| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S M de la Monte, Y K Sohn, N Ganju, J R Wand. P53- and CD95-associated apoptosis in neurodegenerative diseases. Laboratory investigation; a journal of technical methods and pathology. vol 78. issue 4. 1998-05-07. PMID:9564885. |
to determine whether apoptosis in other neurodegenerative diseases is mediated by similar mechanisms, p53 and cd95 expression were examined in postmortem central nervous system tissues from patients with diffuse lewy body disease (dlbd), pick's disease (pkd), progressive supranuclear palsy (psp), multiple system atrophy (msa), parkinson's disease (pd), amyotrophic lateral sclerosis (als), and down's syndrome plus alzheimer's disease (dn+ad). |
1998-05-07 |
2023-08-12 |
Not clear |
| T Meyer, C Münch, B Knappenberger, S Liebau, H Völkel, A C Ludolp. Alternative splicing of the glutamate transporter EAAT2 (GLT-1). Neuroscience letters. vol 241. issue 1. 1998-04-28. PMID:9502218. |
the human glutamate transporter eaat2 (glt-1) is of major importance for synaptic glutamate reuptake, and reportedly, a candidate gene for neurodegenerative diseases such as amyotrophic lateral sclerosis, alzheimer's disease and epilepsy. |
1998-04-28 |
2023-08-12 |
human |
| T Ariga, W D Jarvis, R K Y. Role of sphingolipid-mediated cell death in neurodegenerative diseases. Journal of lipid research. vol 39. issue 1. 1998-03-26. PMID:9469581. |
inappropriate initiation of apoptosis has been proposed to underlie the progressive neuronal attrition associated with various neurodegenerative diseases such as alzheimer's disease (ad), parkinson's disease (pd), amyotrophic lateral sclerosis (als), and other neurological disorders that are characterized by the gradual loss of specific populations of neurons. |
1998-03-26 |
2023-08-12 |
Not clear |
| R I Mesholam, P J Moberg, R N Mahr, R L Dot. Olfaction in neurodegenerative disease: a meta-analysis of olfactory functioning in Alzheimer's and Parkinson's diseases. Archives of neurology. vol 55. issue 1. 1998-02-06. PMID:9443714. |
olfaction in neurodegenerative disease: a meta-analysis of olfactory functioning in alzheimer's and parkinson's diseases. |
1998-02-06 |
2023-08-12 |
Not clear |
| H Han, P H Weinreb, P T Lansbur. The core Alzheimer's peptide NAC forms amyloid fibrils which seed and are seeded by beta-amyloid: is NAC a common trigger or target in neurodegenerative disease? Chemistry & biology. vol 2. issue 3. 1998-01-14. PMID:9383418. |
the core alzheimer's peptide nac forms amyloid fibrils which seed and are seeded by beta-amyloid: is nac a common trigger or target in neurodegenerative disease? |
1998-01-14 |
2023-08-12 |
Not clear |
| D S Woodruff-Pak, M Papk. Huntington's disease and eyeblink classical conditioning: normal learning but abnormal timing. Journal of the International Neuropsychological Society : JINS. vol 2. issue 4. 1997-12-29. PMID:9375181. |
comparisons of hd patients to patients with other neurodegenerative diseases (probable alzheimer's disease (pad) and down syndrome (ds) over the age of 35 with presumed alzheimer-like neuropathology) and to patients with cerebellar lesions demonstrated significantly better ebcc performance in hd. |
1997-12-29 |
2023-08-12 |
human |
| J Kuret, G S Johnson, D Cha, E R Christenson, A J DeMaggio, M F Hoekstr. Casein kinase 1 is tightly associated with paired-helical filaments isolated from Alzheimer's disease brain. Journal of neurochemistry. vol 69. issue 6. 1997-12-12. PMID:9375684. |
because of its tight association with phfs and its phosphate-directed substrate selectivity, casein kinase 1 is positioned to participate in the pathological hyperphosphorylation of tau protein that is observed in neurodegenerative diseases such as alzheimer's disease. |
1997-12-12 |
2023-08-12 |
Not clear |
| D M Araujo, D C Hilt, P J Miller, D Wen, S Jiao, P A Lapcha. ret receptor tyrosine kinase immunoreactivity is altered in glial cell line-derived neurotrophic factor-responsive neurons following lesions of the nigrostriatal and septohippocampal pathways. Neuroscience. vol 80. issue 1. 1997-10-23. PMID:9252216. |
these findings suggest that glial cell line-derived neurotrophic factor may be a protective/restorative agent for a diverse population of neurons and imply that it may be a useful therapeutic tool for a variety of neurodegenerative diseases including parkinson's, huntington's and alzheimer's diseases. |
1997-10-23 |
2023-08-12 |
mouse |
| P Bongioanni, M R Romano, R Sposito, M Castagna, B Boccardi, M Borgn. T-cell tumour necrosis factor-alpha receptor binding in demented patients. Journal of neurology. vol 244. issue 7. 1997-10-20. PMID:9266459. |
dementia of alzheimer type (dat) is a neurodegenerative disease of the central nervous system (cns), in which an unbalanced cytokine network may lead to an altered immunoregulation. |
1997-10-20 |
2023-08-12 |
human |
| P J Babin, C Thisse, M Durliat, M Andre, M A Akimenko, B Thiss. Both apolipoprotein E and A-I genes are present in a nonmammalian vertebrate and are highly expressed during embryonic development. Proceedings of the National Academy of Sciences of the United States of America. vol 94. issue 16. 1997-09-08. PMID:9238027. |
besides its role in cardiovascular diseases, accumulating evidence has suggested that apoe could play a role in neurodegenerative diseases, such as alzheimer disease. |
1997-09-08 |
2023-08-12 |
human |
| G Gegelashvili, A Schousbo. High affinity glutamate transporters: regulation of expression and activity. Molecular pharmacology. vol 52. issue 1. 1997-08-08. PMID:9224806. |
very little is known about the nature of the factors and molecular mechanisms that regulate developmental, regional, and cell type-specific expression of the glutamate transporters and their aberrant functioning in neurodegenerative diseases (e.g., amyotrophic lateral sclerosis and alzheimer's disease). |
1997-08-08 |
2023-08-12 |
Not clear |
| T Nishimura, K Ikeda, H Akiyama, T Arai, H Kondo, M Okochi, Y Furiya, H Mori, T Oda, M Kato, E Isek. Glial tau-positive structures lack the sequence encoded by exon 3 of the tau protein gene. Neuroscience letters. vol 224. issue 3. 1997-07-18. PMID:9131663. |
we have investigated immunohistochemically the expression of exon 3-derived fragment (e-3) of tau protein in brains of patients with alzheimer's disease (ad) and other neurodegenerative diseases in which the abnormal accumulation of tau protein takes place. |
1997-07-18 |
2023-08-12 |
Not clear |
| A A Farooqui, H C Yang, L Horrock. Involvement of phospholipase A2 in neurodegeneration. Neurochemistry international. vol 30. issue 6. 1997-07-07. PMID:9152992. |
this process along with the accumulation of lipid peroxidation products may be associated with neurodegeneration in acute neural trauma (ischemia, head and spinal cord injuries) and neurodegenerative diseases (alzheimer's disease). |
1997-07-07 |
2023-08-12 |
Not clear |
| F Baskin, G M Smith, J A Fosmire, R N Rosenber. Altered apolipoprotein E secretion in cytokine treated human astrocyte cultures. Journal of the neurological sciences. vol 148. issue 1. 1997-06-16. PMID:9125385. |
the combination of these cytokine effects in chronically degenerating brain regions of alzheimer's disease and other neurodegenerative diseases could reduce the amount of apoe available for neuronal regeneration. |
1997-06-16 |
2023-08-12 |
human |
| M G Spillantini, M Goedert, R A Crowther, J R Murrell, M R Farlow, B Ghett. Familial multiple system tauopathy with presenile dementia: a disease with abundant neuronal and glial tau filaments. Proceedings of the National Academy of Sciences of the United States of America. vol 94. issue 8. 1997-05-22. PMID:9108114. |
neurofibrillary lesions made of hyperphosphorylated microtubule-associated protein tau constitute not only one of the defining neuropathological features of alzheimer disease but also are present in a number of other neurodegenerative diseases with dementia. |
1997-05-22 |
2023-08-12 |
Not clear |
| A Kourounakis, N Bodor, J Simpkin. Synthesis and evaluation of brain-targeted chemical delivery systems for the neurotrophomodulator 4-methylcatechol. The Journal of pharmacy and pharmacology. vol 49. issue 1. 1997-04-24. PMID:9120757. |
since various 4-alkylcatechols stimulate nerve growth factor (ngf) biosynthesis both in-vitro and in-vivo, delivery of these agents to the brain may provide beneficial effect for the treatment of neurodegenerative diseases such as alzheimer's. |
1997-04-24 |
2023-08-12 |
rat |
| M J Mahoney, W M Saltzma. Controlled release of proteins to tissue transplants for the treatment of neurodegenerative disorders. Journal of pharmaceutical sciences. vol 85. issue 12. 1997-03-06. PMID:8961138. |
alzheimer's disease involves substantial cholinergic cell deficits; other neurodegenerative diseases involve similar losses of certain cell populations. |
1997-03-06 |
2023-08-12 |
Not clear |
| J D Gabriel. Memory systems analyses of mnemonic disorders in aging and age-related diseases. Proceedings of the National Academy of Sciences of the United States of America. vol 93. issue 24. 1997-01-16. PMID:8942968. |
the effects upon memory of normal aging and two age-related neurodegenerative diseases, alzheimer disease (ad) and parkinson disease, are analyzed in terms of memory systems, specific neural networks that mediate specific mnemonic processes. |
1997-01-16 |
2023-08-12 |
Not clear |
| H J Timmers, D F Swaab, J A van de Nes, H P Kreme. Somatostatin 1-12 immunoreactivity is decreased in the hypothalamic lateral tuberal nucleus of Huntington's disease patients. Brain research. vol 728. issue 2. 1997-01-15. PMID:8864475. |
the function of this nucleus is unknown, but the ntl is affected in a variety of human neurodegenerative diseases, including huntington's disease (hd) and alzheimer's disease. |
1997-01-15 |
2023-08-12 |
human |
| P J McMillan, C A Singer, D M Dors. The effects of ovariectomy and estrogen replacement on trkA and choline acetyltransferase mRNA expression in the basal forebrain of the adult female Sprague-Dawley rat. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 5. 1997-01-03. PMID:8774454. |
cognitive deficits associated with aging and with neurodegenerative diseases such as alzheimer's disease have been attributed to degeneration of cholinergic neurons in the basal forebrain. |
1997-01-03 |
2023-08-12 |
rat |