| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Terreros-Roncal, E P Moreno-Jiménez, M Flor-García, C B Rodríguez-Moreno, M F Trinchero, F Cafini, A Rábano, M Llorens-Martí. Impact of neurodegenerative diseases on human adult hippocampal neurogenesis. Science (New York, N.Y.). vol 374. issue 6571. 2021-12-02. PMID:34672693. |
impact of neurodegenerative diseases on human adult hippocampal neurogenesis. |
2021-12-02 |
2023-08-13 |
human |
| Niki Esfahanian, Morgan Nelson, Rebecca Autenried, J Scott Pattison, Eduardo Callegari, Khosrow Rezvan. Comprehensive Analysis of Proteasomal Complexes in Mouse Brain Regions Detects ENO2 as a Potential Partner of the Proteasome in the Striatum. Cellular and molecular neurobiology. 2021-11-28. PMID:34037901. |
using neuronal cell cultures and brain tissues obtained from mice, we compared proteasomal activities from two distinct brain regions affected in neurodegenerative diseases, the striatum and the hippocampus. |
2021-11-28 |
2023-08-13 |
mouse |
| Caitlin Fowler, Dana Goerzen, Dan Madularu, Gabriel A Devenyi, M Mallar Chakravarty, Jamie Nea. Longitudinal characterization of neuroanatomical changes in the Fischer 344 rat brain during normal aging and between sexes. Neurobiology of aging. vol 109. 2021-11-26. PMID:34775212. |
we identified the greatest vulnerability to aging within the cortex, caudoputamen, hindbrain, and internal capsule, while the influence of sex was strongest in the caudoputamen, hippocampus, nucleus accumbens, and thalamus, many of which are implicated in memory and motor control circuits frequently affected by aging and neurodegenerative disease. |
2021-11-26 |
2023-08-13 |
rat |
| Lech Kaczmarczyk, Nicole Reichenbach, Nelli Blank, Maria Jonson, Lars Dittrich, Gabor C Petzold, Walker S Jackso. Slc1a3-2A-CreERT2 mice reveal unique features of Bergmann glia and augment a growing collection of Cre drivers and effectors in the 129S4 genetic background. Scientific reports. vol 11. issue 1. 2021-11-22. PMID:33686166. |
we found that calcium signals lasted longer and had a higher amplitude in cortical compared to hippocampal astrocytes, genes linked to a single neurodegenerative disease have highly divergent expression patterns, and that ribosome proteins are non-uniformly expressed across brain regions and cell types. |
2021-11-22 |
2023-08-13 |
mouse |
| Candice M Roux, Marianne Leger, Thomas Frere. Memory Disorders Related to Hippocampal Function: The Interest of 5-HT International journal of molecular sciences. vol 22. issue 21. 2021-11-18. PMID:34769511. |
multilevel alterations of hippocampal function have been identified as a common denominator of memory impairments in a number of psychiatric and neurodegenerative diseases. |
2021-11-18 |
2023-08-13 |
Not clear |
| Nasrin Hashemi-Firouzi, Siamak Shahidi, Sara Soleimani As. Chronic stimulation of the serotonergic 5-HT4 receptor modulates amyloid-beta-related impairments in synaptic plasticity and memory deficits in male rats. Brain research. vol 1773. 2021-11-12. PMID:34695393. |
alzheimer's disease (ad) is a neurodegenerative disease characterized by memory decline and impaired hippocampal synaptic plasticity. |
2021-11-12 |
2023-08-13 |
rat |
| Hui Zhang, Jiaming Li, Jie Ren, Shuhui Sun, Shuai Ma, Weiqi Zhang, Yang Yu, Yusheng Cai, Kaowen Yan, Wei Li, Baoyang Hu, Piu Chan, Guo-Guang Zhao, Juan Carlos Izpisua Belmonte, Qi Zhou, Jing Qu, Si Wang, Guang-Hui Li. Single-nucleus transcriptomic landscape of primate hippocampal aging. Protein & cell. vol 12. issue 9. 2021-11-01. PMID:34052996. |
the hippocampus plays a crucial role in learning and memory, and its progressive deterioration with age is functionally linked to a variety of human neurodegenerative diseases. |
2021-11-01 |
2023-08-13 |
human |
| Hui Zhang, Jiaming Li, Jie Ren, Shuhui Sun, Shuai Ma, Weiqi Zhang, Yang Yu, Yusheng Cai, Kaowen Yan, Wei Li, Baoyang Hu, Piu Chan, Guo-Guang Zhao, Juan Carlos Izpisua Belmonte, Qi Zhou, Jing Qu, Si Wang, Guang-Hui Li. Single-nucleus transcriptomic landscape of primate hippocampal aging. Protein & cell. vol 12. issue 9. 2021-11-01. PMID:34052996. |
this rich resource for understanding primate hippocampal aging may provide potential diagnostic biomarkers and therapeutic interventions against age-related neurodegenerative diseases. |
2021-11-01 |
2023-08-13 |
human |
| Chanin Sillapachaiyaporn, Panthakarn Rangsinth, Sunita Nilkhet, Alison T Ung, Siriporn Chuchawankul, Tewin Tencomna. Neuroprotective Effects against Glutamate-Induced HT-22 Hippocampal Cell Damage and Pharmaceuticals (Basel, Switzerland). vol 14. issue 10. 2021-10-26. PMID:34681226. |
neuroprotective effects against glutamate-induced ht-22 hippocampal cell damage and oxidative stress is associated with several diseases, particularly neurodegenerative diseases, commonly found in the elderly. |
2021-10-26 |
2023-08-13 |
Not clear |
| Jiangxia Ni, Yongfei Ren, Tonghui Su, Jia Zhou, Chaoying Fu, Yi Lu, De'an Li, Jing Zhao, Yunxia Li, Yaoyang Zhang, Yanshan Fang, Nan Liu, Yang Geng, Yelin Che. Loss of TDP-43 function underlies hippocampal and cortical synaptic deficits in TDP-43 proteinopathies. Molecular psychiatry. 2021-10-26. PMID:34697451. |
tdp-43 proteinopathy is linked to neurodegenerative diseases that feature synaptic loss in the cortex and hippocampus, although it remains unclear how tdp-43 regulates mature synapses. |
2021-10-26 |
2023-08-13 |
mouse |
| Katerina Placek, Michael Benatar, Joanne Wuu, Evadnie Rampersaud, Laura Hennessy, Vivianna M Van Deerlin, Murray Grossman, David J Irwin, Lauren Elman, Leo McCluskey, Colin Quinn, Volkan Granit, Jeffrey M Statland, Ted M Burns, John Ravits, Andrea Swenson, Jon Katz, Erik P Pioro, Carlayne Jackson, James Caress, Yuen So, Samuel Maiser, David Walk, Edward B Lee, John Q Trojanowski, Philip Cook, James Gee, Jin Sha, Adam C Naj, Rosa Rademakers, Wenan Chen, Gang Wu, J Paul Taylor, Corey T McMilla. Machine learning suggests polygenic risk for cognitive dysfunction in amyotrophic lateral sclerosis. EMBO molecular medicine. vol 13. issue 1. 2021-10-22. PMID:33270986. |
we demonstrate that a polygenic risk score derived using scca relates to longitudinal cognitive decline in the same cohort and also to in vivo cortical thinning in the orbital frontal cortex, anterior cingulate cortex, lateral temporal cortex, premotor cortex, and hippocampus (n = 90) as well as post-mortem motor cortical neuronal loss (n = 87) in independent als cohorts from the university of pennsylvania integrated neurodegenerative disease biobank. |
2021-10-22 |
2023-08-13 |
Not clear |
| Jessica D Panes, Aline Wendt, Oscar Ramirez-Molina, Patricio A Castro, Jorge Fuentealb. Deciphering the role of PGC-1α in neurological disorders: from mitochondrial dysfunction to synaptic failure. Neural regeneration research. vol 17. issue 2. 2021-10-22. PMID:34269182. |
in fact, pgc-1α downregulation in different brain areas (hippocampus, substantia nigra, cortex, striatum and spinal cord) that occurs in function of neurological damage including oxidative stress, neuronal loss, and motor disorders has been seen in several animal and cellular models of neurodegenerative diseases. |
2021-10-22 |
2023-08-13 |
mouse |
| Xintong Wang, Zixu Wang, Jing Cao, Yulan Dong, Yaoxing Che. Ferroptosis Mechanisms Involved in Hippocampal-Related Diseases. International journal of molecular sciences. vol 22. issue 18. 2021-10-22. PMID:34576065. |
damage of hippocampal structure and function are intimately involved in the pathogenic mechanisms underlying neurodegenerative diseases. |
2021-10-22 |
2023-08-13 |
Not clear |
| Yuqing Shen, Jianqiong Zhan. Tight Regulation of Major Histocompatibility Complex I for the Spatial and Temporal Expression in the Hippocampal Neurons. Frontiers in cellular neuroscience. vol 15. 2021-10-22. PMID:34658795. |
with this review, we aim to facilitate a deeper mechanistic understanding into the complex tight regulation of mhc i expression in hippocampus, which are needed as we explore the potential for targeting mhc i for therapeutic intervention in normal aging and in neurodegenerative diseases in the future. |
2021-10-22 |
2023-08-13 |
Not clear |
| Christian Ansgar Hundahl, Jan Fahrenkrug, Jens Hanniba. Neurochemical phenotype of cytoglobin-expressing neurons in the rat hippocampus. Biomedical reports. vol 2. issue 5. 2021-10-21. PMID:25054000. |
the rat hippocampus was chosen due to the abundance of cygb, as well as this limbic structure being an important target in a number of neurodegenerative diseases. |
2021-10-21 |
2023-08-13 |
rat |
| Jiachen Du, Peipeng Liang, Hongjian He, Qiqi Tong, Ting Gong, Tianyi Qian, Yi Sun, Jianhui Zhong, Kuncheng L. Reproducibility of volume and asymmetry measurements of hippocampus, amygdala, and entorhinal cortex on traveling volunteers: a multisite MP2RAGE prospective study. Acta radiologica (Stockholm, Sweden : 1987). vol 62. issue 10. 2021-10-18. PMID:33121264. |
understanding the reproducibility of the parameters of related brain structures-including the hippocampus, amygdala, and entorhinal cortex-in multisite studies is crucial in determining the impact of healthy aging or neurodegenerative diseases. |
2021-10-18 |
2023-08-13 |
human |
| Li-Ling He, Yun-Cui Wang, Ya-Ting Ai, Ling Wang, Si-Meng Gu, Ping Wang, Qing-Hua Long, Hui H. Qiangji Decoction Alleviates Neurodegenerative Changes and Hippocampal Neuron Apoptosis Induced by D-Galactose Frontiers in pharmacology. vol 12. 2021-10-12. PMID:34630111. |
qiangji decoction alleviates neurodegenerative changes and hippocampal neuron apoptosis induced by d-galactose qiangji decoction (qjd), a classic formula, has been widely used to treat brain aging-related neurodegenerative diseases. |
2021-10-12 |
2023-08-13 |
mouse |
| Dalia A Mandour, M A Bendary, Amira E Alseme. Histological and imunohistochemical alterations of hippocampus and prefrontal cortex in a rat model of Alzheimer like-disease with a preferential role of the flavonoid "hesperidin". Journal of molecular histology. vol 52. issue 5. 2021-10-04. PMID:34170456. |
alzheimer's disease (ad) is a chronic age-related neurodegenerative disease characterized by degeneration of the central cholinergic neurons, inflammation and oxidative stress in the basal forebrain, prefrontal cortex and hippocampus. |
2021-10-04 |
2023-08-13 |
rat |
| Corey D M Fulton, David W C Beasley, Dennis A Bente, Kelly T Dinele. Long-term, West Nile virus-induced neurological changes: A comparison of patients and rodent models. Brain, behavior, & immunity - health. vol 7. 2021-10-01. PMID:34589866. |
initial infection in the hippocampus leads to neuronal dysfunction, synapse elimination, and astrocytosis, all of which contribute to memory loss, mimicking findings in neurodegenerative diseases such as alzheimer's disease (ad) and parkinson's disease (pd). |
2021-10-01 |
2023-08-13 |
human |
| Cindy Santiago-Castañeda, Marysol Segovia-Oropeza, Luis Concha, Sandra Adela Orozco-Suárez, Luisa Roch. Propylparaben Reduces the Long-Term Consequences in Hippocampus Induced by Traumatic Brain Injury in Rats: Its Implications as Therapeutic Strategy to Prevent Neurodegenerative Diseases. Journal of Alzheimer's disease : JAD. vol 82. issue s1. 2021-09-23. PMID:33185606. |
propylparaben reduces the long-term consequences in hippocampus induced by traumatic brain injury in rats: its implications as therapeutic strategy to prevent neurodegenerative diseases. |
2021-09-23 |
2023-08-13 |
rat |