| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Wielos. Increased sensitivity to serotonergic agonists after repeated electroconvulsive shock in rats. Pharmacology, biochemistry, and behavior. vol 22. issue 5. 1985-08-09. PMID:2989938. |
the effect of single and repeated electroconvulsive shock (ecs) (once daily for 7 days) on head twitches produced by 5-ht agonists (licl, 5-hydroxytryptophan; 5-htp and 5-methoxytryptamine; 5-mt) was investigated 1 hr, 24 hr, 5 days and 10 days after the last ecs, while locomotor activity induced by serotonergic agonists (fenfluramine, 3-chlorophenylpiperazine; m-cpp) and antagonists (metergoline, cyproheptadine) was only investigated after 24 hr. |
1985-08-09 |
2023-08-11 |
rat |
| S C Fehrer, J L Silsby, M E el Halawan. Cyproheptadine stimulated prolactin release in the young turkey (Meleagris gallopavo). Poultry science. vol 64. issue 5. 1985-07-24. PMID:3158889. |
cyproheptadine pretreatment failed to depress the quipazine (serotonin agonist)-induced prl rise. |
1985-07-24 |
2023-08-11 |
Not clear |
| L M Adams, M A Geye. Effects of DOM and DMT in a proposed animal model of hallucinogenic activity. Progress in neuro-psychopharmacology & biological psychiatry. vol 9. issue 2. 1985-07-18. PMID:3858911. |
pretreatment with the serotonin (5-ht) antagonist cyproheptadine (1.0 mg/kg), which does not block the psychological effects of hallucinogens in humans, selectively blocked dom's reduction of rearings without altering dom's reduction of center entries, crossovers, or holepokes. |
1985-07-18 |
2023-08-11 |
rat |
| S W Lamberts, T Verleun, R Oostero. The mechanism of action of cyproheptadine on prolactin release by cultured anterior pituitary cells. Life sciences. vol 36. issue 23. 1985-07-02. PMID:3923287. |
the present study investigated the mechanism of action of the serotonin receptor-blocking agent cyproheptadine on prl release by normal cultured rat anterior pituitary cells. |
1985-07-02 |
2023-08-11 |
rat |
| S W Lamberts, T Verleun, R Oostero. The mechanism of action of cyproheptadine on prolactin release by cultured anterior pituitary cells. Life sciences. vol 36. issue 23. 1985-07-02. PMID:3923287. |
cyproheptadine (10 nm-10 microm) and its metabolite desmethylcyproheptadine (a compound which has lost its affinity for serotonin receptors) directly inhibited prl release, while serotonin, investigated over a wide concentration range, did not reverse this inhibition. |
1985-07-02 |
2023-08-11 |
rat |
| H S Sharma, P K De. Role of 5-HT on increased permeability of blood-brain barrier under heat stress. Indian journal of physiology and pharmacology. vol 28. issue 4. 1985-07-02. PMID:6242051. |
cyproheptadine and vinblastine pretreatment however, prevented only the increased permeability of bbb, the plasma and brain 5-ht level continued to remain high. |
1985-07-02 |
2023-08-12 |
rat |
| G Boschi, N Launa. Differential effects of neuroleptic and serotonergic drugs on amphetamine-induced hypothermia in mice. Neuropharmacology. vol 24. issue 2. 1985-06-19. PMID:2859540. |
pretreatment with the serotonergic (5-ht) receptor blocker cyproheptadine also potentiated the hypothermia. |
1985-06-19 |
2023-08-11 |
mouse |
| M J Rowan, R Anwy. The effect of prolonged treatment with tricyclic antidepressants on the actions of 5-hydroxytryptamine in the hippocampal slice of the rat. Neuropharmacology. vol 24. issue 2. 1985-06-19. PMID:3157877. |
acute application of the 5-ht receptor antagonists cyproheptadine (10(-5) m) and ketanserin (7.5 x 10(-6) m) completely prevented the appearance of the inhibitory effect of 10(-5) m 5-ht without affecting the excitatory effects. |
1985-06-19 |
2023-08-11 |
rat |
| O Gaffori, J M Van Re. Serotonin and antidepressant drugs antagonize melatonin-induced behavioural changes after injection into the nucleus accumbens of rats. Neuropharmacology. vol 24. issue 3. 1985-06-18. PMID:2859542. |
injection of serotonin antagonists (methysergide and cyproheptadine) into the nucleus accumbens resulted in similar behavioural changes as was found after treatment with melatonin. |
1985-06-18 |
2023-08-11 |
rat |
| J A Zivi. Cyproheptadine reduces or prevents ischemic central nervous system damage. Neurology. vol 35. issue 4. 1985-05-08. PMID:3982650. |
drugs thought to be serotonin agonists did not aggravate the damage, but bufotenin reversed protective effect of cyproheptadine. |
1985-05-08 |
2023-08-11 |
human |
| J A Zivi. Cyproheptadine reduces or prevents ischemic central nervous system damage. Neurology. vol 35. issue 4. 1985-05-08. PMID:3982650. |
the results suggest that serotonin antagonists reduce ischemic cns damage; cyproheptadine may be a potential treatment for ischemic stroke. |
1985-05-08 |
2023-08-11 |
human |
| A Sietniek. Involvement of 5-HT2 receptors in the LSD- and L-5-HTP-induced suppression of lordotic behavior in the female rat. Journal of neural transmission. vol 61. issue 1-2. 1985-05-03. PMID:3872342. |
the effects of the putative 5-ht antagonists lisuride, metergoline, methysergide, mianserin, cinanserin, cyproheptadine, pirenperone and altanserin on the lsd-induced inhibition of l.r. |
1985-05-03 |
2023-08-11 |
rat |
| C Su, T Urun. Excitatory and inhibitory effects of 5-hydroxytryptamine in mesenteric arteries of spontaneously hypertensive rats. European journal of pharmacology. vol 106. issue 2. 1985-04-26. PMID:6529977. |
the vasoconstrictor response to 5-ht was resistant to prazosin but effectively inhibited by cyproheptadine and ketanserin. |
1985-04-26 |
2023-08-12 |
rat |
| C Su, T Urun. Excitatory and inhibitory effects of 5-hydroxytryptamine in mesenteric arteries of spontaneously hypertensive rats. European journal of pharmacology. vol 106. issue 2. 1985-04-26. PMID:6529977. |
the vasoconstrictor responses to norepinephrine and nerve stimulation were markedly potentiated by 5-ht, and this potentiation was blocked by ketanserin at concentrations which inhibited the 5-ht-induced vasoconstriction, while much higher concentrations were required for cyproheptadine. |
1985-04-26 |
2023-08-12 |
rat |
| K G Charlton, T D Johnson, D E Clark. Vasoconstrictor and norepinephrine potentiating action of 5-hydroxykynuramine in the isolated perfused rat kidney: involvement of serotonin receptors and alpha 1-adrenoceptors. Naunyn-Schmiedeberg's archives of pharmacology. vol 328. issue 2. 1985-04-19. PMID:6098835. |
vascular responses to 5-oh-k and 5-ht were inhibited noncompetitively by ketanserin and cyproheptadine. |
1985-04-19 |
2023-08-12 |
rat |
| G Osuide, C Wambebe, S Bodhanka. Effect of some serotoninergic agents on the rectal temperature of the domestic fowl (Gallus domesticus). Neuropharmacology. vol 23. issue 12A. 1985-04-17. PMID:6241299. |
therefore, it was the objective in this project to study the influence of 5-hydroxytryptamine (5-ht), 5-hydroxytryptophan (5-htp), benserazide, carbidopa (mk 486), citalopram, cyproheptadine, methysergide, xylamidine, p-chlorophenylalanine (pcpa) and lysergic acid diethylamide (lsd-25) on the rectal temperature of young chicks. |
1985-04-17 |
2023-08-12 |
Not clear |
| G Osuide, C Wambebe, S Bodhanka. Effect of some serotoninergic agents on the rectal temperature of the domestic fowl (Gallus domesticus). Neuropharmacology. vol 23. issue 12A. 1985-04-17. PMID:6241299. |
cyproheptadine (1.25 mg/kg) antagonised the hypothermic effect of 5-ht (0.1 and 0.8 mg/kg). |
1985-04-17 |
2023-08-12 |
Not clear |
| D Luttinger, M Freedman, L Hamel, S J Ward, M Perron. The effects of serotonin antagonists in a behavioral despair procedure in mice. European journal of pharmacology. vol 107. issue 1. 1985-04-15. PMID:6526071. |
six serotonin antagonists (pizotifen, mianserin, cyproheptadine, ketanserin, trazodone and methysergide) were tested in mice in a behavioral despair procedure. |
1985-04-15 |
2023-08-12 |
mouse |
| J N Crawley, P T Ninan, D Pickar, G P Chrousos, M Linnoila, P Skolnick, S M Pau. Neuropharmacological antagonism of the beta-carboline-induced "anxiety" response in rhesus monkeys. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 5. issue 2. 1985-03-27. PMID:2983041. |
in addition to these adrenergic agents, the serotonin antagonist, cyproheptadine (1 mg/kg), and the gaba-mimetic, 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyrindin-3-ol (1 mg/kg), partially blocked the behavioral, physiological, and biochemical changes after beta-cce. |
1985-03-27 |
2023-08-11 |
monkey |
| R S Moreland, C van Breemen, D F Boh. Mechanism by which serotonin attenuates contractile response of canine mesenteric arterial smooth muscle. The Journal of pharmacology and experimental therapeutics. vol 232. issue 2. 1985-03-21. PMID:2578562. |
methysergide and cyproheptadine, also 5-ht blockers, diminished the attenuation. |
1985-03-21 |
2023-08-11 |
dog |