| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S A Doggrel. Differential antagonism of the initial fast and secondary slow contractile responses of the rat isolated aorta to 5-hydroxytryptamine by mianserin and ketanserin. Journal of autonomic pharmacology. vol 7. issue 2. 1987-11-10. PMID:3654683. |
3 phentolamine, dihydroergotamine, methysergide and cyproheptadine had similar inhibitory effects on the initial fast and secondary slow responses to 5-ht. |
1987-11-10 |
2023-08-11 |
rat |
| S A Doggrel. Differential antagonism of the initial fast and secondary slow contractile responses of the rat isolated aorta to 5-hydroxytryptamine by mianserin and ketanserin. Journal of autonomic pharmacology. vol 7. issue 2. 1987-11-10. PMID:3654683. |
5 one possible explanation of these results is that the rat aorta has no spare 5-ht2 receptors and that in inhibiting responses to 5-ht: (a) phentolamine is a competitive antagonist, (b) mianserin and ketanserin are slowly dissociating antagonists, and (c) dihydroergotamine, methysergide and cyproheptadine are irreversible antagonists. |
1987-11-10 |
2023-08-11 |
rat |
| M F Campos, C Rodrigues F da. Rats and marmosets respond differently to serotonin agonists and antagonists. Psychopharmacology. vol 92. issue 4. 1987-10-19. PMID:3114802. |
the actions of the serotonin precursor 5-hydroxytryptophan (5-htp), the agonist 5-methoxy-n,n-dimetyltryptamine (meodmt) and quipazine (qpz) and the antagonists cyproheptadine, methysergide and metergoline, were studied in the rat and in the common marmoset (callithrix jacchus). |
1987-10-19 |
2023-08-11 |
rat |
| J Y Chang, C Owma. Involvement of specific receptors and calcium mechanisms in serotonergic contractile response of isolated cerebral and peripheral arteries from rats. The Journal of pharmacology and experimental therapeutics. vol 242. issue 2. 1987-09-23. PMID:3612555. |
also the (tonic) contraction induced by high potassium concentration was attenuated, with the same relative potency as in the presence of 5-ht except for cyproheptadine, which was less efficient than nimodipine. |
1987-09-23 |
2023-08-11 |
rat |
| P Leff, G R Martin, J M Mors. Differential classification of vascular smooth muscle and endothelial cell 5-HT receptors by use of tryptamine analogues. British journal of pharmacology. vol 91. issue 2. 1987-08-28. PMID:3607360. |
the receptor mediating endothelium-dependent relaxations was evidently similar to previously described endothelial 5-ht receptors since relaxation responses to alpha-methyl-5-ht were not blocked by atropine, (+/-)-propranolol, yohimbine, indomethacin, ketanserin or mdl-72222, but were non-competitively antagonized by methysergide, methiothepin and cyproheptadine. |
1987-08-28 |
2023-08-11 |
dog |
| N H Majeed, J Silberring, R Przewłock. The in vitro release of immunoreactive dynorphin and alpha-neoendorphin from the perfused rat duodenum. Life sciences. vol 41. issue 4. 1987-08-20. PMID:2885708. |
the effect of 5-ht on the release of ir-dyn and ir-aneo from the duodenum was antagonized by 5-ht antagonist cyproheptadine (10(-6) m). |
1987-08-20 |
2023-08-11 |
rat |
| A Cheung, T R Hall, S Harve. Serotoninergic regulation of corticosterone secretion in domestic fowl. The Journal of endocrinology. vol 113. issue 2. 1987-07-20. PMID:3585229. |
the quipazine-stimulated response was partly prevented by the serotonin antagonist cyproheptadine. |
1987-07-20 |
2023-08-11 |
Not clear |
| A Cheung, T R Hall, S Harve. Serotoninergic regulation of corticosterone secretion in domestic fowl. The Journal of endocrinology. vol 113. issue 2. 1987-07-20. PMID:3585229. |
serotonin, quipazine and cyproheptadine did not affect corticosterone release directly from the adrenal gland incubated in vitro, nor did they affect adrenal responsiveness to acth stimulation. |
1987-07-20 |
2023-08-11 |
Not clear |
| M R Pranzatelli, S R Snodgras. Harmala alkaloids and related beta-carbolines: a myoclonic model and antimyoclonic drugs. Experimental neurology. vol 96. issue 3. 1987-07-02. PMID:3495451. |
5-hydroxytryptamine antagonists were poor blockers, although cyproheptadine and ketanserin significantly reduced mortality. |
1987-07-02 |
2023-08-11 |
rat |
| A C Rovescalli, N Brunello, A Monopoli, E Ongini, G Racagn. Absence of [3H]SCH 23390 specific binding sites in anterior pituitary: dissociation from effects on prolactin secretion. European journal of pharmacology. vol 135. issue 2. 1987-07-01. PMID:3556197. |
similarly the postsynaptic serotonin (5-ht) antagonists metergoline and cyproheptadine did not influence the sch 23390 effect on prl. |
1987-07-01 |
2023-08-11 |
rat |
| G V Idova, M A Cheĭd. [Stimulation of the immune response during blockade of serotonin receptors by cyproheptadine]. Biulleten' eksperimental'noi biologii i meditsiny. vol 103. issue 4. 1987-06-17. PMID:3567337. |
[stimulation of the immune response during blockade of serotonin receptors by cyproheptadine]. |
1987-06-17 |
2023-08-11 |
mouse |
| G V Idova, M A Cheĭd. [Stimulation of the immune response during blockade of serotonin receptors by cyproheptadine]. Biulleten' eksperimental'noi biologii i meditsiny. vol 103. issue 4. 1987-06-17. PMID:3567337. |
the role of serotonin receptors in the inhibitory effect of serotoninergic system on immunogenesis was studied using cyproheptadine, a specific blocker of 5-ht2 receptors. |
1987-06-17 |
2023-08-11 |
mouse |
| M B Given, G E Sander, T D Gile. Evidence for Des-Tyr1-D-Ala2-leucine5-enkephalinamide calcium agonist activity in vascular smooth muscle. Canadian journal of physiology and pharmacology. vol 65. issue 2. 1987-06-17. PMID:3567729. |
however, a significant inhibition was obtained with cyproheptadine (p less than 0.001, n = 5), a 5-hydroxytryptamine (5-ht) receptor antagonist that also has calcium channel blocking activity. |
1987-06-17 |
2023-08-11 |
rat |
| L A Bero, C M Kuh. Role of serotonin in opiate-induced prolactin secretion and antinociception in the developing rat. The Journal of pharmacology and experimental therapeutics. vol 240. issue 3. 1987-04-27. PMID:2435887. |
ten-day-old or adult rats were pretreated with the serotonin antagonist, cyproheptadine (cypro), or the neurotoxin, 5,7-dihydroxytryptamine (5,7-dht). |
1987-04-27 |
2023-08-11 |
rat |
| L R Bus. Effects of the serotonin antagonists, cyproheptadine, ketanserin and mianserin, on cyclic flow reductions in stenosed canine coronary arteries. The Journal of pharmacology and experimental therapeutics. vol 240. issue 2. 1987-03-26. PMID:3806419. |
effects of the serotonin antagonists, cyproheptadine, ketanserin and mianserin, on cyclic flow reductions in stenosed canine coronary arteries. |
1987-03-26 |
2023-08-11 |
human |
| L R Bus. Effects of the serotonin antagonists, cyproheptadine, ketanserin and mianserin, on cyclic flow reductions in stenosed canine coronary arteries. The Journal of pharmacology and experimental therapeutics. vol 240. issue 2. 1987-03-26. PMID:3806419. |
we compared the abilities of three pharmacologically and structurally dissimilar 5-hydroxytryptamine (5-ht2) antagonists, cyproheptadine, ketanserin, and mianserin, to interrupt cyclic flow reductions (cfrs) in stenosed coronary arteries of open-chest dogs. |
1987-03-26 |
2023-08-11 |
human |
| R Young, J A Rosecrans, R A Glenno. Further studies on the dose-dependent stimulus properties of 5-methoxy-N,N-dimethyltryptamine. Pharmacology, biochemistry, and behavior. vol 25. issue 6. 1987-03-17. PMID:3809222. |
once responding was stable, various doses of several serotonin (5-ht) antagonists, i.e., cyproheptadine (cyp), methysergide (uml), cinanserin (cin), and methergoline (mce), were administered in combination with 5-ome dmt, to assess the ability of each antagonist to attenuate each 5-ome dmt-stimulus. |
1987-03-17 |
2023-08-11 |
rat |
| C M Maillet, A J Garbe. Adrenergic and serotonergic regulation of skeletal muscle metabolism in the rat: specificity of the serotonin- and isoproterenol-stimulable adenylyl cyclase in sarcolemma. Molecular and cellular endocrinology. vol 48. issue 2-3. 1987-03-06. PMID:3803707. |
the concentrations of antagonists producing 50% inhibition (ic50) of the maximal adenylyl cyclase stimulation by serotonin were compared to the ic50 obtained with isoproterenol; the ratios were 0.02 for oxprenolol, 0.50 for l-propranolol, 295 for d-propranolol, 2438 for cyproheptadine, 578 for methysergide and greater than 125,000 for lysergic acid diethylamide (lsd). |
1987-03-06 |
2023-08-11 |
rat |
| C Bruns, D Marmé, H Osswal. Stereospecific inhibition of 5-HT-induced increase of intracellular free calcium by (+)- and (-)-desmethoxyverapamil in human platelets. British journal of pharmacology. vol 87. issue 3. 1987-03-02. PMID:3801761. |
5-hydroxytryptamine (5-ht) at 10(-5) m induced a rapid transient increase of [ca2+]i which was antagonized by 10(-7) m ketanserin or cyproheptadine. |
1987-03-02 |
2023-08-11 |
human |
| G Shor-Posner, J A Grinker, C Marinescu, O Brown, S F Leibowit. Hypothalamic serotonin in the control of meal patterns and macronutrient selection. Brain research bulletin. vol 17. issue 5. 1987-02-27. PMID:3801928. |
the effect of drugs presumed to affect brain 5-ht transmission on diet selection was also investigated in groups of rats injected centrally with 5-ht or norfenf or peripherally with either fenfluramine, quipazine or cyproheptadine. |
1987-02-27 |
2023-08-11 |
rat |