| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Glusa, F Markward. Inhibition of 5-hydroxytryptamine-potentiated aggregation of human blood platelets by 5-hydroxytryptamine receptor-blocking agents. Biomedica biochimica acta. vol 43. issue 2. 1984-07-18. PMID:6732757. |
the synergistic effect of 5-ht on aggregation was inhibited by the compounds tested in the order of potency: cyproheptadine, pizotifen, spiperone, methysergide, methiothepine , mianserin, ketanserin, dihydroergotamine. |
1984-07-18 |
2023-08-12 |
human |
| b' M K Krsti\\xc4\\x87, Z S Katusi\\xc4\\x8. Divergent effects of pirenperone, a 5-HT2 antagonist, on the pressor and tachycardic responses to 5-HT in guinea-pigs. Archives internationales de physiologie et de biochimie. vol 91. issue 4. 1984-05-30. PMID:6202264.' |
the effects of pirenperone and cyproheptadine on the pressor and tachycardic responses to 5-hydroxytryptamine (5-ht) and to dimethylphenylpiperazinium (dmpp) were compared. |
1984-05-30 |
2023-08-12 |
Not clear |
| b' M K Krsti\\xc4\\x87, Z S Katusi\\xc4\\x8. Divergent effects of pirenperone, a 5-HT2 antagonist, on the pressor and tachycardic responses to 5-HT in guinea-pigs. Archives internationales de physiologie et de biochimie. vol 91. issue 4. 1984-05-30. PMID:6202264.' |
on the molecular base, pirenperone was 15 times more potent antagonist of the pressor response to 5-ht than cyproheptadine. |
1984-05-30 |
2023-08-12 |
Not clear |
| K W Shyu, M T Lin, T C W. Possible role of central serotoninergic neurons in the development of dental pain and aspirin-induced analgesia in the monkey. Experimental neurology. vol 84. issue 1. 1984-05-11. PMID:6231190. |
on the other hand, inhibition of central 5-ht receptors with central administration of either cyproheptadine (a blocking agent of 5-ht receptors), p-chlorophenylalanine (pcpa, an inhibitor of 5-ht synthesis) or 5,7-dihydroxytryptamine (5,7-dht, a depletor of central 5-ht nerve fibers) produced an enhancement in pain sensitivity (or a decrease in pain threshold). |
1984-05-11 |
2023-08-12 |
monkey |
| K A Halm. The state of research in anorexia nervosa and bulimia. Psychiatric developments. vol 1. issue 3. 1984-05-11. PMID:6369310. |
successful pharmacological approaches have included cyproheptadine (a serotonin antagonist), chlorpromazine and metoclopramide. |
1984-05-11 |
2023-08-12 |
Not clear |
| S J Peroutka, G S Alle. The calcium antagonist properties of cyproheptadine: implications for antimigraine action. Neurology. vol 34. issue 3. 1984-04-17. PMID:6538269. |
cyproheptadine is equipotent (ic50 = 41 to 45 nm) in blocking contractions of canine basilar artery segments induced by serotonin, norepinephrine, potassium, or calcium. |
1984-04-17 |
2023-08-12 |
Not clear |
| W S Willcockson, G R Hillma. Drug effects on the 5-HT response of Schistosoma mansoni. Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology. vol 77. issue 1. 1984-03-29. PMID:6141876. |
the order of potency for 5-ht response antagonism was haloperidol greater than cyproheptadine greater than mianserin greater than trazodone greater than spiperone greater than methysergide. |
1984-03-29 |
2023-08-12 |
Not clear |
| K Masaoka, T Niibe, T Kumasaka, M Sait. [Plasma prolactin response to suckling stimulation in puerperal women]. Nihon Sanka Fujinka Gakkai zasshi. vol 36. issue 1. 1984-03-26. PMID:6699448. |
the effects of the oral administration of two serotonin antagonist (cyproheptadine and metergoline) and the dopamine infusion on plasma prl levels and the response to suckling were investigated during the 1st week postpartum. |
1984-03-26 |
2023-08-12 |
Not clear |
| M Bonnet, G Lespinats, C Burti. Histamine and serotonin suppression of lymphocyte response to phytohemagglutinin and allogeneic cells. Cellular immunology. vol 83. issue 2. 1984-03-21. PMID:6319035. |
cyproheptadine, an anti-h1 histamine and anti-serotonin antagonist, and methysergide, an anti-serotonin antagonist, also blocked histamine and serotonin inhibitory activities. |
1984-03-21 |
2023-08-12 |
Not clear |
| D A Lewis, B M Sherma. Serotonergic stimulation of adrenocorticotropin secretion in man. The Journal of clinical endocrinology and metabolism. vol 58. issue 3. 1984-03-12. PMID:6319452. |
in a separate study, normal men were pretreated with cyproheptadine, a serotonin antagonist, before the administration of fenfluramine. |
1984-03-12 |
2023-08-12 |
Not clear |
| C A Maggi, S Manzini, A Mel. Contribution of cellular and extracellular Ca2+ during 5-hydroxytryptamine-induced contractions of rabbit ear artery. European journal of pharmacology. vol 94. issue 3-4. 1984-02-14. PMID:6418554. |
these findings as well as the results obtained with the receptor antagonists cyproheptadine and phentolamine could be interpreted as an indication that: (a) stimulation of alpha-adrenoceptors by 5-ht is only in part responsible for the contractile effects of 5-ht in rea; (b) additional mechanism(s) activated by 5-ht appear to modulate the duration of both cellular and extracellular ca2+-dependent contractions and, (c) difference(s) in tissular handling of these amines do not appear to play a role in their different contractile effects. |
1984-02-14 |
2023-08-12 |
rabbit |
| P H Hutson, M D Tricklebank, G Curzo. Analgesia induced by brief footshock: blockade by fenfluramine and 5-methoxy-N,N-dimethyltryptamine and prevention of blockade by 5-HT antagonists. Brain research. vol 279. issue 1-2. 1984-01-27. PMID:6315164. |
these decreases are blocked by the 5-ht antagonists, cyproheptadine and methiothepin. |
1984-01-27 |
2023-08-12 |
Not clear |
| T Kimura, S Sato. Presynaptic inhibition by serotonin of cardiac sympathetic transmission in dogs. Clinical and experimental pharmacology & physiology. vol 10. issue 5. 1984-01-27. PMID:6315283. |
administration of serotonin in doses of 10-100 micrograms/kg i.v., during the resting unstimulated state caused tachycardia and pressor responses which were inhibited by cyproheptadine but not by guanethidine. |
1984-01-27 |
2023-08-12 |
Not clear |
| G Engel, M Göthert, E Müller-Schweinitzer, E Schlicker, L Sistonen, P A Stadle. Evidence for common pharmacological properties of [3H]5-hydroxytryptamine binding sites, presynaptic 5-hydroxytryptamine autoreceptors in CNS and inhibitory presynaptic 5-hydroxytryptamine receptors on sympathetic nerves. Naunyn-Schmiedeberg's archives of pharmacology. vol 324. issue 2. 1984-01-07. PMID:6646239. |
when 5-ht receptor antagonists were investigated, metitepin and metergoline showed moderate affinities for the 5-ht autoreceptors in rat brain cortex slices, whereas quipazine had only weak affinity, and ketanserin, metoclopramide, cinanserin and cyproheptadine exhibited no antagonistic property. |
1984-01-07 |
2023-08-12 |
rat |
| M A Blackshear, R L Friedman, E Sanders-Bus. Acute and chronic effects of serotonin (5HT) antagonists on serotonin binding sites. Naunyn-Schmiedeberg's archives of pharmacology. vol 324. issue 2. 1984-01-07. PMID:6646240. |
therefore, these preliminary studies suggest that the loss of 5ht2 binding sites after in vivo treatment with cyproheptadine and with other 5ht antagonists may reflect an adaptive response. |
1984-01-07 |
2023-08-12 |
Not clear |
| A Ray, K K Sharma, M Alkondon, P Se. Possible interrelationship between the biogenic amines involved in the modulation of footshock aggression in rats. Archives internationales de pharmacodynamie et de therapie. vol 265. issue 1. 1984-01-07. PMID:6686000. |
dopamine increased fsa in cyproheptadine and cimetidine but not in pimozide pretreated animals; 5-hydroxytryptamine potentiated fsa in cimetidine and pimozide but not in cyproheptadine pretreated rats; 4-methylhistamine facilitated fsa in pimozide and cyproheptadine but not in cimetidine pretreated groups. |
1984-01-07 |
2023-08-12 |
rat |
| G Osuide, C Wambebe, D Ngu. Studies on the pharmacology of d-amphetamine on maximal electroconvulsive seizure in young chicks. Psychopharmacology. vol 81. issue 2. 1983-12-20. PMID:6415741. |
both the alpha-adrenoceptor antagonist phentolamine, and the serotonin antagonist cyproheptadine, had no significant influence on the anticonvulsant effect of d-amphetamine. |
1983-12-20 |
2023-08-12 |
chicken |
| M Kiraly, R C Ma, N J Du. Serotonin mediates a slow excitatory potential in mammalian celiac ganglia. Brain research. vol 275. issue 2. 1983-12-20. PMID:6605177. |
the slow depolarization evoked by either nerve stimulation or 5-ht was augmented by fluoxetine, a 5-ht reuptake blocker, and depressed by cyproheptadine, a 5-ht receptor blocker; in addition, tryptophan, a precursor of 5-ht, enhanced differentially the slow epsp. |
1983-12-20 |
2023-08-12 |
Not clear |
| L Pawłowski, H Kwiate. The effect of highly selective inhibitors of the uptake of noradrenaline or 5-hydroxytryptamine on TRH-induced hyperthermia in mice. Psychopharmacology. vol 81. issue 1. 1983-12-17. PMID:6138792. |
cyproheptadine (5 mg/kg), an antagonist of 5-hydroxytryptamine receptors (which, like the alpha-adrenoceptor antagonist, produced hypothermia in normal mice) did not prevent the effects of clomipramine or desipramine. |
1983-12-17 |
2023-08-12 |
mouse |
| E G Ezrailson, M L Entman, A J Garbe. Adrenergic and serotonergic regulation of skeletal muscle metabolism in rat. I. The effects of adrenergic and serotonergic antagonists on the regulation of muscle amino acid release, glycogenolysis, and cyclic nucleotide levels. The Journal of biological chemistry. vol 258. issue 20. 1983-12-17. PMID:6313662. |
in contrast, serotonergic antagonists such as methysergide (10(-8)-10(-6) m) and cyproheptadine (10(-8)-10(-6) m) blocked the inhibition of alanine and glutamine release, the stimulations of muscle camp levels and phosphorylase a formation, and the decreased muscle glycogen content effected by serotonin but not by epinephrine. |
1983-12-17 |
2023-08-12 |
rat |