| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R M Quock, A Horit. Differentiaton of neuropharmacological actions of apomorphine and d-amphetamine. Pharmacology, biochemistry, and behavior. vol 5. issue 6. 1977-05-25. PMID:139615. |
apomorphine-induced hyperthemia was antagonized by p-chlorophenylalanine (pcpa), cyproheptadine and cinanserin and was restored in pcpa-pretreated rabbits by regeneration of central serotonin levels, d-amphetamine-induced hyperthermia was reduced by pcpa; restored in pcpa-pretreated animals by regeneration of central serotonin levels; and was uninfluenced by cyproheptadine and cinanserin. |
1977-05-25 |
2023-08-11 |
rabbit |
| B S Sastry, J G Sinclai. Tonic inhibitory influence of a supraspinal monoaminergic system on presynaptic inhibition of an extensor monosynaptic reflex. Brain research. vol 124. issue 1. 1977-05-20. PMID:139193. |
these effects of imipramine and fluoxetine were partially reversed by the 5-ht antagonist, cyproheptadine hydrochloride (5 mg/kg), and completely reversed by the application of a thoracic cold block which prevents supraspinal inputs to the caudal spinal cord. |
1977-05-20 |
2023-08-11 |
Not clear |
| S A Darwish, B L Furma. Effects of levodopa and dopamine of plasma glucose concentration in mice. European journal of pharmacology. vol 41. issue 4. 1977-05-20. PMID:139316. |
the possible involvement of 5ht in the hypoglycaemic response to levodopa was suggested by the blockade of the response by cyproheptadine and methysergide together with the observations that hypoglycaemia is produced by 5htp and by i.c.v. |
1977-05-20 |
2023-08-11 |
mouse |
| N R Lynch, J C Salomo. Passive local anaphylaxis: demonstration of antitumor activity and complementation of intratumor BCG. Journal of the National Cancer Institute. vol 58. issue 4. 1977-05-20. PMID:321794. |
the pla-induced augmentation was inhibited by administration of the histamine and serotonin antagonist cyproheptadine; comparable increases were also induced by the intratumor injection of a histamine and serotonin mixture or bcg. |
1977-05-20 |
2023-08-11 |
mouse |
| J F Beake. An allergist looks at urticaria. Cutis. vol 18. issue 2. 1977-04-28. PMID:138566. |
cyproheptadine hcl (periactin) both a serotonin and histamine antagonist with anticholinergic effect, is also helpful--especially in combination with hydroxyzine. |
1977-04-28 |
2023-08-11 |
Not clear |
| L Pawlowsk. The influence of serotonergic agents on the body temperature. Polish journal of pharmacology and pharmacy. vol 28. issue 6. 1977-03-21. PMID:138132. |
the results obtained suggest that cyproheptadine and methysergide fail to block those central serotonin receptors which produce hypothermia after their stimulation. |
1977-03-21 |
2023-08-11 |
rat |
| H Azuma, K Banno, T Yoshimur. Pharmacological properties of N-(3',4'-dimethoxycinnamoyl) anthranilic acid (N-5'), a new anti-atopic agent. British journal of pharmacology. vol 58. issue 4. 1977-02-24. PMID:63304. |
3 the increased vascular permeability caused by histamine and 5-hydroxytryptamine was significantly inhibited by diphenyldramine or cyproheptadine, but not by n-5' and the anti-inflammatory agents used. |
1977-02-24 |
2023-08-11 |
rat |
| C Ferrari, A Paracchi, M Rondena, P Beck-Peccoz, G Fagli. Effect of two serotonin antagonists on prolactin and thyrotrophin secretion in man. Clinical endocrinology. vol 5. issue 5. 1977-01-29. PMID:991435. |
cyproheptadine, a serotonin antagonist with antihistaminic, anticholinergic and antidopaminergic properties as well, did not affect prolactin secretion, while it reduced the serum tsh response to trh; methergoline, a specific blocker of central serotonin receptors, decreased basal and trh-induced serum prolactin levels, without affecting tsh secretion. |
1977-01-29 |
2023-08-11 |
human |
| L F Oliveira, A D Bretas, R T Sud. 5-Hydroxytryptamine and narcotic-analgesics interactions in the intestine. General pharmacology. vol 7. issue 2-3. 1977-01-03. PMID:10224. |
5-ht blocking agents like lsd, bol, and cyproheptadine did not block either 5-ht or morphine. |
1977-01-03 |
2023-08-11 |
dog |
| A K Sanyal, N G Wato. The possible mechanism for the 'fade' in acid gastric secretion during continuous infusions of pentagastrin. The Journal of physiology. vol 261. issue 2. 1977-01-03. PMID:978581. |
pre-treatment of the cats with the 5-hydroxytryptamine (5-ht) blocking drugs, methysergide and cyproheptadine or with the 5-hydroxytryptamine-depleting drug reserpine completely altered the pattern of secretion to pentagastrin such that the response was similar to that seen during an infusion of histamine. |
1977-01-03 |
2023-08-11 |
Not clear |
| E Apperley, P P Humphrey, G P Lev. Receptors for 5-hydroxytryptamine and noradrenaline in rabbit isolated ear artery and aorta. British journal of pharmacology. vol 58. issue 2. 1976-12-30. PMID:184872. |
in the aorta methysergide, pizotifen and cyproheptadine were potent antagonists of 5-ht and much weaker antagonists of noradrenaline. |
1976-12-30 |
2023-08-11 |
rabbit |
| B S Sastry, J G Sinclai. Serotonin involvement in the blockade of bulbospinal inhibition of the spinal monosynaptic reflex. Brain research. vol 115. issue 3. 1976-12-23. PMID:1086122. |
the serotonin antagonist, cyproheptadine hcl (5 mg/kg), partially reversed the above blocking actions of 5-htp and fluoxetine and enhanced bulbospinal inhibition when administered alone in doses of 2.5-5 mg/kg. |
1976-12-23 |
2023-08-11 |
Not clear |
| D Goldma. Treatment of phenothiazine-induced dyskinesia. Psychopharmacology. vol 47. issue 3. 1976-12-01. PMID:9653. |
since the substances used in the original observations did not become available on the united states market, a compound known to be a serotonin antagonist, cyproheptadine, which was readily available and safe, was used to treat three patients who had phenothiazine-induced dyskinesia. |
1976-12-01 |
2023-08-11 |
Not clear |
| R Francesconi, M Mage. Thermoregulatory effects of monoamine potentiators and inhibitors in the rat. The American journal of physiology. vol 231. issue 1. 1976-11-01. PMID:961854. |
pretreatment with the serotonin inhibitor cyproheptadine (4o mug) attenuated the hyperthermia achieved by central administration of chlorimipramine alone. |
1976-11-01 |
2023-08-11 |
rat |
| E Müller-Schweinitze. Responsiveness of isolated canine cerebral and peripheral arteries to ergotamine. Naunyn-Schmiedeberg's archives of pharmacology. vol 292. issue 2. 1976-09-25. PMID:940593. |
it seemed likely therefore that 5-ht receptors are involved in the vasoconstrictor activity of e. evidence for this was obtained in experiments in which cyproheptadine (cy), a 5-ht antagonist, was used. |
1976-09-25 |
2023-08-11 |
dog |
| b' M J Antonaccio, D Cot\\xc3\\xa. Centrally mediated antihypertensive and bradycardic effects of methysergide in spontaneously hypertensive rats. European journal of pharmacology. vol 36. issue 2. 1976-08-23. PMID:1278233.' |
in pithed shr pretreated with methysergide or cyproheptadine, pressor responses to 5-ht were abolished. |
1976-08-23 |
2023-08-11 |
rat |
| J Marco, J A Hedo, J Martinell, C Calle, M L Villanuev. Potentiation of glucagon secretion by serotonin antagonists in man. The Journal of clinical endocrinology and metabolism. vol 42. issue 2. 1976-07-06. PMID:131129. |
to study the possible implication of endogenous serotonin in the control of glucagon secretion in man, normal volunteers were subjected to alpha-cell stimulation before and after oral treatment with serotonin antagonists (cyproheptadine and methysergide) and with an inhibitor of serotonin synthesis (para-chlorophenylalanine, pcpa). |
1976-07-06 |
2023-08-11 |
human |
| J Plonk, J Feldma. Modification of adrenal function by the anti-serotonin agent cyproheptadine. The Journal of clinical endocrinology and metabolism. vol 42. issue 2. 1976-07-06. PMID:177441. |
the effect of the serotonin antagonist, cyproheptadine (cypro), on metyrapone-induced stimulation of the pituitary-adrenal axis was evaluated in nine normal subjects. |
1976-07-06 |
2023-08-11 |
human |
| R I Schoenfel. Lysergic acid diethylamide- and mescaline-induced attenuation of the effect of punishment in the rat. Science (New York, N.Y.). vol 192. issue 4241. 1976-07-06. PMID:1063447. |
cyproheptadine and alpha-propyldopacetamide, drugs that interfere with the function of neurons that contain serotonin, have a behavioral effect similar to that of lsd and mescaline, which suggests that the attenuation of punishment produced by these hallucinogens may result from decreased activity of such neurons. |
1976-07-06 |
2023-08-11 |
rat |
| J M Feldman, J W Plonk, C H Biven. Inhibitory effect of serotonin antagonists on growth hormone release in acromegalic patients. Clinical endocrinology. vol 5. issue 1. 1976-04-30. PMID:765007. |
we evaluated the effect of the serotonin antagonists cyproheptadine (cypro) and methysergide (methy) on growth hormone secretion in six patients with acromegaly. |
1976-04-30 |
2023-08-11 |
Not clear |