| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tyler Saunders, Ciaran Gunn, Kaj Blennow, Hlin Kvartsberg, Henrik Zetterberg, Susan D Shenkin, Simon R Cox, Ian J Deary, Colin Smith, Declan King, Tara Spires-Jone. Neurogranin in Alzheimer's disease and ageing: A human post-mortem study. Neurobiology of disease. 2023-01-09. PMID:36623608. |
ng levels were quantified in three brain regions associated with cognitive change found during ageing and neurodegenerative diseases, namely the middle temporal gyrus, primary visual cortex and the posterior hippocampus using immunohistochemistry. |
2023-01-09 |
2023-08-14 |
human |
| Liyang Guo, Kirstin M Reed, Ashley Carter, Yan Cheng, Soheil Kazemi Roodsari, Damian Martinez Pineda, Laurie L Wellman, Larry D Sanford, Ming-Lei Gu. Sleep-Disturbance-Induced Microglial Activation Involves CRH-Mediated Galectin 3 and Autophagy Dysregulation. Cells. vol 12. issue 1. 2023-01-08. PMID:36611953. |
these findings suggest that targeting the hippocampal crh system might be a novel therapeutic approach to ameliorate csd-mediated neuroinflammation and neurodegenerative diseases. |
2023-01-08 |
2023-08-14 |
mouse |
| Young-Kook Kim, Yoon Seok Jung, Juhyun Son. Transcriptome Profile in the Mouse Brain of Hepatic Encephalopathy and Alzheimer's Disease. International journal of molecular sciences. vol 24. issue 1. 2023-01-08. PMID:36614117. |
alzheimer's disease (ad), the most common neurodegenerative disease, is characterized by tau hyperphosphorylation, excessive amyloid beta (aβ) accumulation, the formation of fibrillary tangles, hippocampus atrophy, and neuroinflammation. |
2023-01-08 |
2023-08-14 |
mouse |
| Emma L Twait, Kim Blom, Huiberdina L Koek, Maarten H T Zwartbol, Rashid Ghaznawi, Jeroen Hendrikse, Lotte Gerritsen, Mirjam I Geerling. Psychosocial factors and hippocampal subfields: The Medea-7T study. Human brain mapping. 2022-12-30. PMID:36583397. |
specific subfields within the hippocampus have shown vulnerability to chronic stress, highlighting the importance of looking regionally within the hippocampus to understand the role of psychosocial factors in the development of neurodegenerative diseases. |
2022-12-30 |
2023-08-14 |
human |
| Aftab Bakhtiari, Mark B Vestergaard, Krisztina Benedek, Birgitte Fagerlund, Erik Lykke Mortensen, Merete Osler, Martin Lauritzen, Henrik B W Larsson, Ulrich Lindber. Changes in hippocampal volume during a preceding 10-year period do not correlate with cognitive performance and hippocampal blood‒brain barrier permeability in cognitively normal late-middle-aged men. GeroScience. 2022-12-19. PMID:36534276. |
hippocampal blood-brain barrier (bbb) permeability may increase in normal healthy ageing and contribute to neurodegenerative disease. |
2022-12-19 |
2023-08-14 |
human |
| Ayla Batu Öztürk, Nail Can Öztürk, Furkan Aya. Conditioned media of mouse macrophages modulates neuronal dynamics in mouse hippocampal cells. International immunopharmacology. vol 114. 2022-12-16. PMID:36525792. |
many neurodegenerative diseases display both neuroinflammation and impaired neuron production in hippocampus. |
2022-12-16 |
2023-08-14 |
mouse |
| Christopher D Abraham, Stephanie L Pugh, Joseph A Bovi, Vinai Gondi, Minesh P Mehta, Tammie Benzinger, Christopher J Owen, Simon S Lo, Vijayananda Kundapur, Paul D Brown, Alexander Y Sun, Steven P Howard, Albert S DeNittis, Clifford G Robinson, Lisa A Kachni. Association of Pretreatment Hippocampal Volume With Neurocognitive Function in Patients Treated With Hippocampal Avoidance Whole Brain Radiation Therapy for Brain Metastases: Secondary Analysis of NRG Oncology/RTOG 0933. Advances in radiation oncology. vol 7. issue 6. 2022-11-24. PMID:36420209. |
hippocampal volume (hv) is an established predicting factor for neurocognitive function (ncf) in neurodegenerative disease. |
2022-11-24 |
2023-08-14 |
Not clear |
| Felipe Cabral-Miranda, Giovanni Tamburini, Gabriela Martinez, Alvaro O Ardiles, Danilo B Medinas, Yannis Gerakis, Mei-Li Diaz Hung, René Vidal, Matias Fuentealba, Tim Miedema, Claudia Duran-Aniotz, Javier Diaz, Cristobal Ibaceta-Gonzalez, Carleen M Sabusap, Francisca Bermedo-Garcia, Paula Mujica, Stuart Adamson, Kaitlyn Vitangcol, Hernan Huerta, Xu Zhang, Tomohiro Nakamura, Sergio Pablo Sardi, Stuart A Lipton, Brian K Kennedy, Juan Pablo Henriquez, J Cesar Cárdenas, Lars Plate, Adrian G Palacios, Claudio Het. Unfolded protein response IRE1/XBP1 signaling is required for healthy mammalian brain aging. The EMBO journal. 2022-10-31. PMID:36314651. |
proteomic profiling of hippocampal tissue showed that xbp1 expression significantly restore changes associated with aging, including factors associated with synaptic function and pathways linked to neurodegenerative diseases. |
2022-10-31 |
2023-08-14 |
mouse |
| Liang Yu, Jiajia Wang, Ying Xia, Wugang Hou, Xi Yao, Yaru Guo, Jin Wang, Haidong Wei, Shiquan Wan. Adiponectin Promotes Neurogenesis After Transient Cerebral Ischemia Through STAT3 Mediated BDNF Upregulation in Astrocytes. Neurochemical research. 2022-10-31. PMID:36315369. |
adiponectin could increase neurogenesis in the dentate gyrus of hippocampus in neurodegenerative diseases. |
2022-10-31 |
2023-08-14 |
mouse |
| Marta Kot, Pawan Kumar Neglur, Anna Pietraszewska, Leonora Buzansk. Boosting Neurogenesis in the Adult Hippocampus Using Antidepressants and Mesenchymal Stem Cells. Cells. vol 11. issue 20. 2022-10-27. PMID:36291101. |
however, dysregulation of hippocampal neurogenesis with aging, injury, depression and neurodegenerative disease leads to debilitating cognitive impacts. |
2022-10-27 |
2023-08-14 |
human |
| Yarlagadda Anusha-Kiran, Praseeda Mol, Gourav Dey, Firdous Ahmad Bhat, Oishi Chatterjee, Sayali Chandrasekhar Deolankar, Mariamma Phillip, T S Keshava Prasad, M M Srinivas Bharath, Anita Mahadeva. Regional heterogeneity in mitochondrial function underlies region specific vulnerability in human brain ageing: Implications for neurodegeneration. Free radical biology & medicine. 2022-10-04. PMID:36195160. |
selective neuronal vulnerability (snv) of specific neuroanatomical regions such as frontal cortex (fc) and hippocampus (hc) is characteristic of age-associated neurodegenerative diseases (ndds), although its pathogenetic basis remains unresolved. |
2022-10-04 |
2023-08-14 |
human |
| Li Qi, Xiao Li, Shi-Min Liu, Dan-Li Jiao, Dan Hu, Xin-Yao Ju, Shu-Yu Zhao, Shu-Han Si, Li Hu, Guo-Na Li, Bing-Zhe Ma, Shuang Zhou, Chen Zha. Identification of a hippocampal lncRNA-regulating network in a natural aging rat model. BMC neuroscience. vol 23. issue 1. 2022-09-28. PMID:36171542. |
dysregulation of long noncoding rna (lncrna) expression is related to aging and age-associated neurodegenerative diseases, and the lncrna expression profile in the aging hippocampus is not well characterized. |
2022-09-28 |
2023-08-14 |
rat |
| Hongbo Xu, Yan Liu, Xiangzhu Zeng, Ling Wang, Zeng Wan. A Multi-scale Attention-based Convolutional Network for Identification of Alzheimer's Disease based on Hippocampal Subfields. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. vol 2022. 2022-09-10. PMID:36086425. |
the proposed method will be useful for further medical analysis on hippocampal subfields of the brain for diagnosis of neurodegenerative disease. |
2022-09-10 |
2023-08-14 |
Not clear |
| Cristina Cachán-Vega, Ignacio Vega-Naredo, Yaiza Potes, Juan Carlos Bermejo-Millo, Adrian Rubio-González, Claudia García-González, Eduardo Antuña, Manuel Bermúdez, José Gutiérrez-Rodríguez, José Antonio Boga, Ana Coto-Montes, Beatriz Caballer. Chronic Treatment with Melatonin Improves Hippocampal Neurogenesis in the Aged Brain and Under Neurodegeneration. Molecules (Basel, Switzerland). vol 27. issue 17. 2022-09-09. PMID:36080336. |
adult hippocampal neurogenesis is altered during aging and under different neuropsychiatric and neurodegenerative diseases. |
2022-09-09 |
2023-08-14 |
mouse |
| Jiangong Wang, Bin Liu, Fengjiao Sun, Yong Xu, Haiyun Luan, Meizi Yang, Chaoyun Wang, Tiantian Zhang, Zhenyu Zhou, Haijing Ya. Histamine H3R antagonist counteracts the impaired hippocampal neurogenesis in Lipopolysaccharide-induced neuroinflammation. International immunopharmacology. vol 110. 2022-08-18. PMID:35978505. |
adult neurogenesis in hippocampus dentate gyrus (dg) is associated with numerous neurodegenerative diseases such as aging and alzheimer's disease (ad). |
2022-08-18 |
2023-08-14 |
mouse |
| Eriko Abe, Takashi J Fuwa, Kyoka Hoshi, Takashi Saito, Takenobu Murakami, Masakazu Miyajima, Norihiro Ogawa, Hiroyasu Akatsu, Yoshio Hashizume, Yasuhiro Hashimoto, Takashi Hond. Expression of Transferrin Protein and Messenger RNA in Neural Cells from Mouse and Human Brain Tissue. Metabolites. vol 12. issue 7. 2022-07-27. PMID:35888718. |
low tf level in the hippocampus may increases susceptibility to iron-induced oxidative stress, and account for neuron death in neurodegenerative diseases. |
2022-07-27 |
2023-08-14 |
mouse |
| Balaji Kannappan, Tamil Iniyan Gunasekaran, Jan Te Nijenhuis, Muthu Gopal, Deepika Velusami, Gugan Kothandan, Kun Ho Le. Polygenic score for Alzheimer's disease identifies differential atrophy in hippocampal subfield volumes. PloS one. vol 17. issue 7. 2022-07-13. PMID:35830443. |
hippocampal subfield atrophy is a prime structural change in the brain, associated with cognitive aging and neurodegenerative diseases such as alzheimer's disease. |
2022-07-13 |
2023-08-14 |
Not clear |
| Balaji Kannappan, Tamil Iniyan Gunasekaran, Jan Te Nijenhuis, Muthu Gopal, Deepika Velusami, Gugan Kothandan, Kun Ho Le. Polygenic score for Alzheimer's disease identifies differential atrophy in hippocampal subfield volumes. PloS one. vol 17. issue 7. 2022-07-13. PMID:35830443. |
discriminating the genetic predispositions of hippocampal subfield atrophy between cognitive aging and neurodegenerative diseases will be helpful in understanding the disease etiology. |
2022-07-13 |
2023-08-14 |
Not clear |
| Maya A Hanspal, Sébastien Gilloti. A new age in understanding adult hippocampal neurogenesis in Alzheimer's disease. Neural regeneration research. vol 17. issue 12. 2022-06-06. PMID:35662190. |
in this review, we discuss how the recent progress in identifying molecular pathways in adult hippocampal neurogenesis provides a good framework to initiate strategies for drug-based intervention in neurodegenerative diseases, especially in alzheimer's disease. |
2022-06-06 |
2023-08-14 |
human |
| Md Ataur Rahman, M D Hasanur Rahman, A N M Mamun-Or-Rashid, Hongik Hwang, Sooyoung Chung, Bonglee Kim, Hyewhon Rhi. Autophagy Modulation in Aggresome Formation: Emerging Implications and Treatments of Alzheimer's Disease. Biomedicines. vol 10. issue 5. 2022-05-28. PMID:35625764. |
alzheimer's disease (ad) is one of the most prevailing neurodegenerative diseases in the world, which is characterized by memory dysfunction and the formation of tau and amyloid β (aβ) aggregates in multiple brain regions, including the hippocampus and cortex. |
2022-05-28 |
2023-08-13 |
Not clear |