| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shalini Mani, Divya Jindal, Hitesh Chopra, Saurabh Kumar Jha, Sachin Kumar Singh, Gulam Md Ashraf, Mehnaz Kamal, Danish Iqbal, Dinesh Kumar Chellappan, Abhijit Dey, Saikat Dewanjee, Keshav K Singh, Shreesh Ojha, Inderbir Singh, Rupesh K Gautam, Niraj Kumar Jh. ROCK2 Inhibition: A Futuristic Approach for the Management of Alzheimer's Disease. Neuroscience and biobehavioral reviews. 2022-09-19. PMID:36122738. |
in many neurodegenerative diseases (ndds), including alzheimer's disease (ad), mitophagy is disrupted in neurons.mitophagy is regulated by several proteins; recently,rho-associated coiled-coil containing protein kinase 2 (rock2) has been suggested to negatively regulate the parkin-dependent mitophagy pathway.thus, rock2inhibitionmay bea promising therapyfor ndds. |
2022-09-19 |
2023-08-14 |
Not clear |
| Andrea Arighi, Marina Arcaro, Giorgio Giulio Fumagalli, Tiziana Carandini, Anna Margherita Pietroboni, Luca Sacchi, Chiara Fenoglio, Maria Serpente, Federica Sorrentino, Giovanni Isgrò, Federico Turkheimer, Elio Scarpini, Daniela Galimbert. Aquaporin-4 cerebrospinal fluid levels are higher in neurodegenerative dementia: looking at glymphatic system dysregulation. Alzheimer's research & therapy. vol 14. issue 1. 2022-09-17. PMID:36115967. |
aquaporin-4 (aqp4) is a channel protein that plays a fundamental role in glymphatic system, a newly described pathway for fluid exchange in the central nervous system, as well as a central figure in a fascinating new theory for the pathophysiology of neurodegenerative diseases such as alzheimer's disease (ad) and frontotemporal dementia (ftd). |
2022-09-17 |
2023-08-14 |
human |
| Kelly J Atkins, Lisbeth Evered, David A Scott, Christopher Fowler, Colin L Masters, Brendan Silber. Cerebrospinal fluid sampling for research of Alzheimer's disease and other neurodegenerative diseases when lumbar punctures are performed by anaesthetists. BMJ neurology open. vol 4. issue 2. 2022-09-16. PMID:36110925. |
cerebrospinal fluid sampling for research of alzheimer's disease and other neurodegenerative diseases when lumbar punctures are performed by anaesthetists. |
2022-09-16 |
2023-08-14 |
human |
| Yew Mun Lee, Deryn En-Jie Teoh, Kay Yeung, Yih-Cherng Lio. The kingdom of the prolyl-isomerase Pin1: The structural and functional convergence and divergence of Pin1. Frontiers in cell and developmental biology. vol 10. 2022-09-16. PMID:36111342. |
pin1 plays a crucial role in pathogenesis and has been implicated in metabolic disorders, cardiovascular diseases, inflammatory diseases, viral infection, cancer and neurodegenerative diseases such as alzheimer's, parkinson's and huntington's disease. |
2022-09-16 |
2023-08-14 |
Not clear |
| Jian Jing Siew, Yijuang Chern, Kay-Hooi Khoo, Takashi Angat. Roles of Siglecs in neurodegenerative diseases. Molecular aspects of medicine. 2022-09-11. PMID:36089405. |
recent studies have revealed the involvement of microglia in neurodegenerative diseases, such as alzheimer's disease, through the modulation of neuroinflammation. |
2022-09-11 |
2023-08-14 |
Not clear |
| Masoume Alipour, Majid Tebianian, Nahid Tofigh, Reyhaneh Sadat Taheri, Sayed Alireza Mousavi, Asal Naseri, Amin Ahmadi, Nayla Munawar, Koorosh Shahpasan. Active immunotherapy against pathogenic Cis pT231-tau suppresses neurodegeneration in traumatic brain injury mouse models. Neuropeptides. vol 96. 2022-09-10. PMID:36087426. |
traumatic brain injury (tbi), characterized by acute neurological impairment, is associated with a higher incidence of neurodegenerative diseases, particularly chronic traumatic encephalopathy (cte), alzheimer's disease (ad), and parkinson's disease (pd), whose hallmarks include hyperphosphorylated tau protein. |
2022-09-10 |
2023-08-14 |
mouse |
| Qixue Wang, Mengna Lu, Xinyu Zhu, Xinyi Gu, Ting Zhang, Chenyi Xia, Li Yang, Ying Xu, Mingmei Zho. The role of microglia immunometabolism in neurodegeneration: Focus on molecular determinants and metabolic intermediates of metabolic reprogramming. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 153. 2022-09-09. PMID:36076537. |
this paper provides an overview of the metabolic reprogramming of microglia, the major pathways involved in recent advances in five major neurodegenerative diseases of aging (ndas), including alzheimer's disease (ad), parkinson's disease (pd), multiple sclerosis (ms), amyotrophic lateral sclerosis (als), and frontotemporal dementia (ftd), etc. |
2022-09-09 |
2023-08-14 |
Not clear |
| Huifang Guo, Peng Chen, Runfan Luo, Yuting Zhang, Xi Xu, Xingchun Go. The Roles of Ciliary Neurotrophic Factor -- from Neuronutrition to Energy Metabolism. Protein and peptide letters. 2022-09-06. PMID:36065930. |
cntf is related to neurodegenerative diseases, such as parkinson's disease and alzheimer's disease. |
2022-09-06 |
2023-08-14 |
chicken |
| Md Noushad Javed, Faheem Hyder Pottoo, Mohd Javed Naim, Pooja A Chawl. Recent Advancements in CNS Acting Drugs: A Step Towards End of Illness. CNS & neurological disorders drug targets. vol 21. issue 10. 2022-09-05. PMID:36062857. |
progressive degeneration in the morphology and functions of neuronal cells leads to multifactorial pathogenesis conditions of oxidative stress, mitochondrial dysfunction, excitotoxicity, nitric oxide toxicity, and neuro-inflammation to mediate heterogeneous types of neurodegenerative diseases, such as epilepsy, alzheimer's (ad) and parkinson's (pd), more prominently among aging populations. |
2022-09-05 |
2023-08-14 |
Not clear |
| Mauro Montalbano, Lajja Majmundar, Urmi Sengupta, Leiana Fung, Rakez Kaye. Pathological tau signatures and nuclear alterations in neurons, astrocytes and microglia in Alzheimer's disease, progressive supranuclear palsy, and dementia with Lewy bodies. Brain pathology (Zurich, Switzerland). 2022-09-02. PMID:36054524. |
here, we have investigated the immunological and biochemical properties of aggregated tau species in different brain cell types in tau-induced neurodegenerative diseases such as alzheimer's disease (ad), progressive supranuclear palsy (psp), and dementia with lewy bodies (dlb). |
2022-09-02 |
2023-08-14 |
mouse |
| Omid Vakili, Pooria Asili, Zeinab Babaei, Maryam Mirahmad, Atoosa Keshavarzmotamed, Zatollah Asemi, Alireza Maf. Circular RNAs in Alzheimer's Disease: A New Perspective of Diagnostic and Therapeutic Targets. CNS & neurological disorders drug targets. 2022-08-31. PMID:36043720. |
among various neurodegenerative diseases (nds), accumulating evidence has proposed key roles for circrnas in the pathogenesis of alzheimer's disease (ad); although the exact relationship between these rna molecules and ad progression is not clear, they have been believed to mostly act as mirna sponges or gene transcription modulators through correlating with multiple proteins, involved in the accumulation of amyloid β (aβ) peptides, as well as tau protein, as ad's pathological hallmark. |
2022-08-31 |
2023-08-14 |
Not clear |
| Yuqian An, Yi Li, Yujun Hou, Shichao Huang, Gang Pe. Alzheimer's Amyloid- Oxidative medicine and cellular longevity. vol 2022. 2022-08-29. PMID:36035216. |
alzheimer's amyloid- microglia play important roles in maintenance of brain homeostasis, while due to some pathological stimuli in aging-related neurodegenerative diseases including alzheimer's disease, they are malfunctioning. |
2022-08-29 |
2023-08-14 |
Not clear |
| Shinrye Lee, Myungjin Jo, Younghwi Kwon, Yu-Mi Jeon, Seyeon Kim, Kea Joo Lee, Hyung-Jun Ki. PTK2 regulates tau-induced neurotoxicity via phosphorylation of p62 at Ser403. Journal of neurogenetics. 2022-08-24. PMID:36000467. |
tau is a microtubule-associated protein that forms insoluble filaments that accumulate as neurofibrillary tangles in neurodegenerative diseases such as alzheimer's disease and other related tauopathies. |
2022-08-24 |
2023-08-14 |
Not clear |
| Kazuya Tsumagari, Yoshiaki Sato, Aki Shimozawa, Hirofumi Aoyagi, Hideyuki Okano, Junro Kuromits. Co-expression network analysis of human tau-transgenic mice reveals protein modules associated with tau-induced pathologies. iScience. vol 25. issue 8. 2022-08-22. PMID:35992067. |
abnormally accumulated tau protein aggregates are one of the hallmarks of neurodegenerative diseases, including alzheimer's disease (ad). |
2022-08-22 |
2023-08-14 |
mouse |
| Padmanabh Singh, Vijay Paramani. Neuromodulating roles of estrogen and phytoestrogens in cognitive therapeutics through epigenetic modifications during aging. Frontiers in aging neuroscience. vol 14. 2022-08-22. PMID:35992599. |
the decline of e2 after menopause affects learning and memory and increases the risk of neurodegenerative diseases like alzheimer's disease (ad). |
2022-08-22 |
2023-08-14 |
human |
| Erming Wang, Mariana Lemos Duarte, Lauren E Rothman, Dongming Cai, Bin Zhan. Non-coding RNAs and Alzheimer's disease: perspectives from omics studies. Human molecular genetics. 2022-08-22. PMID:35994042. |
neurodegenerative diseases such as alzheimer's disease (ad) are characterized by the progressive loss of neurons in the brain and the spinal cord. |
2022-08-22 |
2023-08-14 |
human |
| Jiangong Wang, Bin Liu, Fengjiao Sun, Yong Xu, Haiyun Luan, Meizi Yang, Chaoyun Wang, Tiantian Zhang, Zhenyu Zhou, Haijing Ya. Histamine H3R antagonist counteracts the impaired hippocampal neurogenesis in Lipopolysaccharide-induced neuroinflammation. International immunopharmacology. vol 110. 2022-08-18. PMID:35978505. |
adult neurogenesis in hippocampus dentate gyrus (dg) is associated with numerous neurodegenerative diseases such as aging and alzheimer's disease (ad). |
2022-08-18 |
2023-08-14 |
mouse |
| Keren Wood, Idit Maharshak, Yosef Koronyo, Maya Koronyo-Hamaou. [THE RETINA AS A TOOL FOR EARLY DIAGNOSIS OF ALZHEIMER DISEASE]. Harefuah. vol 161. issue 8. 2022-08-18. PMID:35979573. |
alzheimer's disease is a neurodegenerative disease pathologically characterized by accumulation of abnormal amyloid-beta (aβ) and tau proteins. |
2022-08-18 |
2023-08-14 |
Not clear |
| Zengtao Wang, Xiaojia Tang, Suresh K Swaminathan, Karunya K Kandimalla, Krishna R Kalar. Mapping the dynamics of insulin-responsive pathways in the blood-brain barrier endothelium using time-series transcriptomics data. NPJ systems biology and applications. vol 8. issue 1. 2022-08-16. PMID:35974022. |
therefore, endothelial insulin resistance could lead to bbb dysfunction, which is associated with neurodegenerative diseases such as alzheimer's disease (ad). |
2022-08-16 |
2023-08-14 |
human |
| Eva Baerends, Katia Soud, Jonas Folke, Anna-Kathrine Pedersen, Simon Henmar, Lisa Konrad, Matthew D Lycas, Yuki Mori, Bente Pakkenberg, David P D Woldbye, Oksana Dmytriyeva, Stanislava Pankratov. Modeling the early stages of Alzheimer's disease by administering intracerebroventricular injections of human native Aβ oligomers to rats. Acta neuropathologica communications. vol 10. issue 1. 2022-08-16. PMID:35974377. |
alzheimer's disease (ad) is a progressive and irreversible neurodegenerative disease characterized by the accumulation of aggregated amyloid beta (aβ) and hyperphosphorylated tau along with a slow decline in cognitive functions. |
2022-08-16 |
2023-08-14 |
human |