| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tetsuro Tago, Muneyuki Sakata, Masakatsu Kanazawa, Shigeyuki Yamamoto, Kenji Ishii, Jun Toyohar. Preclinical validation of a novel brain-penetrant PET ligand for visualization of histone deacetylase 6: a potential imaging target for neurodegenerative diseases. European journal of nuclear medicine and molecular imaging. 2024-03-05. PMID:38441662. |
histone deacetylase 6 (hdac6) has emerged as a therapeutic target for neurodegenerative diseases such as alzheimer's disease. |
2024-03-05 |
2024-03-07 |
Not clear |
| Jessica A Bernar. Cerebello-Hippocampal Interactions in the Human Brain: A New Pathway for Insights Into Aging. Cerebellum (London, England). 2024-03-04. PMID:38438826. |
given the role of both regions in cognition and aging, and emerging evidence indicating that the cerebellum is impacted in age-related neurodegenerative disease such as alzheimer's, i propose that further attention to this circuit is warranted. |
2024-03-04 |
2024-03-07 |
human |
| Kristen H Schuster, Annie J Zalon, Danielle M DiFranco, Alexandra F Putka, Nicholas R Stec, Sabrina I Jarrah, Arsal Naeem, Zaid Haque, Hanrui Zhang, Yuanfang Guan, Hayley S McLoughli. ASOs are an effective treatment for disease-associated oligodendrocyte signatures in premanifest and symptomatic SCA3 mice. Molecular therapy : the journal of the American Society of Gene Therapy. 2024-03-02. PMID:38429929. |
evidence of disease-associated oligodendrocyte signatures has also been reported in other neurodegenerative diseases, including alzheimer's disease, amyotrophic lateral sclerosis, parkinson's disease, and huntington's disease. |
2024-03-02 |
2024-03-04 |
mouse |
| Nadia El Mammeri, Aurelio J Dregni, Pu Duan, Mei Hon. Structures of AT8 and PHF1 phosphomimetic tau: Insights into the posttranslational modification code of tau aggregation. Proceedings of the National Academy of Sciences of the United States of America. vol 121. issue 10. 2024-02-28. PMID:38408247. |
the microtubule-associated protein tau aggregates into amyloid fibrils in alzheimer's disease and other neurodegenerative diseases. |
2024-02-28 |
2024-03-01 |
Not clear |
| Wenting He, Xiuyu Shi, Zhifang Don. The roles of RACK1 in the pathogenesis of Alzheimer's disease. Journal of biomedical research. 2024-02-27. PMID:38410996. |
the receptor for activated c kinase 1 (rack1) is a protein that plays a crucial role in various signaling pathways and is involved in the pathogenesis of alzheimer's disease (ad), a prevalent neurodegenerative disease. |
2024-02-27 |
2024-03-02 |
Not clear |
| Bo-Yu Kuang, Yu-Chen Zhu, Jin-Ping Liang, Shi-Feng Chu, Nai-Hong Chen, Yan-Tao Yan. [Exosome and prevention of Alzheimer's disease: based on theory of kidney storing essence]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 1. 2024-02-25. PMID:38403338. |
alzheimer's disease(ad) is one of the common neurodegenerative diseases, with the main pathological features of aβ deposition and tau phosphorylation, which activate neurotoxic reactions and eventually lead to neuronal dysfunction and cell death, severely impairing the patient's cognitive and memory functions. |
2024-02-25 |
2024-02-28 |
human |
| Alexey Ivanov, Rezeda Shamagsumova, Marina Larina, Gennady Evtugy. Electrochemical Acetylcholinesterase Sensors for Anti-Alzheimer's Disease Drug Determination. Biosensors. vol 14. issue 2. 2024-02-23. PMID:38392012. |
neurodegenerative diseases and alzheimer's disease (ad), as one of the most common causes of dementia, result in progressive losses of cholinergic neurons and a reduction in the presynaptic markers of the cholinergic system. |
2024-02-23 |
2024-02-25 |
Not clear |
| Ryan Arsenault, Steven Marshall, Patrick Salois, Qiao Li, Wandong Zhan. sTREM2 Differentially Affects Cytokine Expression in Myeloid-Derived Cell Models via MAPK-JNK Signaling Pathway. Biology. vol 13. issue 2. 2024-02-23. PMID:38392305. |
mutations in trem2 are linked to several neurodegenerative diseases including alzheimer's disease (ad). |
2024-02-23 |
2024-02-25 |
Not clear |
| Kazuhiro Nakas. Roles of Microglia in Neurodegenerative Diseases. Yonago acta medica. vol 67. issue 1. 2024-02-21. PMID:38380436. |
in recent years, microglia have attracted attention owing to their roles in various neurodegenerative diseases, such as alzheimer's disease, parkinson's disease, and amyotrophic lateral sclerosis. |
2024-02-21 |
2024-02-23 |
Not clear |
| Yeon Kyeong Ko, Eunbi Kim, Eun-Jae Lee, Soo Jeong Nam, Yeshin Kim, Seongheon Kim, Se-Young Choi, Hyun Young Kim, Youngnim Cho. Enrichment of infection-associated bacteria in the low biomass brain bacteriota of Alzheimer's disease patients. PloS one. vol 19. issue 2. 2024-02-10. PMID:38335187. |
alzheimer's disease (ad) is a neurodegenerative disease accompanied by neuroimmune inflammation in the frontal cortex and hippocampus. |
2024-02-10 |
2024-02-12 |
human |
| Tugba Keskin, Orcun Avsar, Sinan Eliacik, Funda Uysal Ta. Investigation of the relationship between Nucleosides, nucleotides & nucleic acids. 2024-02-10. PMID:38340307. |
investigation of the relationship between alzheimer's disease is one of the most common causes of dementia and is a neurodegenerative disease that occurs with memory loss, loss of language, thinking and problem-solving skills. |
2024-02-10 |
2024-02-14 |
Not clear |
| Guillermo Santos-Sánchez, Eduardo Ponce-España, Ana Isabel Álvarez-López, Justo Pedroche, María Del Carmen Millán-Linares, María-Soledad Fernández-Pachón, Patricia Judith Lardone, Ivan Cruz-Chamorro, Antonio Carrillo-Vic. A lupin protein hydrolysate protects the central nervous system from oxidative stress in WD-fed ApoE Molecular nutrition & food research. 2024-02-03. PMID:38308501. |
a lupin protein hydrolysate protects the central nervous system from oxidative stress in wd-fed apoe oxidative stress plays a crucial role in neurodegenerative diseases like parkinson's and alzheimer's. |
2024-02-03 |
2024-02-05 |
human |
| Da Ma, Wenyu Deng, Zain Khera, Thajunnisa A Sajitha, Xinlei Wang, Gadi Wollstein, Joel S Schuman, Sieun Lee, Haolun Shi, Myeong Jin Ju, Joanne Matsubara, Mirza Faisal Beg, Marinko Sarunic, Rebecca M Sappington, Kevin C Cha. Early inner plexiform layer thinning and retinal nerve fiber layer thickening in excitotoxic retinal injury using deep learning-assisted optical coherence tomography. Acta neuropathologica communications. vol 12. issue 1. 2024-02-02. PMID:38303097. |
excitotoxicity from the impairment of glutamate uptake constitutes an important mechanism in neurodegenerative diseases such as alzheimer's, multiple sclerosis, and parkinson's disease. |
2024-02-02 |
2024-02-04 |
rat |
| Ji-Yun Kang, Ji-Yeon Gu, Dong-Cheol Baek, Chang-Gue Son, Jin-Seok Le. A Food & function. 2024-02-02. PMID:38305768. |
a the hippocampal memory deficit stands out as a primary symptom in neurodegenerative diseases, including alzheimer's disease. |
2024-02-02 |
2024-02-04 |
Not clear |
| Zezhong Lv, Lixi Chen, Ping Chen, Huipai Peng, Yi Rong, Wei Hong, Qiang Zhou, Nan Li, Boxing Li, Rosa C Paolicelli, Yang Zha. Clearance of β-amyloid and synapses by the optogenetic depolarization of microglia is complement selective. Neuron. 2024-02-01. PMID:38295790. |
in neurodegenerative diseases, including alzheimer's disease (ad), microglia undergo morphological and functional alterations. |
2024-02-01 |
2024-02-04 |
Not clear |
| Linda L Cha. Olfactory and cognitive decrements in 1991 Gulf War veterans with gulf war illness/chronic multisymptom illness. Environmental health : a global access science source. vol 23. issue 1. 2024-01-30. PMID:38291474. |
because olfactory deficit is a prodromal symptom of neurodegenerative diseases like parkinson's and alzheimer's disease, and because we previously reported suggestive evidence that deployed gw veterans may be at increased risk for mild cognitive impairment (mci) and dementia, the current study examined the relationship between olfactory and cognitive function in deployed gw veterans. |
2024-01-30 |
2024-02-02 |
Not clear |
| Dale B Bosco, Vaclav Kremen, Koichiro Haruwaka, Shunyi Zhao, Lingxiao Wang, Blake A Ebner, Jiaying Zheng, Aastha Dheer, Jadyn F Perry, Manling Xie, Aivi T Nguyen, Gregory A Worrell, Long-Jun W. Impaired microglial phagocytosis promotes seizure development. bioRxiv : the preprint server for biology. 2024-01-23. PMID:38260601. |
trem2 plays an important role in neurodegenerative diseases, such as alzheimer's disease and amyotrophic lateral sclerosis. |
2024-01-23 |
2024-01-25 |
mouse |
| Kaden L Nystuen, Shannon M McNamee, Monica Akula, Kristina M Holton, Margaret M DeAngelis, Neena B Haide. Alzheimer's Disease: Models and Molecular Mechanisms Informing Disease and Treatments. Bioengineering (Basel, Switzerland). vol 11. issue 1. 2024-01-22. PMID:38247923. |
alzheimer's disease (ad) is a complex neurodegenerative disease resulting in progressive loss of memory, language and motor abilities caused by cortical and hippocampal degeneration. |
2024-01-22 |
2024-01-24 |
Not clear |
| Emilia Zgorzynsk. TREM2 in Alzheimer's disease: Structure, function, therapeutic prospects, and activation challenges. Molecular and cellular neurosciences. 2024-01-20. PMID:38244651. |
this review provides a comprehensive overview of trem2 structure and functions, highlighting the role of its variants in the development and progression of alzheimer's disease (ad), a devastating neurodegenerative disease that affects millions of people worldwide. |
2024-01-20 |
2024-01-23 |
Not clear |
| Anisha A DSouza, Praveen Kulkarni, Craig F Ferris, Mansoor M Amiji, Benjamin S Bleie. Mild repetitive TBI reduces brain-derived neurotrophic factor (BDNF) in the substantia nigra and hippocampus: A preclinical model for testing BDNF-targeted therapeutics. Experimental neurology. 2024-01-20. PMID:38244886. |
clinical studies have consistently shown that neurodegenerative diseases (nds) such as parkinson's disease, alzheimer's disease, amyotrophic lateral sclerosis, and huntington's disease show absent or low levels of brain-derived neurotrophic factor (bdnf). |
2024-01-20 |
2024-01-23 |
rat |