| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P R Saxena, P D Verdou. Redistribution by 5-hydroxytryptamine of carotid arterial blood at the expense of arteriovenous anastomotic blood flow. The Journal of physiology. vol 332. 1983-03-17. PMID:7153937. |
cyproheptadine (1 mg kg(-1)) completely reversed the effect of 5-hydroxytryptamine on the total carotid blood flow. |
1983-03-17 |
2023-08-12 |
Not clear |
| b' M K Krsti\\xc4\\x87, Z S Katusi\\xc4\\x8. Divergent effects of cyproheptadine and R 50 656, a 5-HT2 antagonist, on the cardiovascular response to 5-hydroxytryptamine in rats. European journal of pharmacology. vol 85. issue 2. 1983-03-11. PMID:6129985.' |
divergent effects of cyproheptadine and r 50 656, a 5-ht2 antagonist, on the cardiovascular response to 5-hydroxytryptamine in rats. |
1983-03-11 |
2023-08-12 |
rat |
| b' M K Krsti\\xc4\\x87, Z S Katusi\\xc4\\x8. Divergent effects of cyproheptadine and R 50 656, a 5-HT2 antagonist, on the cardiovascular response to 5-hydroxytryptamine in rats. European journal of pharmacology. vol 85. issue 2. 1983-03-11. PMID:6129985.' |
cyproheptadine and r 50 656, a novel 5-ht2 antagonist, produced a dose-dependent suppression of the pressor response to 5-hydroxytryptamine (5-ht), but did not affect the depressor response. |
1983-03-11 |
2023-08-12 |
rat |
| b' M K Krsti\\xc4\\x87, Z S Katusi\\xc4\\x8. Divergent effects of cyproheptadine and R 50 656, a 5-HT2 antagonist, on the cardiovascular response to 5-hydroxytryptamine in rats. European journal of pharmacology. vol 85. issue 2. 1983-03-11. PMID:6129985.' |
the pressor effect of 5-ht was significantly more sensitive to r 50 656 than to cyproheptadine. |
1983-03-11 |
2023-08-12 |
rat |
| b' M K Krsti\\xc4\\x87, Z S Katusi\\xc4\\x8. Divergent effects of cyproheptadine and R 50 656, a 5-HT2 antagonist, on the cardiovascular response to 5-hydroxytryptamine in rats. European journal of pharmacology. vol 85. issue 2. 1983-03-11. PMID:6129985.' |
on the contrary, the tachycardic response to 5-ht was antagonized only with cyproheptadine. |
1983-03-11 |
2023-08-12 |
rat |
| T N Mellin, R D Busch, C C Wang, G Kat. Neuropharmacology of the parasitic trematode, Schistosoma mansoni. The American journal of tropical medicine and hygiene. vol 32. issue 1. 1983-03-11. PMID:6130710. |
the stimulation of motor activity by 5-hydroxytryptamine was blocked by the antagonists metergoline and cyproheptadine in a dose-dependent manner. |
1983-03-11 |
2023-08-12 |
human |
| J Jimenez-Alonso, J Munoz-Avila, L Jaimez, F Pérez-Jimenez, C Bellido, J A Jiménez-Perepére. Cyproheptadine-induced remission of Cushing's disease due to pituitary basophil adenoma. Drug intelligence & clinical pharmacy. vol 16. issue 12. 1983-03-11. PMID:6295736. |
cyproheptadine is a potent antagonist of serotonin and has been used successfully in some patients with cushing's disease, although, generally, in women without radiological evidence of pituitary tumors. |
1983-03-11 |
2023-08-12 |
Not clear |
| T Di Paolo, B Gagné, P Poyet, F Labri. [3H]Apomorphine binding to a GTP-sensitive dopaminergic site in bovine anterior pituitary gland. Canadian journal of biochemistry. vol 60. issue 11. 1983-02-25. PMID:7172091. |
by contrast, adrenergic (phentolamine, propranolol, and clonidine) and serotonergic (serotonin, cyproheptadine, and methysergide) agonists and antagonists do not compete or are weak competitors at micromolar concentrations. |
1983-02-25 |
2023-08-12 |
cattle |
| J S Stollak, R F Furchgot. Use of selective antagonists for determining the types of receptors mediating the actions of 5-hydroxytryptamine and tryptamine in the isolated rabbit aorta. The Journal of pharmacology and experimental therapeutics. vol 224. issue 1. 1983-02-14. PMID:6129317. |
the response to 5-ht was more susceptible to inhibition by competitive antagonists selective for 5-ht receptors, such as cyproheptadine, 5-methylgramine, 5-methoxygramine or 2-bromolysergic acid diethylamide, than was the response to trp; the estimated apparent dissociation constants (kb value) for each antagonist was significantly lower when 5-ht rather than trp was the agonist. |
1983-02-14 |
2023-08-12 |
rabbit |
| A V Konusova, N K Popov. [Role of central and peripheral serotoninergic mechanisms]. Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova. vol 68. issue 10. 1983-02-14. PMID:6217090. |
stimulation of the brain serotonin receptors did not affect the development of hyperthermia, whereas the blockade of brain serotonin receptors by intraventricular injections of cyproheptadine or the depletion of brain serotonin by p-chlorophenylalanine resulted in significantly more obvious hyperthermia than in control. |
1983-02-14 |
2023-08-12 |
rat |
| C D Kilts, R L Commissaris, J J Cordon, R H Rec. Lack of central 5-hydroxytryptamine influence on the anticonflict activity of diazepam. Psychopharmacology. vol 78. issue 2. 1983-02-14. PMID:6217479. |
the 5-ht antagonists methysergide (1 - 18 mg/kg), cyproheptadine (1 - 18 mg/kg), metergoline (0.25 - 2.0 mg/kg) and cinanserin (10 - mg/kg) failed to induce large, reliable increases in punished responding. |
1983-02-14 |
2023-08-12 |
human |
| b' V N Slavnov, G V Valueva, E V Luchitski\\xc4\\xa. [Mechanism of action of cyproheptadine (peritol) on the hypothalamo-pituitary-adrenal axis]. Biulleten\' eksperimental\'noi biologii i meditsiny. vol 94. issue 9. 1983-02-14. PMID:6293623.' |
the present paper is concerned with the mechanism of action of the blocker of serotonin receptors, cyproheptadine (peritol) on the hypothalamohypophyseal-adrenal system activity. |
1983-02-14 |
2023-08-12 |
rat |
| E Przegaliński, A Rawłó. The stimulatory action of phosphodiesterase inhibitors on the flexor reflex of the hind limb in the spinal rat. Journal of neural transmission. vol 55. issue 1. 1982-12-18. PMID:6182270. |
neither the 5-hydroxytryptamine (5-ht) antagonist cyproheptadine nor the alpha-adrenoceptor blocker phenoxybenzamine prevented potentiation of flexor reflex activity by pdeis. |
1982-12-18 |
2023-08-12 |
rat |
| R M Brazenor, J A Angu. Actions of serotonin antagonists on dog coronary artery. European journal of pharmacology. vol 81. issue 4. 1982-12-02. PMID:6126378. |
ergotamine, dihydroergotamine, bromocriptine, lisuride, ergometrine, ketanserin, trazodone, cyproheptadine and pizotifen caused non-competitive antagonism of serotonin concentration-response curves. |
1982-12-02 |
2023-08-12 |
dog |
| B Cox, C Enni. Characterization of 5-hydroxytryptaminergic autoreceptors in the rat hypothalamus. The Journal of pharmacy and pharmacology. vol 34. issue 7. 1982-12-02. PMID:6126540. |
methiothepin produced a similar effect to metergoline whilst cyproheptadine and methysergide were less potent as antagonists of 5-ht and were not competitive. |
1982-12-02 |
2023-08-12 |
rat |
| G Thoma. Mechanism of ionophore A23187 induction of plasma protein leakage and of its inhibition by indomethacin. European journal of pharmacology. vol 81. issue 1. 1982-12-02. PMID:6180911. |
studies with mepyramine and cyproheptadine indicated that histamine and 5-hydroxytryptamine (5-ht) partially contribute to the ionophore action and experiments with compound 48/80 supported these findings. |
1982-12-02 |
2023-08-12 |
rat |
| C Forster, E T Whalle. Analysis of the 5-hydroxytryptamine induced contraction of the human basilar arterial strip compared with the rat aortic strip in vitro. Naunyn-Schmiedeberg's archives of pharmacology. vol 319. issue 1. 1982-10-12. PMID:7110367. |
3) methysergide, cyproheptadine and methergoline were competitive, selective antagonists against 5-ht on the rat aorta with pa2 values of 7.97, 8.76 and 9.49 respectively. |
1982-10-12 |
2023-08-12 |
human |
| R B McCall, S J Humphre. Involvement of serotonin in the central regulation of blood pressure: evidence for a facilitating effect on sympathetic nerve activity. The Journal of pharmacology and experimental therapeutics. vol 222. issue 1. 1982-08-26. PMID:6177852. |
intravenous administration of the 5-ht antagonists methysergide (0.025-1.6 mg/kg), metergoline (0.01-0.32 mg/kg), cyproheptadine (0.05-1.6 mg/kg) and cinanserin (0.2-6.4 mg/kg) was associated with a prolonged dose-related inhibition of snd. |
1982-08-26 |
2023-08-12 |
Not clear |
| R B McCall, S J Humphre. Involvement of serotonin in the central regulation of blood pressure: evidence for a facilitating effect on sympathetic nerve activity. The Journal of pharmacology and experimental therapeutics. vol 222. issue 1. 1982-08-26. PMID:6177852. |
methysergide, metergoline and cyproheptadine failed to reduce snd in cats pretreated with the 5-ht synthesis inhibitor p-chlorophenylalanine. |
1982-08-26 |
2023-08-12 |
Not clear |
| J F Bruni, R L Hawkins, S S Ye. Serotonergic mechanism in the control of beta-endorphin and ACTH release in male rats. Life sciences. vol 30. issue 15. 1982-08-07. PMID:6283286. |
injection of the 5-ht antagonist, cyproheptadine, significantly decreased plasma beta-ep-li. |
1982-08-07 |
2023-08-12 |
rat |