| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N J Penington, R J Reiffenstei. Lack of effect of antagonists on serotonin-induced inhibition in rat hippocampus. Canadian journal of physiology and pharmacology. vol 64. issue 11. 1987-02-18. PMID:3791042. |
four putative central nervous system 5-hydroxytryptamine antagonists, methysergide, cyproheptadine, metergoline, and ketanserin and also lysergic acid diethylamide were applied by iontophoresis to firing ca1 hippocampal pyramidal cells to test their action on the inhibition produced by 5-hydroxytryptamine. |
1987-02-18 |
2023-08-11 |
rat |
| M Augue. [Effect of histamine on the isolated aorta of the rabbit. Study of cyproheptadine]. Journal de pharmacologie. vol 17. issue 3. 1987-02-06. PMID:3795970. |
cyproheptadine displaced to the right in a parallel manner the dose response curve of noradrenaline (pa2 = 6.6) and of serotonin (pa2 = 8.9) and reduced the contracting effects of kcl (ic50 = 7.3 10(-7) m) and of angiotensin ii (ic50 = 4 x 10(5) m). |
1987-02-06 |
2023-08-11 |
rabbit |
| P B Kaplowitz, S Jenning. Enhancement of linear growth and weight gain by cyproheptadine in children with hypopituitarism receiving growth hormone therapy. The Journal of pediatrics. vol 110. issue 1. 1987-02-05. PMID:3794875. |
cyproheptadine (cp), an antihistamine serotonin antagonist drug with appetite-stimulating activity, was given to children with growth hormone (gh) deficiency to test the hypothesis that increased weight gain would enhance the effect of gh on linear growth. |
1987-02-05 |
2023-08-11 |
Not clear |
| M L Vitale, M N Parisi, S R Chiocchio, J H Tramezzan. Serotonin induces gonadotrophin release through stimulation of LH-releasing hormone release from the median eminence. The Journal of endocrinology. vol 111. issue 2. 1987-01-30. PMID:3098890. |
the stimulatory effect of 5-ht was blocked by the addition of cyproheptadine (l mumol/l) in the perifusion fluid. |
1987-01-30 |
2023-08-11 |
rat |
| Y Nakagami, T Suda, F Yajima, T Ushiyama, N Tomori, T Sumitomo, H Demura, K Shizum. Effects of serotonin, cyproheptadine and reserpine on corticotropin-releasing factor release from the rat hypothalamus in vitro. Brain research. vol 386. issue 1-2. 1987-01-16. PMID:3022879. |
effects of serotonin, cyproheptadine and reserpine on corticotropin-releasing factor release from the rat hypothalamus in vitro. |
1987-01-16 |
2023-08-11 |
rat |
| Y Nakagami, T Suda, F Yajima, T Ushiyama, N Tomori, T Sumitomo, H Demura, K Shizum. Effects of serotonin, cyproheptadine and reserpine on corticotropin-releasing factor release from the rat hypothalamus in vitro. Brain research. vol 386. issue 1-2. 1987-01-16. PMID:3022879. |
we investigated the effects of serotonin, cyproheptadine and reserpine on corticotropin-releasing factor (crf) release from the rat hypothalamus, and the effect of cyproheptadine on crf-induced adrenocorticotropic hormone (acth) secretion from the anterior pituitary (ap) in vitro using a perifusion system for rat hypothalami and ap, and a rat crf radioimmunoassay. |
1987-01-16 |
2023-08-11 |
rat |
| P Klarskov, J Hørby-Peterse. Influence of serotonin on lower urinary tract smooth muscle in vitro. British journal of urology. vol 58. issue 5. 1987-01-07. PMID:3779352. |
the serotonin antagonists ketanserin, methysergide and cyproheptadine partly inhibited the effect of serotonin. |
1987-01-07 |
2023-08-11 |
human |
| A Portolés, J M Rojo, R Día. Influence of mouse genotype on passive systemic anaphylaxis by immune complexes. Infection and immunity. vol 54. issue 3. 1986-12-30. PMID:3096895. |
cyproheptadine, a blocker of serotonin and histamine receptors, and imidazol-alpha-ketoglutarate, an inhibitor of thromboxane synthesis, inhibited psa, indicating that platelet aggregation, possibly mediated by activated components of the complement cascade, is an important feature in the development of psa reactions in this system. |
1986-12-30 |
2023-08-11 |
mouse |
| M P Mattson, E Spazian. Regulation of the stress-responsive X-organ--Y-organ axis by 5-hydroxytryptamine in the crab, Cancer antennarius. General and comparative endocrinology. vol 62. issue 3. 1986-12-12. PMID:2945758. |
the 5ht synthesis inhibitor p-chlorophenylalanine (pcpa; 60 micrograms) or the 5ht receptor antagonist cyproheptadine (cph; 100 micrograms) caused significant rises in serum ecdysteroids in intact, but not in de-eyestalked, crabs; with four injections over 48 hr, a rise was evident at 12 hr, continued through 72 hr, and returned to control levels within 4 days post-treatment. |
1986-12-12 |
2023-08-11 |
Not clear |
| S Yoshida, T Kug. Probable pre- and postsynaptic modifications by 5-hydroxytryptamine of contractile responses to electrical stimulation of isolated guinea-pig vas deferens. Japanese journal of pharmacology. vol 41. issue 3. 1986-11-20. PMID:2876119. |
these inhibitory and potentiating actions of 5-hydroxytryptamine were reversed by cyproheptadine and 2-bromolysergic acid diethylamide. |
1986-11-20 |
2023-08-11 |
Not clear |
| H Bekemeier, R Hirschelman. Influence of serotonin, serotonin antagonists, some vasoactive substances and temperature on carrageenin-induced tail thrombosis in rats and mice. Agents and actions. vol 18. issue 5-6. 1986-11-20. PMID:3766313. |
serotonin (1-2 mg/kg) but is decreased by cyproheptadine and ketanserin (minimal effective dose less than 1 mg/kg) as well as by preceding serotonin depletion by comp. |
1986-11-20 |
2023-08-11 |
mouse |
| H Bekemeier, R Hirschelman. Influence of serotonin, serotonin antagonists, some vasoactive substances and temperature on carrageenin-induced tail thrombosis in rats and mice. Agents and actions. vol 18. issue 5-6. 1986-11-20. PMID:3766313. |
the effect of exogenous serotonin is antagonized by ketanserin and cyproheptadine, respect. |
1986-11-20 |
2023-08-11 |
mouse |
| V K Shukla, S K Garg, S K Kulkarn. Modification by clonidine of harmine-induced tremors in mice: involvement of serotoninergic system. Archives internationales de pharmacodynamie et de therapie. vol 282. issue 1. 1986-11-19. PMID:3490237. |
on the other hand, the 5-ht antagonist cyproheptadine potentiated the protective effect of sub-effective doses of clonidine. |
1986-11-19 |
2023-08-11 |
mouse |
| T M Turpaev, O P Iurchenko, N G Grigor'e. [Changes in the acetylcholine responses of perfused neurons of Limnaea stagnalis during internal and external exposure of the cell]. Neirofiziologiia = Neurophysiology. vol 18. issue 3. 1986-09-16. PMID:3736710. |
the blocker of serotonin receptors, cyproheptadine, blocks the enhancing effect of serotonin on the intracellular addition of the mediator, but mimics the inhibitory effect of serotonin on acetylcholine response. |
1986-09-16 |
2023-08-11 |
Not clear |
| M L Vitale, M de las Nieves Parisi, S R Chiocchio, J H Tramezzan. Serotonin stimulates gonadotrophin release by acting directly on the median eminence. Acta physiologica et pharmacologica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y de la Asociacion Latinoamericana de Farmacologia. vol 35. issue 4. 1986-07-24. PMID:2940808. |
pretreatment with the 5-ht receptor blocker cyproheptadine (1 um) completely inhibited the stimulatory effect of 5-ht. |
1986-07-24 |
2023-08-11 |
rat |
| J A Zivin, U DeGirolam. Studies of the influence of biogenic amines on central nervous system ischemia. Stroke. vol 17. issue 3. 1986-07-23. PMID:2424154. |
using biochemical and histological methods we tested the effects of the serotonin inhibitors cyproheptadine and brom-lsd in a highly reproducible rabbit spinal cord ischemia model. |
1986-07-23 |
2023-08-11 |
rabbit |
| H S Sharma, P K De. Probable involvement of 5-hydroxytryptamine in increased permeability of blood-brain barrier under heat stress in young rats. Neuropharmacology. vol 25. issue 2. 1986-05-23. PMID:2939361. |
pretreatment with cyproheptadine and vinblastine, however, prevented only the increased permeability of the blood-brain barrier; the plasma and level of 5-ht in brain continued to remain high. |
1986-05-23 |
2023-08-11 |
rat |
| T Inoue, Y Kato, A Shimatsu, K Tojo, N Yanaihara, H Imur. Stimulation by serotonin of immunoreactive peptide histidine isoleucine release from rat hypothalamus in vitro. Neuroscience letters. vol 64. issue 1. 1986-05-07. PMID:3754315. |
phi-li release induced by 5-ht (10(-5) m) was abolished by cyproheptadine (10(-4) m), a 5-ht antagonist. |
1986-05-07 |
2023-08-11 |
rat |
| K Takeuchi, H Ohtsuki, S Okab. Pathogenesis of compound 48/80-induced gastric lesions in rats. Digestive diseases and sciences. vol 31. issue 4. 1986-05-07. PMID:3956335. |
oral administration of methysergide and cyproheptadine (serotonin antagonists) and fpl-52694 (a mast cell stabilizer) potently inhibited the compound 48/80-induced lesions. |
1986-05-07 |
2023-08-11 |
rat |
| K G Charlton, R A Bond, D E Clark. An inhibitory prejunctional 5-HT1-like receptor in the isolated perfused rat kidney. Apparent distinction from the 5-HT1A, 5-HT1B and 5-HT1C subtypes. Naunyn-Schmiedeberg's archives of pharmacology. vol 332. issue 1. 1986-04-22. PMID:3951568. |
the inhibitory effect of 5-ht on the electrically-evoked release of tritium was antagonized in a concentration-dependent manner by methiothepin (ic50 = 4 x 10(-9) mol/l), metergoline (ic50 = 4 x 10(-8) mol/l) and methysergide (ic50 = 1.3 x 10(-7) mol/l) but not by cyproheptadine, ketanserin, mesulergine, (-)-propranolol, (+/-)-pindolol, (+/-)-cyanopindolol, metoclopramide or phentolamine. |
1986-04-22 |
2023-08-11 |
rat |