| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J P Roperch, V Alvaro, S Prieur, M Tuynder, M Nemani, F Lethrosne, L Piouffre, M C Gendron, D Israeli, J Dausset, M Oren, R Amson, A Telerma. Inhibition of presenilin 1 expression is promoted by p53 and p21WAF-1 and results in apoptosis and tumor suppression. Nature medicine. vol 4. issue 7. 1999-04-07. PMID:9662377. |
previously, we cloned a cdna fragment, tsip 2 (tumor suppressor inhibited pathway clone 2), that detects by northern blot analysis of m1-ltr6 cells a 3-kb mrna downregulated during p53-induced apoptosis. |
1999-04-07 |
2023-08-12 |
mouse |
| M Podhorska-Okolow, M Sandri, S Zampieri, B Brun, K Rossini, U Carrar. Apoptosis of myofibres and satellite cells: exercise-induced damage in skeletal muscle of the mouse. Neuropathology and applied neurobiology. vol 24. issue 6. 1999-03-31. PMID:9888162. |
groups of five mice were sacrificed immediately after the end of the exercise, and after a rest period of 6 or 96 h. the amount of apoptosis in leg muscles was assessed by electron microscopy, by the terminal deoxynucleotidyl transferase assay and by electrophoretic detection of fragmented dna; the expression of bcl-2, bax, fas, ice, p53 and ubiquitin was examined by immunohistochemistry and western blot. |
1999-03-31 |
2023-08-12 |
mouse |
| F Sirzén, B Zhivotovsky, A Nilsson, J Bergh, R Lewensoh. Higher spontaneous apoptotic index in small cell compared with non-small cell lung carcinoma cell lines; lack of correlation with Bcl-2/Bax. Lung cancer (Amsterdam, Netherlands). vol 22. issue 1. 1999-03-15. PMID:9869102. |
important molecular determinants of apoptosis were studied by western blot. |
1999-03-15 |
2023-08-12 |
Not clear |
| R Araya, T Uehara, Y Nomur. Hypoxia induces apoptosis in human neuroblastoma SK-N-MC cells by caspase activation accompanying cytochrome c release from mitochondria. FEBS letters. vol 439. issue 1-2. 1998-12-23. PMID:9849900. |
to confirm the involvement of caspase-3 during apoptosis, western blot analysis was performed using anti-caspase-3 antibody. |
1998-12-23 |
2023-08-12 |
human |
| S B Goodman, K Kugu, S H Chen, S Preutthipan, K I Tilly, J L Tilly, A M Dharmaraja. Estradiol-mediated suppression of apoptosis in the rabbit corpus luteum is associated with a shift in expression of bcl-2 family members favoring cellular survival. Biology of reproduction. vol 59. issue 4. 1998-12-07. PMID:9746731. |
northern blot analysis revealed an increase in bax mrna levels and a decrease in bcl-x mrna levels coincident with luteal cell apoptosis induced by estradiol withdrawal. |
1998-12-07 |
2023-08-12 |
rabbit |
| H C Toh, L Sun, C H Koh, S E A. Vinorelbine induces apoptosis and caspase-3 (CPP32) expression in leukemia and lymphoma cells: a comparison with vincristine. Leukemia & lymphoma. vol 31. issue 1-2. 1998-11-17. PMID:9720729. |
by western blot analysis, we demonstrated that cpp32 or caspase-3, a critical apoptosis inducer, and its active subunits p20 and p11 were upregulated in chemo- and apoptosis-sensitive lymphoma and leukemia cells treated with nvb. |
1998-11-17 |
2023-08-12 |
Not clear |
| Y Akao, H Mizoguchi, S Kojima, T Naoe, N Ohishi, K Yag. Arsenic induces apoptosis in B-cell leukaemic cell lines in vitro: activation of caspases and down-regulation of Bcl-2 protein. British journal of haematology. vol 102. issue 4. 1998-10-16. PMID:9734658. |
the arsenic-induced apoptosis in kocl44 and lyh7 cells was found to be linked to caspases by western blot and enzymological analyses. |
1998-10-16 |
2023-08-12 |
drosophila_melanogaster |
| Y Akao, H Mizoguchi, S Kojima, T Naoe, N Ohishi, K Yag. Arsenic induces apoptosis in B-cell leukaemic cell lines in vitro: activation of caspases and down-regulation of Bcl-2 protein. British journal of haematology. vol 102. issue 4. 1998-10-16. PMID:9734658. |
the amount of bcl-2 was reduced during apoptosis in lyh7 as judged by western blot analysis. |
1998-10-16 |
2023-08-12 |
drosophila_melanogaster |
| T Mukhopadhyay, J A Rot. Superinduction of wild-type p53 protein after 2-methoxyestradiol treatment of Ad5p53-transduced cells induces tumor cell apoptosis. Oncogene. vol 17. issue 2. 1998-08-06. PMID:9674709. |
treating these cells with 2-meoe2 resulted in superinduction of wt p53 protein expression followed by apoptosis, as shown by terminal deoxynucleotidyl transferase (tdt) staining, and upregulation of wt p53 expression, as shown by western blot analysis. |
1998-08-06 |
2023-08-12 |
human |
| K Erkkilä, V Hirvonen, E Wuokko, M Parvinen, L Dunke. N-acetyl-L-cysteine inhibits apoptosis in human male germ cells in vitro. The Journal of clinical endocrinology and metabolism. vol 83. issue 7. 1998-07-29. PMID:9661638. |
this apoptosis, detected by southern blot analysis of dna fragmentation, by dna labeling in situ, and by morphological analysis under the electron microscope, was significantly inhibited by testosterone at concentrations of 10(-6) and 10(-7) mol/l. |
1998-07-29 |
2023-08-12 |
human |
| H Yamaguchi, H Ukita, H Murakami, S Chiba, Y Oshima, A Ogata, M Ikeda, A Matsumoto, A Satone, W Ide, I Hashimoto, H Kamad. [Induction of apoptosis through NGF/p75NTR in human glioma cells treated with propentofylline]. No to shinkei = Brain and nerve. vol 50. issue 5. 1998-07-24. PMID:9621361. |
in the present study, to examine whether signal cascade via ngf/p75ntr participates the apoptosis in human glioma cells treated with ppf, we investigated the immunohistochemical study using anti-mouse monoclonal antibody, immunoprecipitation and northern blot analysis for p75ntr, nf-kappa b in human glioma cells (u251mg, t98g, u87) treated with ppf. |
1998-07-24 |
2023-08-12 |
human |
| S Pervaiz, J L Hirpara, M V Clémen. Caspase proteases mediate apoptosis induced by anticancer agent preactivated MC540 in human tumor cell lines. Cancer letters. vol 128. issue 1. 1998-07-10. PMID:9652788. |
western blot analysis of poly (adp-ribose) polymerase, a caspase substrate, showed the classical cleavage pattern (116 to 89 kda) associated with apoptosis in pmc540-treated cell lysates. |
1998-07-10 |
2023-08-12 |
human |
| S D Lim, S I Bae, I G Kim, S C Park, S I Chung, M Nomizu, H K Kleinman, W H Ki. Tissue transglutaminase is not increased during apoptosis of HT-1080 human fibrosarcoma cells. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 50. issue 1. 1998-06-04. PMID:9570506. |
western blot analysis showed that the ttgase protein level did not change during this process of apoptosis. |
1998-06-04 |
2023-08-12 |
human |
| S R D'Mello, F Aglieco, M R Roberts, K Borodezt, J W Haycoc. A DEVD-inhibited caspase other than CPP32 is involved in the commitment of cerebellar granule neurons to apoptosis induced by K+ deprivation. Journal of neurochemistry. vol 70. issue 5. 1998-05-18. PMID:9572264. |
western blot analyses, however, failed to detect an increase in processing/activation of cpp32 or in the proteolysis of a cpp32 substrate, poly(adp-ribose) polymerase, during the induction of apoptosis in granule neurons. |
1998-05-18 |
2023-08-12 |
Not clear |
| C Gambacorti-Passerini, P le Coutre, L Mologni, M Fanelli, C Bertazzoli, E Marchesi, M Di Nicola, A Biondi, G M Corneo, D Belotti, E Pogliani, N B Lydo. Inhibition of the ABL kinase activity blocks the proliferation of BCR/ABL+ leukemic cells and induces apoptosis. Blood cells, molecules & diseases. vol 23. issue 3. 1998-03-24. PMID:9446752. |
the in vivo phosphorylation of the bcr/abl protein was evaluated by western blot, while apoptosis was detected by the annexin v/propidium binding test. |
1998-03-24 |
2023-08-12 |
Not clear |
| J H Gill, N H James, R A Roberts, C Div. The non-genotoxic hepatocarcinogen nafenopin suppresses rodent hepatocyte apoptosis induced by TGFbeta1, DNA damage and Fas. Carcinogenesis. vol 19. issue 2. 1998-03-24. PMID:9498280. |
western blot analysis did not support a role for either p53 or p21waf1 in etoposide-induced apoptosis in rat hepatocytes. |
1998-03-24 |
2023-08-12 |
mouse |
| K Sugimoto, K Yamada, M Egashira, Y Yazaki, H Hirai, A Kikuchi, K Oshim. Temporal and spatial distribution of DNA topoisomerase II alters during proliferation, differentiation, and apoptosis in HL-60 cells. Blood. vol 91. issue 4. 1998-03-03. PMID:9454772. |
western blot analysis confirmed that topo iibeta protein was completely degraded into smaller fragments and lost its c-terminal end during apoptosis. |
1998-03-03 |
2023-08-12 |
Not clear |
| S S Magal, A Jackman, X F Pei, R Schlegel, L Sherma. Induction of apoptosis in human keratinocytes containing mutated p53 alleles and its inhibition by both the E6 and E7 oncoproteins. International journal of cancer. vol 75. issue 1. 1998-01-22. PMID:9426696. |
reduced apoptosis in hacat cells expressing e6 or e7 also was observed after treatment with the alkylating agent mitomycin c. western blot analysis of p53 and p21/waf-1/cip-1, a downstream effector of p53, did not reveal any changes in the levels of these proteins after uvc irradiation in either hacat cells or hacat cells expressing hpv16 e6 or e7. |
1998-01-22 |
2023-08-12 |
human |
| Y Ishikawa, T Yokoo, M Kitamur. c-Jun/AP-1, but not NF-kappa B, is a mediator for oxidant-initiated apoptosis in glomerular mesangial cells. Biochemical and biophysical research communications. vol 240. issue 2. 1997-12-23. PMID:9388508. |
northern blot analysis and transient transfection assays using reporter plasmids showed that h2o2 activated both ap-1 and nf-kappa b. downregulation of c-jun/ap-1 using a transdominant negative mutant of c-jun, an antisense c-jun, or a pharmacologic inhibitor curcumin inhibited the h2o2-initiated apoptosis. |
1997-12-23 |
2023-08-12 |
Not clear |
| G C Gobé, J Halliday, I S Dunn, B V Harmon, E Schoch, S M Khan, D J Alla. Expression and localization of the retinoblastoma gene during radiation-induced apoptosis in neonatal rat kidney. Experimental cell research. vol 235. issue 2. 1997-10-16. PMID:9299159. |
we have used our knowledge of this model to analyze control (sham-treated) and irradiated renal tissue for rb mrna transcript levels and localization (northern blot and in situ hybridization (ish)), prb expression (western blot and immunolocalization), apoptosis and mitosis (light and electron microscopy, and dna gel electrophoresis for apoptosis), and cells in s-phase ([3h]thymidine uptake and autoradiography). |
1997-10-16 |
2023-08-12 |
rat |