| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S A Doggrel. Further analysis of the inhibitory effects of dihydroergotamine, cyproheptadine and ketanserin on the responses of the rat aorta to 5-hydroxytryptamine. Journal of autonomic pharmacology. vol 12. issue 4. 1992-10-01. PMID:1512277. |
the aim of the present study was to analyse the inhibitory effects of dihydroergotamine, cyproheptadine and ketanserin on the rat aorta contractile responses to 5-ht. |
1992-10-01 |
2023-08-11 |
rat |
| S A Doggrel. Further analysis of the inhibitory effects of dihydroergotamine, cyproheptadine and ketanserin on the responses of the rat aorta to 5-hydroxytryptamine. Journal of autonomic pharmacology. vol 12. issue 4. 1992-10-01. PMID:1512277. |
then the reversibility of the inhibitory effects of phentolamine, dihydroergotamine, cyproheptadine and ketanserin against the fast and slow response of the rat aorta to 5-ht were determined. |
1992-10-01 |
2023-08-11 |
rat |
| S A Doggrel. Further analysis of the inhibitory effects of dihydroergotamine, cyproheptadine and ketanserin on the responses of the rat aorta to 5-hydroxytryptamine. Journal of autonomic pharmacology. vol 12. issue 4. 1992-10-01. PMID:1512277. |
phentolamine, dihydroergotamine, cyproheptadine and ketanserin inhibited the fast and slow responses to 5-ht. |
1992-10-01 |
2023-08-11 |
rat |
| S A Doggrel. Further analysis of the inhibitory effects of dihydroergotamine, cyproheptadine and ketanserin on the responses of the rat aorta to 5-hydroxytryptamine. Journal of autonomic pharmacology. vol 12. issue 4. 1992-10-01. PMID:1512277. |
phentolamine and ketanserin and the higher concentrations of dihydroergotamine and cyproheptadine tested had greater inhibitory effects on the fast than slow 5-ht responses possibly because the fast 5-ht response did not always reach equilibrium in the presence of antagonists. |
1992-10-01 |
2023-08-11 |
rat |
| S A Doggrel. Further analysis of the inhibitory effects of dihydroergotamine, cyproheptadine and ketanserin on the responses of the rat aorta to 5-hydroxytryptamine. Journal of autonomic pharmacology. vol 12. issue 4. 1992-10-01. PMID:1512277. |
the inhibitory effects on 5-ht responses of phentolamine at 10(-6)-10(-5) m were readily reversible, those of cyproheptadine at 10(-9)-10(-8) m and ketanserin at 10(-8) m were slowly reversible and those of dihydroergotamine at 10(-9)-10(-8) m were irreversible by washing in drug-free krebs. |
1992-10-01 |
2023-08-11 |
rat |
| S A Doggrel. Further analysis of the inhibitory effects of dihydroergotamine, cyproheptadine and ketanserin on the responses of the rat aorta to 5-hydroxytryptamine. Journal of autonomic pharmacology. vol 12. issue 4. 1992-10-01. PMID:1512277. |
the inhibitory effects of phentolamine and ketanserin were not altered by increasing the treatment time whereas some of the effects of cyproheptadine and the effects of dihydroergotamine on responses to 5-ht were increased by prolonging the contact time with the antagonist from 75 to 150 min. |
1992-10-01 |
2023-08-11 |
rat |
| I Heinroth-Hoffmann, C Giessler, H J Mes. Relevance of vasoactive mediators for the blood pressure effects of intravenous arachidonic acid injection in rats. Prostaglandins, leukotrienes, and essential fatty acids. vol 46. issue 3. 1992-09-18. PMID:1508952. |
the receptor antagonist of platelet activating factor bn 52021 and the serotonin and histamine receptor antagonist cyproheptadine also reduced txb2 amounts, in murine blood without any effects on blood pressure behaviour. |
1992-09-18 |
2023-08-11 |
rat |
| H J Mest, I Hörhold, T Rein, A Riedel, C Broque. Effect of BN 52256 and other mediator antagonists on ouabain-induced cardiac arrhythmia in a model of anaphylaxis in guinea-pigs. Pharmacological research. vol 25. issue 2. 1992-08-25. PMID:1635894. |
antagonists of paf (web 2170), histamine (clemastine) and 5-ht (cyproheptadine) in doses of 5.0 mg/kg, 5.0 mg/kg and 0.5 mg/kg, respectively, can increase the threshold dose of ouabain-induced arrhythmias signalling an antiarrhythmic effect. |
1992-08-25 |
2023-08-11 |
Not clear |
| C Kao, D J Schaeffer, G L Jackso. Different neuroendocrine systems modulate pulsatile luteinizing hormone secretion in photosuppressed and photorefractory ewes. Biology of reproduction. vol 46. issue 3. 1992-07-31. PMID:1617016. |
injection of cyproheptadine, a serotonin antagonist (3 mg/kg); and again 7 days later after i.v. |
1992-07-31 |
2023-08-11 |
Not clear |
| Y Imai, M Hayashi, S Oh-ish. Involvement of platelet-activating factor in zymosan-induced rat pleurisy. Lipids. vol 26. issue 12. 1992-07-30. PMID:1819742. |
pretreatment with cyproheptadine (5 mg/kg), an inhibitor of both histamine and serotonin, significantly suppressed pleural fluid accumulation and the exudation rate at 0.5 hr. |
1992-07-30 |
2023-08-11 |
rat |
| P S Grigson, C F Flahert. Cyproheptadine prevents the initial occurrence of successive negative contrast. Pharmacology, biochemistry, and behavior. vol 40. issue 2. 1992-05-04. PMID:1839569. |
in experiment 1, the occurrence of this contrast effect was prevented by the administration of the nonspecific serotonin antagonist cyproheptadine (3.0 or 6.0 mg/kg). |
1992-05-04 |
2023-08-11 |
rat |
| P S Grigson, C F Flahert. Cyproheptadine prevents the initial occurrence of successive negative contrast. Pharmacology, biochemistry, and behavior. vol 40. issue 2. 1992-05-04. PMID:1839569. |
these results of experiments 2 and 3 demonstrated that the contrast-reducing action of cyproheptadine was not mediated by the antiserotonergic properties of the drug since systemic administration of the serotonin synthesis inhibitor, pcpa (150 or 300 mg/kg), failed to influence either the occurrence of contrast or the attenuation of contrast by cyproheptadine. |
1992-05-04 |
2023-08-11 |
rat |
| P G Kostyuk, E A Lukyanetz, P A Doroshenk. Effects of serotonin and cAMP on calcium currents in different neurones of Helix pomatia. Pflugers Archiv : European journal of physiology. vol 420. issue 1. 1992-04-29. PMID:1313172. |
methiothepin (10-50 microm), a 5-ht1,2 receptor antagonist, irreversibly inhibited the potentiating effect of 5-ht, while antagonists of 5-ht2 receptors cyproheptadine (10-50 microm) or ketanserine (10-60 microm) and of 5-ht3 receptors isc 205-930 (10-50 microm) or cocaine (5-25 microm) had no effect on ica and its enhancement by 5-ht. |
1992-04-29 |
2023-08-11 |
Not clear |
| L Marzio, P Blennerhassett, D Vermillion, S Chiverton, S Collin. Distribution of mast cells in intestinal muscle of nematode-sensitized rats. The American journal of physiology. vol 262. issue 3 Pt 1. 1992-04-23. PMID:1550236. |
contraction was inhibited by the mast cell stabilizer doxantrazole and the 5-hydroxytryptamine (5-ht) antagonist cyproheptadine. |
1992-04-23 |
2023-08-11 |
rat |
| R A Baines, R G Downe. Pharmacological characterization of a 5-hydroxytryptamine-sensitive receptor/adenylate cyclase complex in the mandibular closer muscles of the cricket, Gryllus domestica. Archives of insect biochemistry and physiology. vol 16. issue 3. 1992-04-21. PMID:1665996. |
however, the mammalian antagonists for 5-ht receptors, spiperone, mianserin, and ketanserin as well as the anti-histaminic cyproheptadine were all effective antagonists in this preparation. |
1992-04-21 |
2023-08-11 |
cricket |
| P Govitrapong, V Prapapanich, M Ebad. Identification of serotonin 5HT2 receptors in bovine pineal gland. Journal of pineal research. vol 11. issue 3-4. 1992-04-06. PMID:1795228. |
in displacement experiments, the concentrations of the drugs required to inhibit 50% of the specific binding of [3h]-spiperone in descending order of potency were methysergide greater than ritanserin greater than pirenperone greater than pipamperone greater than ketanserin greater than cyproheptadine greater than m-trifluoromethylphenyl-piperazine greater than prazosin greater than 5-methoxy-n-n-dimethyltryptamine hydrogen oxalate greater than 1-(3-chlorophenol) piperazine greater than serotonin. |
1992-04-06 |
2023-08-11 |
rat |
| S K Salzman, M A Puniak, Z J Liu, R P Maitland-Heriot, G M Freeman, C A Agrest. The serotonin antagonist mianserin improves functional recovery following experimental spinal trauma. Annals of neurology. vol 30. issue 4. 1992-03-26. PMID:1789683. |
the ability of the serotonin antagonist mianserin to improve neurological recovery after graded impact trauma to the thoracic region of the spinal cord was compared to that of cyproheptadine and ketanserin in pentobarbital-anesthetized rats. |
1992-03-26 |
2023-08-11 |
rat |
| H Tanii, M Hayashi, K Hashimot. Behavioral syndrome induced by allylnitrile, crotononitrile or 2-pentenenitrile in rats. Neuropharmacology. vol 30. issue 8. 1992-03-11. PMID:1723510. |
the head-twitching, which was most consistently observed, was suppressed by serotonin (5-ht) antagonists, cyproheptadine or methysergide or by the 5-ht depleter, dl-p-chlorophenylalanine but was accentuated by the 5-ht releaser, dl-p-chloroamphetamine. |
1992-03-11 |
2023-08-11 |
rat |
| M R Stanford, J Robbins, E Kasp, D C Dumond. Passive administration of antibody against retinal S-antigen induces electroretinographic supernormality. Investigative ophthalmology & visual science. vol 33. issue 1. 1992-02-20. PMID:1730546. |
the erg response in vivo and in vitro was dose dependent and was abolished in vivo by pretreatment with cyproheptadine (a serotonin antagonist). |
1992-02-20 |
2023-08-11 |
rat |
| A R Mercer, N J Emptage, T J Care. Pharmacological dissociation of modulatory effects of serotonin in Aplysia sensory neurons. Science (New York, N.Y.). vol 254. issue 5039. 1992-02-12. PMID:1662413. |
the classical 5ht antagonist cyproheptadine (cyp) permits dissociation of three forms of serotonergic modulation in these sns: (i) cyp reversibly blocks spike-broadening induced either by exogenous application of 5ht or by sensitizing stimulation of a tail nerve. |
1992-02-12 |
2023-08-11 |
aplysia |