| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dave J Hayes, Niall W Duncan, Jiameng Xu, Georg Northof. A comparison of neural responses to appetitive and aversive stimuli in humans and other mammals. Neuroscience and biobehavioral reviews. vol 45. 2015-04-16. PMID:25010558. |
ventromedial prefrontal cortex, ventral tegmental area) or aversive (e.g. |
2015-04-16 |
2023-08-13 |
human |
| Stephan Lammel, Elizabeth E Steinberg, Csaba Földy, Nicholas R Wall, Kevin Beier, Liqun Luo, Robert C Malenk. Diversity of transgenic mouse models for selective targeting of midbrain dopamine neurons. Neuron. vol 85. issue 2. 2015-03-24. PMID:25611513. |
ventral tegmental area (vta) dopamine (da) neurons have been implicated in reward, aversion, salience, cognition, and several neuropsychiatric disorders. |
2015-03-24 |
2023-08-13 |
mouse |
| Kelly Hennigan, Kimberlee D'Ardenne, Samuel M McClur. Distinct midbrain and habenula pathways are involved in processing aversive events in humans. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 1. 2015-03-20. PMID:25568114. |
robust activation to aversive relative to neutral events was observed in the habenula and two regions within the ventral midbrain: one located within the ventral tegmental area (vta) and the other in the substantia nigra (sn). |
2015-03-20 |
2023-08-13 |
Not clear |
| Kelly Hennigan, Kimberlee D'Ardenne, Samuel M McClur. Distinct midbrain and habenula pathways are involved in processing aversive events in humans. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 1. 2015-03-20. PMID:25568114. |
aversive processing increased functional connectivity between the vta and the habenula, putamen, and medial prefrontal cortex, whereas the sn exhibited a different pattern of functional connectivity. |
2015-03-20 |
2023-08-13 |
Not clear |
| Kelly Hennigan, Kimberlee D'Ardenne, Samuel M McClur. Distinct midbrain and habenula pathways are involved in processing aversive events in humans. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 1. 2015-03-20. PMID:25568114. |
our findings provide evidence for a network comprising the vta and sn, the habenula, and mesocorticolimbic structures that supports processing aversive events in humans. |
2015-03-20 |
2023-08-13 |
Not clear |
| David H Root, Carlos A Mejias-Aponte, Jia Qi, Marisela Morale. Role of glutamatergic projections from ventral tegmental area to lateral habenula in aversive conditioning. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 42. 2015-02-06. PMID:25319687. |
the ventral tegmental area (vta) plays roles in both reward and aversion. |
2015-02-06 |
2023-08-13 |
mouse |
| David H Root, Carlos A Mejias-Aponte, Jia Qi, Marisela Morale. Role of glutamatergic projections from ventral tegmental area to lateral habenula in aversive conditioning. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 42. 2015-02-06. PMID:25319687. |
we conclude that there is a glutamatergic signal from vta vglut2-mesohabenular neurons that plays a role in aversion by activating lhb glutamatergic receptors. |
2015-02-06 |
2023-08-13 |
mouse |
| Taryn E Grieder, Melissa A Herman, Candice Contet, Laura A Tan, Hector Vargas-Perez, Ami Cohen, Michal Chwalek, Geith Maal-Bared, John Freiling, Joel E Schlosburg, Laura Clarke, Elena Crawford, Pascale Koebel, Vez Repunte-Canonigo, Pietro P Sanna, Andrew R Tapper, Marisa Roberto, Brigitte L Kieffer, Paul E Sawchenko, George F Koob, Derek van der Kooy, Olivier Georg. VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation. Nature neuroscience. vol 17. issue 12. 2015-02-06. PMID:25402857. |
vta crf neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation. |
2015-02-06 |
2023-08-13 |
Not clear |
| Taryn E Grieder, Melissa A Herman, Candice Contet, Laura A Tan, Hector Vargas-Perez, Ami Cohen, Michal Chwalek, Geith Maal-Bared, John Freiling, Joel E Schlosburg, Laura Clarke, Elena Crawford, Pascale Koebel, Vez Repunte-Canonigo, Pietro P Sanna, Andrew R Tapper, Marisa Roberto, Brigitte L Kieffer, Paul E Sawchenko, George F Koob, Derek van der Kooy, Olivier Georg. VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation. Nature neuroscience. vol 17. issue 12. 2015-02-06. PMID:25402857. |
local downregulation of crh mrna and specific pharmacological blockade of crf1 receptors in the vta reversed the effect of nicotine on gabaergic input to dopaminergic neurons, prevented the aversive effects of nicotine withdrawal and limited the escalation of nicotine intake. |
2015-02-06 |
2023-08-13 |
Not clear |
| S Fenu, E Espa, C Cadoni, G Di Chiar. Conditioned saccharin avoidance induced by infusion of amphetamine in the nucleus accumbens shell and morphine in the ventral tegmental area: behavioral and biochemical study. Behavioural brain research. vol 269. 2015-01-15. PMID:24780866. |
conditioned saccharin avoidance induced by infusion of amphetamine in the nucleus accumbens shell and morphine in the ventral tegmental area: behavioral and biochemical study. |
2015-01-15 |
2023-08-13 |
rat |
| David H Root, Carlos A Mejias-Aponte, Shiliang Zhang, Hui-Ling Wang, Alexander F Hoffman, Carl R Lupica, Marisela Morale. Single rodent mesohabenular axons release glutamate and GABA. Nature neuroscience. vol 17. issue 11. 2015-01-12. PMID:25242304. |
the lateral habenula (lhb) is involved in reward, aversion, addiction and depression through descending interactions with several brain structures, including the ventral tegmental area (vta). |
2015-01-12 |
2023-08-13 |
mouse |
| Elena Vashchinkina, Anne Panhelainen, Teemu Aitta-Aho, Esa R Korp. GABAA receptor drugs and neuronal plasticity in reward and aversion: focus on the ventral tegmental area. Frontiers in pharmacology. vol 5. 2014-12-16. PMID:25505414. |
gabaa receptor drugs and neuronal plasticity in reward and aversion: focus on the ventral tegmental area. |
2014-12-16 |
2023-08-13 |
Not clear |
| Elena Vashchinkina, Anne Panhelainen, Teemu Aitta-Aho, Esa R Korp. GABAA receptor drugs and neuronal plasticity in reward and aversion: focus on the ventral tegmental area. Frontiers in pharmacology. vol 5. 2014-12-16. PMID:25505414. |
the vta dopamine neurons project to forebrain centers such as the nucleus accumbens and medial prefrontal cortex, and receive afferent projections from these brain regions and especially from the extended amygdala and lateral habenula, forming the major part of the reward and aversion circuitry. |
2014-12-16 |
2023-08-13 |
Not clear |
| Miriam Melis, Claudia Sagheddu, Marta De Felice, Alberto Casti, Camilla Madeddu, Saturnino Spiga, Anna Lisa Muntoni, Kenneth Mackie, Giovanni Marsicano, Giancarlo Colombo, Maria Paola Castelli, Marco Pisti. Enhanced endocannabinoid-mediated modulation of rostromedial tegmental nucleus drive onto dopamine neurons in Sardinian alcohol-preferring rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 38. 2014-11-11. PMID:25232109. |
by inhibiting the activity of da neurons in the vta, gaba projections from the rostromedial tegmental nucleus (rmtg) are well suited to shift the balance between drug-induced reward and aversion. |
2014-11-11 |
2023-08-13 |
rat |
| Andrey E Ryabinin, Davelle L Cocking, Simranjit Kau. Inhibition of VTA neurons activates the centrally projecting Edinger-Westphal nucleus: evidence of a stress-reward link? Journal of chemical neuroanatomy. vol 54. 2014-08-11. PMID:23792226. |
these results indicate that activity of ewcp is inhibited by tonic activity of dopaminergic vta neurons, and that unilateral projections of vta onto ucn1-containing ewcp neurons provide a link between systems regulating approach and avoidance behaviors. |
2014-08-11 |
2023-08-12 |
mouse |
| Stephan Lammel, Byung Kook Lim, Robert C Malenk. Reward and aversion in a heterogeneous midbrain dopamine system. Neuropharmacology. vol 76 Pt B. 2014-07-29. PMID:23578393. |
here we will focus on recent advances in understanding the neural circuits mediating reward and aversion in the vta and how stress as well as drugs of abuse, in particular cocaine, alter circuit function within a heterogeneous midbrain da system. |
2014-07-29 |
2023-08-12 |
Not clear |
| Christie D Fowler, Paul J Kenn. Nicotine aversion: Neurobiological mechanisms and relevance to tobacco dependence vulnerability. Neuropharmacology. vol 76 Pt B. 2014-07-29. PMID:24055497. |
third, the role of the habenular complex in nicotine aversion, primarily medial habenular projections to the interpeduncular nucleus (ipn) but also lateral habenular projections to rostromedial tegmental nucleus (rmtg) and ventral tegmental area (vta) are reviewed. |
2014-07-29 |
2023-08-12 |
Not clear |
| Hector Vargas-Perez, Amine Bahi, Mary Rose Bufalino, Ryan Ting-A-Kee, Geith Maal-Bared, Jenny Lam, Ahmed Fahmy, Laura Clarke, Jennifer K Blanchard, Brett R Larsen, Scott Steffensen, Jean-Luc Dreyer, Derek van der Koo. BDNF signaling in the VTA links the drug-dependent state to drug withdrawal aversions. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 23. 2014-07-25. PMID:24899712. |
using lentivirus-mediated gene transfer to locally knock down the expression of the bdnf receptor tropomyosin-receptor-kinase type b in rats and mice, we observed that chronic opiate administration activates bdnf-related neuronal plasticity in the vta that is necessary for both the establishment of an opiate-dependent state and aversive withdrawal motivation. |
2014-07-25 |
2023-08-13 |
mouse |
| Vladimir I Chefer, Cristina M Bäckman, Eduardo D Gigante, Toni S Shippenber. Kappa opioid receptors on dopaminergic neurons are necessary for kappa-mediated place aversion. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 13. 2014-07-01. PMID:23921954. |
intra- ventral tegmental area (vta) delivery of kors using an adeno-associated viral gene construct, resulted in phenotypic rescue of the kor-mediated nac da response and aversive behavior in datcre-kor ko animals. |
2014-07-01 |
2023-08-12 |
mouse |
| Vladimir I Chefer, Cristina M Bäckman, Eduardo D Gigante, Toni S Shippenber. Kappa opioid receptors on dopaminergic neurons are necessary for kappa-mediated place aversion. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 13. 2014-07-01. PMID:23921954. |
these results provide evidence that kors on vta da neurons are necessary to mediate kor-mediated aversive behavior. |
2014-07-01 |
2023-08-12 |
mouse |