| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M D Gedevanishvili, L E Tsutsunav. [Pharmacologic analysis of the stimulating effect of serotonin on proliferation in cell cultures]. Tsitologiia. vol 20. issue 6. 1978-12-02. PMID:99848. |
the stimulatory effect is completely prevented by pretreatment of cultured cells with serotonin antagonists of tipindole, morphine or cyproheptadine type which do not affect cell proliferation. |
1978-12-02 |
2023-08-11 |
human |
| G R Hageman, F Urthaler, T N Jame. Neural pathways of a cardiogenic hypertensive chemoreflex. The American journal of physiology. vol 235. issue 3. 1978-11-29. PMID:696846. |
cyproheptadine (1 mg/kg iv) regularly abolished both the reflex and the chemoreceptor afferent neural traffic, but injection of a 10 times higher concentration of serotonin (1 mg/ml) readily surmounted the blockade and restored the chemoreceptor neural traffic. |
1978-11-29 |
2023-08-11 |
Not clear |
| B Costall, R J Naylor, V Nohri. Climbing behaviour induced by apomorphine in mice: a potential model for the detection of neuroleptic activity. European journal of pharmacology. vol 50. issue 1. 1978-10-18. PMID:28233. |
the involvement of serotonin with climbing was extended to the actions of the neuroleptics: the antagonistic effects of typical neuroleptics (haloperidol, fluphenazine, loxapine) were markedly enhanced by combination with methysergide or cyproheptadine whilst the effects of clozapine, sulpiride and thioridazine were significantly reduced. |
1978-10-18 |
2023-08-11 |
mouse |
| J S Meyer, N S Buckholtz, W O Bogga. Serotonergic stimulation of pituitary-adrenal activity in the mouse. Neuroendocrinology. vol 26. issue 5. 1978-10-18. PMID:150549. |
corticosterone (cs) responses to 5-htp were uninfluenced by pretreatment with a tryptophan hydroxylase inhibitor, p-chlorophenylalanine (pcpa), but were significantly potentiated by a serotonin (5-ht) reuptake inhibitor (lilly 110140), attenuated by two 5-ht receptor blockers, cyproheptadine and methergoline, and almost completely abolished by 2 extracerebral aromatic l-amino acid decarboxylase inhibitors, mk 486 and a low dose of ro 4-4602. |
1978-10-18 |
2023-08-11 |
mouse |
| B V Clineschmidt, J C McGuffin, A B Pflueger, J A Totar. A 5-hydroxytryptamine-like mode of anorectic action for 6-chloro-2-[1-piperazinyl]-pyrazine (MK-212). British journal of pharmacology. vol 62. issue 4. 1978-08-28. PMID:656703. |
2 pretreatment with methergoline, a 5-hydroxytryptamine (5-ht) antagonist, reduced the magnitude of the anorectic effect of 1.5 and 3 mg/kg of mk-212, while the anti-5-ht agents, cyproheptadine and cinanserin, were likewise effective against the 3 mg/kg dose. |
1978-08-28 |
2023-08-11 |
rat |
| D Chadwick, M Hallett, P Jenner, C D Marsde. 5-hydroxytryptophan-induced myoclonus in guinea pigs. A physiological and pharmacological investigations. Journal of the neurological sciences. vol 35. issue 1. 1978-04-17. PMID:304885. |
the 5-htp-induced syndrome is antagonised by a central decarboxylase inhibitor (nsd-1035) and by agents which block 5-ht receptors (methysergide and cyproheptadine). |
1978-04-17 |
2023-08-11 |
Not clear |
| D Tsang, S La. Effect of monoamine receptor agonists and antagonists on cyclic AMP accumulation in human cerebral cortex slices. Canadian journal of physiology and pharmacology. vol 55. issue 6. 1978-03-29. PMID:23211. |
chlorpromazine blocked the increase of cyclic amp formation induced by noradrenaline, dopamine or serotonin, while cyproheptadine, a putative central serotonergic antagonist, was ineffective. |
1978-03-29 |
2023-08-11 |
human |
| Z Rolińsk. The role of serotonergic and cholinergic systems in the aggression-stereotypy complex produced by amphetamine in mice. Polish journal of pharmacology and pharmacy. vol 29. issue 6. 1978-03-21. PMID:304574. |
serotonin antagonists: methysergide and cyproheptadine, did not potentiate clearly the aggressive component of asc. |
1978-03-21 |
2023-08-11 |
mouse |
| Z Kapturkiewicz, H Sowińsk. The effect of piribedil on body temperature in mice and rats. Polish journal of pharmacology and pharmacy. vol 29. issue 6. 1978-03-21. PMID:600860. |
administration of agents acting on serotonin receptors (cyproheptadine, p-chlorophenylalanine) or of a classical anticholinergic drug, atropine, did not change the hypothermizing effect of piribedil in rats. |
1978-03-21 |
2023-08-11 |
mouse |
| J E Hardebo, L Edvinsson, C Owman, N A Svendgaar. Potentiation and antagonism of serotonin effects on intracranial and extracranial vessels. Possible implications in migraine. Neurology. vol 28. issue 1. 1978-02-23. PMID:563539. |
the vasoconstrictor action of serotonin and its interaction with drugs (methysergide, pizotifen, cyproheptadine, ergotamine, dihydroergotamine) that have serotonin-antagonistic properties and that are used in the treatment of migraine were studied on isolated feline and human intracranial and extracranial arteries in vitro. |
1978-02-23 |
2023-08-11 |
human |
| K Golembiowska-Nikitin, G Wiszniowska, J Marcha. The effect of serotonin receptor blocking agents--cyproheptadine and danitracen--on serotonin turnover in the rat brain. Polish journal of pharmacology and pharmacy. vol 29. issue 5. 1978-02-18. PMID:145590. |
the effect of serotonin receptor blocking agents--cyproheptadine and danitracen--on serotonin turnover in the rat brain. |
1978-02-18 |
2023-08-11 |
rat |
| K Golembiowska-Nikitin, G Wiszniowska, J Marcha. The effect of serotonin receptor blocking agents--cyproheptadine and danitracen--on serotonin turnover in the rat brain. Polish journal of pharmacology and pharmacy. vol 29. issue 5. 1978-02-18. PMID:145590. |
cyproheptadine (cph), 0.5 mg/kg ip, did not affect the cerebral serotonin (5-ht) level, but elevated the level of 5-hydroxyindoleacetic acid (5-hiaa). |
1978-02-18 |
2023-08-11 |
rat |
| J L Ambrus, C M Ambrus, L Thurbe. Study of platelet aggregation in vivo: V effect of the antiserotonin agent cyproheptadine. Journal of medicine. vol 8. issue 5. 1978-02-18. PMID:412905. |
the antiserotonin agent cyproheptadine (periactin) was shown to be an effective antagonist of in vivo platelet aggregation induced in monkeys not only with serotonin but also with adp. |
1978-02-18 |
2023-08-11 |
monkey |
| S Epstein, S Hamilto. Cyproheptadine inhibition of stimulated plasma renin activity. The Journal of clinical endocrinology and metabolism. vol 45. issue 6. 1978-02-18. PMID:591619. |
cyproheptadine (periactin), a serotonin antagonist, was then administered (2 mg orally four times daily) for 7 days and the pra response to frusemide re-evaluated in the 4 subjects. |
1978-02-18 |
2023-08-11 |
human |
| S Epstein, S Hamilto. Cyproheptadine inhibition of stimulated plasma renin activity. The Journal of clinical endocrinology and metabolism. vol 45. issue 6. 1978-02-18. PMID:591619. |
our results show that serotonin, presumably acting via central pathways, may play a role in renin regulation and that this pathway can be inhibited by cyproheptadine. |
1978-02-18 |
2023-08-11 |
human |
| D C Remy, K E Rittle, C A Hunt, P S Anderson, E L Engelhardt, B V Clineschmidt, A Scriabin. (+)- and (-)-3-Methoxycyproheptadine. A comparative evaluation of the antiserotonin, antihistaminic, anticholinergic, and orexigenic properties with cyproheptadine. Journal of medicinal chemistry. vol 20. issue 12. 1978-02-18. PMID:592336. |
as a peripheral serotonin antagonist, (+/-)-4 was found to be one-half as potent as cyproheptadine (1b). |
1978-02-18 |
2023-08-11 |
Not clear |
| M Stuart, L Lazarus, G A Smythe, S Moore, V Sar. Biogenic amine control of growth hormone secretion in the fetal and neonatal rat. Neuroendocrinology. vol 22. issue 4. 1977-11-25. PMID:1030499. |
injections of the serotonin blocker cyproheptadine (cypro) and a catecholamine, dopamine (da), each led to reductions in the level of serum gh in 21 to 22 day fetuses and in neonates up to 3 days after birth. |
1977-11-25 |
2023-08-11 |
rat |
| M Nakamura, H Fukushim. Effect of benzodiazepines on central serotonergic neuron systems. Psychopharmacology. vol 53. issue 2. 1977-10-20. PMID:197556. |
cyproheptadine blocked the potentiating effect of benzodiazepines on the head twitches induced by both 5-ht (i.c.) |
1977-10-20 |
2023-08-11 |
mouse |
| D Weinstein, Y Pfeifer, E Sadovsky, W Z Polishuk, F G Sulma. Effect of indomethacin and cyproheptadine on onset of labour in rats. Archives internationales de pharmacodynamie et de therapie. vol 226. issue 1. 1977-07-23. PMID:869638. |
indomethacin being a prostaglandin antagonist and cyproheptadine a serotinin antagonist, it may be concluded that neither prostaglandin nor serotonin are decisive for the intricate process which triggers parturition. |
1977-07-23 |
2023-08-11 |
rat |
| E Mogilnicka, J Scheel-Krüger, V Klimek, K Golembiowska-Nikiti. The influence of antiserotonergic agents on the action of dopaminergic drugs. Polish journal of pharmacology and pharmacy. vol 29. issue 1. 1977-06-11. PMID:140371. |
the effect of drugs blocking serotonin receptors: cyproheptadine, methysergide, and methergoline, and of serotonin synthesis inhibitor, p-chlorophenylalanine on the stereotyped behavior and number of rearings of the rats receiving apomorphine, amphetamine, nomifensine and 1,3-dimethyl-5-aminoadamantane was investigated. |
1977-06-11 |
2023-08-11 |
rat |