| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Goldberg, M Hanani, S Nissa. Effects of serotonin on the internal anal sphincter: in vivo manometric study in rats. Gut. vol 27. issue 1. 1986-04-17. PMID:3949237. |
other 5-ht antagonists such as cyproheptadine, ketanserin, chlorpromazine, amitriptyline and ergotamine failed to reduce or block the internal anal sphincter relaxation due to 5-ht, nor did they alter the rectoanal reflex. |
1986-04-17 |
2023-08-11 |
rat |
| L E Tremblay, P J Bedar. Effect of clonidine on motoneuron excitability in spinalized rats. Neuropharmacology. vol 25. issue 1. 1986-04-11. PMID:3005904. |
the depressant effect of clonidine in animals pretreated with 5-htp was prevented by yohimbine (1.25 mg/kg), while the depressant action of the serotonin antagonist, cyproheptadine was not. |
1986-04-11 |
2023-08-11 |
rat |
| R C Ma, N J Du. Excitation of lateral horn neurons of the neonatal rat spinal cord by 5-hydroxytryptamine. Brain research. vol 389. issue 1-2. 1986-04-07. PMID:3948020. |
the 5-ht depolarization was reversibly blocked by methysergide and cyproheptadine and enhanced by fluoxetine, a 5-ht-uptake inhibitor. |
1986-04-07 |
2023-08-11 |
rat |
| S Korsgaard, J Gerlach, E Christensso. Behavioral aspects of serotonin-dopamine interaction in the monkey. European journal of pharmacology. vol 118. issue 3. 1986-03-05. PMID:4085556. |
pretreatment with the 5-ht antagonists cyproheptadine and mianserin increased amphetamine-induced locomotor activity, reactivity and repetitive movements and decreased haloperidol-induced dystonia and parkinsonism. |
1986-03-05 |
2023-08-11 |
human |
| F De Clerck, B Xhonneux, J P Tollenaere, P A Jansse. Dependence of the antagonism at human platelet 5-HT2 receptors by ketanserin on the reaction pH. Thrombosis research. vol 40. issue 5. 1986-02-24. PMID:2935970. |
the potency for the inhibition of 5-hydroxytryptamine (5-ht)-induced human platelet aggregation by ketanserin, pipamperone, spiperone, cyproheptadine and bw 501 in vitro decreased as the reaction ph increased progressively from 7.4 to 8.6, the largest shift (x 1125) in ic50 value (ph 7.4: 4 x 10(-9) m; ph 8.6: 4.5 x 10(-6) m) being found for ketanserin. |
1986-02-24 |
2023-08-11 |
human |
| Y Sakai, H Kimura, K Okamot. Pharmacological characterization of serotonin receptor induced by rat brain messenger RNA in Xenopus oocytes. Brain research. vol 362. issue 1. 1986-02-24. PMID:3002552. |
this serotonin action was suppressed by serotonin antagonists such as methysergide, cyproheptadine and ketanserin. |
1986-02-24 |
2023-08-11 |
rat |
| I Paegelow, H Werner, M Hagen, U Wartner, P Lang. Influence of serotonin on lymphokine secretion in vitro. International journal of immunopharmacology. vol 7. issue 6. 1986-02-20. PMID:3908346. |
the serotonin antagonists methysergide, pizotiphen, cyproheptadine and ketanserin inhibited the secretion of the serotonin-elicited factors, whereas the histamine-type 2 antagonist metiamide had no inhibitory effect. |
1986-02-20 |
2023-08-11 |
mouse |
| L S Brady, J E Barret. Effects of serotonin receptor agonists and antagonists on schedule-controlled behavior of squirrel monkeys. The Journal of pharmacology and experimental therapeutics. vol 235. issue 2. 1985-12-20. PMID:2932546. |
the behavioral effects of the serotonin (5-ht) precursor l-5-hydroxytryptophan (l-5-htp) and the phenylpiperazine 5-ht agonists 6-chloro-2-(1-piperazinyl)pyrazine (mk-212), 1-(m-trifluromethylphenyl) piperazine (tfmpp), 1-(m-chlorophenyl)piperazine (cpp) and 2-(1-piperazinyl)quinoline (quipazine) were compared with those of the putative 5-ht antagonists metergoline, methysergide, cyproheptadine, cinanserin and ketanserin under a multiple 5-min fixed-interval schedule of food or electric shock presentation in squirrel monkeys. |
1985-12-20 |
2023-08-11 |
monkey |
| R D Spealma. Discriminative-stimulus effects of midazolam in squirrel monkeys: comparison with other drugs and antagonism by Ro 15-1788. The Journal of pharmacology and experimental therapeutics. vol 235. issue 2. 1985-12-20. PMID:2932547. |
administration of the 5-hydroxytryptamine antagonists cyproheptadine and cinanserin also resulted in greater than 90% of responses on the midazolam-associated lever in about half the subjects, although these effects were observed only with cumulative doses that markedly reduced the overall rate of responding. |
1985-12-20 |
2023-08-11 |
human |
| C Robaut, M P Fillion, S Dufois, C Fayolle-Bauguen, J C Rousselle, G Gillet, S Benkirane, G Fillio. Multiple high affinity binding sites for 5-hydroxytryptamine: a new class of sites distinct from 5-HT1 and S2. Brain research. vol 346. issue 2. 1985-12-20. PMID:4052778. |
methiothepin, cinanserin and cyproheptadine displaced 5-ht from these sites whereas ergot derivatives did not. |
1985-12-20 |
2023-08-11 |
rat |
| P R Saxena, A Lawan. A comparison of cardiovascular and smooth muscle effects of 5-hydroxytryptamine and 5-carboxamidotryptamine, a selective agonist of 5-HT1 receptors. Archives internationales de pharmacodynamie et de therapie. vol 277. issue 2. 1985-12-18. PMID:2933009. |
analysis with mecamylamine, cyproheptadine and ketanserin indicated that the initial bradycardia and hypotension, and the pressor and tachycardic responses to 5-ht were due to, respectively, the m and 5-ht2 receptors. |
1985-12-18 |
2023-08-11 |
rat |
| P R Saxena, A Lawan. A comparison of cardiovascular and smooth muscle effects of 5-hydroxytryptamine and 5-carboxamidotryptamine, a selective agonist of 5-HT1 receptors. Archives internationales de pharmacodynamie et de therapie. vol 277. issue 2. 1985-12-18. PMID:2933009. |
the prolonged hypotensive effects of both 5-ht and 5-ct were apparently mediated by 5-ht1 receptors, since they were unaffected by cyproheptadine or ketanserin, but were antagonized by high doses (greater than 2.5 mg.kg-1) of methysergide, which has an appreciable affinity for 5-ht1 binding sites. |
1985-12-18 |
2023-08-11 |
rat |
| D A Lewis, B M Sherma. Serotonergic regulation of prolactin and growth hormone secretion in man. Acta endocrinologica. vol 110. issue 2. 1985-11-27. PMID:4060968. |
in a separate study, subjects were pre-treated with cyproheptadine, a serotonin antagonist, before the administration of fenfluramine. |
1985-11-27 |
2023-08-11 |
human |
| P R Saxena, E J Mylecharane, J Heiliger. Analysis of the heart rate effects of 5-hydroxytryptamine in the cat; mediation of tachycardia by 5-HT1-like receptors. Naunyn-Schmiedeberg's archives of pharmacology. vol 330. issue 2. 1985-11-05. PMID:2931607. |
the tachycardic responses to 5-ht in spinal cats were little affected by 0.5 mg x kg-1 doses of mdl 72222 or of the 5-ht2 receptor antagonists, ketanserin, ritanserin or cyproheptadine. |
1985-11-05 |
2023-08-11 |
rat |
| M Ishibashi, T Fukushima, T Yamaj. Cyproheptadine-mediated inhibition of growth hormone and prolactin release from pituitary adenoma cells of acromegaly and gigantism in culture. Acta endocrinologica. vol 109. issue 4. 1985-10-23. PMID:2994332. |
this effect of cyproheptadine was not blocked by coincubation with serotonin. |
1985-10-23 |
2023-08-11 |
human |
| P R Saxena, J Heiligers, E J Mylecharane, R Ti. Excitatory 5-hydroxytryptamine receptors in the cat urinary bladder are of the M- and 5-HT2-type. Journal of autonomic pharmacology. vol 5. issue 2. 1985-09-24. PMID:3160710. |
injection of mdl 72222 (300 micrograms/kg) after ketanserin (300 micrograms/kg), or of 100 micrograms/kg of methysergide or cyproheptadine, or 300 micrograms/kg of ketanserin after mdl 72222 (300 micrograms/kg), led to blockade of both phases of the response to 5-ht. |
1985-09-24 |
2023-08-11 |
cat |
| H Fink, R Morgenster. Locomotor effects of lisuride: a consequence of dopaminergic and serotonergic actions. Psychopharmacology. vol 85. issue 4. 1985-09-12. PMID:2991961. |
hypermotility induced by high doses of lisuride was partially suppressed by the serotonin antagonist cyproheptadine and not further enhanced by lsd. |
1985-09-12 |
2023-08-11 |
rat |
| H Matsuoka, M Ishii, A Goto, T Sugimot. Role of serotonin type 2 receptors in regulation of aldosterone production. The American journal of physiology. vol 249. issue 2 Pt 1. 1985-09-11. PMID:2992285. |
to investigate the possible roles of serotonin type 1 and 2 receptors in the regulation of aldosterone production, we examined the effects of cyproheptadine (a serotonin antagonist that inhibits both type 1 and 2 receptors) and ketanserin (a serotonin type 2 selective antagonist) on aldosterone and camp production in collagenase dispersed rat adrenal capsular cells. |
1985-09-11 |
2023-08-11 |
rat |
| H Matsuoka, M Ishii, A Goto, T Sugimot. Role of serotonin type 2 receptors in regulation of aldosterone production. The American journal of physiology. vol 249. issue 2 Pt 1. 1985-09-11. PMID:2992285. |
serotonin, ranging in concentration from 10(-9) to 10(-3) m, significantly increased aldosterone production in a dose-dependent fashion after 2 h of incubation at 37 degrees c. cyproheptadine and ketanserin showed comparable inhibitory effects on basal aldosterone production. |
1985-09-11 |
2023-08-11 |
rat |
| H Matsuoka, M Ishii, A Goto, T Sugimot. Role of serotonin type 2 receptors in regulation of aldosterone production. The American journal of physiology. vol 249. issue 2 Pt 1. 1985-09-11. PMID:2992285. |
serotonin significantly increased camp production at a dose of 10(-6) m. both cyproheptadine and ketanserin significantly decreased basal camp production at doses of 10(-5) m. these serotonin antagonists preferentially inhibited serotonin-stimulated camp production. |
1985-09-11 |
2023-08-11 |
rat |