| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D S Goldbloom, S H Kenned. Adverse interaction of fluoxetine and cyproheptadine in two patients with bulimia nervosa. The Journal of clinical psychiatry. vol 52. issue 6. 1991-07-26. PMID:2055898. |
the authors report two cases of bulimia nervosa in which the serotonin antagonist effect of cyproheptadine appeared to cancel out the therapeutic benefits of the serotonin-specific uptake inhibitor fluoxetine. |
1991-07-26 |
2023-08-11 |
Not clear |
| E J Mylecharan. 5-HT2 receptor antagonists and migraine therapy. Journal of neurology. vol 238 Suppl 1. 1991-07-18. PMID:2045831. |
5-hydroxytryptamine (5-ht; serotonin) has been implicated in the pathophysiology of migraine, and several drugs with potent 5-ht2 receptor blocking activity (methysergide, pizotifen, cyproheptadine and mianserin) have been recognized as being clinically effective in migraine prophylaxis, although the selective 5-ht2 receptor antagonist ketanserin (the principal agent used to identify 5-ht2 receptor-mediated actions) seems to be ineffective in migraine. |
1991-07-18 |
2023-08-11 |
Not clear |
| M Y Wang, N J Du. 5-Hydroxytryptamine responses in neonate rat motoneurones in vitro. The Journal of physiology. vol 430. 1991-05-23. PMID:2150862. |
the depolarizing response was mimicked by the 5-ht2 receptor agonist (+2-)-1(2,5-dimethyoxy-4-iodophenyl)-2-aminopropane hydrochloride (doi) and blocked by 5-ht antagonists methysergide and cyproheptadine and by 5-ht2 antagonists ketanserin and spiperone; methiothepin and mdl 72222 were without effect. |
1991-05-23 |
2023-08-11 |
rat |
| M E Siegfried, L R Bus. Dual antagonism by L-636,499 of serotonin and thromboxane A2 induced aggregation of canine platelets. Thrombosis research. vol 60. issue 5. 1991-05-16. PMID:2084956. |
we evaluated the ability of l-636,499 (3-carboxyl-dibenzo-[b,f] thiepen-5,5-dioxide), a compound structurally similar to cyproheptadine, to antagonize u46619 (a txa2/pgh2 mimetic) and serotonin (5-hydroxytryptamine; 5ht)-induced aggregation of canine platelets in vitro. |
1991-05-16 |
2023-08-11 |
Not clear |
| B Q Wang, P X Che. [Effect of stimulating midbrain periaqueductal gray on the electrical response of somatosensory cortex to C-fiber input in cats]. Sheng li xue bao : [Acta physiologica Sinica]. vol 42. issue 3. 1991-05-09. PMID:2082468. |
injection, cyproheptadine and naloxone could antagonize the inhibitory effect of pag stimulation on c-cep, indicating that endogenous opiate-like substance and serotonin might play an important role in the transmission of the ascending inhibitory pathways from pag. |
1991-05-09 |
2023-08-11 |
Not clear |
| B R Xing, S G Gan, Q Gu, J H Xia, Y M Guo, Y Z Che. [Effects of serotonin on the electric activity of paraventricular neurons of in vitro rat hypothalamic slices]. Sheng li xue bao : [Acta physiologica Sinica]. vol 42. issue 3. 1991-05-09. PMID:2082475. |
after perfusing the brain slices with artificial cerebro-spinal fluid containing serotonin (10(-6) mol/l) for 3 min, discharge rate of 16 units is significantly increased with latency 1.21 +/- 1.21 (mean + sd) min, this response is blocked by serotonin antagonist, cyproheptadine. |
1991-05-09 |
2023-08-11 |
rat |
| T Siegal, T Siega. Participation of serotonergic mechanisms in the pathophysiology of experimental neoplastic spinal cord compression. Neurology. vol 41. issue 4. 1991-05-08. PMID:1707147. |
blocking 5-ht receptors by cyproheptadine, evaluated 30 hours after onset of paralysis and treatment, resulted in a reduction in the high water content, vascular permeability, and prostaglandin e2 synthesis in the compressed cord. |
1991-05-08 |
2023-08-11 |
rat |
| W Wang, R C M. The role of serotonin in non-cholinergic excitatory transmission in the guinea pig inferior mesenteric ganglion. Brain research. vol 531. issue 1-2. 1991-04-01. PMID:1705152. |
furthermore, the ls-epsps elicited in 5-ht-sensitive neurons as well as the 5-ht-induced depolarization were reversibly suppressed by cyproheptadine, a 5-ht antagonist, and enhanced by fluoxetine, a 5-ht reuptake inhibitor. |
1991-04-01 |
2023-08-11 |
Not clear |
| H Y Lei, J Y Wang, T T Chang, C C Wan. Hepatitis B surface antigen induces an early-type hypersensitivity. Clinical and experimental immunology. vol 83. issue 2. 1991-03-19. PMID:1993355. |
the observation that cyproheptadine, not dexamethasone, inhibited eth suggests that it is mediated through the release of histamine and/or serotonin. |
1991-03-19 |
2023-08-11 |
mouse |
| A R Adolp. Pharmacological actions of peptides and indoleamines on turtle retinal ganglion cells. Visual neuroscience. vol 3. issue 5. 1991-03-13. PMID:2577268. |
lsd (lysergic acid diethylamide) and cyproheptadine, which act on 5-ht2 receptors, antagonize 5-ht actions in this retina. |
1991-03-13 |
2023-08-11 |
Not clear |
| S W Ying, L P Nile. 3-[(3-cholamidopropyl)dimethylammonio]-1-propane sulfonate-solubilized binding sites for 2-[125I]iodomelatonin in chick brain retain sensitivity to guanine nucleotides. Journal of neurochemistry. vol 56. issue 2. 1991-02-26. PMID:1846401. |
inhibition studies indicated the following order of pharmacological affinities for both membrane and solubilized sites: 2-iodomelatonin greater than melatonin greater than 6-chloromelatonin much greater than prazosin greater than n-acetylserotonin much greater than serotonin greater than metergoline greater than ketanserin greater than propranolol greater than phentolamine greater than cyproheptadine. |
1991-02-26 |
2023-08-11 |
chicken |
| B Borowsky, C M Kuh. Monoamine mediation of cocaine-induced hypothalamo-pituitary-adrenal activation. The Journal of pharmacology and experimental therapeutics. vol 256. issue 1. 1991-02-22. PMID:1671094. |
in contrast, neither the 5-ht antagonist cyproheptadine, the alpha-1 antagonist prazosin nor the beta adrenergic antagonist propranolol attenuated the acth response to cocaine. |
1991-02-22 |
2023-08-11 |
rat |
| H G Cryer, R N Garrison, P D Harris, B H Greenwald, N L Alsi. Prostaglandins mediate skeletal muscle arteriole dilation in hyperdynamic bacteremia. The American journal of physiology. vol 259. issue 3 Pt 2. 1990-10-11. PMID:2204277. |
topical application of cyproheptadine, an antagonist of both histamine and serotonin receptors, to the cremaster muscle did not alter the e. coli-induced constriction of large arterioles or the dilation of small arterioles in the cremaster microcirculation. |
1990-10-11 |
2023-08-11 |
rat |
| R A Macia, R A Gabel, M J Reginato, W D Matthew. Hypotension induced by growth-hormone-releasing peptide is mediated by mast cell serotonin release in the rat. Toxicology and applied pharmacology. vol 104. issue 3. 1990-09-14. PMID:1696753. |
pretreatment with cyproheptadine (2.5 mg/kg, iv), a dual serotonin/histamine antagonist, or ketanserin (3 mg/kg, iv), a selective serotonin antagonist, prevented the gh-rp-6-induced hypotension and lethality. |
1990-09-14 |
2023-08-11 |
rat |
| A Arimura, M Nagata, A Watanabe, K Nakamura, M Takeuchi, M Harad. Production of active and passive anaphylactic shock in the WBB6F1 mouse, a mast cell-deficient strain. Experientia. vol 46. issue 7. 1990-08-30. PMID:2373200. |
lethal shock could be prevented by cv-3988 but not by cyproheptadine, which suggests that the shock is mediated by paf but not by histamine and serotonin. |
1990-08-30 |
2023-08-11 |
mouse |
| H Barbeau, S Rossigno. The effects of serotonergic drugs on the locomotor pattern and on cutaneous reflexes of the adult chronic spinal cat. Brain research. vol 514. issue 1. 1990-07-31. PMID:2357531. |
cyproheptadine, a 5-ht antagonist, partially or completely antagonised these effects. |
1990-07-31 |
2023-08-11 |
cat |
| T Kato, S Yamawak. A pharmacological study of veratrine-induced hyperthermia in the rat: a model of neuroleptic malignant syndrome. Hiroshima journal of medical sciences. vol 38. issue 4. 1990-07-13. PMID:2637245. |
hyperthermia induced by haloperidol plus veratrine was significantly inhibited by systemic administration of serotonin antagonists (cyproheptadine 10 mg/kg, ritanserin 3 mg/kg). |
1990-07-13 |
2023-08-11 |
rat |
| R H Rosskamp, F Haverkamp, G von Kalckreut. The effect of cyproheptadine on plasma growth hormone (GH) and on somatostatin response to GH-releasing hormone in man. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 22. issue 5. 1990-07-12. PMID:1971804. |
cyproheptadine (cph)--a putative serotonin antagonist--is known to inhibit growth hormone (gh) response to various pharmacological stimuli, as well as during sleep. |
1990-07-12 |
2023-08-11 |
human |
| M Fantino, L Brondel, A H Swiergiel, O Lebe. Reduction of negative alliesthesia for sweet gustatory stimuli by cyproheptadine, a serotonin antagonist. Life sciences. vol 46. issue 19. 1990-07-05. PMID:2345485. |
reduction of negative alliesthesia for sweet gustatory stimuli by cyproheptadine, a serotonin antagonist. |
1990-07-05 |
2023-08-11 |
human |
| M Fantino, L Brondel, A H Swiergiel, O Lebe. Reduction of negative alliesthesia for sweet gustatory stimuli by cyproheptadine, a serotonin antagonist. Life sciences. vol 46. issue 19. 1990-07-05. PMID:2345485. |
cyproheptadine (ch) is a serotonin antagonist that increases food intake and body weight. |
1990-07-05 |
2023-08-11 |
human |