| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Peng Yuan, Carlo Condello, C Dirk Keene, Yaming Wang, Thomas D Bird, Steven M Paul, Wenjie Luo, Marco Colonna, David Baddeley, Jaime Grutzendle. TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy. Neuron. vol 90. issue 4. 2017-08-03. PMID:27196974. |
haplodeficiency of the microglia gene trem2 increases risk for late-onset alzheimer's disease (ad) but the mechanisms remain uncertain. |
2017-08-03 |
2023-08-13 |
mouse |
| Julien Muffat, Yun Li, Bingbing Yuan, Maisam Mitalipova, Attya Omer, Sean Corcoran, Grisilda Bakiasi, Li-Huei Tsai, Patrick Aubourg, Richard M Ransohoff, Rudolf Jaenisc. Efficient derivation of microglia-like cells from human pluripotent stem cells. Nature medicine. vol 22. issue 11. 2017-07-31. PMID:27668937. |
microglia, the only lifelong resident immune cells of the central nervous system (cns), are highly specialized macrophages that have been recognized to have a crucial role in neurodegenerative diseases such as alzheimer's, parkinson's and adrenoleukodystrophy (ald). |
2017-07-31 |
2023-08-13 |
mouse |
| Hadas Keren-Shaul, Amit Spinrad, Assaf Weiner, Orit Matcovitch-Natan, Raz Dvir-Szternfeld, Tyler K Ulland, Eyal David, Kuti Baruch, David Lara-Astaiso, Beata Toth, Shalev Itzkovitz, Marco Colonna, Michal Schwartz, Ido Ami. A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease. Cell. vol 169. issue 7. 2017-07-24. PMID:28602351. |
a unique microglia type associated with restricting development of alzheimer's disease. |
2017-07-24 |
2023-08-13 |
mouse |
| Gunjan D Manocha, Angela M Floden, Keiko Rausch, Joshua A Kulas, Brett A McGregor, Lalida Rojanathammanee, Kelley R Puig, Kendra L Puig, Sanjib Karki, Michael R Nichols, Diane C Darland, James E Porter, Colin K Comb. APP Regulates Microglial Phenotype in a Mouse Model of Alzheimer's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 32. 2017-07-14. PMID:27511018. |
therefore, we hypothesized that app serves this function in microglia during alzheimer's disease. |
2017-07-14 |
2023-08-13 |
mouse |
| Stefka Gyoneva, Sharon A Swanger, Jing Zhang, David Weinshenker, Stephen F Trayneli. Altered motility of plaque-associated microglia in a model of Alzheimer's disease. Neuroscience. vol 330. 2017-07-11. PMID:27288150. |
altered motility of plaque-associated microglia in a model of alzheimer's disease. |
2017-07-11 |
2023-08-13 |
mouse |
| Katrin I Andreasson, Adam D Bachstetter, Marco Colonna, Florent Ginhoux, Clive Holmes, Bruce Lamb, Gary Landreth, Daniel C Lee, Donovan Low, Marina A Lynch, Alon Monsonego, M Kerry O'Banion, Milos Pekny, Till Puschmann, Niva Russek-Blum, Leslie A Sandusky, Maj-Linda B Selenica, Kazuyuki Takata, Jessica Teeling, Terrence Town, Linda J Van Eldi. Targeting innate immunity for neurodegenerative disorders of the central nervous system. Journal of neurochemistry. vol 138. issue 5. 2017-06-14. PMID:27248001. |
this mini review series originated from the 4th venusberg meeting on neuroinflammation held in bonn, germany, 7-9th may 2015, presenting updates on innate immunity in acute brain injury and chronic neurodegenerative disorders, such as traumatic brain injury and alzheimer disease, on the role of astrocytes and microglia, as well as technical developments that may help elucidate neuroinflammatory mechanisms and establish clinical relevance. |
2017-06-14 |
2023-08-13 |
Not clear |
| Katrin I Andreasson, Adam D Bachstetter, Marco Colonna, Florent Ginhoux, Clive Holmes, Bruce Lamb, Gary Landreth, Daniel C Lee, Donovan Low, Marina A Lynch, Alon Monsonego, M Kerry O'Banion, Milos Pekny, Till Puschmann, Niva Russek-Blum, Leslie A Sandusky, Maj-Linda B Selenica, Kazuyuki Takata, Jessica Teeling, Terrence Town, Linda J Van Eldi. Targeting innate immunity for neurodegenerative disorders of the central nervous system. Journal of neurochemistry. vol 138. issue 5. 2017-06-14. PMID:27248001. |
microglial ontogeny and induced pluripotent stem cell-derived microglia, advances of trem2 signaling, and the cytokine paradox in alzheimer's disease are further contributions to this article. |
2017-06-14 |
2023-08-13 |
Not clear |
| Katrin I Andreasson, Adam D Bachstetter, Marco Colonna, Florent Ginhoux, Clive Holmes, Bruce Lamb, Gary Landreth, Daniel C Lee, Donovan Low, Marina A Lynch, Alon Monsonego, M Kerry O'Banion, Milos Pekny, Till Puschmann, Niva Russek-Blum, Leslie A Sandusky, Maj-Linda B Selenica, Kazuyuki Takata, Jessica Teeling, Terrence Town, Linda J Van Eldi. Targeting innate immunity for neurodegenerative disorders of the central nervous system. Journal of neurochemistry. vol 138. issue 5. 2017-06-14. PMID:27248001. |
this mini review series originated from the 4th venusberg meeting on neuroinflammation held in bonn, germany, 7-9th may 2015, presenting updates on innate immunity in acute brain injury and chronic neurodegenerative disorders, such as traumatic brain injury and alzheimer's disease, on the role of astrocytes and microglia, as well as technical developments that may help elucidate neuroinflammatory mechanisms and establish clinical relevance. |
2017-06-14 |
2023-08-13 |
Not clear |
| Katrin I Andreasson, Adam D Bachstetter, Marco Colonna, Florent Ginhoux, Clive Holmes, Bruce Lamb, Gary Landreth, Daniel C Lee, Donovan Low, Marina A Lynch, Alon Monsonego, M Kerry O'Banion, Milos Pekny, Till Puschmann, Niva Russek-Blum, Leslie A Sandusky, Maj-Linda B Selenica, Kazuyuki Takata, Jessica Teeling, Terrence Town, Linda J Van Eldi. Targeting innate immunity for neurodegenerative disorders of the central nervous system. Journal of neurochemistry. vol 138. issue 5. 2017-06-14. PMID:27248001. |
microglial ontogeny and induced pluripotent stem cell-derived microglia, advances of trem2 signaling, and the cytokine paradox in alzheimer's disease are further contributions to this article. |
2017-06-14 |
2023-08-13 |
Not clear |
| Teng Jiang, Ying-Dong Zhang, Qi Chen, Qing Gao, Xi-Chen Zhu, Jun-Shan Zhou, Jian-Quan Shi, Huan Lu, Lan Tan, Jin-Tai Y. TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice. Neuropharmacology. vol 105. 2017-06-13. PMID:26802771. |
as a novel risk gene for alzheimer's disease (ad), triggering receptor expressed on myeloid cells 2 (trem2) gene encodes a type i transmembrane receptor that is uniquely expressed by the microglia in the brain. |
2017-06-13 |
2023-08-13 |
mouse |
| Roger F Butterwort. Neurosteroids in hepatic encephalopathy: Novel insights and new therapeutic opportunities. The Journal of steroid biochemistry and molecular biology. vol 160. 2017-06-12. PMID:26589093. |
morphological changes to neuroglia (both astrocytes and microglia) occur in he consisting of cytotoxic brain edema (astrocyte swelling) in acute liver failure and alzheimer type-2 astrocytosis in cirrhosis. |
2017-06-12 |
2023-08-13 |
mouse |
| Elodie Martin, Céline Boucher, Bertrand Fontaine, Cécile Delarass. Distinct inflammatory phenotypes of microglia and monocyte-derived macrophages in Alzheimer's disease models: effects of aging and amyloid pathology. Aging cell. vol 16. issue 1. 2017-06-05. PMID:27723233. |
distinct inflammatory phenotypes of microglia and monocyte-derived macrophages in alzheimer's disease models: effects of aging and amyloid pathology. |
2017-06-05 |
2023-08-13 |
mouse |
| Elodie Martin, Céline Boucher, Bertrand Fontaine, Cécile Delarass. Distinct inflammatory phenotypes of microglia and monocyte-derived macrophages in Alzheimer's disease models: effects of aging and amyloid pathology. Aging cell. vol 16. issue 1. 2017-06-05. PMID:27723233. |
alzheimer's disease (ad) is a neurodegenerative disease characterized by formation of amyloid-β (aβ) plaques, activated microglia, and neuronal cell death leading to progressive dementia. |
2017-06-05 |
2023-08-13 |
mouse |
| Zhen Fan, David J Brooks, Aren Okello, Paul Ediso. An early and late peak in microglial activation in Alzheimer's disease trajectory. Brain : a journal of neurology. vol 140. issue 3. 2017-05-29. PMID:28122877. |
we hypothesized that there is microglial activation early on in alzheimer's disease trajectory, where in the initial phase, microglia may be trying to repair the damage, while later on in the disease these microglia could be ineffective and produce proinflammatory cytokines leading to progressive neuronal damage. |
2017-05-29 |
2023-08-13 |
human |
| Yachao Xing, Ning Li, Di Zhou, Gang Chen, Kun Jiao, Wenli Wang, Yingying Si, Yue Ho. Sesquiterpene Coumarins from Ferula sinkiangensis Act as Neuroinflammation Inhibitors. Planta medica. vol 83. issue 1-02. 2017-05-22. PMID:27420353. |
neuroinflammation mediated by microglia cells plays a critical role in the development of alzheimer's disease. |
2017-05-22 |
2023-08-13 |
Not clear |
| Mu Zhang, Yanyan Wang, Fei Qian, Ping Li, Xiaojun X. Hypericin inhibits oligomeric amyloid β42-induced inflammation response in microglia and ameliorates cognitive deficits in an amyloid β injection mouse model of Alzheimer's disease by suppressing MKL1. Biochemical and biophysical research communications. vol 481. issue 1-2. 2017-05-22. PMID:27825966. |
hypericin inhibits oligomeric amyloid β42-induced inflammation response in microglia and ameliorates cognitive deficits in an amyloid β injection mouse model of alzheimer's disease by suppressing mkl1. |
2017-05-22 |
2023-08-13 |
mouse |
| Duk-Yeon Cho, Hyun Myung Ko, Joonsoo Kim, Byung-Wook Kim, Yo-Sep Yun, Jeong-In Park, Palanivel Ganesan, Jin-Tae Lee, Dong-Kug Cho. Scoparone Inhibits LPS-Simulated Inflammatory Response by Suppressing IRF3 and ERK in BV-2 Microglial Cells. Molecules (Basel, Switzerland). vol 21. issue 12. 2017-05-09. PMID:27983636. |
microglia activation and the release of various inflammatory cytokines are largely related to neurological diseases, including parkinson's, alzheimer's, and other brain diseases. |
2017-05-09 |
2023-08-13 |
Not clear |
| Vanessa Porrini, Ilenia Sarnico, Marina Benarese, Caterina Branca, Mariana Mota, Annamaria Lanzillotta, Arianna Bellucci, Edoardo Parrella, Lara Faggi, Pierfranco Spano, Bruno Pietro Imbimbo, Marina Pizz. Neuroprotective and Anti-Apoptotic Effects of CSP-1103 in Primary Cortical Neurons Exposed to Oxygen and Glucose Deprivation. International journal of molecular sciences. vol 18. issue 1. 2017-04-24. PMID:28106772. |
csp-1103 (formerly chf5074) has been shown to reverse memory impairment and reduce amyloid plaque as well as inflammatory microglia activation in preclinical models of alzheimer's disease. |
2017-04-24 |
2023-08-13 |
mouse |
| A S M Hung, Y Liang, Tony C H Chow, H C Tang, Sharon L Y Wu, M S M Wai, D T Ye. Mutated tau, amyloid and neuroinflammation in Alzheimer disease-A brief review. Progress in histochemistry and cytochemistry. vol 51. issue 1. 2017-04-21. PMID:26851150. |
this review discussed the importance of mutated tau, amyloid and neuroinflammatory factors and microglia in alzheimer disease. |
2017-04-21 |
2023-08-13 |
Not clear |
| Jintao Bao, Liangjun Zheng, Qi Zhang, Xinya Li, Xuefei Zhang, Zeyang Li, Xue Bai, Zhong Zhang, Wei Huo, Xuyang Zhao, Shujiang Shang, Qingsong Wang, Chen Zhang, Jianguo J. Deacetylation of TFEB promotes fibrillar Aβ degradation by upregulating lysosomal biogenesis in microglia. Protein & cell. vol 7. issue 6. 2017-04-20. PMID:27209302. |
microglia play a pivotal role in clearance of aβ by degrading them in lysosomes, countering amyloid plaque pathogenesis in alzheimer's disease (ad). |
2017-04-20 |
2023-08-13 |
mouse |