| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Morán, C Velasco, T Salvador, M L Martín, L San Romá. Inhibitory 5-hydroxytryptamine receptors involved in pressor effects obtained by stimulation of sympathetic outflow from spinal cord in pithed rats. British journal of pharmacology. vol 113. issue 4. 1995-04-19. PMID:7889292. |
this inhibitory action of 5-ht was depressed by cyproheptadine and methiothepin but was not modified by ketanserin or mdl-72222. |
1995-04-19 |
2023-08-12 |
rat |
| T H Schürmeye. [Exogenous effects on ACTH and cortisol secretion]. Fortschritte der Medizin. vol 113. issue 1-2. 1995-04-07. PMID:7883264. |
the liberation of crh and acth is stimulated by the appetite suppressant, serotonin, and inhibited by the appetite-stimulating antagonist cyproheptadine and by glucocorticoids. |
1995-04-07 |
2023-08-12 |
human |
| M V Nechaeva, I K Zhurkovich, N G Kovrov, T M Turpae. [The role of serotonin and noradrenaline in regulating the motor activity of the chick amnion]. Zhurnal evoliutsionnoi biokhimii i fiziologii. vol 29. issue 4. 1995-02-22. PMID:7831973. |
in experiments on chick embryos from various age groups, studies have been made of the effect of a blockader of serotonin receptors--cyproheptadine--and blockader of adrenoreceptors--propranolol--on rhythmic activity of the amnion in vivo after injection of the substances into amniotic fluid. |
1995-02-22 |
2023-08-12 |
chicken |
| L X Zhang, Z Y Li. [Effects of microiontophoretically applied GABA and 5-HT on the electric activities of neurons in nucleus parafascicularis of thalamus in rats]. Sheng li xue bao : [Acta physiologica Sinica]. vol 46. issue 3. 1994-12-06. PMID:7973808. |
(2) mia 5-ht has both excitatory and inhibitory effects on the pain discharge of pf neurons, while only the former could be blocked by mia cyproheptadine. |
1994-12-06 |
2023-08-12 |
rat |
| R I Lappin, E L Auchinclos. Treatment of the serotonin syndrome with cyproheptadine. The New England journal of medicine. vol 331. issue 15. 1994-10-13. PMID:8084345. |
treatment of the serotonin syndrome with cyproheptadine. |
1994-10-13 |
2023-08-12 |
Not clear |
| C F Flaherty, J Turovsky, K L Kraus. Relative hedonic value modulates anticipatory contrast. Physiology & behavior. vol 55. issue 6. 1994-08-30. PMID:8047570. |
the serotonin antagonist cyproheptadine increased absolute lick frequencies, but did not alter contrast. |
1994-08-30 |
2023-08-12 |
Not clear |
| N A Abdullah, M Hirata, K Matsumoto, H Aizawa, R Inoue, S Hamano, S Ikeda, Z Xie, N Hara, Y It. Contraction and depolarization induced by fetal bovine serum in airway smooth muscle. The American journal of physiology. vol 266. issue 5 Pt 1. 1994-07-07. PMID:8203546. |
methysergide (10(-6) m) or cyproheptadine (10(-6) m), nonspecific antagonists to serotonin receptors, 5-hydroxytryptamines (5-ht1 and 5-ht2), markedly reduced the fbs-induced increase in the muscle tone to approximately 20% of the original value but did not abolish the response. |
1994-07-07 |
2023-08-12 |
dog |
| J I Chuang, M T Li. Pineal stimulation produces both hypertension and tachycardia in rats. Brain research bulletin. vol 33. issue 5. 1994-06-21. PMID:8186991. |
in addition, postsynaptic blockade of serotonin receptors with cyproheptadine (2-5 mg/kg, iv) produced both hypotension and bradycardia, while stimulation of 5-ht receptors with doi (10-250 micrograms/kg, iv) produced both hypertension and tachycardia in rats. |
1994-06-21 |
2023-08-12 |
rat |
| M A Chaĭdo, G V Idova, L V Devoĭn. [The serotonin-dependent suppression of the immune response by kappa-opiate receptors]. Biulleten' eksperimental'noi biologii i meditsiny. vol 116. issue 9. 1994-04-06. PMID:7906960. |
the opioid-induced immunosuppression was shown to be due to interaction with the serotoninergic system since it had no effect after preliminary blockade of s-2 serotonin postsynaptic receptors with cyproheptadine. |
1994-04-06 |
2023-08-12 |
mouse |
| B C Baguley, G Cole, L L Thomsen, Z L. Serotonin involvement in the antitumour and host effects of flavone-8-acetic acid and 5,6-dimethylxanthenone-4-acetic acid. Cancer chemotherapy and pharmacology. vol 33. issue 1. 1994-02-01. PMID:8269593. |
on the other hand, administration of the serotonin 5-hydroxytryptamine-2 (5-ht2) antagonist cyproheptadine (20 mg/kg) inhibited both the plasma nitrate response and, to a lesser extent, the induction of tumour haemorrhagic necrosis by 5,6-mexaa, faa and tnf. |
1994-02-01 |
2023-08-12 |
Not clear |
| R M Fasanell. Relief of benign essential blepharospasm and ? memory loss by cyproheptadine. Connecticut medicine. vol 57. issue 8. 1994-01-04. PMID:8243089. |
a search for more effective serotonin antagonists without the anticholinergic and antihistaminic side effects of cyproheptadine is needed and is in process. |
1994-01-04 |
2023-08-12 |
Not clear |
| C M Beasley, D N Masica, J H Heiligenstein, D E Wheadon, R L Zerb. Possible monoamine oxidase inhibitor-serotonin uptake inhibitor interaction: fluoxetine clinical data and preclinical findings. Journal of clinical psychopharmacology. vol 13. issue 5. 1993-12-17. PMID:8227489. |
a discussion of eight selected clinical cases of acute adverse reactions (seven with fatal outcomes; one with a favorable response after cyproheptadine therapy) reported to eli lilly and company in which an maoi was initiated concurrently or shortly after the discontinuation of fluoxetine and a review of preclinical data suggest a possible role of serotonin and/or serotonin-dopamine interactions in the hypermetabolic state that may occur when a serotonin uptake inhibitor and an maoi are coadministered, although alternative etiologic processes are possible as well. |
1993-12-17 |
2023-08-12 |
Not clear |
| J Ananth, M Wohl, V Ranganath, M Besha. Rapid cycling patients: conceptual and etiological factors. Neuropsychobiology. vol 27. issue 4. 1993-12-03. PMID:8232838. |
currently this condition has been reported to be secondary to lithium, tricyclic antidepressants and other agents such as cyproheptadine, a serotonin antagonist, piribedil, propranolol and levodopa. |
1993-12-03 |
2023-08-12 |
Not clear |
| I M Chapman, J O Willoughb. Interactions between the effects of opioid, serotonin and alpha-2-adrenergic receptor agonists on growth hormone release in the male rat. Intravenous administration. Neuroendocrinology. vol 57. issue 5. 1993-11-17. PMID:8105397. |
the 5-hydroxytryptamine antagonist cyproheptadine (0.5 mg/kg i.v.) |
1993-11-17 |
2023-08-12 |
rat |
| N J Emptage, T J Care. Long-term synaptic facilitation in the absence of short-term facilitation in Aplysia neurons. Science (New York, N.Y.). vol 262. issue 5131. 1993-11-05. PMID:8211146. |
three independent experimental approaches showed that long-term facilitation can normally be expressed in the absence of short-term facilitation: (i) the 5-ht antagonist cyproheptadine blocked the induction of short-term but not long-term facilitation; (ii) concentrations of 5-ht below threshold for the induction of short-term facilitation nonetheless induced long-term facilitation; and (iii) localized application of 5-ht to the sensory neuron cell body and proximal synapses induced long-term facilitation in distal synapses that were not exposed to 5-ht and had not expressed short-term facilitation. |
1993-11-05 |
2023-08-12 |
aplysia |
| Y Cui, T F Lee, L C Wan. Thermoregulatory responses following injection of 5-hydroxytryptamine into the septohippocampal complex in rats. Pharmacology, biochemistry, and behavior. vol 45. issue 4. 1993-10-26. PMID:8415834. |
further, the hypothermic response to intraseptal injection of 5-ht was only attenuated by systemic pretreatment with cyproheptadine, but not by naloxone or scopolamine, indicating that the hypothermic response is mediated by 5-ht receptor, but not by endogenous opioid and cholinergic systems. |
1993-10-26 |
2023-08-12 |
rat |
| S Le Corre, P Cheminea. Serotonergic 5HT2 receptors mediate the inhibitory action of serotonin on luteinizing hormone secretion in ovariectomized, estradiol-treated ewes that are refractory to short days. Biology of reproduction. vol 49. issue 1. 1993-09-22. PMID:8353180. |
previous studies with high doses of cyproheptadine suggested that serotonergic (5ht) neural mechanisms participate in the photoperiodic inhibition of secretion of lh in ovariectomized estradiol-treated ewes. |
1993-09-22 |
2023-08-12 |
Not clear |
| E Glusa, M Richte. Endothelium-dependent relaxation of porcine pulmonary arteries via 5-HT1C-like receptors. Naunyn-Schmiedeberg's archives of pharmacology. vol 347. issue 5. 1993-08-05. PMID:8391650. |
apart from the blockade of the contractile effects, mesulergine, cyproheptadine and mianserin (0.1-3.0 mumol/l, each) induced a parallel shift to the right of the concentration-response curve for the relaxation induced by alpha-methyl-5-ht or 5-ht. |
1993-08-05 |
2023-08-12 |
Not clear |
| B Kacsóh, B E Tóth, C E Grosveno. Neuroendocrine control of immunoreactive growth hormone and bioactive prolactin secretion in neonatal rats: ontogeny and interactions between the serotonergic, cholinergic and alpha 2-adrenergic systems. Neuroendocrinology. vol 57. issue 2. 1993-07-12. PMID:8389993. |
the effects of the alpha 2-agonist clonidine (clo), the serotonin (5-ht) precursor 5-hydroxy-l-tryptophan (5-htp), the 5-ht2/histamine (h1) antagonist cyproheptadine (cypro), the muscarinic cholinergic antagonist atropine (atr), and an affinity-purified polyclonal anti-rat growth hormone-releasing hormone (rghrh) immunoglobulin on serum concentrations of growth hormone (gh) and prolactin (prl) were tested in 2- and 10-day-old litter-mate rat pups. |
1993-07-12 |
2023-08-12 |
rat |
| S B Deshpande, J E Warnic. Thyrotropin releasing hormone-induced potentiation of spinal monosynaptic reflex in rats in vitro. Indian journal of experimental biology. vol 31. issue 2. 1993-06-30. PMID:8500826. |
neither serotonin antagonists (spiperone, ketanserin, cyproheptadine or 3-troponyl-indole-3-carboxylate) nor adrenergic antagonists (phentolamine or haloperidol) could attenuate trh-induced potentiation. |
1993-06-30 |
2023-08-12 |
rat |