| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Z Roliński, M Herbu. The role of the serotonergic system in foot shock-induced behavior in mice. Psychopharmacology. vol 73. issue 3. 1981-08-10. PMID:6454158. |
at the same time, following the results obtained in fsif tests and locomotor activity tests, it can be inferred that the 5-ht antagonists used (methysergide, cyproheptadine, metergoline, cinnarizine, and pizotifen) do not act specifically in this model of aggression. |
1981-08-10 |
2023-08-12 |
mouse |
| F J White, J B Appe. A neuropharmacological analysis of the discriminative stimulus properties of fenfluramine. Psychopharmacology. vol 73. issue 2. 1981-07-20. PMID:6785800. |
the fenfluramine cue, like the quipazine cue, was antagonized by the 5-ht antagonists cyproheptadine and methiothepin. |
1981-07-20 |
2023-08-12 |
rat |
| F J White, J B Appe. A neuropharmacological analysis of the discriminative stimulus properties of fenfluramine. Psychopharmacology. vol 73. issue 2. 1981-07-20. PMID:6785800. |
both of these partial substitutions were reduced by cyproheptadine; therefore, it was concluded that these effects may be due to the common ability of cocaine, fluoxetine, and fenfluramine to inhibit 5-ht uptake. |
1981-07-20 |
2023-08-12 |
rat |
| E S Vizi, L G Hársing, G Zsill. Evidence of the modulatory role of serotonin in acetylcholine release from striatal interneurons. Brain research. vol 212. issue 1. 1981-07-09. PMID:7225867. |
serotonin antagonists (cyproheptadine, mianserine and methysergide) prevented the effect of serotonin agonists. |
1981-07-09 |
2023-08-12 |
rat |
| G Dieguez, B Gómez, S Lluc. Analysis of the cerebrovascular effects of 5-hydroxytryptamine in unanesthetized goats. The Journal of pharmacology and experimental therapeutics. vol 216. issue 3. 1981-05-13. PMID:6259325. |
infusion of lysergic acid diethylamide (0.2-0.4 micrograms/kg/min), methysergide or cyproheptadine (2-5 micrograms/kg/min) partially abolished the cerebral vasoconstriction produced by 5-ht. |
1981-05-13 |
2023-08-12 |
Not clear |
| G R Hageman, T N James, F Urthale. Blocking effects of cyproheptadine and methysergide upon two different cardiovascular responses to serotonin. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). vol 165. issue 3. 1981-04-24. PMID:7465555. |
blocking effects of cyproheptadine and methysergide upon two different cardiovascular responses to serotonin. |
1981-04-24 |
2023-08-12 |
Not clear |
| G B Fregnan, T Chiel. Classical neuroleptics and deconditioning activity after single or repeated treatment. Role of different cerebral neurotransmitters. Arzneimittel-Forschung. vol 30. issue 11. 1981-03-27. PMID:6109537. |
the acute administration of some neuroleptics in combination with other centrally active drugs, endowed with different mechanism of action, yielded the following results on car: amphetamine (a dopaminergic stimulant) readily antagonized the effect of lr 511 and haloperidol; chlorpheniramine and diphenhydramine (antihistaminics) minimized the effect of small doses of lr 511 and haloperidol while they did not alter that of larger doses; atropine (an anti-cholinergic), metergoline (an anti-5-hydroxytryptaminic (5-ht) and cyproheptadine (an anti-5-ht possessing antihistaminic and anticholinergic properties) protentiated the effect of lr 511 while in part reduced that of haloperidol. |
1981-03-27 |
2023-08-12 |
rat |
| G Böhmer, H R Dinse, M Fallert, T J Somme. Microelectrophoretic application of antagonists of putative neurotransmitters onto various types of bulbar respiratory neurons. Archives italiennes de biologie. vol 117. issue 1. 1981-03-24. PMID:45300. |
cyproheptadine, an antagonist of 5-ht, excited most e neurons. |
1981-03-24 |
2023-08-11 |
Not clear |
| J A Board, R J Fierr. Effect of cyproheptadine on chlorpromazine stimulation of prolactin in women. American journal of obstetrics and gynecology. vol 139. issue 2. 1981-03-17. PMID:6109449. |
in five normal women, the expected chlorpromazine-induced rise in serum prolactin was inhibited by pretreatment with a serotonin antagonist, cyproheptadine. |
1981-03-17 |
2023-08-12 |
Not clear |
| M D Tricklebank, P N Drewitt, G Curzo. The effect of L-tryptophan on motor activity and its prevention by an extracerebral decarboxylase inhibitor and by 5-HT receptor blockers. Psychopharmacology. vol 69. issue 2. 1981-03-17. PMID:6779309. |
tryptophan did not cause significant hypoactivity in rats pretreated with the 5-hydroxytryptamine (5-ht) receptor antagonists methysergide, cyproheptadine and metergoline. |
1981-03-17 |
2023-08-12 |
rat |
| M P Holsapple, M Schnur, G K Yi. Pharmacological modulation of edema mediated by prostaglandin, serotonin and histamine. Agents and actions. vol 10. issue 4. 1981-02-19. PMID:7446315. |
cdm and cyproheptadine both antagonized paw edema induced by albumin (5ht and histamine-mediated) and by the direct injection of 5ht and histamine, whereas aspirin and the pg antagonist, sc-19220, were ineffective. |
1981-02-19 |
2023-08-12 |
Not clear |
| J F Deaki. On the neurochemical basis of self-stimulation with midbrain raphe electrode placements. Pharmacology, biochemistry, and behavior. vol 13. issue 4. 1981-01-29. PMID:6449012. |
bar-pressing for electrical stimulation of the median raphe nucleus in rats was not attenuated by 5ht receptor blockade with metergoline or cyproheptadine, by 5ht depletion induced with parachloroamphetamine or by prior destruction of ascending 5ht pathways with intracerebral microinjections of 5,7-dihydroxytryptamine. |
1981-01-29 |
2023-08-12 |
rat |
| G Fillion, D Beaudoin, J C Rousselle, J Jaco. [3H]5-HT binding sites and 5-HT-sensitive adenylate cyclase in glial cell membrane fraction. Brain research. vol 198. issue 2. 1980-11-25. PMID:7407603. |
the corresponding site is serotoninergic specific: [3h]5-ht binding is inhibited by 5-ht agonists (5 oh nm-dmt, 5-meoht, 5-meoh-dmt, nn-dmt) or antagonists (cinanserine, cyproheptadine, methysergide, lsd) and not (or poorly) inhibited by non-serotoninergic related drugs. |
1980-11-25 |
2023-08-12 |
Not clear |
| J Koenig, M A Mayfield, R J Coppings, S M McCann, L Krulic. Role of central nervous system neurotransmitters in mediating the effects of morphine on growth hormone- and prolactin-secretion in the rat. Brain research. vol 197. issue 2. 1980-11-24. PMID:6105900. |
depletion of brain serotonin stores with p-chlorophenylalanine (300 mg/kg) or 5,7-dihydroxytryptamine or administration of serotonin receptor blocker, cyproheptadine (2.5 mg/kg), did not diminish the gh respnse to mor but it inhibited, or in the case of 5,7-dht treatment abolished the activation of prl secretion. |
1980-11-24 |
2023-08-12 |
rat |
| D Chadwick, M Hallett, P Jenner, C D Marsde. Observations on chloralose-induced myoclonus in guinea-pigs. British journal of pharmacology. vol 69. issue 3. 1980-10-24. PMID:6156735. |
5 pretreatment of animals with drugs that increase brain 5-ht action (l-tryptophan with a monoamine oxidase inhibitor, or 5-hydroxytryptophan), or antagonize the action of 5-ht (cyproheptadine) did not abolish or obviously increase chloralose-induced myoclonus. |
1980-10-24 |
2023-08-12 |
Not clear |
| R B McCall, G K Aghajania. Pharmacological characterization of serotonin receptors in the facial motor nucleus: a microiontophoretic study. European journal of pharmacology. vol 65. issue 2-3. 1980-10-24. PMID:7398786. |
microiontophoretic application (5--10 aa) or intravenous administration of methysergide (0.5--1.0 mg/kg), cyproheptadine (0.5--1.0 mg/kg), cinanserin (0.5--1.0 mg/kg), or metergoline (50--100 micrograms/kg) antagonized the facilitating effect of 5-ht but not that of norepinephrine (ne) on facial motoneurons. |
1980-10-24 |
2023-08-12 |
Not clear |
| A A Martinez, M F Lokhandwal. Evidence for a presynaptic inhibitory action of 5-hydroxytryptamine on sympathetic neurotransmission to the myocardium. European journal of pharmacology. vol 63. issue 4. 1980-09-28. PMID:6248349. |
prior treatment with cyproheptadine prevented the depressor effect of 5-ht and significantly antagonized the inhibitory action of 5-ht on the positive chronotropic effect of cardiac nerve stimulation. |
1980-09-28 |
2023-08-12 |
Not clear |
| A A Martinez, M F Lokhandwal. Evidence for a presynaptic inhibitory action of 5-hydroxytryptamine on sympathetic neurotransmission to the myocardium. European journal of pharmacology. vol 63. issue 4. 1980-09-28. PMID:6248349. |
these results suggest that 5-ht inhibits sympathetic neurotransmission of the myocardium via an action on 'trypaminergic' receptors which may be located on sympathetic nerve terminal and that these receptors can be selectively blocked by cyproheptadine but not by methysergide. |
1980-09-28 |
2023-08-12 |
Not clear |
| F P Nijkamp, J M Van Re. Effects of endorphins on different parts of the gastrointestinal tract of rat and guinea-pig in vitro. British journal of pharmacology. vol 68. issue 4. 1980-08-15. PMID:6247000. |
atropine, hexamethonium, burimamide, mepyramine, propranolol and indomethacin did not influence the response to met-enkephalin.5 in the presence of tetrodotoxin, the ed(50) for met-enkephalin and the maximal contractor response induced by met-enkephalin, appeared to be increased.6 the 5-hydroxytryptamine (5-ht) antagonists, methysergide and cyproheptadine, reduced the contractor response in a non-competitive manner. |
1980-08-15 |
2023-08-12 |
rat |
| L Krulich, R J Coppings, A Giachetti, S M McCann, M A Mayfiel. Lack of evidence that the central serotoninergic system plays a role in the activation of prolactin secretion following inhibition of dopamine synthesis or blockade of dopamine receptors in the male rat. Neuroendocrinology. vol 30. issue 3. 1980-06-16. PMID:6445044. |
in contrast, the serotonin blocker methysergide, but not cyproheptadine, inhibited the prolactin-releasing effect of alpha mt or alpha-flupentixol, a da receptor blocker, but not of spiroperidol, another da receptor blocker. |
1980-06-16 |
2023-08-12 |
rat |