| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A C Lo, L J Houenou, R W Oppenhei. Apoptosis in the nervous system: morphological features, methods, pathology, and prevention. Archives of histology and cytology. vol 58. issue 2. 1995-12-14. PMID:7576866. |
recently, apoptosis has been suggested to be involved in the abnormal neuronal death that occurs following axonal injury or in neurodegenerative diseases such as amyotrophic lateral sclerosis and alzheimer's. |
1995-12-14 |
2023-08-12 |
mouse |
| W M Purcell, C K Atterwil. Mast cells in neuroimmune function: neurotoxicological and neuropharmacological perspectives. Neurochemical research. vol 20. issue 5. 1995-09-21. PMID:7643958. |
the 'cross-talk' between mast cells, lymphocytes, neurons and glia constitutes a neuroimmune axis which is implicated in a range of neurodegenerative diseases with an inflammatory and/or autoimmune component, such as multiple sclerosis and alzheimer's disease. |
1995-09-21 |
2023-08-12 |
Not clear |
| J A Schneider, M Gearing, R S Robbins, W de l'Aune, S S Mirr. Apolipoprotein E genotype in diverse neurodegenerative disorders. Annals of neurology. vol 38. issue 1. 1995-08-16. PMID:7611717. |
while the apolipoprotein e (apoe) epsilon 4 allele is a recognized risk factor for alzheimer's disease (ad), an association of epsilon 4 with other neurodegenerative diseases (nds) has not been extensively explored. |
1995-08-16 |
2023-08-12 |
Not clear |
| Y Lamour, M H Bassant, B Potier, J M Billard, P Duta. [Aging of memory mechanisms]. Comptes rendus des seances de la Societe de biologie et de ses filiales. vol 188. issue 5-6. 1995-07-20. PMID:7780790. |
in neurodegenerative diseases (and specially in alzheimer's disease) amnesia is often the prominent symptom, but the brain lesions are not restricted to the hippocampal formation. |
1995-07-20 |
2023-08-12 |
human |
| M B Feany, D W Dickso. Widespread cytoskeletal pathology characterizes corticobasal degeneration. The American journal of pathology. vol 146. issue 6. 1995-07-13. PMID:7778678. |
the further definition of cbd pathology refines the diagnosis and pathophysiological understanding of this unique disease and has important implications for other neurodegenerative diseases, like alzheimer's disease, characterized by abnormal tau deposition. |
1995-07-13 |
2023-08-12 |
Not clear |
| D F Emerich, S R Winn, J Harper, J P Hammang, E E Baetge, J H Kordowe. Implants of polymer-encapsulated human NGF-secreting cells in the nonhuman primate: rescue and sprouting of degenerating cholinergic basal forebrain neurons. The Journal of comparative neurology. vol 349. issue 1. 1995-03-16. PMID:7852623. |
these findings support the use of polymer-encapsulated cell therapy as a potential treatment for neurodegenerative diseases such as alzheimer disease where basal forebrain degeneration is a consistent pathological feature. |
1995-03-16 |
2023-08-12 |
human |
| D M Araujo, P A Lapcha. Induction of immune system mediators in the hippocampal formation in Alzheimer's and Parkinson's diseases: selective effects on specific interleukins and interleukin receptors. Neuroscience. vol 61. issue 4. 1995-03-02. PMID:7838374. |
the present study determined whether molecules normally associated with immune signalling processes, specifically the lymphokines interleukin-1 beta, -2, -3 and -6, can be detected in the human hippocampal formation, and whether their levels are altered in neurodegenerative diseases such as alzheimer's and parkinson's diseases. |
1995-03-02 |
2023-08-12 |
human |
| A Vamvakidè. [Nootropic activity of glycinergic derivatives in relation to their dualistic effects on cerebral monoamines]. Bollettino chimico farmaceutico. vol 133. issue 6. 1994-11-08. PMID:7917183. |
the pharmacological consequences of these considerations on the memory impairment, associated or not with neurodegenerative phenomena, are envisaged and could suggest the use of low doses of glycinergic compounds in the memory impairments non associated with neurodegeneration and high doses of these compounds in the treatment of the cognitive impairments observed in the neurodegenerative diseases (alzheimer) or in the ageing of the brain. |
1994-11-08 |
2023-08-12 |
Not clear |
| S H Han, G Einstein, K H Weisgraber, W J Strittmatter, A M Saunders, M Pericak-Vance, A D Roses, D E Schmeche. Apolipoprotein E is localized to the cytoplasm of human cortical neurons: a light and electron microscopic study. Journal of neuropathology and experimental neurology. vol 53. issue 5. 1994-10-10. PMID:8083695. |
isoform-specific interactions with microtubule-associated proteins, such as tau or map2c, could influence the rate of pathology in neurodegenerative diseases such as alzheimer's disease. |
1994-10-10 |
2023-08-12 |
human |
| V Haroutunian, M Davidson, P D Kanof, D P Perl, P Powchik, M Losonczy, J McCrystal, D P Purohit, L M Bierer, K L Davi. Cortical cholinergic markers in schizophrenia. Schizophrenia research. vol 12. issue 2. 1994-08-31. PMID:8043524. |
cortical cholinergic deficits have been implicated in the cognitive deficits produced by a variety of neurodegenerative diseases including alzheimer's disease (ad). |
1994-08-31 |
2023-08-12 |
Not clear |
| E R Whittemore, A R Korotzer, A Etebari, C W Cotma. Carbachol increases intracellular free calcium in cultured rat microglia. Brain research. vol 621. issue 1. 1993-12-09. PMID:8106116. |
furthermore, since cholinergic fibers have been shown to infiltrate neuritic plaques in alzheimer's disease (ad) and microglia have been reported to be activated in plaques, these results suggest that interactions between select neurotransmitters and microglia may play a key role in neurodegenerative diseases. |
1993-12-09 |
2023-08-12 |
rat |
| H C Lee, M P Fellenz-Maloney, M Liscovitch, J K Blusztaj. Phospholipase D-catalyzed hydrolysis of phosphatidylcholine provides the choline precursor for acetylcholine synthesis in a human neuronal cell line. Proceedings of the National Academy of Sciences of the United States of America. vol 90. issue 21. 1993-12-09. PMID:8234260. |
abnormalities in the regulation of this pathway may contribute to selective vulnerability of cholinergic neurons in certain neurodegenerative diseases, e.g., alzheimer disease. |
1993-12-09 |
2023-08-12 |
human |
| B Oderfeld-Nowak, A Bacia, M Gradkowska, M Fusco, G Vantini, A Leon, L Alo. In vivo activated brain astrocytes may produce and secrete nerve growth factor-like molecules. Neurochemistry international. vol 21. issue 3. 1993-06-24. PMID:1303169. |
our findings may be of importance in considerations concerning trophic support to the cholinergic neurons of the basal forebrain nuclei whose impaired function is essentially responsible for some cognitive deficits in neurodegenerative diseases such as alzheimer disease. |
1993-06-24 |
2023-08-11 |
rat |
| M E Appleyar. Secreted acetylcholinesterase: non-classical aspects of a classical enzyme. Trends in neurosciences. vol 15. issue 12. 1993-02-11. PMID:1282748. |
loss of ache and its non-classical actions would have a profound effect on brain function in neurodegenerative diseases such as alzheimer's disease where there is widespread loss of ache-containing neurons. |
1993-02-11 |
2023-08-11 |
Not clear |
| Y Ohyagi, K Takahashi, Y Satoh, T Makifuchi, T Tabir. Cerebral cortical amyloid protein precursor mRNA expression is similar in Alzheimer's disease and other neurodegenerative diseases. Journal of the neurological sciences. vol 111. issue 1. 1992-11-12. PMID:1402996. |
the expression of 3 beta-amyloid protein precursor (app) mrnas (695, 751, and 770) in the cerebral cortex in alzheimer's disease and other neurodegenerative diseases was analyzed by the s1 nuclease protection assay. |
1992-11-12 |
2023-08-11 |
Not clear |
| P Hartikainen, K J Reinikainen, H Soininen, J Sirviö, R Soikkeli, P J Riekkine. Neurochemical markers in the cerebrospinal fluid of patients with Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis and normal controls. Journal of neural transmission. Parkinson's disease and dementia section. vol 4. issue 1. 1992-04-09. PMID:1347220. |
several neurotransmitter markers were investigated in the cerebrospinal fluid (csf) from patients with alzheimer's disease (ad) (n = 27), parkinson's disease (pd) (n = 35) and als (n = 26) and from control subjects (n = 34) to compare the possible alterations in the biochemical profiles of these different neurodegenerative diseases. |
1992-04-09 |
2023-08-11 |
human |
| T Ebenda. NGF in CNS: experimental data and clinical implications. Progress in growth factor research. vol 1. issue 3. 1991-10-01. PMID:2562358. |
the involvement of ngf in human neurodegenerative diseases is not established but the application of ngf to degenerating cholinergic neurons in alzheimer patients may prove useful. |
1991-10-01 |
2023-08-11 |
human |
| J Barnett, J Chow, B Nguyen, D Eggers, E Osen, K Jarnagin, N Saldou, K Straub, L Gu, L Erdo. Physicochemical characterization of recombinant human nerve growth factor produced in insect cells with a baculovirus vector. Journal of neurochemistry. vol 57. issue 3. 1991-09-04. PMID:1861144. |
because rhngf from insect cells can be obtained in large quantities, purified to near homogeneity, and is similar to natural ngf with regard to physicochemical properties and biological activity, it is suitable for further evaluation in animal models as a therapeutic molecule for neurodegenerative diseases such as alzheimer's disease. |
1991-09-04 |
2023-08-11 |
mouse |
| K Yamada, K Fuji, T Nabeshima, T Kameyam. Neurotoxicity induced by continuous infusion of quinolinic acid into the lateral ventricle in rats. Neuroscience letters. vol 118. issue 1. 1991-01-31. PMID:2147984. |
these results suggest that continuous infusion of qa into the lateral ventricle could be a useful technique for the study of chronic neurodegenerative diseases including alzheimer's disease. |
1991-01-31 |
2023-08-11 |
rat |
| E K Perr. Nerve growth factor and the basal forebrain cholinergic system: a link in the etiopathology of neurodegenerative dementias? Alzheimer disease and associated disorders. vol 4. issue 1. 1990-05-07. PMID:2180439. |
the discovery of a specific association between nerve growth factor (ngf) and basal forebrain cholinergic neurons (bfcns) marks the beginning of a new era of research into neurodegenerative diseases such as alzheimer disease (ad). |
1990-05-07 |
2023-08-11 |
human |