| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Silva, J R Montague, T F Lopez, L M Mud. Growth factor effects on survival and development of calbindin immunopositive cultured septal neurons. Brain research bulletin. vol 51. issue 1. 2000-02-18. PMID:10654578. |
alzheimer's disease (ad) is a neurodegenerative disease characterized by dementia, senile plaques, fibrillary tangles, and a reduction of cholinergic neurons in areas of the brain, including the septal nucleus. |
2000-02-18 |
2023-08-12 |
rat |
| Y Od. Choline acetyltransferase: the structure, distribution and pathologic changes in the central nervous system. Pathology international. vol 49. issue 11. 2000-01-13. PMID:10594838. |
central cholinergic neurones are involved in several neurodegenerative diseases such as alzheimer's disease and amyotrophic lateral sclerosis, in which disturbance of the central cholinergic system does not appear to be closely related to the etiology, but rather to the development of clinical symptoms. |
2000-01-13 |
2023-08-12 |
mouse |
| K Spittaels, C Van den Haute, J Van Dorpe, K Bruynseels, K Vandezande, I Laenen, H Geerts, M Mercken, R Sciot, A Van Lommel, R Loos, F Van Leuve. Prominent axonopathy in the brain and spinal cord of transgenic mice overexpressing four-repeat human tau protein. The American journal of pathology. vol 155. issue 6. 1999-12-28. PMID:10595944. |
this transgenic model, overexpressing the longest isoform of human tau protein, recapitulates features of known neurodegenerative diseases, including alzheimer's disease and other tauopathies. |
1999-12-28 |
2023-08-12 |
mouse |
| D W Dickso. Neuropathologic differentiation of progressive supranuclear palsy and corticobasal degeneration. Journal of neurology. vol 246 Suppl 2. 1999-12-10. PMID:10525997. |
ballooned neurons are frequent and nearly a sine qua non for cbd, but they are found in psp at a frequency similar to that of other neurodegenerative diseases, such as alzheimer's disease. |
1999-12-10 |
2023-08-12 |
Not clear |
| Y Tatebayashi, K Iqbal, I Grundke-Iqba. Dynamic regulation of expression and phosphorylation of tau by fibroblast growth factor-2 in neural progenitor cells from adult rat hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 13. 1999-07-15. PMID:10377336. |
the nature of the extracellular signals that regulate the expression and the phosphorylation of the microtubule-associated protein tau, which is aberrantly hyperphosphorylated in alzheimer disease and other adult-onset neurodegenerative diseases, is not known. |
1999-07-15 |
2023-08-12 |
rat |
| I Bednar, X Zhang, R Dastranj-Sedghi, A Nordber. Differential changes of nicotinic receptors in the rat brain following ibotenic acid and 192-IgG saporin lesions of the nucleus basalis magnocellularis. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 16. issue 7-8. 1999-07-07. PMID:10198814. |
the basal forebrain cholinergic neurons are implicated in the pathogenesis of neurodegenerative diseases including alzheimer's disease (ad). |
1999-07-07 |
2023-08-12 |
rat |
| R Seidl, S Fang-Kircher, B Bidmon, N Cairns, G Lube. Apoptosis-associated proteins p53 and APO-1/Fas (CD95) in brains of adult patients with Down syndrome. Neuroscience letters. vol 260. issue 1. 1999-06-18. PMID:10027687. |
upregulation of p53 and apo-1/fas (cd95) precedes apoptosis in many cell types, and a potential role for these molecules has already been demonstrated in alzheimer's disease (ad) and several other neurodegenerative diseases. |
1999-06-18 |
2023-08-12 |
Not clear |
| M V Aksenova, M Y Aksenov, R M Payne, J Q Trojanowski, M L Schmidt, J M Carney, D A Butterfield, W R Markesber. Oxidation of cytosolic proteins and expression of creatine kinase BB in frontal lobe in different neurodegenerative disorders. Dementia and geriatric cognitive disorders. vol 10. issue 2. 1999-04-27. PMID:10026391. |
the presence of the biomarkers of oxidative damage, protein carbonyl formation and the inactivation of oxidatively sensitive brain creatine kinase (ck bb, cytosolic isoform), were studied in frontal lobe autopsy specimens obtained from patients with different age-related neurodegenerative diseases: alzheimer's disease (ad), pick's disease (pkd), diffuse lewy body disease (dlbd), parkinson's disease (pd), and age-matched control subjects. |
1999-04-27 |
2023-08-12 |
human |
| D L Gelowitz, I A Paterso. Neuronal sparing and behavioral effects of the antiapoptotic drug, (-)deprenyl, following kainic acid administration. Pharmacology, biochemistry, and behavior. vol 62. issue 2. 1999-04-26. PMID:9972692. |
given deprenyl's antiapoptotic actions, it is proposed that (-)deprenyl may be beneficial in the treatment of a variety of neurodegenerative diseases where evidence of apoptosis exists, such as parkinson's and alzheimer's disease, by slowing the disease process itself. |
1999-04-26 |
2023-08-12 |
human |
| M S Saporito, E R Brown, S Carswell, A M DiCamillo, M S Miller, C Murakata, N T Neff, J L Vaught, F A Hau. Preservation of cholinergic activity and prevention of neuron death by CEP-1347/KT-7515 following excitotoxic injury of the nucleus basalis magnocellularis. Neuroscience. vol 86. issue 2. 1999-03-16. PMID:9881861. |
thus, cep-1347/kt-7515 may have therapeutic potential in neurodegenerative diseases, such as alzheimer's disease, in which basal forebrain cholinergic neurons degenerate. |
1999-03-16 |
2023-08-12 |
rat |
| J A Harder, A A Aboobaker, T C Hodgetts, R M Ridle. Learning impairments induced by glutamate blockade using dizocilpine (MK-801) in monkeys. British journal of pharmacology. vol 125. issue 5. 1999-02-26. PMID:9846639. |
this demonstration of a cognitive deficit associated with glutamatergic blockade in a primate may be useful in understanding the contribution of glutamatergic dysfunction to cognitive decline in neurodegenerative disease, especially alzheimer's disease. |
1999-02-26 |
2023-08-12 |
human |
| J Nourooz-Zadeh, E H Liu, B Yhlen, E E Anggård, B Halliwel. F4-isoprostanes as specific marker of docosahexaenoic acid peroxidation in Alzheimer's disease. Journal of neurochemistry. vol 72. issue 2. 1999-02-11. PMID:9930747. |
our data with alzheimer's disease suggest that analysis of f4-isoprostanes will provide new opportunities to study lipid peroxidation in the neurodegenerative diseases. |
1999-02-11 |
2023-08-12 |
human |
| K K Burkhart, D C Beard, R A Lehman, M L Billingsle. Alterations in tau phosphorylation in rat and human neocortical brain slices following hypoxia and glucose deprivation. Experimental neurology. vol 154. issue 2. 1999-02-04. PMID:9878182. |
highly phosphorylated tau does not bind microtubules and is the main component of the paired helical filaments seen in alzheimer's and related neurodegenerative diseases. |
1999-02-04 |
2023-08-12 |
human |
| M Hong, V Zhukareva, V Vogelsberg-Ragaglia, Z Wszolek, L Reed, B I Miller, D H Geschwind, T D Bird, D McKeel, A Goate, J C Morris, K C Wilhelmsen, G D Schellenberg, J Q Trojanowski, V M Le. Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17. Science (New York, N.Y.). vol 282. issue 5395. 1998-12-28. PMID:9836646. |
tau proteins aggregate as cytoplasmic inclusions in a number of neurodegenerative diseases, including alzheimer's disease and hereditary frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17). |
1998-12-28 |
2023-08-12 |
Not clear |
| N Sasaki, R Fukatsu, K Tsuzuki, Y Hayashi, T Yoshida, N Fujii, T Koike, I Wakayama, R Yanagihara, R Garruto, N Amano, Z Makit. Advanced glycation end products in Alzheimer's disease and other neurodegenerative diseases. The American journal of pathology. vol 153. issue 4. 1998-10-28. PMID:9777946. |
in this study, we examined the immunohistochemical localization of ages, amyloid beta protein (a beta), apolipoprotein e (apoe), and tau protein in senile plaques, neurofibrillary tangles (nfts), and cerebral amyloid angiopathy (caa) in alzheimer's disease and other neurodegenerative diseases (progressive supranuclear palsy, pick's disease, and guamanian amyotrophic lateral sclerosis/parkinsonism-dementia complex). |
1998-10-28 |
2023-08-12 |
Not clear |
| M J Marino, S T Rouse, A I Levey, L T Potter, P J Con. Activation of the genetically defined m1 muscarinic receptor potentiates N-methyl-D-aspartate (NMDA) receptor currents in hippocampal pyramidal cells. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 19. 1998-10-26. PMID:9736760. |
this work demonstrates that the m1-muscarinic receptor gene product modulates excitatory synaptic transmission, and it has important implications in the study of learning and memory as well as the design of drugs to treat neurodegenerative diseases such as alzheimer's. |
1998-10-26 |
2023-08-12 |
Not clear |
| F H Calderón, R von Bernhardi, G De Ferrari, S Luza, R Aldunate, N C Inestros. Toxic effects of acetylcholinesterase on neuronal and glial-like cells in vitro. Molecular psychiatry. vol 3. issue 3. 1998-10-08. PMID:9672900. |
acetylcholinesterase (ache), the enzyme involved in the hydrolysis of the neurotransmitter acetylcholine, has been implicated in non-cholinergic actions which may play a role in neurodegenerative diseases such as alzheimer's disease. |
1998-10-08 |
2023-08-12 |
Not clear |
| C Aoki, T Nakanishi, N Sogawa, K Ishii, N Ogawa, M Takigawa, H Furut. Stimulatory effects of 4-methylcatechol, dopamine and levodopa on the expression of metallothionein-III (GIF) mRNA in immortalized mouse brain glial cells (VR-2g). Brain research. vol 792. issue 2. 1998-07-20. PMID:9593981. |
metallothionein (mt)-iii, originally discovered as a growth inhibitory factor (gif), is a brain specific isomer of mts and is markedly reduced in the brain of alzheimer's disease patients (ad) and in several other neurodegenerative diseases. |
1998-07-20 |
2023-08-12 |
mouse |
| M Dragunow, G A MacGibbon, P Lawlor, N Butterworth, B Connor, C Henderson, M Walton, A Woodgate, P Hughes, R L Faul. Apoptosis, neurotrophic factors and neurodegeneration. Reviews in the neurosciences. vol 8. issue 3-4. 1998-06-05. PMID:9548234. |
in this review we describe the evidence implicating apoptosis in neurodegenerative diseases with a particular emphasis on alzheimer's disease. |
1998-06-05 |
2023-08-12 |
human |
| S K Singhrao, P Thomas, J D Wood, J C MacMillan, J W Neal, P S Harper, A L Jone. Huntingtin protein colocalizes with lesions of neurodegenerative diseases: An investigation in Huntington's, Alzheimer's, and Pick's diseases. Experimental neurology. vol 150. issue 2. 1998-05-22. PMID:9527890. |
huntingtin protein colocalizes with lesions of neurodegenerative diseases: an investigation in huntington's, alzheimer's, and pick's diseases. |
1998-05-22 |
2023-08-12 |
Not clear |