| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Apperley, W Feniuk, P P Humphrey, G P Lev. Evidence for two types of excitatory receptor for 5-hydroxytryptamine in dog isolated vasculature. British journal of pharmacology. vol 68. issue 2. 1980-05-30. PMID:7357206. |
1 as part of an investigation into the mode of action of anti-migraine drugs, a study of the excitatory receptors for 5-hydroxytryptamine (5-ht) has been carried out in a range of isolated vascular preparations from the dog.2 5-ht contracted the dog isolated femoral artery and saphenous vein over the concentration-range 1.0 x 10(-8) to 5.0 x 10(-6) mol/l.3 in the femoral artery methysergide and cyproheptadine were potent, competitive and specific antagonists of the contractile responses to 5-ht, with pa(2) values of 8.52 and 8.55 respectively.4 in the saphenous vein, methysergide was only a weak antagonist of 5-ht. |
1980-05-30 |
2023-08-12 |
dog |
| E Apperley, W Feniuk, P P Humphrey, G P Lev. Evidence for two types of excitatory receptor for 5-hydroxytryptamine in dog isolated vasculature. British journal of pharmacology. vol 68. issue 2. 1980-05-30. PMID:7357206. |
cyproheptadine was a weak and unsurmountable antagonist of contractile responses to 5-ht and methysergide.5 contractile responses to 5-ht and methysergide in the saphenous vein were not antagonized by morphine (3.0 x 10(-5) mol/l), indomethacin (5.0 x 10(-5) mol/l), phentolamine (5.0 x 10(-7) mol/l), propranolol (1.0 x 10(-6) mol/l), atropine (1.0 x 10(-6) mol/l), mepyramine (1.0 x 10(-6) mol/l) or cimetidine (1.0 x 10(-5) mol/l).6 in the external carotid and lingual arteries the pattern of activity obtained with methysergide and cyproheptadine was the same as that in the femoral artery, while in the auricular artery the pattern of activity was the same as that in the saphenous vein.7 the results are consistent with the hypothesis that there are two types of receptor mediating 5-ht-induced vasoconstriction in dog vasculature. |
1980-05-30 |
2023-08-12 |
dog |
| E Przegaliński, A Lewandowsk. The effect of etoperidone, a new potential antidepressant drug, on the central serotonin system. Journal of neural transmission. vol 46. issue 4. 1980-04-17. PMID:529000. |
this stimulating action was abolished by 5-ht antagonists (cyproheptadine, danitracen) and by the drug metabolism inhibitor skf-525a, but not by the 5-ht uptake inhibitor clomipramine. |
1980-04-17 |
2023-08-11 |
mouse |
| J D Warbritton, R M Stewart, R J Baldessarin. Increased sensitivity to intracerebroventricular infusion of serotonin and deaminated indoles after lesioning rat with dihydroxytryptamine. Brain research. vol 183. issue 2. 1980-04-17. PMID:6153283. |
the putative serotonin antagonists, cyproheptadine and methiothepin (i.p. |
1980-04-17 |
2023-08-12 |
rat |
| L Pawłowski, J Ruczyńska, E Wojtasi. An evidence for the central serotoninergic activity of viloxazine. Polish journal of pharmacology and pharmacy. vol 31. issue 4. 1980-03-17. PMID:523336. |
this effect of viloxazine was inhibited by serotonin receptor blockers, cyproheptadine, danitracen and metergoline, and by serotonin uptake blocking agents imipramine and clomipramine. |
1980-03-17 |
2023-08-11 |
rat |
| K Rácz, I Wolf, R Kiss, G Lada, S Vida, E Glá. Corticosteroidogenesis by isolated human adrenal cells: effect of serotonin and serotonin antagonists. Experientia. vol 35. issue 11. 1980-02-26. PMID:228968. |
the results indicate that serotonin increases corticosterone production, while the serotonin antagonists cyproheptadine and methysergide depress adrenal steroid - particularly cortisol and aldosterone - biosynthesis. |
1980-02-26 |
2023-08-11 |
human |
| F C Colpaert, C J Niemegeers, P A Jansse. In vivo evidence of partial agonist activity exerted by purported 5-hydroxytryptamine antagonists. European journal of pharmacology. vol 58. issue 4. 1980-02-15. PMID:510385. |
tests for stimulus generalization in rats so trained indicated that the purported 5-ht antagonists cyproheptadine (1.25 and 10 mg/kg), methysergide (0.16 to 10 mg/kg) and mianserin (2.5 to 40 mg/kg) produced partial generalization with lsd. |
1980-02-15 |
2023-08-11 |
rat |
| W Feniuk, P P Humphrey, A D Watt. Presynaptic inhibitory action of 5-hydroxytryptamine in dog isolated saphenous vein. British journal of pharmacology. vol 67. issue 2. 1980-01-28. PMID:497528. |
this suggests that the contractions were mediated predominantly through noradrenaline release from postganglionic noradrenergic nerves.3 contractions produced by intermittent electrical stimulation at 2 hz were inhibited by 5-hydroxy-tryptamine (1.0 x 10(-9) to 1.0 x 10(-7) mol/l) in a concentration-dependent manner whilst contractions induced by exogenous noradrenaline were not affected.4 the inhibitory action of 5-hydroxytryptamine was most marked at low frequencies of stimulation and with low pulse numbers.5 high external calcium concentrations (3.9 and 5.2 x 10(-3) mol/l) reduced the inhibitory action of 5-hydroxytryptamine.6 cyproheptadine (1.0 x 10(-8) mol/l to 1.0 x 10(-6) mol/l) or morphine (1.0 x 10(-7) mol/l to 1.0 x 10(-5) mol/l) did not antagonize the inhibitory action of 5-hydroxytryptamine. |
1980-01-28 |
2023-08-11 |
dog |
| C Ferrari, C Barbieri, R Caldara, V Magnoni, G P Testori, M Romuss. Improved oral glucose tolerance following antiserotonin treatment in patients with chemical diabetes. European journal of clinical pharmacology. vol 15. issue 6. 1980-01-24. PMID:499287. |
the effects of short-term treatment with either placebo or two serotonin antagonists, cyproheptadine and metergoline, on oral glucose tolerance and insulin secretion have been evaluated in normal subjects and in patients with chemical diabetes. |
1980-01-24 |
2023-08-11 |
human |
| M Cooper, J H Wylli. Some properties of 5-hydroxytryptamine receptors in the hindquarters of the rat. British journal of pharmacology. vol 67. issue 1. 1980-01-19. PMID:497523. |
4 the 5-hydroxytryptamine (5-ht) antagonists, methysergide and cyproheptadine, although very potent, displayed antagonism of a non-competitive type whereas a series of phenothiazines and phentolamine displayed competitive antagonism against 5-ht. |
1980-01-19 |
2023-08-11 |
rat |
| V M Ganatra, V R Dhumal, J D Bhatt, K S Sachde. Antagonism of some contractile responses to prostaglandins by cyproheptadine. Archives internationales de pharmacodynamie et de therapie. vol 240. issue 2. 1980-01-19. PMID:508004. |
cyproheptadine blocks the responses to pge1, pgf2 alpha, acetylcholine, 5-hydroxytryptamine in extremely small concentrations varying from 10 ng to 1 microgram/ml. |
1980-01-19 |
2023-08-11 |
rat |
| V M Ganatra, V R Dhumal, J D Bhatt, K S Sachde. Antagonism of some contractile responses to prostaglandins by cyproheptadine. Archives internationales de pharmacodynamie et de therapie. vol 240. issue 2. 1980-01-19. PMID:508004. |
it is concluded that cyproheptadine nonspecifically antagonised the responses to acetylcholine, 5-hydroxytryptamine, pge1 and pgf2 alpha in extremely small concentrations. |
1980-01-19 |
2023-08-11 |
rat |
| F Cerrito, M Raiter. Serotonin release is modulated by presynaptic autoreceptors. European journal of pharmacology. vol 57. issue 4. 1979-12-27. PMID:488172. |
other 5ht antagonists (cyproheptadine, methysergide and mianserin) were inactive and may therefore act preferentially at the postsynaptic receptors. |
1979-12-27 |
2023-08-11 |
Not clear |
| Z Roliński, M Herbu. Determination of the role of serotonergic and cholinergic systems in apomorphine--induced aggressiveness in rats. Polish journal of pharmacology and pharmacy. vol 31. issue 2. 1979-12-20. PMID:573894. |
however, cyproheptadine was the only one of four 5-ht antagonists used which potentiated the aggressive behavior. |
1979-12-20 |
2023-08-11 |
rat |
| K Yamada, T Furukaw. Serotonergic function in mouse head twitches induced by lithium and reserpine. Psychopharmacology. vol 61. issue 3. 1979-08-16. PMID:109889. |
the head twitches induced by lithium in combination with reserpine were strongly inhibited by antiserotonin drugs, methysergide and cyproheptadine, and also by a serotonin synthesis inhibitor, p-chlorophenylalanine (pcpa), when administered between lithium and reserpine. |
1979-08-16 |
2023-08-11 |
mouse |
| O M Cramer, C A Barracloug. The actions of serotonin, norepinephrine, and epinephrine on hypothalamic processes leading to adenohypophyseal luteinizing hormone release. Endocrinology. vol 103. issue 3. 1979-05-26. PMID:570497. |
lilly 110140 (3.2 x 10(-4) m), and cyproheptadine (2.9 x 10(-4) m) blocked the inhibitory effects of serotonin. |
1979-05-26 |
2023-08-11 |
rat |
| D P Boisvert, B K Weir, T R Overton, R J Reiffenstein, M G Grac. Cerebrovascular responses to subarachnoid blood and serotonin in the monkey. Journal of neurosurgery. vol 50. issue 4. 1979-05-24. PMID:106096. |
preliminary in vitro experiments were performed to determine the serum concentration of serotonin in the monkey, and the ability of cyproheptadine to block serotonin and serum-induced contractions in monkey cerebral arteries. |
1979-05-24 |
2023-08-11 |
monkey |
| D Jordan, C Poncet, R Mornex, G Ponsi. Participation of serotonin in thyrotropin release. I. Evidence for the action of serotonin on thyrotropin releasing hormone release. Endocrinology. vol 103. issue 2. 1979-05-23. PMID:105891. |
this stimulating effect of 5-ht was completely prevented by pretreatment with cyproheptadine, a blocker of 5-ht receptors, whereas fluphenazine, a dopamine receptor blocker, was unable to block it. |
1979-05-23 |
2023-08-11 |
rat |
| F De Clerck, L Van Gorp, O Vanparijs, M Borgers, F Awouter. Oxatomide protects Trichinella spiralis infected mice from lethal anaphylaxis. Agents and actions. vol 8. issue 6. 1979-04-28. PMID:742554. |
in contrast to cyproheptadine, oxatomide offered little protection against serotonin toxicity in mice. |
1979-04-28 |
2023-08-11 |
mouse |
| J M Girault, J J Jaco. Serotonin antagonists and central hyperthermia produced by biogenic amines in conscious rabbits. European journal of pharmacology. vol 53. issue 2. 1979-03-28. PMID:32059. |
previous studies have shown that the hyperthermia produced by intracerebroventricular injection of 5-hydroxytryptamine (5-ht) to conscious rabbits was antagonized by cyproheptadine and increased by lsd. |
1979-03-28 |
2023-08-11 |
Not clear |