| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrew J Petersen, Stacey A Rimkus, David A Wassarma. ATM kinase inhibition in glial cells activates the innate immune response and causes neurodegeneration in Drosophila. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 11. 2012-05-08. PMID:22355133. |
atm knockdown in glial cells, but not neurons, was sufficient to cause neuron and glial cell death, a reduction in mobility and longevity, and elevated expression of innate immune response genes in glial cells, indicating that a non-cell-autonomous mechanism contributes to neurodegeneration in a-t. taken together, these data suggest that early-onset cns neurodegeneration in a-t is similar to late-onset cns neurodegeneration in diseases such as alzheimer's in which uncontrolled inflammatory response mediated by glial cells drives neurodegeneration. |
2012-05-08 |
2023-08-12 |
drosophila_melanogaster |
| Arne Ittner, Yazi D Ke, Janet van Eersel, Amadeus Gladbach, Jürgen Götz, Lars M Ittne. Brief update on different roles of tau in neurodegeneration. IUBMB life. vol 63. issue 7. 2012-01-11. PMID:21698753. |
both alzheimer's disease (ad) and almost every second case of frontotemporal lobar degeneration (ftld) are characterized by the deposition of hyperphosphorylated forms of the microtubule-associated protein tau in neurons and/or glia. |
2012-01-11 |
2023-08-12 |
Not clear |
| Alberto Serrano-Pozo, Matthew L Mielke, Teresa Gómez-Isla, Rebecca A Betensky, John H Growdon, Matthew P Frosch, Bradley T Hyma. Reactive glia not only associates with plaques but also parallels tangles in Alzheimer's disease. The American journal of pathology. vol 179. issue 3. 2011-12-09. PMID:21777559. |
reactive glia not only associates with plaques but also parallels tangles in alzheimer's disease. |
2011-12-09 |
2023-08-12 |
human |
| Annik Prat, Maik Behrendt, Edwige Marcinkiewicz, Sebastien Boridy, Ram M Sairam, Nabil G Seidah, Dusica Maysinge. A novel mouse model of Alzheimer's disease with chronic estrogen deficiency leads to glial cell activation and hypertrophy. Journal of aging research. vol 2011. 2011-11-10. PMID:21969914. |
a novel mouse model of alzheimer's disease with chronic estrogen deficiency leads to glial cell activation and hypertrophy. |
2011-11-10 |
2023-08-12 |
mouse |
| Eitan Okun, Kathleen J Griffioen, Mark P Mattso. Toll-like receptor signaling in neural plasticity and disease. Trends in neurosciences. vol 34. issue 5. 2011-09-16. PMID:21419501. |
tlr signaling in immune cells, glia and neurons can play roles in the pathogenesis of stroke, alzheimer's disease (ad) and multiple sclerosis (ms). |
2011-09-16 |
2023-08-12 |
Not clear |
| K Takano, K Shiraiwa, M Moriyama, Y Nakamur. Transglutaminase 2 expression induced by lipopolysaccharide stimulation together with NO synthase induction in cultured astrocytes. Neurochemistry international. vol 57. issue 7. 2011-09-07. PMID:20817067. |
activation of glia has been observed in neurodegenerative diseases such as parkinson's disease (pd), alzheimer's disease (ad), multiple sclerosis and brain ischemia. |
2011-09-07 |
2023-08-12 |
rat |
| V I Baksheev, N M Kolomoet. [Melatonin: its role in the system of neurohumoral regulation in man. Part 2]. Klinicheskaia meditsina. vol 89. issue 2. 2011-06-30. PMID:21574434. |
extensive studies of mt protective action in nervous diseases are underway with special reference to spinal cord, brain, neuron and glial cell lesions; experimental cerebral stroke, parkinson's and alzheimer's diseases. |
2011-06-30 |
2023-08-12 |
human |
| L F Agnati, D Guidolin, F Baluska, G Leo, P W Barlow, C Carone, S Genedan. A new hypothesis of pathogenesis based on the divorce between mitochondria and their host cells: possible relevance for Alzheimer's disease. Current Alzheimer research. vol 7. issue 4. 2011-02-24. PMID:19860724. |
in this way, neurodegenerative states are propagated between cells (glia and/or neurons) of the central nervous system (cns) and that this leads to conditions such as alzheimer's and parkinson's disease. |
2011-02-24 |
2023-08-12 |
human |
| Barbara Kaltschmidt, Christian Kaltschmid. NF-kappaB in the nervous system. Cold Spring Harbor perspectives in biology. vol 1. issue 3. 2010-09-28. PMID:20066105. |
in glia, nf-kappab is inducible and regulates inflammatory processes that exacerbate diseases such as autoimmune encephalomyelitis, ischemia, and alzheimer's disease. |
2010-09-28 |
2023-08-12 |
mouse |
| Adnan Ero. Are paradoxical cell cycle activities in neurons and glia related to the metabolic theory of Alzheimer's disease? Journal of Alzheimer's disease : JAD. vol 19. issue 1. 2010-08-10. PMID:20061632. |
are paradoxical cell cycle activities in neurons and glia related to the metabolic theory of alzheimer's disease? |
2010-08-10 |
2023-08-12 |
Not clear |
| Paul Fole. Lipids in Alzheimer's disease: A century-old story. Biochimica et biophysica acta. vol 1801. issue 8. 2010-08-10. PMID:20471492. |
three neuropathological features attracted the attention of alzheimer in his examination of the brain of auguste deter: abnormal fibrillary structures, cortical depositions now termed "plaques," and glial proliferation, whereby he noted remarkable lipid granule accumulation in the glia. |
2010-08-10 |
2023-08-12 |
Not clear |
| A I Pogue, J G Cui, Y Y Li, Y Zhao, F Culicchia, W J Luki. Micro RNA-125b (miRNA-125b) function in astrogliosis and glial cell proliferation. Neuroscience letters. vol 476. issue 1. 2010-07-19. PMID:20347935. |
a strong positive correlation between mirna-125b abundance and the glial cell markers glial fibrillary acidic protein (gfap) and vimentin, and cdkn2a down-regulation was noted in advanced alzheimer's disease (ad) and in down's syndrome (ds) brain, chronic neurological disorders associated with astrogliosis. |
2010-07-19 |
2023-08-12 |
human |
| Carol A Colton, Donna M Wilcoc. Assessing activation states in microglia. CNS & neurological disorders drug targets. vol 9. issue 2. 2010-07-12. PMID:20205642. |
however, in chronic neurodegenerative diseases such as alzheimer's disease where in vivo analyses are critical to understanding the long-term disease processes, our knowledge of the integrated tissue immune response and the outcome of this immune activity to neurons and other glia over the extended course of disease is more limited. |
2010-07-12 |
2023-08-12 |
Not clear |
| Gerson Chadi, Jessica Ruivo Maximino, Gabriela Pintar de Oliveir. The importance of molecular histology to study glial influence on neurodegenerative disorders. Focus on recent developed single cell laser microdissection. Journal of molecular histology. vol 40. issue 4. 2010-03-23. PMID:19882358. |
here we reviewed the role of glial cell signaling on neurodegenerative disorders like ischemia, parkinson and alzheimer diseases, and also amyotrophic lateral sclerosis and what has been published with regards to single cell laser capture microdissection technique in the molecular biology investigation on these issues. |
2010-03-23 |
2023-08-12 |
human |
| James T Koerber, Ryan Klimczak, Jae-Hyung Jang, Deniz Dalkara, John G Flannery, David V Schaffe. Molecular evolution of adeno-associated virus for enhanced glial gene delivery. Molecular therapy : the journal of the American Society of Gene Therapy. vol 17. issue 12. 2010-02-25. PMID:19672246. |
despite the clinical relevance of glia for homeostasis in neural tissue, and as causal contributors in genetic disorders such as alzheimer's and amyotrophic lateral sclerosis, efforts to develop more efficient gene delivery vectors for glia have met with limited success. |
2010-02-25 |
2023-08-12 |
human |
| Justin D Lathia, Mark P Mattson, Aiwu Chen. Notch: from neural development to neurological disorders. Journal of neurochemistry. vol 107. issue 6. 2009-04-09. PMID:19094054. |
recent findings suggest that notch signaling in neurons, glia, and nscs may be involved in pathological changes that occur in disorders such as stroke, alzheimer's disease and cns tumors. |
2009-04-09 |
2023-08-12 |
Not clear |
| Russel J Reiter, Ahmet Korkma. Clinical aspects of melatonin. Saudi medical journal. vol 29. issue 11. 2009-01-30. PMID:18997997. |
in this capacity, melatonin reduces experimental cataractogenesis, traumatic injury to the spinal cord and brain, and protects against oxidative damage to neurons and glia in models of stroke, parkinsonism, and alzheimer's disease. |
2009-01-30 |
2023-08-12 |
human |
| Stephen D Skape. The brain as a target for inflammatory processes and neuroprotective strategies. Annals of the New York Academy of Sciences. vol 1122. 2008-04-21. PMID:18077562. |
the importance of glial cell-propagated inflammation (i.e., neuroinflammation) disorders such as alzheimer's disease (ad) was viewed previously as a bystander effect, or epiphenomenon, with inflammation occurring when damaged neurons elicit an activation response by glia. |
2008-04-21 |
2023-08-12 |
Not clear |
| Denah M Appelt, Maria R Roupas, Deana S Way, Marcus G Bell, Elizabeth V Albert, Christine J Hammond, Brian J Bali. Inhibition of apoptosis in neuronal cells infected with Chlamydophila (Chlamydia) pneumoniae. BMC neuroscience. vol 9. 2008-04-10. PMID:18218130. |
chlamydophila (chlamydia) pneumoniae is an intracellular bacterium that has been identified within cells in areas of neuropathology found in alzheimer disease (ad), including endothelia, glia, and neurons. |
2008-04-10 |
2023-08-12 |
Not clear |
| Rommy von Bernhard. Glial cell dysregulation: a new perspective on Alzheimer disease. Neurotoxicity research. vol 12. issue 4. 2008-04-09. PMID:18201950. |
glial cell dysregulation: a new perspective on alzheimer disease. |
2008-04-09 |
2023-08-12 |
Not clear |