| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C G Kardinal, C L Loprinzi, D J Schaid, A C Hass, A M Dose, L M Athmann, J A Mailliard, G W McCormack, J B Gerstner, M F Schra. A controlled trial of cyproheptadine in cancer patients with anorexia and/or cachexia. Cancer. vol 65. issue 12. 1990-06-28. PMID:2187585. |
extensive clinical data demonstrate a weight enhancing effect for the serotonin antagonist, cyproheptadine, in several clinical situations. |
1990-06-28 |
2023-08-11 |
Not clear |
| N Gurevich, P H Wu, P L Carle. Serotonin agonist and antagonist actions in hippocampal CA1 neurons. Canadian journal of physiology and pharmacology. vol 68. issue 5. 1990-06-28. PMID:2340447. |
the 5-ht2 antagonists, cyproheptadine and mianserin, and a nonspecific 5-ht antagonist, methysergide, also caused a prolonged hyperpolarization with decreased input resistance. |
1990-06-28 |
2023-08-11 |
Not clear |
| H H Berendsen, F Jenck, C L Broekkam. Involvement of 5-HT1C-receptors in drug-induced penile erections in rats. Psychopharmacology. vol 101. issue 1. 1990-06-27. PMID:2343074. |
these compounds have in common a strong affinity for the 5-ht1c receptor, mcpp (0.46 mg/kg)-induced pe could be antagonized by the 5-ht antagonists metergoline, cyproheptadine, mesulergine, mianserin, ritanserin and ketanserin. |
1990-06-27 |
2023-08-11 |
rat |
| B Lomonte, G Rojas, J M Gutiérrez, G Ramíre. Isolation of a galactose-binding lectin from the venom of the snake Bothrops godmani (Godmann's pit viper). Toxicon : official journal of the International Society on Toxinology. vol 28. issue 1. 1990-05-31. PMID:2109909. |
administration of cyproheptadine, a histamine and serotonin antagonist, before injection of the lectin. |
1990-05-31 |
2023-08-11 |
mouse |
| H Hashemzadeh-Gargari, W O Friese. Modulation of swimming activity in the medicinal leech by serotonin and octopamine. Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology. vol 94. issue 1. 1990-05-30. PMID:2576740. |
swim-induction by 5-ht is blocked by the presence of 10 microm cyproheptadine (a 5-ht antagonist). |
1990-05-30 |
2023-08-11 |
Not clear |
| A H Swiergiel, G Peter. Failure of serotonin antagonist pizotifen to stimulate feeding or weight gain in free-feeding rats. Pharmacology, biochemistry, and behavior. vol 35. issue 1. 1990-04-26. PMID:2315371. |
since it has been reported that other 5-ht antagonists, e.g., cyproheptadine, methysergide, and ritanserin can enhance feeding, it is of some interest that pizotifen failed to affect food intake or weight gain in rats. |
1990-04-26 |
2023-08-11 |
rat |
| C Schremmer, R Morgenstern, H Fink, T Ot. Atypical neuroleptics suppress dopaminergic behavioral supersensitivity. Psychopharmacology. vol 100. issue 3. 1990-04-17. PMID:1969173. |
the atypical neuroleptics sulpiride (5.0-20.0 mg/kg ip), thioridazine (1.0-5.25 mg/kg ip) and clozapine (0.5-2.0 mg/kg ip) and the 5-ht antagonists cyproheptadine (0.2 mg/kg ip) and ritanserin (0.01 mg/kg ip) suppressed the augmented apomorphine response in 6-ohda-lesioned animals to the level of the apomorphine effect in controls. |
1990-04-17 |
2023-08-11 |
rat |
| G E Bilder, C J Kasiewski, M H Perron. Phorbol-12,13-dibutyrate-induced vasoconstriction in vivo: characterization of response in genetic hypertension. The Journal of pharmacology and experimental therapeutics. vol 252. issue 2. 1990-04-16. PMID:2313587. |
the tonic vasoconstriction induced by pdbu was not antagonized by prazosin, rauwolscine, cyproheptadine, [sar1lle8]-angiotensin ii but was inhibited reversibly by microbial pkc-inhibitors, k252a and staurosporine at concentrations (1.56-2.8 micrograms/kg/min) which did not block vasoconstriction by phenylephrine or 5-hydroxytryptamine. |
1990-04-16 |
2023-08-11 |
rat |
| H Ono, N Nagano, M Yamada, H Fukud. Effects of a new analog of thyrotropin-releasing hormone, N alpha-[(S)-4-oxo-2-azetidinyl) carbonyl]-L-histidyl-L-prolinamide dehydrate (YM-14673) on spinal reflex potentials and flexor reflexes in spinalized rats. Neuropharmacology. vol 29. issue 1. 1990-03-19. PMID:2106102. |
the stimulant action of trh and ym-14673 on the flexor reflexes was not antagonized by prazosin, chlorpromazine, haloperidol or cyproheptadine, suggesting no involvement of the release of catecholamines or serotonin in the stimulant effects of trh and its analog. |
1990-03-19 |
2023-08-11 |
rat |
| A Y Lin, Y C Ru. [Inhibitory effect of silybin on the activity of 5-lipoxygenase of the porcine cerebral basilar artery]. Zhongguo yao li xue bao = Acta pharmacologica Sinica. vol 10. issue 5. 1990-03-09. PMID:2618728. |
the acetylcholine, histamine and 5-ht released by the ileum was preblocked by atropine 1 mumol/l, diphenhydramine 1 mumol/l and cyproheptadine 3 nmol/l. |
1990-03-09 |
2023-08-11 |
Not clear |
| S Conway, L Richardson, S Speciale, R Moherek, H Mauceri, L Krulic. Interaction between norepinephrine and serotonin in the neuroendocrine control of growth hormone release in the rat. Endocrinology. vol 126. issue 2. 1990-03-05. PMID:1688789. |
in this model, systemically administered alpha 2-agonists [clonidine (clon) or uk14,304] were tested against 5ht antagonists (meterogoline or cyproheptadine) or 5ht synthesis inhibitors (p-chlorophenylalanine methylester hydrochloride). |
1990-03-05 |
2023-08-11 |
rat |
| R A Macia, A C Silver, R A Gabel, G K Campbell, N Hanna, M J DiMartin. Hypotension induced by vasopressin antagonists in rats: role of mast cell degranulation. Toxicology and applied pharmacology. vol 102. issue 1. 1990-02-22. PMID:1688665. |
finally, cyproheptadine (10 mg/kg), an antagonist at both the serotonin and the histamine receptors, blunted the effects of sk&f 101926 on map and blocked the lethality. |
1990-02-22 |
2023-08-11 |
rat |
| S Verma, G S Chhina, V Mohan Kumar, B Sing. Inhibition of male sexual behavior by serotonin application in the medial preoptic area. Physiology & behavior. vol 46. issue 2. 1990-01-30. PMID:2602475. |
injection of serotonin in the medial preoptic area resulted in an inhibition, whereas cyproheptadine (a serotonin antagonist) produced a slight facilitation, of male sexual behavior. |
1990-01-30 |
2023-08-11 |
rat |
| R K Simpson, D K Fischer, B L Ehn. Neurogenic hyperthermia in subarachnoid hemorrhage. Southern medical journal. vol 82. issue 12. 1990-01-23. PMID:2595429. |
persistent elevation of body temperature did not respond to standard therapy, but successful treatment was achieved with cyproheptadine and indomethacin, presumably through antagonism of serotonin and prostaglandin activity. |
1990-01-23 |
2023-08-11 |
Not clear |
| J Backo. Predicting new effective treatments of alcohol addiction on the basis of their properties of inhibition of noradrenergic activity and/or thromboxane or on the activation of the dopamine reward system and/or beta-endorphin. Medical hypotheses. vol 29. issue 4. 1990-01-05. PMID:2573815. |
on the basis of their properties of noradrenergic and/or thromboxane inhibition, or on their activation of the dopaminergic reward system and/or beta-endorphin, the following substances or treatments are predicted to be effective in treating alcohol or drug addiction: ginger; carbon dioxide; dietary sulfur; methionine; calcium; lhrh; high intensity light; interferon; negative ions; serotonin antagonists such as methysergide and cyproheptadine; guanabenz and guenfacine; antihistamines; head-out water immersion; x-irradiation; and forced unilateral left nostril breathing. |
1990-01-05 |
2023-08-11 |
Not clear |
| N Khanna, A Ray, M Alkondon, P Se. Effect of beta-adrenoceptor antagonists and some related drugs on maximal electroshock seizures in mice. Indian journal of experimental biology. vol 27. issue 2. 1989-12-07. PMID:2572545. |
cholinergic agents, physostigmine (0.01-1.0 mg/kg), and atropine (1 and 10 mg/kg), the serotonin antagonist, cyproheptadine (0.05 mg/kg), and the prostaglandin synthesis inhibitor, indomethacin (10 mg/kg), were also without effect on the mes extensor phase. |
1989-12-07 |
2023-08-11 |
mouse |
| E W Hillhouse, N G Milto. Effect of acetylcholine and 5-hydroxytryptamine on the secretion of corticotrophin-releasing factor-41 and arginine vasopressin from the rat hypothalamus in vitro. The Journal of endocrinology. vol 122. issue 3. 1989-12-04. PMID:2572662. |
5-ht caused a dose-dependent (10 pmol-1 nmol/l) stimulation of crf-41 release without any effect on avp release, and this effect was antagonized by cyproheptadine, suggesting the participation of specific 5-ht receptors. |
1989-12-04 |
2023-08-11 |
rat |
| C T Tsa. Involvement of serotonin in mediation of inhibition of substantia nigra neurons by noxious stimuli. Brain research bulletin. vol 23. issue 1-2. 1989-11-30. PMID:2529952. |
extracellular recording of spontaneous firing of snc neurons were made to investigate how such inhibition would be influenced by treatment with 5,7-dihydroxytryptamine (5,7-dht) or p-chlorophenylalanine (pcpa) or by iv injection of the serotonin antagonist, cyproheptadine. |
1989-11-30 |
2023-08-11 |
rat |
| H Frycová, J Mety. [Anti-allergic properties of pipethiaden--a new preventive agent for migraine]. Ceskoslovenska farmacie. vol 38. issue 6. 1989-11-02. PMID:2790993. |
in comparative pharmacological experiments with pizotifen and cyproheptadine an attempt was made to estimate the relative role of histamine and 5-hydroxytryptamine 5-ht) mediators in the employed experimental procedures in rats. |
1989-11-02 |
2023-08-11 |
rat |
| K F Strek, K R Spencer, V J DeNobl. Manipulation of serotonin protects against an hypoxia-induced deficit of a passive avoidance response in rats. Pharmacology, biochemistry, and behavior. vol 33. issue 1. 1989-10-26. PMID:2528749. |
the 5-ht antagonists ketanserin, mianserin, methysergide, and cyproheptadine and the 5-ht uptake inhibitors fluoxetine and zimeldine were evaluated for their ability to protect against an hypoxia-induced performance deficit in a passive avoidance (pa) task. |
1989-10-26 |
2023-08-11 |
rat |