| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F J White, J B Appe. The role of dopamine and serotonin in the discriminative stimulus effects of lisuride. The Journal of pharmacology and experimental therapeutics. vol 221. issue 2. 1982-07-22. PMID:7077537. |
in antagonism tests, only drug capable of blocking da receptors, haloperidol and methiothepin, attenuated the lhm cues; the 5-ht antagonists cyproheptadine, bc-105 and xylamidine were ineffective. |
1982-07-22 |
2023-08-12 |
rat |
| F J White, J B Appe. Training dose as a factor in LSD-saline discrimination. Psychopharmacology. vol 76. issue 1. 1982-07-19. PMID:6805003. |
substitution tests with direct serotonin (5-ht) agonists (quipazine, mk-212, 5-methoxy-n,n-dimethyltryptamine) and antagonism tests with central 5-ht antagonists (methiothepin and cyproheptadine) indicated that 5-ht is involved in mediating the in vivo effects of lsd and that training dose co-determines (along with the dose of the test compound) the extent of substitution or antagonism. |
1982-07-19 |
2023-08-12 |
rat |
| R J Barrett, M A Blackshear, E Sanders-Bus. Discriminative stimulus properties of L-5-hydroxytryptophan: behavioral evidence for multiple serotonin receptors. Psychopharmacology. vol 76. issue 1. 1982-07-19. PMID:6805004. |
nevertheless, the classical 5-ht antagonists methysergide, cyproheptadine, metergoline, and methiothepin did not block the l-5-htp-related discriminative stimulus. |
1982-07-19 |
2023-08-12 |
rat |
| M D Gedevanishvili, L E Tsutsunava, N A Malazonii. [Serotonin independently stimulates fibroblast adhesion and multiplication in culture]. Tsitologiia. vol 24. issue 2. 1982-06-14. PMID:7073851. |
adhesion- and growth- stimulatory activities were blocked by serotonin antagonists - cyproheptadine and tipindole, demonstrating that the specific binding of bioamine with cell receptors is essential in both the cases. |
1982-06-14 |
2023-08-12 |
human |
| R K Goyal, N M Patel, S C Verm. Comparative studies of the effects of 5-hydroxytryptamine and noradrenaline on the rat anococcygeus muscle. Agents and actions. vol 11. issue 6-7. 1982-06-14. PMID:7340461. |
cyproheptadine (1.0 x 10(-6) m), a specific 5ht receptor blocker, failed to inhibit the responses to either 5ht or na. |
1982-06-14 |
2023-08-12 |
rat |
| M D Tricklebank, P H Hutson, G Curzo. Analgesia induced by brief footshock is inhibited by 5-hydroxytryptamine but unaffected by antagonists of 5-hydroxytryptamine or by naloxone. Neuropharmacology. vol 21. issue 1. 1982-05-27. PMID:7063108. |
however, agonists, quipazine and trifluoromethylphenylpiperazine, with greater reported affinities for 5ht binding sites on rat brain membranes than mk212 were without effect as were the antagonists metergoline, methysergide, cyproheptadine, mianserine and methiothepin. |
1982-05-27 |
2023-08-12 |
rat |
| J Mattil. Studies on the mechanism of the GABAergic inhibition of TSH secretion in male rats. Acta pharmacologica et toxicologica. vol 48. issue 4. 1982-05-12. PMID:6278833. |
the inhibitory effects of two gabaergic drugs muscimol (1 mg/kg subcutaneously) and aminooxyacetic acid (10 mg/kg intraperitoneally) were not antagonized by picrotoxin (1-4 mg/kg intraperitoneally), by phenoxybenzamine (2.5 or 5 mg/kg intraperitoneally), by two 5-ht antagonists cyproheptadine (5 mg/kg intraperitoneally and r 41468 (2.5 mg/kg intraperitoneally) or by pimozide (0.5, 1.5 or 2.5 mg/kg subcutaneously). |
1982-05-12 |
2023-08-12 |
rat |
| M A Johns, E C Azmitia, D T Kriege. Specific in vitro uptake of serotonin by cells in the anterior pituitary of the rat. Endocrinology. vol 110. issue 3. 1982-04-22. PMID:7056230. |
1) to test the specificity and saturability of uptake of 5ht in the anterior pituitary, pituitary tissue was incubated (37 c) with [3h]5ht (10(-8)-10(-6) m) in the presence and absence of excess (10(-5) m) unlabeled 5ht, norepinephrine, fluoxetine (fluox), metergoline, or cyproheptadine. |
1982-04-22 |
2023-08-12 |
rat |
| M A Johns, E C Azmitia, D T Kriege. Specific in vitro uptake of serotonin by cells in the anterior pituitary of the rat. Endocrinology. vol 110. issue 3. 1982-04-22. PMID:7056230. |
the total uptake of [3h]5ht was not altered by norepinephrine or metergoline, but was significantly reduced (p less than 0.01-0.001) by fluox and cyproheptadine. |
1982-04-22 |
2023-08-12 |
rat |
| R Langwiński, S Fideck. Central action of narcotic analgesics. IX. Participation of serotonin in the development of tolerance to cataleptogenic effects of morphine in rats. Polish journal of pharmacology and pharmacy. vol 33. issue 4. 1982-04-12. PMID:6460229. |
blockade of 5-ht neurotransmission by pizotifen or cyproheptadine inhibited the development of morphine tolerance, while the increase of it by imipramine did not alter the development of this tolerance . |
1982-04-12 |
2023-08-12 |
rat |
| T P Blackburn, B Cox, C G Heapy, T F Le. Possible mechanism of 5-methoxy-N,N-dimethyltryptamine-induced turning behaviour in DRN lesioned rats. Pharmacology, biochemistry, and behavior. vol 16. issue 1. 1982-04-12. PMID:7058215. |
this turning behaviour was blocked by pretreatment with putative 5-ht antagonists, methysergide, cyproheptadine and cinanserin. |
1982-04-12 |
2023-08-12 |
rat |
| I Mounsey, K A Brady, J Carroll, R Fisher, D N Middlemis. K+-evoked [3H]-5-HT release from rat frontal cortex slices: the effect of 5-HT agonists and antagonists. Biochemical pharmacology. vol 31. issue 1. 1982-04-12. PMID:7059349. |
at a concentration of 1 microm, the 5-ht antagonists drugs cinanserin and mianserin produced a small but significant reversal of the 5-ht induced inhibition of k+-evoked [3h]-5-ht release, but methysergide, metergoline and cyproheptadine were completely without effect at this concentration. |
1982-04-12 |
2023-08-12 |
rat |
| J Hardcastle, P T Hardcastle, J S Redfer. Action of 5-hydroxytryptamine on intestinal ion transport in the rat. The Journal of physiology. vol 320. 1982-03-26. PMID:6275078. |
the 5-ht response in vivo was unaffected by atropine, cyproheptadine, propranolol and hexamethonium. |
1982-03-26 |
2023-08-12 |
rat |
| H Fink, W Oelssne. LSD mescaline and serotonin injected into medial raphe nucleus potentiate apomorphine hypermotility. European journal of pharmacology. vol 75. issue 4. 1982-03-22. PMID:7318915. |
the potentiating effect of lsd or serotonin was suppressed by simultaneous injections of methysergide (0.05 microgram) or cyproheptadine (0.05 microgram) into the medial raphe nucleus. |
1982-03-22 |
2023-08-12 |
rat |
| M Sypniewska, E Przegalińsk. The effect of pyrazidol on the central serotonergic system. Polish journal of pharmacology and pharmacy. vol 33. issue 3. 1982-03-22. PMID:7322945. |
this stimulation was abolished by a central serotonin blocking agent, cyproheptadine, but unchanged by an agent inhibiting the uptake of 5-hydroxytryptamine, clomipramine. |
1982-03-22 |
2023-08-12 |
rat |
| M Davis, D I Astracha. Spinal modulation of acoustic startle: opposite effects of clonidine and d-amphetamine. Psychopharmacology. vol 75. issue 3. 1982-03-13. PMID:6119728. |
these effects were blocked by ip injection of the alpha 1-adrenergic antagonist wb-4101, but not the serotonin antagonist cyproheptadine. |
1982-03-13 |
2023-08-12 |
Not clear |
| R Langwiński, S Fideck. Central action of narcotic analgesics. VII. The role of serotonin in the development of morphine tolerance in the locomotor activity test in mice and rats. Polish journal of pharmacology and pharmacy. vol 33. issue 2. 1982-02-25. PMID:6458804. |
although cyproheptadine and pizotifen did not alter the development of morphine tolerance in rats, nevertheless, it seems from these results that serotonin neurotransmission is of some importance in the development of tolerance to morphine. |
1982-02-25 |
2023-08-12 |
mouse |
| S R Coughlin, M A Moskowitz, H N Antoniades, L Levin. Serotonin receptor-mediated stimulation of bovine smooth muscle cell prostacyclin synthesis and its modulation by platelet-derived growth factor. Proceedings of the National Academy of Sciences of the United States of America. vol 78. issue 11. 1982-02-12. PMID:7031670. |
an increase in prostacyclin synthesis was elicited by the addition of a serotonin agonist, quipazine (1 microm and above), and antagonized by the serotonin receptor blockers cyproheptadine, methysergide, or methiothepin but not by other aminergic receptor-blocking drugs (e.g., phentolamine or propranolol). |
1982-02-12 |
2023-08-12 |
cattle |
| H Moritoki, C S. Potentiating effects of 5-hydroxytryptamine and histamine on nerve stimulation-induced contractions of the rabbit mesenteric artery. Archives internationales de pharmacodynamie et de therapie. vol 252. issue 2. 1982-01-20. PMID:7305557. |
the potentiating effect of 5-ht was partly reduced by cyproheptadine and by prolonged treatment with methysergide. |
1982-01-20 |
2023-08-12 |
rabbit |
| A R Gree. Pharmacological studies on serotonin-mediated behaviour. Journal de physiologie. vol 77. issue 2-3. 1981-12-22. PMID:6457143. |
the behaviour produced by administration of tcp/l-tryptophan or 5-methoxy n,n-dimethyl tryptamine was inhibited by the suggested 5-ht antagonists, methysergide, methergoline and (--)-propranolol, but not by cinanserin, mianserin and cyproheptadine, other putative antagonists. |
1981-12-22 |
2023-08-12 |
rat |