| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F Sohrabji, K W Peeples, O A Marroqui. Local and cortical effects of olfactory bulb lesions on trophic support and cholinergic function and their modulation by estrogen. Journal of neurobiology. vol 45. issue 2. 2000-12-07. PMID:11018768. |
collectively, these results indicate that neural injury to one limb of the forebrain cholinergic system may result in collateral damage to other limbs of this system, suggesting a mechanism for the progression of neurodegenerative diseases, such as alzheimer's disease, that involve the cholinergic system. |
2000-12-07 |
2023-08-12 |
Not clear |
| H Ksiezak-Reding, D He, W Gordon-Krajcer, Y Kress, S Lee, D W Dickso. Induction of Alzheimer-specific Tau epitope AT100 in apoptotic human fetal astrocytes. Cell motility and the cytoskeleton. vol 47. issue 3. 2000-12-07. PMID:11056524. |
in alzheimer's and other neurodegenerative diseases, hyperphosphorylated tau accumulates in affected neuronal and glial cells in the form of paired helical filaments (phfs). |
2000-12-07 |
2023-08-12 |
human |
| P Mayer, P Brunel, C Chaplain, C Piedecoq, F Calmel, P Schambel, P Chopin, T Wurch, P J Pauwels, M Marien, J L Vidaluc, T Imber. New substituted 1-(2,3-dihydrobenzo[1, 4]dioxin-2-ylmethyl)piperidin-4-yl derivatives with alpha(2)-adrenoceptor antagonist activity. Journal of medicinal chemistry. vol 43. issue 20. 2000-11-08. PMID:11020279. |
the emergence of a novel theory concerning the role of noradrenaline in the progression and the treatment of neurodegenerative diseases such as parkinson's and alzheimer's diseases has provided a new impetus toward the discovery of novel compounds acting at alpha(2)-adrenoceptors. |
2000-11-08 |
2023-08-12 |
Not clear |
| A M Fagan, D M Holtzma. Astrocyte lipoproteins, effects of apoE on neuronal function, and role of apoE in amyloid-beta deposition in vivo. Microscopy research and technique. vol 50. issue 4. 2000-10-04. PMID:10936884. |
the genetic association between the e4 isoform of apolipoprotein e (apoe) and increased risk for alzheimer's disease (ad) has prompted interest in the neurobiology of apoe and the possible relationship between lipoprotein metabolism in the brain and neurodegenerative disease. |
2000-10-04 |
2023-08-12 |
mouse |
| M Minami, M Sato. [Chemokines as mediators for intercellular communication in the brain]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 115. issue 4. 2000-10-02. PMID:10876803. |
chemokines such as mcp-1, mip-1 alpha and cinc were shown to be induced by various neuroinflammatory stimuli, suggesting that they are involved in various neurodegenerative diseases such as multiple sclerosis, alzheimer's disease, stroke and aids dementia syndrome. |
2000-10-02 |
2023-08-12 |
Not clear |
| S Parola, P Liberin. Assessing olfaction in the Italian population: methodology and clinical application. Italian journal of neurological sciences. vol 20. issue 5. 2000-08-29. PMID:10933437. |
in recent years, particular emphasis has been attributed to the early and severe olfactory impairment in neurodegenerative diseases, such as alzheimer's dementia and parkinson's disease. |
2000-08-29 |
2023-08-12 |
Not clear |
| J A Court, M A Piggott, S Lloyd, N Cookson, C G Ballard, I G McKeith, R H Perry, E K Perr. Nicotine binding in human striatum: elevation in schizophrenia and reductions in dementia with Lewy bodies, Parkinson's disease and Alzheimer's disease and in relation to neuroleptic medication. Neuroscience. vol 98. issue 1. 2000-08-24. PMID:10858614. |
although tobacco use in the control group was associated with increased [3h]nicotine binding (21-38%), and neuroleptic treatment in dementia with lewy bodies and alzheimer's disease was associated with reduced [3h]nicotine binding (up to 29%), differences between neurodegenerative disease groups and controls persisted in subgroups of alzheimer's disease cases (26-33%, n=6, in the ventral striatum) and dementia with lewy body cases (30-49%, n=7, in both dorsal and ventral striatum) who had received no neuroleptic medication compared to controls who had not smoked (n=10). |
2000-08-24 |
2023-08-12 |
human |
| J E Duda, V M Lee, J Q Trojanowsk. Neuropathology of synuclein aggregates. Journal of neuroscience research. vol 61. issue 2. 2000-08-18. PMID:10878583. |
beginning with the isolation of the fragment of alpha-synuclein (alpha-syn) known as the non-abeta component of amyloid plaques (nac peptide) from alzheimer's disease (ad) brains, alpha-syn has been increasingly implicated in the pathogenesis of neurodegenerative diseases, which now are classified as synucleinopathies. |
2000-08-18 |
2023-08-12 |
Not clear |
| S Doré, S Kar, W H Zheng, R Quirio. Rediscovering good old friend IGF-I in the new millenium: possible usefulness in Alzheimer's disease and stroke. Pharmaceutica acta Helvetiae. vol 74. issue 2-3. 2000-08-09. PMID:10812969. |
the effects, particularly those of igf-i on key markers of the alzheimer's (ad) brains namely cholinergic dysfunction, neuronal amyloid toxicity, tau phosphorylation and glucose metabolism suggest the potential usefulness of this growth factor in the treatment of neurodegenerative diseases. |
2000-08-09 |
2023-08-12 |
Not clear |
| H Braak, K Del Tredici, J Bohl, H Bratzke, E Braa. Pathological changes in the parahippocampal region in select non-Alzheimer's dementias. Annals of the New York Academy of Sciences. vol 911. 2000-08-09. PMID:10911877. |
in progressive neurodegenerative diseases, such as alzheimer's disease, argyrophilic grain disease, pick's disease, idiopathic parkinson syndrome, and huntington's disease, the transentorhinal and entorhinal regions are particularly susceptible to severe pathological changes. |
2000-08-09 |
2023-08-12 |
human |
| C A Sogawa, I Miyazaki, N Sogawa, M Asanuma, N Ogawa, H Furut. Antioxidants protect against dopamine-induced metallothionein-III (GIF) mRNA expression in mouse glial cell line (VR-2g). Brain research. vol 853. issue 2. 2000-06-21. PMID:10640628. |
metallothionein (mt)-iii, originally discovered as a growth inhibitory factor (gif), is a brain specific isomer of mts and is markedly reduced in the brain of patients with alzheimer's disease (ad) or other neurodegenerative diseases. |
2000-06-21 |
2023-08-12 |
mouse |
| G S Robertson, S J Crocker, D W Nicholson, J B Schul. Neuroprotection by the inhibition of apoptosis. Brain pathology (Zurich, Switzerland). vol 10. issue 2. 2000-06-06. PMID:10764048. |
consistent with the proposal that apoptosis plays a central in role human neurodegenerative disease, caspase-3 activation has recently been observed in stroke, spinal cord trauma, head injury and alzheimer's disease. |
2000-06-06 |
2023-08-12 |
mouse |
| Z K Wszolek, K Markopoulo. Olfactory dysfunction in Parkinson's disease. Clinical neuroscience (New York, N.Y.). vol 5. issue 2. 2000-05-09. PMID:10785834. |
olfactory dysfunction is also associated with other neurodegenerative diseases such as alzheimer's disease (ad), huntington's disease (hd), as well as with normal aging. |
2000-05-09 |
2023-08-12 |
Not clear |
| S Schildein, J P Huston, R K Schwartin. Injections of tacrine and scopolamine into the nucleus accumbens: opposing effects of immediate vs delayed posttrial treatment on memory of an open field. Neurobiology of learning and memory. vol 73. issue 1. 2000-05-03. PMID:10686121. |
they may be relevant, for example, for understanding the psychopathology of alzheimer's disease, since the nucleus accumbens is one of the sites where cholinergic neurons are lost in this neurodegenerative disease. |
2000-05-03 |
2023-08-12 |
Not clear |
| M K Ahlijanian, N X Barrezueta, R D Williams, A Jakowski, K P Kowsz, S McCarthy, T Coskran, A Carlo, P A Seymour, J E Burkhardt, R B Nelson, J D McNeis. Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 6. 2000-04-25. PMID:10706614. |
hyperphosphorylation of microtubule-associated proteins such as tau and neurofilament may underlie the cytoskeletal abnormalities and neuronal death seen in several neurodegenerative diseases including alzheimer's disease. |
2000-04-25 |
2023-08-12 |
mouse |
| M K Ahlijanian, N X Barrezueta, R D Williams, A Jakowski, K P Kowsz, S McCarthy, T Coskran, A Carlo, P A Seymour, J E Burkhardt, R B Nelson, J D McNeis. Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 6. 2000-04-25. PMID:10706614. |
the overexpression of an activator of cdk5 in transgenic mice results in increased cdk5 activity that is sufficient to produce hyperphosphorylation of tau and neurofilament as well as cytoskeletal disruptions reminiscent of alzheimer's disease and other neurodegenerative diseases. |
2000-04-25 |
2023-08-12 |
mouse |
| Q Hu, L W Jin, M Y Starbuck, G M Marti. Broadly altered expression of the mRNA isoforms of FE65, a facilitator of beta amyloidogenesis, in Alzheimer cerebellum and other brain regions. Journal of neuroscience research. vol 60. issue 1. 2000-04-12. PMID:10723070. |
we quantitated the two isoforms in middle temporal cortex, middle frontal cortex, cerebellar cortex and caudate nucleus of 17 alzheimer disease (ad) patients, 12 normal controls and 9 non-ad neurodegenerative disease controls by reverse transcription-competitive polymerase chain reaction (rt-cpcr). |
2000-04-12 |
2023-08-12 |
human |
| L F Jarskog, J H Gilmor. Developmental expression of Bcl-2 protein in human cortex. Brain research. Developmental brain research. vol 119. issue 2. 2000-04-11. PMID:10675772. |
apoptosis is essential for normal human neurodevelopment and is increasingly recognized for its role in various neurodegenerative diseases such as alzheimer's and parkinson's diseases. |
2000-04-11 |
2023-08-12 |
human |
| W A Pedersen, S L Chan, M P Mattso. A mechanism for the neuroprotective effect of apolipoprotein E: isoform-specific modification by the lipid peroxidation product 4-hydroxynonenal. Journal of neurochemistry. vol 74. issue 4. 2000-04-11. PMID:10737598. |
inheritance of the apolipoprotein e (apoe) epsilon4 allele increases the risk for alzheimer's disease and may also influence the pathogenesis of other neurodegenerative diseases such as amyotrophic lateral sclerosis (als). |
2000-04-11 |
2023-08-12 |
mouse |
| M Durliat, M André, P J Babi. Conserved protein motifs and structural organization of a fish gene homologous to mammalian apolipoprotein E. European journal of biochemistry. vol 267. issue 2. 2000-03-07. PMID:10632725. |
besides its role in cardiovascular diseases, apoe polymorphism contributes to susceptibility to neurodegenerative diseases, such as alzheimer's disease. |
2000-03-07 |
2023-08-12 |
human |