| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Engelhard. [On the pharmacology of 9,10-dihydro-10-(1-methyl-4-piperidylidene)-9-anthrol (WA 335), a histamine and serotonin antagonist (author's transl)]. Arzneimittel-Forschung. vol 25. issue 11. 1976-03-01. PMID:1049. |
the substance 9,10-dihydro-10-(1-methyl-4-piperidylidene)-9-anthrol (wa 335) was examined for its antagonistic effects against histamine and serotonin, for its atropine-like properties as well as for a series of other qualities in comparison with cyproheptadine and pimethixene. |
1976-03-01 |
2023-08-11 |
rat |
| J Kähling, H Ziegler, H Ballhaus. [Central action of WA-335-BS, a substance with peripheral antiserotonin and antihistaminic activity]. Arzneimittel-Forschung. vol 25. issue 11. 1976-03-01. PMID:1050. |
in rats and mice the serotonin and histamine antagonistic drug 9,10-dihydro-10-(1-methyl-4-piperidylidene)-9-anthrol (wa 335-bs) caused stronger central sedative effects than did cyproheptadine. |
1976-03-01 |
2023-08-11 |
rat |
| J M Feldman, J W Plonk, C H Biven. The role of cortisol and growth hormone in the counter-regulation of insulin-induced hypoglycemia. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 7. issue 5. 1976-01-16. PMID:1183916. |
four normal volunteers underwent a control insulin tolerance test (itt) and an insulin tolerance test (itt) after two days administration of the serotonin antagonist cyproheptadine (cypro). |
1976-01-16 |
2023-08-11 |
human |
| J M Feldman, J W Plonk, C H Bivens, H E Lebovit. Glucose intolerance in the carcinoid syndrome. Diabetes. vol 24. issue 7. 1975-12-04. PMID:125668. |
two days' administration of the serotonin antagonist cyproheptadine (cypro) to eight of the patients with "active tumors" resulted in a significant increase in the "insulinogenic index" (50%) but a nonsignificant increase in the kg (12%). |
1975-12-04 |
2023-08-11 |
human |
| R G Browne, B T H. Role of serotonin in the discriminative stimulus properties of mescaline. Pharmacology, biochemistry, and behavior. vol 3. issue 3. 1975-11-06. PMID:125425. |
following the establishment of discriminative response control by mescaline, the animals were tested for stimulus generalization produced by mescaline after: (a) blockade of periphreral and central serotonin (5-ht) receptors with cinanserin, methysergide, or cyproheptadine; (b) blockade of peripheral 5-ht receptors with xylamidine tosylate; and (c) depletion of brain 5-ht with the tryptophan hydroxylase inhibitor p-chlorophenylalanine (pcpa). |
1975-11-06 |
2023-08-11 |
rat |
| J Plank, J M Feldma. Adrenal function in the carcinoid syndrome: effects of the serotonin antagonist cyproheptadine. Metabolism: clinical and experimental. vol 24. issue 9. 1975-10-30. PMID:1171350. |
adrenal function in the carcinoid syndrome: effects of the serotonin antagonist cyproheptadine. |
1975-10-30 |
2023-08-11 |
human |
| J Plank, J M Feldma. Adrenal function in the carcinoid syndrome: effects of the serotonin antagonist cyproheptadine. Metabolism: clinical and experimental. vol 24. issue 9. 1975-10-30. PMID:1171350. |
six of these patients pretreated with cyproheptadine (cypro), a serotonin antagonist, experienced a 36% mean decrease in 17-hydroxycorticosteroid excretion, a finding that was not present when three of them were treated with triprolidine (tpro), an antihistamine. |
1975-10-30 |
2023-08-11 |
human |
| J C Gilbert, L I Goldber. Characterization by cyproheptadine of the dopamine-induced contraction in canine isolated arteries. The Journal of pharmacology and experimental therapeutics. vol 193. issue 2. 1975-10-10. PMID:1142100. |
a serotonin antagonist, cyproheptadine, 10- minus 7, 3 x 10- minus 7 and 10-minus 6 m, inhibited dopamine (pa2 = 7.46 plus or minus 0.11), tryptamine (pa2 = 7.38 plus or minus 0.09) and serotonin-induced contractions (pa2 = 7.59 plus or minus 0.09). |
1975-10-10 |
2023-08-11 |
Not clear |
| J C Gilbert, L I Goldber. Characterization by cyproheptadine of the dopamine-induced contraction in canine isolated arteries. The Journal of pharmacology and experimental therapeutics. vol 193. issue 2. 1975-10-10. PMID:1142100. |
in protection experiments, preincubation with serotonin (10-minus 5 m) for 10 minutes protected serotonin and tryptamine receptors from cyproheptadine (3 x 10-minus 7 m) and phenoxybenzamine (10-minus 6 m) blockade. |
1975-10-10 |
2023-08-11 |
Not clear |
| J C Gilbert, L I Goldber. Characterization by cyproheptadine of the dopamine-induced contraction in canine isolated arteries. The Journal of pharmacology and experimental therapeutics. vol 193. issue 2. 1975-10-10. PMID:1142100. |
since dopamine, tryptamine and serotonin, unlike norepinephrine, were sensitive to cyproheptadine blockade, dopamine-induced contraction appeared to be mediated by a receptor closely related to serotonin receptors. |
1975-10-10 |
2023-08-11 |
Not clear |
| K von Hungen, S Roberts, D F Hil. Serotonin-sensitive adenylate cyclase activity of immature rat brain. Brain research. vol 84. issue 2. 1975-05-21. PMID:1078637. |
stimulation of collicular adenylate cyclase by serotonin was significantly but incompletely blocked by serotonin antagonists, including d-lysergic acid diethylamide (d-lsd), 2-bromo-d-lysergic acid diethylamide, methysergide, 1-methyl-8 beta-carbobenzyloxy-aminomethyl-10 alpha-ergoline and cyproheptadine. |
1975-05-21 |
2023-08-11 |
rat |
| K von Hungen, S Roberts, D F Hil. Serotonin-sensitive adenylate cyclase activity of immature rat brain. Brain research. vol 84. issue 2. 1975-05-21. PMID:1078637. |
of the compounds which produced a partial blockage of serotonin action, d-lsd, cyproheptadine and chlorpromazine were themselves capable of stimulating adenylate cyclase activity. |
1975-05-21 |
2023-08-11 |
rat |
| J J Jacob, J M Giraul. The influence of cyproheptadine and of D-lysergamide on the rise in temperature induced by intracerebroventricular 5-hydroxytryptamine, noradrenaline and dopamine in conscious rabbits. European journal of pharmacology. vol 27. issue 1. 1974-10-31. PMID:4854891. |
the influence of cyproheptadine and of d-lysergamide on the rise in temperature induced by intracerebroventricular 5-hydroxytryptamine, noradrenaline and dopamine in conscious rabbits. |
1974-10-31 |
2023-08-11 |
Not clear |
| G A Smythe, L Lazaru. Suppression of human growth hormone secretion by melatonin and cyproheptadine. The Journal of clinical investigation. vol 54. issue 1. 1974-08-28. PMID:4600047. |
pituitary growth hormone (gh) release in the rat is stimulated via serotoninergic pathways and can be inhibited by treatment with compounds that act as serotonin antagonists, such as cyproheptadine or the pineal gland hormone, melatonin. |
1974-08-28 |
2023-08-11 |
human |
| G A Smythe, L Lazaru. Suppression of human growth hormone secretion by melatonin and cyproheptadine. The Journal of clinical investigation. vol 54. issue 1. 1974-08-28. PMID:4600047. |
to investigate a possible role for serotonin in the control of human gh release, the effects of cyproheptadine and melatonin administration on the gh responses of normal male subjects were examined. |
1974-08-28 |
2023-08-11 |
human |
| J W Plonk, C H Bivens, J M Feldma. Inhibition of hypoglycemia-induced cortisol secretion by the serotonin antagonist cyproheptadine. The Journal of clinical endocrinology and metabolism. vol 38. issue 5. 1974-06-19. PMID:4823925. |
inhibition of hypoglycemia-induced cortisol secretion by the serotonin antagonist cyproheptadine. |
1974-06-19 |
2023-08-11 |
Not clear |
| J A Nathanson, P Greengar. Serotonin-sensitive adenylate cyclase in neural tissue and its similarity to the serotonin receptor: a possible site of action of lysergic acid diethylamide. Proceedings of the National Academy of Sciences of the United States of America. vol 71. issue 3. 1974-06-12. PMID:4595572. |
the activation of this enzyme by serotonin was selectively inhibited by extremely low concentrations of d-lysergic acid diethylamide (lsd), 2-bromo-lsd, and cyproheptadine, agents which are known to block certain serotonin receptors in vivo. |
1974-06-12 |
2023-08-11 |
Not clear |
| E Sadovsky, A Dora, Y Pfeifer, W Z Polishuk, R Rachamimoff, F G Sulma. Effect of the serotonin antagonist cyproheptadine on uterine and duodenal muscle contractions in rats. Gynecologic investigation. vol 4. issue 3. 1974-05-22. PMID:4784724. |
effect of the serotonin antagonist cyproheptadine on uterine and duodenal muscle contractions in rats. |
1974-05-22 |
2023-08-11 |
rat |
| E Sadovsky, A Dora, Y Pfeifer, W Z Polishuk, F G Sulma. Attempts to delay labor in rats by a serotonin antagonist, cyproheptadine. Israel journal of medical sciences. vol 9. issue 11. 1974-04-11. PMID:4778407. |
attempts to delay labor in rats by a serotonin antagonist, cyproheptadine. |
1974-04-11 |
2023-08-11 |
rat |
| G A Smythe, L Lazaru. Blockade of serotonin induced GH secretion in rats by melatonin and cyproheptadine. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 5. issue 3. 1973-08-31. PMID:4714553. |
blockade of serotonin induced gh secretion in rats by melatonin and cyproheptadine. |
1973-08-31 |
2023-08-11 |
rat |