as shown by formalin. |
2009-03-10 |
2023-08-12 |
mouse |
| Dean Papaliodis, William Boucher, Duraisamy Kempuraj, Margaret Michaelian, Adams Wolfberg, Michael House, Theoharis C Theoharide. Niacin-induced "flush" involves release of prostaglandin D2 from mast cells and serotonin from platelets: evidence from human cells in vitro and an animal model. The Journal of pharmacology and experimental therapeutics. vol 327. issue 3. 2009-01-05. PMID:18784348. |
the phenothiazine prochlorperazine, the h(1), serotonin receptor antagonist cyproheptadine, and the specific serotonin receptor-2a antagonist ketanserin inhibit niacin-induced temperature increase by 90% (n = 5, p < 0.05), 90 and 50% (n = 3, p < 0.05), and 85% (n = 6, p = 0.0008), respectively, in this animal model. |
2009-01-05 |
2023-08-12 |
human |
| B U K Li, Frank Lefevre, Gisela G Chelimsky, Richard G Boles, Susanne P Nelson, Donald W Lewis, Steven L Linder, Robert M Issenman, Colin D Rudolp. North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition consensus statement on the diagnosis and management of cyclic vomiting syndrome. Journal of pediatric gastroenterology and nutrition. vol 47. issue 3. 2008-12-18. PMID:18728540. |
therapeutic recommendations include lifestyle changes, prophylactic therapy (eg, cyproheptadine in children 5 years or younger and amitriptyline for those older than 5), and acute therapy (eg, 5-hydroxytryptamine receptor agonists, termed triptans herein, as abortive therapy, and 10% dextrose and ondansetron for those requiring intravenous hydration). |
2008-12-18 |
2023-08-12 |
Not clear |
| C L Qu, F Q Huo, F S Huang, Y Q Li, J S Tang, H Ji. The role of 5-HT receptor subtypes in the ventrolateral orbital cortex of 5-HT-induced antinociception in the rat. Neuroscience. vol 152. issue 2. 2008-07-10. PMID:18295406. |
pretreatment with 5-ht receptor antagonists (1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl] piperazine hydrobromide (nan-190), cyproheptadine hydrochloride (cpt) and 1-methyl-n-(8-methyl-8-azabicyclo[3.2.3]-oct-3-yl)-1h-indazole-3-carboxamide maleate salt (ly-278,584)), specific for 5-ht(1a), 5-ht(2) and 5-ht(3) receptors, respectively, partially reversed the 5-ht-evoked inhibition. |
2008-07-10 |
2023-08-12 |
rat |
| Dae-Kwon Kim, Hyoung-June Kim, Hyuk Kim, Jae-Young Koh, Kwang-Mi Kim, Min-Soo Noh, Jung-Ju Kim, Chang-Hoon Le. Involvement of serotonin receptors 5-HT1 and 5-HT2 in 12(S)-HPETE-induced scratching in mice. European journal of pharmacology. vol 579. issue 1-3. 2008-04-15. PMID:18037400. |
additionally, chlopheniramine (h(1) receptor antagonist) did not suppress 12(s)-hpete-induced scratching, but cyproheptadine (h(1) receptor and serotonin 5-ht(2) receptor antagonist) potently suppressed the same response. |
2008-04-15 |
2023-08-12 |
mouse |
| Kaneez Fatima Shad, Sheik Arshad Saee. The metabolism of serotonin in neuronal cells in culture and platelets. Experimental brain research. vol 183. issue 3. 2008-04-04. PMID:17912506. |
this synergistic interaction between serotonin (2-5 microm) and a23187 (0.5-2 microm) was inhibited by serotonin receptor blockers [methysergide (ic50 = 18 microm) and cyproheptadine (ic50, 20 microm)] and calcium channel blockers (verapamil and diltiazem, ic50 = 20 and 40 microm, respectively) that indicate both mechanisms are receptor mediated. |
2008-04-04 |
2023-08-12 |
human |
| Elizabeth K Schooley, Joseph B McGee Turner, Renee D Jiji, Christine M Spinka, Carol R Reiner. Effects of cyproheptadine and cetirizine on eosinophilic airway inflammation in cats with experimentally induced asthma. American journal of veterinary research. vol 68. issue 11. 2008-01-10. PMID:17975984. |
to determine whether oral administration of cyproheptadine or cetirizine blocks the action of serotonin and histamine, respectively, and results in diminished eosinophilic airway inflammation in cats with experimentally induced asthma. |
2008-01-10 |
2023-08-12 |
Not clear |
| Silvana Soriano Frassetto, Angela Della Santa Rubio, Janaína Jardim Lopes, Patrícia Pereira, Clarice Brum, Márcia Khazzaka, Anapaula Sommer Vinagr. Locomotor and peripheral effects of sibutramine modulated by 5-HT2 receptors. Canadian journal of physiology and pharmacology. vol 84. issue 12. 2007-05-31. PMID:17487231. |
on the other hand, cyproheptadine antagonizes serotonin 5-ht(2a), 5-ht(2b), and 5-ht(2c), histamine h1, and muscarinic (m) receptors. |
2007-05-31 |
2023-08-12 |
rat |
| Habib Abul Muntasir, Mohiuddin Ahmed Bhuiyan, Masaji Ishiguro, Masanobu Ozaki, Takafumi Nagatom. Inverse agonist activity of sarpogrelate, a selective 5-HT2A-receptor antagonist, at the constitutively active human 5-HT2A receptor. Journal of pharmacological sciences. vol 102. issue 2. 2006-12-22. PMID:17031071. |
thus, the purpose of the present study was to investigate the inverse agonist activity of sarpogrelate, a selective 5-ht(2a)-receptor antagonist, and its active metabolite, m-1; and we compared their activities with those of other 5-ht(2a)-receptor antagonists such as ritanserin, ketanserin, and cyproheptadine. |
2006-12-22 |
2023-08-12 |
human |
| Takashi Yamamoto, Seiji Niwa, Satoshi Iwayama, Hajime Koganei, Shin-ichi Fujita, Tomoko Takeda, Morikazu Kito, Yukitsugu Ono, Yuki Saitou, Akira Takahara, Seinosuke Iwata, Hiroshi Yamamoto, Masataka Shoj. Discovery, structure-activity relationship study, and oral analgesic efficacy of cyproheptadine derivatives possessing N-type calcium channel inhibitory activity. Bioorganic & medicinal chemistry. vol 14. issue 15. 2006-09-22. PMID:16616501. |
antiallergic drug cyproheptadine (cyp) is known to have inhibitory activities for l-type calcium channels in addition to histamine and serotonin receptors. |
2006-09-22 |
2023-08-12 |
rat |
| A O Shpakov, V N Shipilov, V M Bondarev. Sensitivity of adenylyl cyclase signaling system of the mollusk Anodonta cygnea ganglions to serotonin and adrenergic agonists. Annals of the New York Academy of Sciences. vol 1040. 2006-08-29. PMID:15891091. |
the ac-stimulating action of serotonin and isoproterenol was blocked by cyproheptadine and adrenergic antagonists, respectively. |
2006-08-29 |
2023-08-12 |
Not clear |
| Bettina C Prato. Serotonin syndrome. The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses. vol 38. issue 2. 2006-06-28. PMID:16681290. |
serotonin antagonists, specifically cyproheptadine, have been used, but the documented benefits are purely anecdotal. |
2006-06-28 |
2023-08-12 |
Not clear |
| Mayur S Tripathi, Bhagavan S Jandhyal. Evaluation of the protective effects of histamine and 5-hydroxytryptamine receptor antagonists against the lethal toxicity induced by oxygen free radicals in rats. Clinical and experimental hypertension (New York, N.Y. : 1993). vol 28. issue 2. 2006-06-27. PMID:16546837. |
in contrast, pretreatment of the rats with nonspecific 5-ht antagonists, methysergide and cyproheptadine, and a selective 5-ht(2) receptor antagonist, ketanserin, markedly enhanced the survival rate to 80-90%. |
2006-06-27 |
2023-08-12 |
rat |
| Adel El-Bialy, Michael Shenoda, Chris Caraan. Refractory coronary vasospasm following drug-eluting stent placement treated with cyproheptadine. The Journal of invasive cardiology. vol 18. issue 2. 2006-06-08. PMID:16446528. |
the patient's symptoms were resistant to treatment with maximum doses of two calcium channel antagonists and oral and intravenous nitrates, but responded to cyproheptadine, a nonselective serotonin antagonist. |
2006-06-08 |
2023-08-12 |
human |
| F Ozdener, Z Gülbas, K Erol, V Ozdemi. 5-Hydroxytryptamine-2A receptor gene (HTR 2 A) candidate polymorphism (T 102 C): Role for human platelet function under pharmacological challenge ex vivo. Methods and findings in experimental and clinical pharmacology. vol 27. issue 6. 2006-01-20. PMID:16179957. |
because the circulating catecholamine hormone epinephrine can augment platelet aggregation, pharmacodynamic response (aggregation and its inhibition by 5-ht(2a) receptor antagonist cyproheptadine) was measured in the presence of both serotonin and epinephrine, to mimic the clinical situation in patients. |
2006-01-20 |
2023-08-12 |
human |
| Ellen A Walker, Stephen J Kohut, Richard W Hass, Edward K Brown, Anupama Prabandham, Timothy Lefeve. Selective and nonselective serotonin antagonists block the aversive stimulus properties of MK212 and m-chlorophenylpiperazine (mCPP) in mice. Neuropharmacology. vol 49. issue 8. 2006-01-17. PMID:16165167. |
acquisition of conditioned taste aversions was blocked by nonselective serotonin antagonists cyproheptadine, bromo-lsd, metergoline, methysergide and mianserin. |
2006-01-17 |
2023-08-12 |
mouse |
| Nicoletta Sonino, Marco Boscaro, Francesco Fall. Pharmacologic management of Cushing syndrome : new targets for therapy. Treatments in endocrinology. vol 4. issue 2. 2005-06-06. PMID:15783246. |
these agents include serotonin antagonists (cyproheptadine, ketanserin, ritanserin), dopamine agonists (bromocriptine, cabergoline), gaba agonists (valproic acid [sodium valproate]), and somatostatin analogs (octreotide). |
2005-06-06 |
2023-08-12 |
Not clear |
| E O Iwalewa, E O Agban. Effects of autacoid inhibitors and of an antagonist on malaria infection in mice. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 37. issue 8. 2005-04-04. PMID:15273821. |
the effects of p-chlorophenylalanine, an inhibitor of serotonin synthesis, indomethacin, an inhibitor of prostaglandin synthesis, cyproheptadine, a serotonin, bradykinin and histamine antagonist, were assessed separately and in combination with chloroquine (cq) in vom strains of swiss albino mice (18-22 g) of either sex infected intraperitoneally with 1 x 10(7) plasmodium yoelii nigeriensis-induced malaria. |
2005-04-04 |
2023-08-12 |
mouse |
| Francisco A Oliveira, Roberto C P Lima-Junior, Wilcare M Cordeiro, Gerardo M Vieira-Júnior, Mariana H Chaves, Fernanda R C Almeida, Regilane M Silva, Flavia A Santos, Vietla S N Ra. Pentacyclic triterpenoids, alpha,beta-amyrins, suppress the scratching behavior in a mouse model of pruritus. Pharmacology, biochemistry, and behavior. vol 78. issue 4. 2005-03-04. PMID:15301927. |
the animals were pretreated orally with alpha,beta-amyrins (50, 100 and 200 mg/kg) or cyproheptadine (10 mg/kg), an antagonist of histamine and serotonin receptors and 2 h later, they were given subcutaneous injections of dextran t40 (75 mg/kg) or compound 48/80 (3 mg/kg) into the rostral back, and scratching was quantified for 20 min. |
2005-03-04 |
2023-08-12 |
mouse |