| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Ikeguchi, A Kurod. Mianserin, a 5-HT2 receptor antagonist, in the treatment of delirium: an open study. European journal of neurology. vol 1. issue 3. 2013-12-03. PMID:24283529. |
the rapidity of the improvement may be attributable to mianserin's antagonism at the 5-ht2 receptors, and such serotonin antagonism at the 5-ht2 receptors may be important in treating delirium.- |
2013-12-03 |
2023-08-12 |
Not clear |
| W J Xu, Y Zhao, F Q Huo, J Q Du, J S Tan. Involvement of ventrolateral orbital cortex 5-HT 1-7 receptors in 5-HT induced depression of spared nerve injury allodynia. Neuroscience. vol 238. 2013-10-17. PMID:23485814. |
microinjection of selective 5-ht1a, 5-ht2, 5-ht3, 5-ht4, 5-ht5a, 5-ht6 and 5-ht7 receptor antagonists, 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl] piperazine hydrobromide (nan-190) (10μg), cyproheptadine (50ng), granisetron hydrochloride (granisetron) (10μg), 1-[2-[(methylsulfonyl)-amino]ethyl]-4-piperidinyl]methyl1-methyl-1h-indole-3-carboxylate (gr113808) (5μg), sb699551 dihydrochloride (sb699551) (10μg), sb258585 dihydrochloride (sb258585) (2μg) or sb269970 hydrochloride (sb269970) (10μg) into the vlo 5-min prior to 5-ht (10μg) injection, all antagonized the 5-ht-induced inhibition of allodynia. |
2013-10-17 |
2023-08-12 |
rat |
| Andrea E Corcoran, George B Richerson, Michael B Harri. Serotonergic mechanisms are necessary for central respiratory chemoresponsiveness in situ. Respiratory physiology & neurobiology. vol 186. issue 2. 2013-09-20. PMID:23454177. |
hypercapnic responses were also assessed during exposure to ketanserin (5-ht2 receptor antagonist), and 8-oh-dpat (inhibiting 5-ht neurons via 5-ht1a autoreceptors). |
2013-09-20 |
2023-08-12 |
rat |
| Jessica M D'Amico, Katherine C Murray, Yaqing Li, K Ming Chan, Mark G Finlay, David J Bennett, Monica A Gorassin. Constitutively active 5-HT2/α1 receptors facilitate muscle spasms after human spinal cord injury. Journal of neurophysiology. vol 109. issue 6. 2013-09-10. PMID:23221402. |
in animals, the recovery of motoneuron excitability in the months following a complete spinal cord injury is mediated, in part, by increases in constitutive serotonin (5-ht2) and norepinephrine (α1) receptor activity, which facilitates the reactivation of calcium-mediated persistent inward currents (capics) without the ligands serotonin and norepinephrine below the injury. |
2013-09-10 |
2023-08-12 |
human |
| M Coppola, R Mondol. Methoxetamine: from drug of abuse to rapid-acting antidepressant. Medical hypotheses. vol 79. issue 4. 2013-07-08. PMID:22819129. |
furthermore, it acts as an agonist at dopamine d2, serotonin 5ht2, muscarinic cholinergic, sigma-1, opioid mu and k receptors. |
2013-07-08 |
2023-08-12 |
Not clear |
| Jocelien D A Olivier, Christiaan H Vinkers, Berend Olivie. The role of the serotonergic and GABA system in translational approaches in drug discovery for anxiety disorders. Frontiers in pharmacology. vol 4. 2013-06-20. PMID:23781201. |
in this review, we illustrate the complex interplay between genes and environment in anxiety processes by reviewing preclinical and clinical studies on the serotonin transporter (5-htt), 5-ht1a receptor, 5-ht2 receptor, and gabaa receptor. |
2013-06-20 |
2023-08-12 |
human |
| Silvia Fano, Gürsel Çalışkan, Uwe Heineman. Differential effects of blockade of ERG channels on gamma oscillations and excitability in rat hippocampal slices. The European journal of neuroscience. vol 36. issue 12. 2013-06-11. PMID:23050739. |
agents such as sertindole and astemizole affect heart action by inducing long-qt syndrome, suggesting that apart from their neuronal actions through histamine receptors, 5-ht2 serotonin receptors and d2 dopamine receptors they also affect ether-a-go-go channels and particularly ether-a-go-go-related (erg) potassium (k(+)) channels, comprising the k(v) 11.1, k(v) 11.2 and k(v) 11.3 voltage-gated potassium currents. |
2013-06-11 |
2023-08-12 |
rat |
| Ilia D Kostadinov, Delian P Delev, Ivanka I Kostadinov. Antinociceptive effect of clomipramine through interaction with serotonin 5-HT2 and 5-HT3 receptor subtypes. Folia medica. vol 54. issue 4. 2013-03-12. PMID:23441472. |
antinociceptive effect of clomipramine through interaction with serotonin 5-ht2 and 5-ht3 receptor subtypes. |
2013-03-12 |
2023-08-12 |
Not clear |
| b' Miroslava Ja\\xc5\\xa1ovi\\xc4\\x87-Ga\\xc5\\xa1i\\xc4\\x87, Olivera Vukovi\\xc4\\x87, Maja Pantovi\\xc4\\x87, Tijana Cveti\\xc4\\x87, Nadja Mari\\xc4\\x87-Bojovi\\xc4\\x8. Antipsychotics--history of development and field of indication, new wine--old glassess. Psychiatria Danubina. vol 24 Suppl 3. 2013-01-24. PMID:23114814.' |
according to one of the hypothesis, "new", so called atypical antipsychotic drugs strongly block the serotonin (5-ht2), and weakly block the dopamine (d2) receptors. |
2013-01-24 |
2023-08-12 |
Not clear |
| Marquinta L Harvey, Cody L Swallows, Matthew A Coope. A double dissociation in the effects of 5-HT2A and 5-HT2C receptors on the acquisition and expression of conditioned defeat in Syrian hamsters. Behavioral neuroscience. vol 126. issue 4. 2012-12-20. PMID:22708954. |
in sum, these results suggest that serotonin acts at separate 5-ht2 receptors to facilitate the acquisition and expression of defeat-induced changes in social behavior. |
2012-12-20 |
2023-08-12 |
Not clear |
| Nagahisa Okamoto, Kota Sakamoto, Maki Yamad. Transient serotonin syndrome by concurrent use of electroconvulsive therapy and selective serotonin reuptake inhibitor: a case report and review of the literature. Case reports in psychiatry. vol 2012. 2012-12-06. PMID:23213590. |
the serotonin syndrome, which is characterized by psychiatric, autonomic nervous and neurological symptoms, is considered to be caused by excessive stimulation of the 5-ht1a and 5-ht2 receptors in the gray matter and spinal cord of the central nervous system, after the start of dosing or increase of the dose of a serotoninergic drug. |
2012-12-06 |
2023-08-12 |
Not clear |
| Jean Costenti. [Treatment of insomnia. Pharmacological approaches and their limitations]. Bulletin de l'Academie nationale de medecine. vol 195. issue 7. 2012-08-14. PMID:22812162. |
this pre-eminence of gabaergic transmission should not make us ignore other important transmitters and their receptors as potential targets for new hypnotic drugs; these include histamine (and h1 receptors), dopamine (d1 and d2), norepinephrine (alpha1), serotonin (5ht2), glutamate (nmda), acetylcholine (nicotinic), hypocretin (ox1 and ox2), melatonin (mlt1 and mlt2), prostaglandin e2 (ep), prostaglandin d2 (dp1), and endocannabinoids (cb1). |
2012-08-14 |
2023-08-12 |
Not clear |
| Mark Sanford, Gillian M Keatin. Quetiapine: a review of its use in the management of bipolar depression. CNS drugs. vol 26. issue 5. 2012-08-10. PMID:22519923. |
quetiapine is an antagonist at both serotonin 5-ht2 and dopamine d2 receptors, and its antipsychotic effects are thought to stem from interactions at these receptors. |
2012-08-10 |
2023-08-12 |
Not clear |
| M Schulze, O Siol, D Robaa, F K U Mueller, C Enzensperger, C Fleck, J Lehman. Molecular combination of the dopamine and serotonin scaffolds yield in novel antipsychotic drug candidates - characterization by in vivo experiments. Arzneimittel-Forschung. vol 62. issue 5. 2012-06-28. PMID:22488415. |
the investigated azecines displayed low cytotoxicity, and the affinities for human dopamine d1-d5 and serotonin 5-ht2 a receptors were in a nanomolar range. |
2012-06-28 |
2023-08-12 |
human |
| Waldemar Kryszkowski, Kinga Bobińska, Monika Talarowska, Agata Orzechowska, Antoni Florkowski, Piotr Gałeck. [Trazodone in the treatment of addiction]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego. vol 31. issue 186. 2012-05-01. PMID:22239013. |
counted among the sari (serotonin reuptake inhibitor and antagonist), shows antagonism to serotonergic receptors (5-ht2 receptors), while an inhibitor of serotonin reuptake. |
2012-05-01 |
2023-08-12 |
Not clear |
| K S Raevskiĭ, V B Narkevich, P M Klodt, V S Kudri. [Possible role of serotonin 5-HT2 receptors in mechanism of afobazole anxiolytic action: neurochemical study of inter-line differences in mice]. Eksperimental'naia i klinicheskaia farmakologiia. vol 74. issue 12. 2012-04-26. PMID:22379873. |
[possible role of serotonin 5-ht2 receptors in mechanism of afobazole anxiolytic action: neurochemical study of inter-line differences in mice]. |
2012-04-26 |
2023-08-12 |
mouse |
| Li-Na Qiao, Yong-Sheng Yang, Jun-Ying Wang, Yong-Hui Gao, Yan-Jing Han, Shu-Ping Chen, Chang-Fu Ji, Jun-Ling Li. [Effects of electroacupuncture at "Futu" (LI 18), etc. on expression of spinal 5-HT 1 AR mRNA, 5-HT 2 AR mRNA and protein in rats with neck incision pain]. Zhen ci yan jiu = Acupuncture research. vol 36. issue 6. 2012-04-24. PMID:22379782. |
on the expression of 5-ht 1 a receptor (r) mrna, 5-ht2 ar mrna and protein in the spinal cord of rats with neck incision pain, so as to explore its underlying mechanism in relieving incision pain. |
2012-04-24 |
2023-08-12 |
rat |
| Tomotaka Murotani, Tomoko Ishizuka, Yuka Isogawa, Michitaka Karashima, Atsushi Yamatodan. Possible involvement of serotonin 5-HT2 receptor in the regulation of feeding behavior through the histaminergic system. Neuropharmacology. vol 61. issue 1-2. 2012-04-17. PMID:21514311. |
possible involvement of serotonin 5-ht2 receptor in the regulation of feeding behavior through the histaminergic system. |
2012-04-17 |
2023-08-12 |
mouse |
| José A Apu. The extraction, isolation and purification of an endogenous regulator for the 5-HT2 receptor. Pharmacological research. vol 64. issue 4. 2012-01-19. PMID:21683793. |
early studies indicated that serotonin, a primary transmitter in the central nervous system, may not represent the primary endogenous regulator for the 5-ht2 receptor labeled by [3h]-ketanserin. |
2012-01-19 |
2023-08-12 |
rat |
| Adriana Galistu, Cristina Modde, Maria Cristina Pireddu, Flavia Franconi, Gino Serra, Paolo S D'Aquil. Clozapine increases reward evaluation but not overall ingestive behaviour in rats licking for sucrose. Psychopharmacology. vol 216. issue 3. 2011-11-29. PMID:21360098. |
serotonin 5-ht2 receptors seem to play a role in determining this profile. |
2011-11-29 |
2023-08-12 |
rat |