| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Renzo Mancuso, Jaume Del Valle, Marta Morell, Mercé Pallás, Rosario Osta, Xavier Navarr. Lack of synergistic effect of resveratrol and sigma-1 receptor agonist (PRE-084) in SOD1G⁹³A ALS mice: overlapping effects or limited therapeutic opportunity? Orphanet journal of rare diseases. vol 9. 2014-11-12. PMID:24885036. |
amyotrophic lateral sclerosis (als) is an adult onset neurodegenerative disease characterized by the loss of motoneurons (mns) in the spinal cord, brainstem and motor cortex, causing progressive paralysis and death. |
2014-11-12 |
2023-08-13 |
mouse |
| Megan S Keiser, Ryan L Boudreau, Beverly L Davidso. Broad therapeutic benefit after RNAi expression vector delivery to deep cerebellar nuclei: implications for spinocerebellar ataxia type 1 therapy. Molecular therapy : the journal of the American Society of Gene Therapy. vol 22. issue 3. 2014-11-03. PMID:24419082. |
spinocerebellar ataxia type 1 (sca1) is an autosomal dominant, late-onset neurodegenerative disease caused by a polyglutamine (polyq) expansion in the ataxin-1 protein, which causes progressive neurodegeneration in cerebellar purkinje cells and brainstem nuclei. |
2014-11-03 |
2023-08-12 |
mouse |
| Changsung Kim, Hee Chul Lee, Jung-Joon Sun. Amyotrophic lateral sclerosis - cell based therapy and novel therapeutic development. Experimental neurobiology. vol 23. issue 3. 2014-09-26. PMID:25258567. |
amyotrophic lateral sclerosis (als) is a neurodegenerative disease, characterized by the predominant loss of motor neurons (mns) in primary motor cortex, the brainstem, and the spinal cord, causing premature death in most cases. |
2014-09-26 |
2023-08-13 |
human |
| Ana Navarro, Elena Méndez, Celso Diaz, Eva del Valle, Eva Martínez-Pinilla, Cristina Ordóñez, Jorge Tolivi. Lifelong expression of apolipoprotein D in the human brainstem: correlation with reduced age-related neurodegeneration. PloS one. vol 8. issue 10. 2014-05-28. PMID:24167586. |
we propose that strong brainstem expression of apo d throughout adult life contributes to resistance against neurodegenerative disease and age-related degeneration, possibly by preventing oxidative stress and ensuing lipid peroxidation. |
2014-05-28 |
2023-08-12 |
human |
| Irene G Salado, Miriam Redondo, Murilo L Bello, Concepción Perez, Nicole F Liachko, Brian C Kraemer, Laetitia Miguel, Magalie Lecourtois, Carmen Gil, Ana Martinez, Daniel I Pere. Protein kinase CK-1 inhibitors as new potential drugs for amyotrophic lateral sclerosis. Journal of medicinal chemistry. vol 57. issue 6. 2014-05-27. PMID:24592867. |
amyotrophic lateral sclerosis (als) is a neurodegenerative disease where motor neurons in cortex, brain stem, and spinal cord die progressively, resulting in muscle wasting, paralysis, and death. |
2014-05-27 |
2023-08-12 |
drosophila_melanogaster |
| Li Yu, Yingjun Guan, Xin Wu, Yanchun Chen, Zhijun Liu, Hongmei Du, Xin Wan. Wnt Signaling is altered by spinal cord neuronal dysfunction in amyotrophic lateral sclerosis transgenic mice. Neurochemical research. vol 38. issue 9. 2014-03-10. PMID:23784673. |
amyotrophic lateral sclerosis (als) is a chronic neurodegenerative disease characterized by progressive degeneration of the motor neurons in the cortex, brainstem, and spinal cord. |
2014-03-10 |
2023-08-12 |
mouse |
| Zhang-Yu Zou, Qing Sun, Ming-Sheng Liu, Xiao-Guang Li, Li-Ying Cu. Mutations in the profilin 1 gene are not common in amyotrophic lateral sclerosis of Chinese origin. Neurobiology of aging. vol 34. issue 6. 2013-12-11. PMID:23357624. |
amyotrophic lateral sclerosis (als) is a progressive neurodegenerative disease primarily involving the corticospinal tract, brainstem, and anterior cells of the spinal cord. |
2013-12-11 |
2023-08-12 |
human |
| Letizia Mazzini, Alessandro Vercelli, Ivana Ferrero, Marina Boido, Roberto Cantello, Franca Fagiol. Transplantation of mesenchymal stem cells in ALS. Progress in brain research. vol 201. 2013-11-15. PMID:23186722. |
amyotrophic lateral sclerosis (als) is a devastating incurable, neurodegenerative disease that targets motor neurons (mns) in the primary motor cortex, brainstem, and spinal cord, leading to muscle atrophy, paralysis, and death due to respiratory failure within 2-5 years. |
2013-11-15 |
2023-08-12 |
Not clear |
| Ramón Palacios Bote, M A Fernández-Gi. Degeneration of the brainstem. Seminars in ultrasound, CT, and MR. vol 34. issue 2. 2013-09-19. PMID:23522779. |
magnetic resonance imaging (mri) is the most sensitive imaging technique for assessing brainstem involvement in neurodegenerative diseases. |
2013-09-19 |
2023-08-12 |
Not clear |
| Ramón Palacios Bote, M A Fernández-Gi. Degeneration of the brainstem. Seminars in ultrasound, CT, and MR. vol 34. issue 2. 2013-09-19. PMID:23522779. |
our purpose is to describe the neurodegenerative diseases that predominantly affect the brainstem highlighting the imaging findings most useful for diagnosis. |
2013-09-19 |
2023-08-12 |
Not clear |
| Thomas Polak, Daniel Zeller, Andreas J Fallgatter, Florian G Metzge. Vagus somatosensory-evoked potentials are prolonged in patients with multiple sclerosis with brainstem involvement. Neuroreport. vol 24. issue 5. 2013-09-05. PMID:23407276. |
we now aimed at a further confirmation of this view independent from neurodegenerative diseases and hypothesized that vsep in multiple sclerosis with brainstem affection show prolonged latencies, too. |
2013-09-05 |
2023-08-12 |
Not clear |
| Thomas Polak, Daniel Zeller, Andreas J Fallgatter, Florian G Metzge. Vagus somatosensory-evoked potentials are prolonged in patients with multiple sclerosis with brainstem involvement. Neuroreport. vol 24. issue 5. 2013-09-05. PMID:23407276. |
the method could be suitable for the demonstration of the involvement of differential brainstem nuclei in various neurodegenerative diseases. |
2013-09-05 |
2023-08-12 |
Not clear |
| Hui Sun, Sarah Knippenberg, Nadine Thau, Daniela Ragancokova, Sonja Körner, Dongya Huang, Reinhard Dengler, Klaus Döhler, Susanne Petr. Therapeutic potential of N-acetyl-glucagon-like peptide-1 in primary motor neuron cultures derived from non-transgenic and SOD1-G93A ALS mice. Cellular and molecular neurobiology. vol 33. issue 3. 2013-09-04. PMID:23271639. |
amyotrophic lateral sclerosis (als) is a fatal neurodegenerative disease characterized by the death of motor neurons (mn) in the motor cortex, brain stem, and spinal cord. |
2013-09-04 |
2023-08-12 |
mouse |
| Christian Lambert, Rumana Chowdhury, Thomas H B Fitzgerald, Stephen M Fleming, Antoine Lutti, Chloe Hutton, Bogdan Draganski, Richard Frackowiak, John Ashburne. Characterizing aging in the human brainstem using quantitative multimodal MRI analysis. Frontiers in human neuroscience. vol 7. 2013-08-23. PMID:23970860. |
this study provides detailed quantitative analysis of the internal architecture of the brainstem and provides a baseline for further studies of neurodegenerative diseases that are characterized by early, pre-clinical involvement of the brainstem, such as parkinson's and alzheimer's diseases. |
2013-08-23 |
2023-08-12 |
human |
| Guan-Ting Liu, Chi-Shin Hwang, Chia-Hung Hsieh, Chih-Hao Lu, Sunny Li-Yun Chang, Jin-Ching Lee, Chien-Fu Huang, Hao-Teng Chan. Eosinophil-derived neurotoxin is elevated in patients with amyotrophic lateral sclerosis. Mediators of inflammation. vol 2013. 2013-08-19. PMID:23533305. |
amyotrophic lateral sclerosis (als) is a progressive neurodegenerative disease characterized by loss of motor neurons in the brainstem, motor cortex, and spinal cord. |
2013-08-19 |
2023-08-12 |
Not clear |
| Hulya Erbagci, Munevver Keser, Selim Kervancioglu, Nese Kizilka. Estimation of the brain stem volume by stereological method on magnetic resonance imaging. Surgical and radiologic anatomy : SRA. vol 34. issue 9. 2013-05-20. PMID:22526167. |
neuron loss that occurs in some neurodegenerative diseases can lead to volume alterations by causing atrophy in the brain stem. |
2013-05-20 |
2023-08-12 |
human |
| Hulya Erbagci, Munevver Keser, Selim Kervancioglu, Nese Kizilka. Estimation of the brain stem volume by stereological method on magnetic resonance imaging. Surgical and radiologic anatomy : SRA. vol 34. issue 9. 2013-05-20. PMID:22526167. |
as a result, we believe that the measurement of brain stem volume with an objective and efficient calculation method will contribute to the early diagnosis of neurodegenerative diseases, as well as to determine the rate of disease progression, and the outcomes of treatment. |
2013-05-20 |
2023-08-12 |
human |
| Ruojia Li, Rachel Strykowski, Michael Meyer, Patrick Mulcrone, Dan Krakora, Masatoshi Suzuk. Male-specific differences in proliferation, neurogenesis, and sensitivity to oxidative stress in neural progenitor cells derived from a rat model of ALS. PloS one. vol 7. issue 11. 2013-04-24. PMID:23144905. |
amyotrophic lateral sclerosis (als) is a fatal neurodegenerative disease characterized by progressive motor dysfunction and the loss of large motor neurons in the spinal cord and brain stem. |
2013-04-24 |
2023-08-12 |
rat |
| Heiko Braak, Dietmar Rudolf Thal, Jakob Matschke, Estifanos Ghebremedhin, Kelly Del Tredic. Age-related appearance of dendritic inclusions in catecholaminergic brainstem neurons. Neurobiology of aging. vol 34. issue 1. 2013-04-23. PMID:22503003. |
our results reveal a hitherto unknown alteration within specific neuronal types of the human brainstem that may be independent of the sequestosome-ubiquitin-proteasomal pathway and unrelated to proteinaceous aggregate-formation of neurodegenerative diseases. |
2013-04-23 |
2023-08-12 |
human |
| L R Herron, G B Mile. Gender-specific perturbations in modulatory inputs to motoneurons in a mouse model of amyotrophic lateral sclerosis. Neuroscience. vol 226. 2013-04-22. PMID:23000617. |
the fatal neurodegenerative disease amyotrophic lateral sclerosis (als) is characterised by loss of motoneurons of the brainstem and spinal cord, and corticospinal neurons of the motor cortex. |
2013-04-22 |
2023-08-12 |
mouse |