| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R S Moreland, C van Breemen, D F Boh. Mechanism by which serotonin attenuates contractile response of canine mesenteric arterial smooth muscle. The Journal of pharmacology and experimental therapeutics. vol 232. issue 2. 1985-03-21. PMID:2578562. |
these results are compatible with the following interpretation: 1) 5-ht attenuates both receptor- and nonreceptor-mediated contractions of vascular smooth muscle; 2) this attenuation is the result of an increased sodium influx that stimulates the electrogenic sodium pump to cause membrane hyperpolarization and decreased stimulated calcium influx; and 3) the effects of 5-ht are mediated by 5-ht receptors that are blocked by methysergide and cyproheptadine but not by ketanserin. |
1985-03-21 |
2023-08-11 |
dog |
| Y Hirata, H Nakashima, M Uchihashi, M Tomita, T Fujita, M Iked. Effects of bromocriptine and cyproheptadine on basal and corticotropin-releasing factor (CRF)-induced ACTH release in a patient with Nelson's syndrome. Endocrinologia japonica. vol 31. issue 5. 1985-03-19. PMID:6097444. |
the effects of bromocriptine, a dopamine agonist, and cyproheptadine, a serotonin antagonist, on basal and corticotropin-releasing factor (crf)-stimulated acth release were investigated in a 40-year-old female patient with nelson's syndrome. |
1985-03-19 |
2023-08-12 |
Not clear |
| K A Hube. Electrical stimulus-secretion coupling in rabbit ileal mucosa. The Journal of pharmacology and experimental therapeutics. vol 231. issue 3. 1985-01-22. PMID:6209386. |
because of the failure of antagonists or desensitization to affect the response to efs, we eliminated the following agents as possible mediators: acetylcholine (pre- and postganglionic), norepinephrine, dopamine, 5-hydroxytryptamine, histamine, prostaglandins, adenosine triphosphate, bombesin, neurotensin and substance p. pyrilamine, diphenhydramine and cyproheptadine in high concentration (0.1 mm) reduced markedly the isc response to efs for reasons unrelated to histamine antagonism. |
1985-01-22 |
2023-08-12 |
rabbit |
| M M Goldenberg, R D Meure. A pharmacologic analysis of the action of platelet-activating factor in the induction of hindpaw edema in the rat. Prostaglandins. vol 28. issue 2. 1985-01-04. PMID:6505225. |
the h1 and h2 antihistamines, mepyramine and cimetidine, the serotonin/histamine antagonist, cyproheptadine, and the serotonin antagonist, methysergide, were ineffective in reducing paf-induced paw edema. |
1985-01-04 |
2023-08-12 |
rat |
| P F Vonvoigtlander, R A Lewis, G L Nef. Kappa opioid analgesia is dependent on serotonergic mechanisms. The Journal of pharmacology and experimental therapeutics. vol 231. issue 2. 1984-12-19. PMID:6092612. |
several reputed serotonin antagonists (cyproheptadine, ketanserin and pirenperone) also antagonized u-50,488h analgesia. |
1984-12-19 |
2023-08-12 |
mouse |
| H L Nash, D I Wallis, G As. 5-HT antagonists and blockade of neuronal (5-HT) receptors on ganglion cells. General pharmacology. vol 15. issue 4. 1984-12-13. PMID:6149168. |
substances which had no effect on 5-ht responses included methysergide and other compounds related to lsd, cinanserin, cyproheptadine, phenylbiguanide and morphine. |
1984-12-13 |
2023-08-12 |
Not clear |
| T Nabeshima, K Yamaguchi, M Hiramatsu, M Amano, H Furukawa, T Kameyam. Serotonergic involvement in phencyclidine-induced behaviors. Pharmacology, biochemistry, and behavior. vol 21. issue 3. 1984-12-11. PMID:6208563. |
the pcp-induced stereotyped behaviors (backpedalling, head weaving and turning) were attenuated by serotonin (5-ht) depleters [reserpine, p-chlorophenylalanine, p-chloroamphetamine (pca)] and 5-ht receptor antagonist (cyproheptadine). |
1984-12-11 |
2023-08-12 |
rat |
| M D McGoon, P M Vanhoutt. Aggregating platelets contract isolated canine pulmonary arteries by releasing 5-hydroxytryptamine. The Journal of clinical investigation. vol 74. issue 3. 1984-10-24. PMID:6470141. |
the serotonergic antagonists cyproheptadine, ketanserin, and methysergide caused concentration-dependent inhibition and eventually abolition of contractions evoked by platelets and 5-hydroxytryptamine. |
1984-10-24 |
2023-08-12 |
Not clear |
| G R Hageman, F Urthaler, T N Jame. Parasympathetic and sympathetic efferent traffic during a cardiogenic hypertensive chemoreflex. Cardiovascular research. vol 18. issue 9. 1984-10-22. PMID:6467275. |
these autonomic efferent discharges were not elicited by administration of serotonin into the carotid artery, but were abolished by pretreatment with the serotonin antagonist, cyproheptadine. |
1984-10-22 |
2023-08-12 |
Not clear |
| G R Hageman, F Urthaler, T N Jame. Parasympathetic and sympathetic efferent traffic during a cardiogenic hypertensive chemoreflex. Cardiovascular research. vol 18. issue 9. 1984-10-22. PMID:6467275. |
cyproheptadine blockade could be overcome by increasing the serotonin concentration tenfold. |
1984-10-22 |
2023-08-12 |
Not clear |
| M A Trevethick, W Feniuk, P P Humphre. 5-hydroxytryptamine-induced relaxation of neonatal porcine vena cava in vitro. Life sciences. vol 35. issue 5. 1984-09-20. PMID:6205240. |
methysergide (1 micron) but not cyproheptadine (0.1 micron), specifically antagonised the 5-ht induced increase in cyclic amp with an estimated pa2 of 7.19. |
1984-09-20 |
2023-08-12 |
Not clear |
| D J Minnema, J S Hendry, J A Rosecran. Discriminative stimulus properties of pizotifen maleate (BC105): a putative serotonin antagonist. Psychopharmacology. vol 83. issue 2. 1984-09-20. PMID:6431474. |
the results of this study suggest that different ds properties are associated with the different putative 5-ht antagonists and that pizotifen and cyproheptadine, in addition to their reported 5-ht antagonist properties, share a common property that is also associated with promethazine, probably involving antihistaminergic activity. |
1984-09-20 |
2023-08-12 |
rat |
| S J McNall, T E Mansou. Novel serotonin receptors in Fasciola. Characterization by studies on adenylate cyclase activation and [3H]LSD binding. Biochemical pharmacology. vol 33. issue 17. 1984-09-19. PMID:6466386. |
inhibition of 5-ht stimulation of adenylate cyclase by a series of 5-ht antagonists revealed a potency order of lsd = 2-bromo-lsd greater than methiothepin greater than metergoline = cyproheptadine greater than methysergide greater than spiroperidol. |
1984-09-19 |
2023-08-12 |
Not clear |
| N J Dun, M Kiraly, R C M. Evidence for a serotonin-mediated slow excitatory potential in the guinea-pig coeliac ganglia. The Journal of physiology. vol 351. 1984-09-12. PMID:6205146. |
were reversibly suppressed by cyproheptadine (20-50 microm), a serotonin antagonist, and enhanced by fluoxetine (30-50 microm), a serotonin reuptake inhibitor. |
1984-09-12 |
2023-08-12 |
Not clear |
| L Pawłowski, H Kwiate. No correlation exists between antidepressant activity and the ability of 5-HT uptake inhibitors to interact with 5-HT receptors of the rat stomach fundus strip. The Journal of pharmacy and pharmacology. vol 36. issue 6. 1984-08-31. PMID:6146670. |
of 12 inhibitors tested, only doxepine, amitriptyline, clomipramine, imipramine, ro 11-2465 (cyan-imipramine), citalopram and fluvoxamine antagonized the contraction induced by 10(-6) m 5-ht with ic50 values below 10(-4) m. amitriptyline, doxepine and cyproheptadine, at concentrations inhibiting the effect of 5-ht, did not antagonize the strip contractions induced by 3 x 10(-3) m bacl2, while the remaining compounds that antagonized 5-ht-induced contractions, also antagonized--with at least a similar potency--the contractions induced by bacl2. |
1984-08-31 |
2023-08-12 |
rat |
| V Reylon, H H Siddiqu. Anti-spasmogenic effect of cyproheptadine on guinea-pig ileum. Indian journal of physiology and pharmacology. vol 27. issue 4. 1984-08-30. PMID:6678244. |
antagonistic activity of cyproheptadine against common spasmogens, like acetylcholine, histamine, serotonin, bradykinin and angiotensin, was studied on isolated guinea-pig ileum. |
1984-08-30 |
2023-08-12 |
Not clear |
| V Reylon, H H Siddiqu. Anti-spasmogenic effect of cyproheptadine on guinea-pig ileum. Indian journal of physiology and pharmacology. vol 27. issue 4. 1984-08-30. PMID:6678244. |
cyproheptadine produced a reversible antagonism of non-competitive type and was most effective against serotonin. |
1984-08-30 |
2023-08-12 |
Not clear |
| A P Leccese, W H Lynes. The effects of putative 5-hydroxytryptamine receptor active agents on D-amphetamine self-administration in controls and rats with 5,7-dihydroxytryptamine median forebrain bundle lesions. Brain research. vol 303. issue 1. 1984-08-21. PMID:6610461. |
the putative 5-ht antagonists utilized, cyproheptadine and methysergide, unpredictably reduced self-injection frequency of non-lesioned animals in a dose related manner. |
1984-08-21 |
2023-08-12 |
rat |
| D J Pettibone, A B Pfluege. Effects of methiothepin and lysergic acid diethylamide on serotonin release in vitro and serotonin synthesis in vivo: possible relation to serotonin autoreceptor function. Journal of neurochemistry. vol 43. issue 1. 1984-07-19. PMID:6726257. |
using this system, methiothepin (1-10 microm) demonstrated 5-ht autoreceptor antagonist activity by enhancing 5-ht release, while several recognized postsynaptic 5-ht receptor antagonists were inactive: mianserin, cinanserin, cyproheptadine, methysergide. |
1984-07-19 |
2023-08-12 |
rat |
| D J Pettibone, A B Pfluege. Effects of methiothepin and lysergic acid diethylamide on serotonin release in vitro and serotonin synthesis in vivo: possible relation to serotonin autoreceptor function. Journal of neurochemistry. vol 43. issue 1. 1984-07-19. PMID:6726257. |
conversely, compounds which were not active as 5-ht autoreceptor antagonists in vitro (i.e., cyproheptadine, methysergide, cinanserin) did not influence the effect of lsd on 5-ht synthesis. |
1984-07-19 |
2023-08-12 |
rat |