| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Siegal, T Siega. Serotonergic manipulations in experimental neoplastic spinal cord compression. Journal of neurosurgery. vol 78. issue 6. 1993-06-10. PMID:7683713. |
serotonergic manipulations include in vivo inhibition of serotonin (5-ht) synthesis by p-chlorophenylalanine (p-cpa) and in vivo blockage of serotonin type 2 (5-ht2) receptors either by the selective antagonist ketanserin or by cyproheptadine. |
1993-06-10 |
2023-08-12 |
rat |
| I M Chapman, R Kapoor, J O Willoughb. Endogenous catecholamines modulate growth hormone release in the conscious rat during hypoglycaemia but not in the basal state. Journal of neuroendocrinology. vol 5. issue 2. 1993-06-04. PMID:8097943. |
to investigate the role of endogenous catecholamines and 5-hydroxytryptamine in the control of growth hormone (gh) secretion, secretory profiles of gh and prolactin were measured in conscious, male rats following intravenous administration of either 1) alpha 2 antagonist idazoxan 2 mg/kg, a dose that blocked alpha 2 agonist induced gh rise, 2) alpha 1 antagonist prazosin 1 mg/kg, 3) non-specific beta-blocker propranolol 1.5 mg/kg, a dose that prevented beta 2 agonist (salbutamol) induced inhibition, 4) serotonin antagonist cyproheptadine 0.5 mg/kg, a dose that inhibited serotonin agonist quipazine induced gh rise, or 5) control. |
1993-06-04 |
2023-08-12 |
rat |
| G Boschi, N Launay, R Rip. Involvement of hydroxylated metabolites in amphetamine-induced hypothermia in mice. General pharmacology. vol 24. issue 1. 1993-05-28. PMID:8097741. |
neither the 5-hydroxytryptamine (5-ht) receptor blocker, cyproheptadine, nor the 5-ht receptor agonist, quipazine, modified metabolite-induced hypothermia. |
1993-05-28 |
2023-08-12 |
mouse |
| b' J Perales, C Z Amorim, S L Rocha, G B Domont, H Moussatch\\xc3\\xa. Neutralization of the oedematogenic activity of Bothrops jararaca venom on the mouse paw by an antibothropic fraction isolated from opossum (Didelphis marsupialis) serum. Agents and actions. vol 37. issue 3-4. 1993-04-15. PMID:1295374.' |
the bjv oedema was not inhibited by the anti-histamine meclizine, the inhibitor of histamine and serotonin, cyproheptadine, paf-acether antagonist web 2170 or by the anti-leukotrienes c4/d4, ly 171883. |
1993-04-15 |
2023-08-11 |
mouse |
| H Kaneko, T Mitsuma, K Morise, K Uchida, A Furusawa, Y Maeda, K Nakada, K Adach. Effect of serotonin on the immunoreactive thyrotropin-releasing hormone concentrations of the rat stomach. Digestion. vol 53. issue 3-4. 1993-04-01. PMID:1291403. |
either serotonin, cyproheptadine or gr38032f was injected intraperitoneally, and the rats were decapitated at various times after the injection. |
1993-04-01 |
2023-08-11 |
rat |
| H Kaneko, T Mitsuma, K Morise, K Uchida, A Furusawa, Y Maeda, K Nakada, K Adach. Effect of serotonin on the immunoreactive thyrotropin-releasing hormone concentrations of the rat stomach. Digestion. vol 53. issue 3-4. 1993-04-01. PMID:1291403. |
the effects of serotonin on ir-trh concentrations of the stomach were significantly blocked by the pretreatment of cyproheptadine and gr38032f. |
1993-04-01 |
2023-08-11 |
rat |
| J R Cazalets, Y Sqalli-Houssaini, F Clara. Activation of the central pattern generators for locomotion by serotonin and excitatory amino acids in neonatal rat. The Journal of physiology. vol 455. 1993-02-17. PMID:1362441. |
it decreased from around 10 s at 2 x 10(-5) m to 5 s at 10(-4) m. the effects of serotonin were blocked by a 5-ht1 antagonist (propranolol) and by 5-ht2 antagonists (ketanserin, cyproheptadine, mianserin). |
1993-02-17 |
2023-08-11 |
rat |
| K Hellstrand, S Hermodsso. Serotonergic 5-HT1A receptors regulate a cell contact-mediated interaction between natural killer cells and monocytes. Scandinavian journal of immunology. vol 37. issue 1. 1993-02-04. PMID:7678181. |
the effect of serotonin was mediated by 5-ht1a-type serotonin receptors (5-ht1ar) as indicated by mimicry exerted by 5-ht1ar agonists such as 8-oh-dpat and (+)-alk, partial antagonism by the 5-ht1ar antagonists pindolol and cyproheptadine, and lack of antagonism by the 5-ht2r antagonist ketanserin or the 5-ht3r antagonist ondansetron. |
1993-02-04 |
2023-08-12 |
human |
| C S Venugopalan, E P Holme. Blockade of electrical field stimulation-induced nonadrenergic noncholinergic (NANC) excitatory response of the guinea pig ileum. Research communications in chemical pathology and pharmacology. vol 78. issue 2. 1993-02-03. PMID:1282271. |
only the serotonin antagonist cyproheptadine produced a dose-dependent blockade. |
1993-02-03 |
2023-08-11 |
Not clear |
| M S Barnette, M Grous, C D Manning, W J Price, A H Nelson, W E Bondinell, F C Barone, H S Ormsbe. 5-Hydroxytryptamine (5-HT) and SK&F 103829 contract canine lower esophageal sphincter smooth muscle by stimulating 5-HT2 receptors. Receptor. vol 2. issue 3. 1993-02-02. PMID:1472950. |
nonsurmountable antagonism of the contraction induced by 5-ht and sk&f 103289 was observed with several 5-ht2 antagonists, i.e., methysergide, ketanserin, cyproheptadine, and ly 53857. |
1993-02-02 |
2023-08-11 |
Not clear |
| S P Blackford, P J Little, C M Kuh. Mu- and kappa-opiate receptor control of prolactin secretion in rats: ontogeny and interaction with serotonin. Endocrinology. vol 131. issue 6. 1992-12-30. PMID:1332851. |
serotonin mediation of opiate-induced changes in prl secretion was explored across ontogeny by testing cyproheptadine (cypro) blockade of agonist responses in 5-, 10-, 20-, and 60-day-old rats. |
1992-12-30 |
2023-08-11 |
rat |
| C W Callaway, N Rempel, R Y Peng, M A Geye. Serotonin 5-HT1-like receptors mediate hyperactivity in rats induced by 3,4-methylenedioxymethamphetamine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 7. issue 2. 1992-12-21. PMID:1358088. |
among nonselective 5-ht antagonists, methiothepin was effective and methysergide and cyproheptadine were ineffective as antagonists of s-mdma-induced hypermotility. |
1992-12-21 |
2023-08-11 |
rat |
| M E Olds, A Yuwile. Effects of acute and chronic fenfluramine on self-stimulation and its facilitation by amphetamine. European journal of pharmacology. vol 216. issue 3. 1992-12-09. PMID:1425928. |
the serotonin antagonist, ketanserine (0.1 mg/kg), but not cyproheptadine (0.1 mg/kg i.p. |
1992-12-09 |
2023-08-11 |
rat |
| E M Hoenicke, S A Vanecek, J H Wood. The discriminative stimulus effects of clozapine in pigeons: involvement of 5-hydroxytryptamine1C and 5-hydroxytryptamine2 receptors. The Journal of pharmacology and experimental therapeutics. vol 263. issue 1. 1992-11-20. PMID:1403790. |
in substitution tests, compounds that shared antagonistic action at 5-hydroxytryptamine (5-ht)1c and 5-ht2 receptors produced discriminative stimulus effects similar to clozapine: cyproheptadine, metergoline, mianserin, pizotifen and fluperlapine. |
1992-11-20 |
2023-08-11 |
Not clear |
| M T Lin, C F S. Spinal 5-HT pathways and the antinociception induced by intramedullary clonidine in rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 346. issue 3. 1992-11-19. PMID:1407017. |
selective destruction of spinal 5-ht neurons produced by intraspinal injection of 5,7-dihydroxytryptamine (5,7-dht; 10 micrograms) or postsynaptic blockade of spinal 5-ht receptors produced by intrathecal injection of cyproheptadine (1 microgram; a mixed 5-ht1/5-ht2 antagonist) also abolished clonidine-induced antinociception. |
1992-11-19 |
2023-08-11 |
rat |
| Z Cai, P P McCasli. Amitriptyline, desipramine, cyproheptadine and carbamazepine, in concentrations used therapeutically, reduce kainate- and N-methyl-D-aspartate-induced intracellular Ca2+ levels in neuronal culture. European journal of pharmacology. vol 219. issue 1. 1992-11-06. PMID:1397050. |
cyproheptadine (0.5-1 microm), a serotonin antagonist that is structurally similar to amitriptyline, causes similar effects as reported above for the tcas; however, ketanserine (10 microm), also a serotonin antagonist but without the tricyclic nucleus, is less effective in this regard. |
1992-11-06 |
2023-08-11 |
Not clear |
| A M Northove. Inhibition by calcium antagonists of shape changes induced in vitro by pro-inflammatory mediators in venous endothelial cells. Agents and actions. vol 36. issue 3-4. 1992-10-22. PMID:1382377. |
the responses to 5ht were also reduced by cyproheptadine hcl (3 x 10(-6) m). |
1992-10-22 |
2023-08-11 |
rat |
| R E Roudebush, H U Bryan. Pharmacologic manipulation of graft versus host induced splenomegaly. Agents and actions. vol 35. issue 3-4. 1992-10-16. PMID:1529801. |
however, at high dose levels (30 mg/kg) piroxicam enhanced while amitriptyline and cyproheptadine (a mixed serotonin and histamine antagonist) suppressed gvh induced splenomegaly. |
1992-10-16 |
2023-08-11 |
Not clear |
| G Gerasimov, T Chernova, N Goncharo. Monoamine regulation of prolactin and TSH secretion in hypothyroidism. Acta medica Austriaca. vol 19 Suppl 1. 1992-10-06. PMID:1519463. |
), cyproheptadine (serotonin antagonist, 4 mg per os) and trh tests. |
1992-10-06 |
2023-08-11 |
Not clear |
| S A Doggrel. Further analysis of the inhibitory effects of dihydroergotamine, cyproheptadine and ketanserin on the responses of the rat aorta to 5-hydroxytryptamine. Journal of autonomic pharmacology. vol 12. issue 4. 1992-10-01. PMID:1512277. |
further analysis of the inhibitory effects of dihydroergotamine, cyproheptadine and ketanserin on the responses of the rat aorta to 5-hydroxytryptamine. |
1992-10-01 |
2023-08-11 |
rat |