| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Manda, F Nishigaki, J Mori, K Shimomur. Important role of serotonin in the antitumor effects of recombinant human tumor necrosis factor-alpha in mice. Cancer research. vol 48. issue 15. 1988-08-24. PMID:3390820. |
ketanserin, cyproheptadine, and spiperone [serotonin (5-ht) receptor blockers] inhibited or attenuated the antitumor effects of rtnf-alpha, but the other types of receptor blockers tested (histamine h1 and h2, adrenaline alpha and beta, dopamine, and acetylcholine receptor blockers) did not. |
1988-08-24 |
2023-08-11 |
mouse |
| J F Nash, H Y Meltzer, G A Gudelsk. Elevation of serum prolactin and corticosterone concentrations in the rat after the administration of 3,4-methylenedioxymethamphetamine. The Journal of pharmacology and experimental therapeutics. vol 245. issue 3. 1988-07-29. PMID:2898523. |
conversely, neither (-)-pindolol, a beta antagonist that also blocks 5-ht1a-mediated responses, nor the nonspecific 5-ht antagonists, cyproheptadine and metergoline, had an effect on mdma-induced corticosterone secretion. |
1988-07-29 |
2023-08-11 |
rat |
| T M Turpaev, O P Yurchenko, N G Grigorie. Alteration of the acetylcholine response by intra- and extracellular serotonin application in intracellularly perfused neurons of Lymnaea stagnalis. Cellular and molecular neurobiology. vol 7. issue 4. 1988-07-22. PMID:2837328. |
the decreasing effect of serotonin on ach currents is mimicked by cyproheptadine, an antagonist of serotonin receptors, and by the intracellular application of cyclic amp (camp) forskolin. |
1988-07-22 |
2023-08-11 |
Not clear |
| T M Turpaev, O P Yurchenko, N G Grigorie. Alteration of the acetylcholine response by intra- and extracellular serotonin application in intracellularly perfused neurons of Lymnaea stagnalis. Cellular and molecular neurobiology. vol 7. issue 4. 1988-07-22. PMID:2837328. |
the enhancing effect of intracellularly applied serotonin on ach currents is blocked by cyproheptadine and is not obtained by the intracellular administration of camp and forskolin. |
1988-07-22 |
2023-08-11 |
Not clear |
| M Y Liu, C F Su, M T Li. The antinociceptive role of a bulbospinal serotonergic pathway in the rat brain. Pain. vol 33. issue 1. 1988-07-22. PMID:2898126. |
postsynaptic blockade of cns 5-ht receptors produced by intraventricular injection of cyproheptadine also reduced the stimulation-produced analgesia. |
1988-07-22 |
2023-08-11 |
rat |
| A H Bom, D J Duncker, P R Saxena, P D Verdou. 5-Hydroxytryptamine-induced tachycardia in the pig: possible involvement of a new type of 5-hydroxytryptamine receptor. British journal of pharmacology. vol 93. issue 3. 1988-07-14. PMID:3370393. |
a number of drugs which antagonize responses mediated by different 5-ht receptors--phenoxybenzamine, methiothepin, metergoline, methysergide and mesulergine ('5-ht1-like' and 5-ht2 receptors), ketanserin, cyproheptadine, pizotifen and mianserin (5-ht2 receptors), and mdl 72222 and ics 205-930 (5-ht3 receptors)--did not attenuate the chronotropic responses to 5-ht. |
1988-07-14 |
2023-08-11 |
rat |
| J Bergman, R D Spealma. Behavioral effects of histamine H1 antagonists: comparison with other drugs and modification by haloperidol. The Journal of pharmacology and experimental therapeutics. vol 245. issue 2. 1988-06-16. PMID:2896793. |
the dopamine uptake inhibitors cocaine (0.01-1.0 mg/kg) and bupropion (0.1-10.0 mg/kg) had behavioral effects similar to those of chlorpheniramine, diphenhydramine, pyrilamine and tripelennamine, whereas the muscarinic antagonist atropine (0.03-1.0 mg/kg), the serotonin 5-hydroxytryptamine/5-hydroxytryptamine antagonist cyproheptadine (0.03-1.0 mg/kg), the norepinephrine uptake inhibitor desmethylimipramine (0.03-3.0 mg/kg) and the benzodiazepine diazepam (0.3-30.0 mg/kg) produced only dose-related decreases in response rate. |
1988-06-16 |
2023-08-11 |
human |
| T Yamamoto, M Ohno, K Takao, S Uek. Anti-serotonin action in combination with noradrenaline-stimulating action is important for inhibiting muricide in midbrain raphe-lesioned rats. Neuropharmacology. vol 27. issue 2. 1988-05-06. PMID:3352870. |
serotonin antagonists, such as cyproheptadine (10 mg/kg), cinanserin (10 mg/kg) and pirenperone (1 mg/kg), given alone showed little suppression of muricide in rats with raphe lesions, although the first two drugs were inhibitory at very large doses. |
1988-05-06 |
2023-08-11 |
rat |
| L A Bero, S N Lurie, C M Kuh. Early ontogeny of kappa-opioid receptor regulation of prolactin secretion in the rat. Brain research. vol 465. issue 1-2. 1988-04-19. PMID:2894234. |
u50488-induced prl secretion was not attenuated by cyproheptadine in adults or neonates, suggesting that the kappa-opioid mechanism operates independently of serotonin. |
1988-04-19 |
2023-08-11 |
rat |
| M Davis, J V Cassella, J H Kehn. Serotonin does not mediate anxiolytic effects of buspirone in the fear-potentiated startle paradigm: comparison with 8-OH-DPAT and ipsapirone. Psychopharmacology. vol 94. issue 1. 1988-04-18. PMID:2894698. |
large lesions of the dorsal and median raphe nuclei or ip injections of the serotonin antagonists cinanserin (10 mg/kg) or cyproheptadine (5 mg/kg) did not alter fear-potentiated startle, nor did these treatments prevent buspirone (5 or 10 mg/kg sc) from blocking fear-potentiated startle. |
1988-04-18 |
2023-08-11 |
Not clear |
| G J Marek, L S Seide. Effects of selective 5-hydroxytryptamine-2 and nonselective 5-hydroxytryptamine antagonists on the differential-reinforcement-of-low-rate 72-second schedule. The Journal of pharmacology and experimental therapeutics. vol 244. issue 2. 1988-04-12. PMID:2894458. |
the rank order potency series for the maximal increase in the reinforcement rate after administration of the 5-ht antagonists was ketanserin greater than pipamperone greater than trazodone greater than cyproheptadine greater than cinanserin greater than metergoline greater than methysergide, in close agreement with the selectivity of these drugs for the 5-ht2 relative to the 5-ht1 receptor subtypes. |
1988-04-12 |
2023-08-11 |
rat |
| A W Baird, A W Cuthber. Neuronal involvement in type 1 hypersensitivity reactions in gut epithelia. British journal of pharmacology. vol 92. issue 3. 1988-03-18. PMID:3427274. |
of methysergide, ketanserin, cyproheptadine and ics 205-930, only the latter inhibited both the response to 5-ht and to antigen challenge. |
1988-03-18 |
2023-08-11 |
Not clear |
| A W Baird, A W Cuthber. Neuronal involvement in type 1 hypersensitivity reactions in gut epithelia. British journal of pharmacology. vol 92. issue 3. 1988-03-18. PMID:3427274. |
ketanserin had no effect on the responses to 5-ht, but both ketanserin and cyproheptadine inhibited the challenge to beta lg. |
1988-03-18 |
2023-08-11 |
Not clear |
| C Haslam, R Stevens, T P Donoho. The influence of cyproheptadine on immobilization and oestradiol benzoate induced anorexia in ovariectomized rats. Psychopharmacology. vol 93. issue 2. 1988-02-03. PMID:3122252. |
to determine whether serotonergic mechanisms are involved in the stress- and oestrogen-induced anorexia, the 5-ht antagonist cyproheptadine was given to ovariectomized rats that were immobilized and treated with oestradiol benzoate. |
1988-02-03 |
2023-08-11 |
rat |
| C Haslam, R Stevens, T P Donoho. The influence of cyproheptadine on immobilization and oestradiol benzoate induced anorexia in ovariectomized rats. Psychopharmacology. vol 93. issue 2. 1988-02-03. PMID:3122252. |
the food intake of immobilized rats treated with cyproheptadine was similar to control values, suggesting 5-ht involvement in the stress-induced anorexia. |
1988-02-03 |
2023-08-11 |
rat |
| J M Witkin, R S Mansbach, J E Barrett, G T Bolger, P Skolnick, B Weissma. Behavioral studies with anxiolytic drugs. IV. Serotonergic involvement in the effects of buspirone on punished behavior of pigeons. The Journal of pharmacology and experimental therapeutics. vol 243. issue 3. 1988-02-02. PMID:2891840. |
a serotonin agonist, mk-212 (0.01 mg/kg), antagonized whereas the 5-ht antagonist, cyproheptadine (0.01 mg/kg), potentiated the effects of buspirone without having behavioral effects of their own. |
1988-02-02 |
2023-08-11 |
rat |
| M Hirafuji, Y Akiyama, Y Ogur. Receptor-mediated stimulation of aortic prostacyclin release by 5-hydroxytryptamine. European journal of pharmacology. vol 143. issue 2. 1988-02-02. PMID:3121367. |
prostacyclin release stimulated by 5-ht was depressed by non-specific 5-ht antagonists, methysergide, mianserin and cyproheptadine. |
1988-02-02 |
2023-08-11 |
rat |
| P J Bédard, L E Tremblay, H Barbeau, M Filion, R Maheux, C L Richards, T DiPaol. Action of 5-hydroxytryptamine, substance P, thyrotropin-releasing hormone and clonidine on motoneurone excitability. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. vol 14. issue 3 Suppl. 1988-01-13. PMID:2445457. |
in a pilot trial, cyproheptadine, a 5-ht antagonist was shown to decrease the manifestations of spasticity in patients with a partial spinal lesion. |
1988-01-13 |
2023-08-11 |
rat |
| H Ono, M Miyamoto, M Kobayashi, H Fukud. 5-Hydroxytryptamine agonistic action of methysergide and the absence of supersensitivity to 5-HT agonists in spinal flexor reflexes in rats. Neuropharmacology. vol 26. issue 9. 1987-12-07. PMID:3670560. |
these results suggest that methysergide may have an agonistic action on the 5-ht receptors in spinal cord and that supersensitivity to 5-htp in rats treated with 5,6-dihydroxytryptamine was due to the lack of uptake of 5-ht into terminals of descending 5-ht fibres or to the change in 5-ht receptors which were not sensitive to 5-meodmt, lsd, methysergide or cyproheptadine. |
1987-12-07 |
2023-08-11 |
rat |
| S A Doggrel. Differential antagonism of the initial fast and secondary slow contractile responses of the rat isolated aorta to 5-hydroxytryptamine by mianserin and ketanserin. Journal of autonomic pharmacology. vol 7. issue 2. 1987-11-10. PMID:3654683. |
the effects of antagonists (prazosin, idazoxan, phentolamine, dihydroergotamine, methysergide, cyproheptadine, mianserin and ketanserin) on these initial fast and secondary slow contractile responses to 5-ht were studied. |
1987-11-10 |
2023-08-11 |
rat |