| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Ni, L X Jing, S She. [The role of medial medulla in the depressive responses in pulmonary and carotid arteries to injection of acetylcholine at fourth ventricle]. Sheng li xue bao : [Acta physiologica Sinica]. vol 41. issue 3. 1989-10-19. PMID:2781312. |
it was found that (1) electrolytic destruction of medial medulla significantly diminished the depressive responses to ach in pulmonary and carotid arteries; (2) destruction of nucleus tractus solitarius (nts) at the level of the medullary obex did not affect the depressive responses in both arteries; obex did not affect the depressive responses in both arteries; (3) microinjection of 5-hydroxytryptamine (5-ht) blockers, cyproheptadine and 2-bromolysergic acid diethylamide (bol), into the fourth ventricle or medial medulla could lessen the depressive responses to ach in pulmonary and carotid arteries; (4) microinjection of naloxone in the same way could partially abolish the depressive responses. |
1989-10-19 |
2023-08-11 |
Not clear |
| L A Connell, D I Walli. 5-Hydroxytryptamine depolarizes neonatal rat motorneurones through a receptor unrelated to an identified binding site. Neuropharmacology. vol 28. issue 6. 1989-08-29. PMID:2755565. |
mesulergine, metergoline and cyproheptadine also antagonised responses of motorneurones to 5-ht, producing a surmountable blockade. |
1989-08-29 |
2023-08-11 |
rat |
| W A Banks, A J Kasti. Effect of neurotransmitters on the system that transports Tyr-MIF-1 and the enkephalins across the blood-brain barrier: a dominant role for serotonin. Psychopharmacology. vol 98. issue 3. 1989-08-17. PMID:2568658. |
cyproheptadine, a serotonin antagonist, stimulated transport. |
1989-08-17 |
2023-08-11 |
Not clear |
| D J Fletcher, M A Hanson, P J Moore, J G Nijhuis, M J Parke. Stimulation of breathing movements by L-5-hydroxytryptophan in fetal sheep during normoxia and hypoxia. The Journal of physiology. vol 404. 1989-08-11. PMID:3267025. |
to investigate its mechanism of action, l-5-htp was administered in conjunction with the 5-hydroxy-tryptamine (5-ht) antagonists ketanserin or cyproheptadine. |
1989-08-11 |
2023-08-11 |
Not clear |
| R Hendriks, J C Bornstein, J B Furnes. Evidence for two types of 5-hydroxytryptamine receptor on secretomotor neurons of the guinea-pig ileum. Naunyn-Schmiedeberg's archives of pharmacology. vol 339. issue 4. 1989-08-01. PMID:2472554. |
we conclude that there are ics 205-930 sensitive 5-ht receptors on cholinergic secretomotor neurons, and ics 205-930, methysergide, and cyproheptadine insensitive 5-ht receptors on non-cholinergic secretomotor neurons. |
1989-08-01 |
2023-08-11 |
Not clear |
| C E Ketelaars, J Bruinvel. The anti-conflict effect of cyproheptadine is not mediated by its 5-hydroxytryptamine antagonistic property. Life sciences. vol 44. issue 23. 1989-07-25. PMID:2499742. |
the anti-conflict effect of cyproheptadine is not mediated by its 5-hydroxytryptamine antagonistic property. |
1989-07-25 |
2023-08-11 |
rat |
| J T Eells, D M Wilkiso. Effects of intraocular mescaline and LSD on visual-evoked responses in the rat. Pharmacology, biochemistry, and behavior. vol 32. issue 1. 1989-07-17. PMID:2734330. |
the serotonin receptor antagonists, cyproheptadine and methysergide, antagonized the mescaline-induced depression of the fep in accordance with neurochemical and behavioral evidence that mescaline acts as a partial agonist on serotonin receptors. |
1989-07-17 |
2023-08-11 |
rat |
| O Güntürkün, A Grothues, A Hautkappe, F Visé, N Wawrzyniak, U Zwillin. Serotonergic modulation of ingestive behavior in pigeons. Pharmacology, biochemistry, and behavior. vol 32. issue 2. 1989-07-12. PMID:2524843. |
the effects of peripheral administration of the serotonin agonist zimeldine and the serotonin antagonist cyproheptadine on food and water consumption were evaluated in domestic pigeons. |
1989-07-12 |
2023-08-11 |
Not clear |
| E Adler-Graschinsky, A B Elgoyhen, N V Butt. Different receptor subtypes mediate the dual presynaptic effects of 5-hydroxytryptamine on peripheral sympathetic neurones. Journal of autonomic pharmacology. vol 9. issue 1. 1989-06-29. PMID:2524497. |
the 5-ht2 receptor antagonists, ketanserin (0.01 and 0.1 microm) and cyproheptadine (1 microm), did not prevent the inhibitory effect of 5-ht in the guinea-pig atria. |
1989-06-29 |
2023-08-11 |
cat |
| J L Sartin, R J Kemppainen, D N Marple, R Carnes, G Dieberg, E H Olive. Effects of parachlorophenylalanine, quipazine and cyproheptadine on growth hormone and adrenocorticotropin secretion in steers. Domestic animal endocrinology. vol 4. issue 1. 1989-05-18. PMID:2853663. |
parachlorophenylalanine (pcpa; serotonin synthesis inhibitor), quipazine (serotonin receptor agonist) and cyproheptadine (serotonin receptor antagonist) were utilized in holstein steers to determine whether serotonin receptors mediate stimulatory actions on gh and acth secretion. |
1989-05-18 |
2023-08-11 |
Not clear |
| E Glusa, F Markward. Influence of endothelium on the vasoconstrictor effect of dihydroergotamine in the isolated rat aorta. Archives internationales de pharmacodynamie et de therapie. vol 296. 1989-05-10. PMID:3240023. |
the 5-ht antagonist cyproheptadine (2 mumol/l) inhibited the dihydroergotamine-induced vasoconstriction, that means, 5-ht receptors are involved in the vasoconstrictor effect. |
1989-05-10 |
2023-08-11 |
rat |
| C W Hennig, W C Steinhoff, S A Braughle. Tonic immobility and the serotonergic system in chickens: differential blockade of receptors by cyproheptadine and cinanserin. Physiology & behavior. vol 44. issue 1. 1989-04-28. PMID:3237811. |
cyproheptadine, a serotonergic antagonist, eliminated increases generated by low doses of serotonin and reduced durations in control subjects, but had no effect on the attenuation produced by high doses of the drug. |
1989-04-28 |
2023-08-11 |
human |
| E Glus. Effect of verapamil on platelet aggregation. Folia haematologica (Leipzig, Germany : 1928). vol 115. issue 4. 1989-04-13. PMID:2465955. |
the influence of the calcium channel blocker verapamil on the aggregation of human blood platelets was studied in vitro in comparison with the calcium channel blocker diltiazem and with the 5-ht antagonist cyproheptadine. |
1989-04-13 |
2023-08-11 |
human |
| D L Vermillion, P B Ernst, R Scicchitano, S M Collin. Antigen-induced contraction of jejunal smooth muscle in the sensitized rat. The American journal of physiology. vol 255. issue 6 Pt 1. 1989-01-26. PMID:3202167. |
contraction was resistant to atropine or tetrodotoxin but was inhibited by the 5-hydroxytryptamine (5-ht) antagonist cyproheptadine and by 5-ht desensitization. |
1989-01-26 |
2023-08-11 |
rat |
| H Müller, E Glusa, F Markward. Dual effect of dihydroergotamine at vascular 5-hydroxytryptamine receptors in pithed rats. Pharmacology. vol 37. issue 4. 1988-12-30. PMID:2904153. |
this pressor effect was noncompetitively inhibited by the 5-hydroxytryptamine (5-ht) receptor antagonists pizotifen and cyproheptadine (0.1 mg/kg each). |
1988-12-30 |
2023-08-11 |
rat |
| S J Won, M T Li. 5-Hydroxytryptamine receptors in the hypothalamus mediate thermoregulatory responses in rabbits. Naunyn-Schmiedeberg's archives of pharmacology. vol 338. issue 3. 1988-12-30. PMID:3194035. |
the effects of microinjection of 5-hydroxytryptamine (5-ht) or its antagonists methysergide (a 5-ht1 receptor antagonist), cyproheptadine (a mixed 5-ht1/5-ht2 receptor antagonist), or ketanserin (a 5-ht2 receptor antagonist) into the preoptic anterior hypothalamus on thermoregulatory responses were assessed in conscious rabbits at different ambient temperatures (ta). |
1988-12-30 |
2023-08-11 |
rabbit |
| L R Bush, D C Rem. Effects of 3-methoxycyproheptadine in a canine model of coronary thrombosis. The Journal of pharmacology and experimental therapeutics. vol 247. issue 2. 1988-12-21. PMID:3183974. |
thus, (-)-3-meo-cyp, a 5-ht2 antagonist devoid of anticholinergic activity and less antihistamine activity than either its enantiomer or parent drug, cyproheptadine, exerts dose-dependent antithrombotic effects in this canine model, providing further evidence that serotonin plays an important role in platelet aggregation and thrombosis. |
1988-12-21 |
2023-08-11 |
Not clear |
| E Menéndez Abraham, P Morán Viesca, A Velasco Plaza, B Marí. Modifications of the sexual activity in male rats following administration of antiserotoninergic drugs. Behavioural brain research. vol 30. issue 3. 1988-12-06. PMID:3178996. |
the influence of cyproheptadine (cph), methysergide and 5-hydroxytryptamine (5-ht) was studied on male sexual activity. |
1988-12-06 |
2023-08-11 |
rat |
| S A Doggrel. No evidence for the differential antagonism of the initial fast and secondary slow contractile responses of the rat portal vein to phenylephrine, 5-hydroxytryptamine or methacholine. Journal of autonomic pharmacology. vol 8. issue 2. 1988-11-15. PMID:2902098. |
in the presence of cocaine, mianserin (10(-9)-10(-8) m), cyproheptadine, (10(-10)-10(-9) m), methysergide (10(-8) m), ketanserin (10(-10)-10(-9) m) and ly 53857 (at 10(-9)-10(-8) m) had similar inhibitory effects on the initial fast and secondary slow responses to 5-ht, namely a parallel rightward displacement of the concentration-response curves. |
1988-11-15 |
2023-08-11 |
rat |
| G A Kennett, G Curzo. Evidence that mCPP may have behavioural effects mediated by central 5-HT1C receptors. British journal of pharmacology. vol 94. issue 1. 1988-09-12. PMID:3401632. |
the hypoactivity induced by mcpp was opposed by three antagonists with high affinity for the 5-hydroxytryptamine (5-ht1c) site; metergoline, mianserin, cyproheptadine and possibly also by a fourth antagonist mesulergine. |
1988-09-12 |
2023-08-11 |
rat |