| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Seema Saksena, Ravinder K Gill, Sangeeta Tyagi, Waddah A Alrefai, Zaheer Sarwar, Krishnamurthy Ramaswamy, Pradeep K Dudej. Involvement of c-Src and protein kinase C delta in the inhibition of Cl(-)/OH- exchange activity in Caco-2 cells by serotonin. The Journal of biological chemistry. vol 280. issue 12. 2005-04-21. PMID:15637072. |
(ii) the specific agonists for 5-ht3, m-chlorophenylbiguanide, and 5-ht4, 3-(4-allylpiperazin-1-yl)-2-quinoxaline chloronitrile, mimicked the effects of serotonin. |
2005-04-21 |
2023-08-12 |
human |
| Seema Saksena, Ravinder K Gill, Sangeeta Tyagi, Waddah A Alrefai, Zaheer Sarwar, Krishnamurthy Ramaswamy, Pradeep K Dudej. Involvement of c-Src and protein kinase C delta in the inhibition of Cl(-)/OH- exchange activity in Caco-2 cells by serotonin. The Journal of biological chemistry. vol 280. issue 12. 2005-04-21. PMID:15637072. |
(iii) tropisetron dual inhibitor for both the 5-ht3/4 receptor subtypes significantly blocked the inhibition, whereas specific 5-ht3 (y-25130) or 5-ht4 receptor (rs39604) antagonist failed to block the inhibitory effects of 5-ht. |
2005-04-21 |
2023-08-12 |
human |
| Eirik Qvigstad, Trond Brattelid, Ivar Sjaastad, Kjetil Wessel Andressen, Kurt A Krobert, Jon Arne Birkeland, Ole M Sejersted, Alberto J Kaumann, Tor Skomedal, Jan-Bjørn Osnes, Finn Olav Lev. Appearance of a ventricular 5-HT4 receptor-mediated inotropic response to serotonin in heart failure. Cardiovascular research. vol 65. issue 4. 2005-04-19. PMID:15721867. |
appearance of a ventricular 5-ht4 receptor-mediated inotropic response to serotonin in heart failure. |
2005-04-19 |
2023-08-12 |
human |
| M D Gersho. Review article: serotonin receptors and transporters -- roles in normal and abnormal gastrointestinal motility. Alimentary pharmacology & therapeutics. vol 20 Suppl 7. 2005-04-12. PMID:15521849. |
5-ht acting at 5-ht4 receptors enhances the release of transmitters from their terminals and from other terminals in prokinetic reflex pathways. |
2005-04-12 |
2023-08-12 |
mouse |
| Sylvain Robert, Marjorie Maillet, Eric Morel, Jean-Marie Launay, Rodolphe Fischmeister, Luc Mercken, Frank Lezoualc'. Regulation of the amyloid precursor protein ectodomain shedding by the 5-HT4 receptor and Epac. FEBS letters. vol 579. issue 5. 2005-04-05. PMID:15710402. |
the serotonin 5-hydroxytryptamine (5-ht4) receptor is of potential interest for the treatment of alzheimer's disease because it increases memory and learning. |
2005-04-05 |
2023-08-12 |
Not clear |
| Sylvain Robert, Marjorie Maillet, Eric Morel, Jean-Marie Launay, Rodolphe Fischmeister, Luc Mercken, Frank Lezoualc'. Regulation of the amyloid precursor protein ectodomain shedding by the 5-HT4 receptor and Epac. FEBS letters. vol 579. issue 5. 2005-04-05. PMID:15710402. |
in this study, we investigated the effect of zinc metalloprotease inhibitors on the amyloid precursor protein (app) processing induced by the serotonin 5-ht4 receptor in vitro. |
2005-04-05 |
2023-08-12 |
Not clear |
| Wanda Bosshard, Rebecca Dreher, Jean-François Schnegg, Christophe J Bül. The treatment of chronic constipation in elderly people: an update. Drugs & aging. vol 21. issue 14. 2005-03-23. PMID:15554750. |
several promising compounds such as the new serotonin 5-ht4 receptor agonists (tegaserod, prucalopride) and neurotrophin-3 (nt3) have not been adequately tested in older individuals. |
2005-03-23 |
2023-08-12 |
Not clear |
| Tobias Lehr, Rudolf Schip. An antagonistic 5-HT receptor system in the auricles of the systemic heart complex of Sepia officinalis L. (Cephalopoda) shows 5-HT1 and 5-HT4 subtype properties. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 138. issue 2. 2005-03-15. PMID:15450869. |
in pharmacological bioassays on isolated ring-shaped auricle preparations of sepia officinalis, the action of the specific 5-hydroxytryptamine (5-ht) agonists 8-oh-dpat (5-ht1a), cp-93129 (5-ht1b), tfmpp (5-ht1b) and rs-67333 (5-ht4) on these autonomously contractile compartments was studied. |
2005-03-15 |
2023-08-12 |
Not clear |
| Chang Young Jeong, Jeong Il Choi, Myung Ha Yoo. Roles of serotonin receptor subtypes for the antinociception of 5-HT in the spinal cord of rats. European journal of pharmacology. vol 502. issue 3. 2005-03-08. PMID:15476746. |
intrathecal 5-ht suppressed both phases of behaviors produced by 5% formalin, and this was blocked by antagonists for 5-ht(1b) (3-[3-(dimethylamino)propyl]-4-hy-droxy-n-[4-(4-pyridinyl)phenyl]benzamide dihydrochloride, gr 55562), 5-ht(2c) (n-ormethylclozapine/8-chloro-11-(1-piperazinyl)-5h-dibenzo[b,e][1,4]diazepine, d-mc), 5-ht3 (1-methyl-n-(8-methyl-8-azabicyclo[3.2.1]-oct-3-yl)-1h-indazole-3-carboxamide maleate, ly-278,584) and 5-ht4 receptors (4-amino-5-chloro-2-metho-xy-benzoic acid 2-(diethylamino)ethyl ester hydrochloride, sdz-205,557), but not the 5-ht(1d) receptor antagonist 3-[4-(4-chlorophenyl)piperazin-1-yl]-1,1-diphenyl-2-propanol hydrochloride (brl 15572). |
2005-03-08 |
2023-08-12 |
rat |
| Chang Young Jeong, Jeong Il Choi, Myung Ha Yoo. Roles of serotonin receptor subtypes for the antinociception of 5-HT in the spinal cord of rats. European journal of pharmacology. vol 502. issue 3. 2005-03-08. PMID:15476746. |
intrathecal administration of agonists for 5-ht(1a) (3-(n,n-dipropylaminoethyl)-1h-indole-5-carboxamide maleate, dipropyl-5ct), 5-ht(1b) (7-trifluoromethyl-4(4-met-hyl-1-piperazinyl)-pyrrolo[1,2-a]quinoxaline maleate, cgs-12066a), 5-ht(2c) (6-ch-loro-2-(1-piperazinyl)pyrazine hydrochloride, mk 212), 5-ht3 (n-(3-chlorophenyl)imidodicarbonimidic diamide hydrochloride, m-cpbg) and 5-ht4 receptors (2-[1-(4-piperonyl)piperazinyl]benzothiazole, bztz) suppressed both phases of the formalin response. |
2005-03-08 |
2023-08-12 |
rat |
| Chang Young Jeong, Jeong Il Choi, Myung Ha Yoo. Roles of serotonin receptor subtypes for the antinociception of 5-HT in the spinal cord of rats. European journal of pharmacology. vol 502. issue 3. 2005-03-08. PMID:15476746. |
the results of the present study indicate that spinal 5-ht(1b,) 5-ht(2c,) 5-ht3 and 5-ht4 receptors, but not the 5-ht(1d) receptor, mediate antinociception produced by 5-ht in the formalin test. |
2005-03-08 |
2023-08-12 |
rat |
| Trond Brattelid, Ane M Kvingedal, Kurt A Krobert, Kjetil W Andressen, Trond Bach, Marit E Hystad, Alberto J Kaumann, Finn Olav Lev. Cloning, pharmacological characterisation and tissue distribution of a novel 5-HT4 receptor splice variant, 5-HT4(i). Naunyn-Schmiedeberg's archives of pharmacology. vol 369. issue 6. 2005-02-22. PMID:15118808. |
in transiently transfected hek293 cells cisapride was a partial agonist compared to serotonin at 5-ht4(b), 5-ht4(g) and 5-ht4(i) receptors. |
2005-02-22 |
2023-08-12 |
human |
| Trond Brattelid, Ane M Kvingedal, Kurt A Krobert, Kjetil W Andressen, Trond Bach, Marit E Hystad, Alberto J Kaumann, Finn Olav Lev. Cloning, pharmacological characterisation and tissue distribution of a novel 5-HT4 receptor splice variant, 5-HT4(i). Naunyn-Schmiedeberg's archives of pharmacology. vol 369. issue 6. 2005-02-22. PMID:15118808. |
in membranes from hek293 cells stably expressing 5-ht4(g) (3,000 fmol/mg protein) or 5-ht4(i) (500 fmol/mg protein), serotonin and 5-meot were full agonists while cisapride was full agonist at 5-ht4(g) and partial agonist at 5-ht4(i), probably due to different receptor expression levels. |
2005-02-22 |
2023-08-12 |
human |
| Geoffrey Andrew Lambert, Cathy Donaldson, Karen Lisa Hoskin, Peter Michael Boers, Alessandro Stefano Zagam. Dilatation induced by 5-HT in the middle meningeal artery of the anaesthetised cat. Naunyn-Schmiedeberg's archives of pharmacology. vol 369. issue 6. 2005-02-22. PMID:15197536. |
dose-response curves of vascular resistance changes to intravenous injection of 5-ht were not significantly affected by way100635 (5-ht1a antagonist), gr127935 (5-ht(1b/1d) antagonist), methiothepin (5-ht2c and 5-ht7 antagonist), ketanserin (5-ht2a antagonist), sb203186 (5-ht4 antagonist) or cervical sympathectomy, but were blocked by the 5-ht(3/4) antagonist tropisetron, the 5-ht3 antagonist ondansetron, the ganglion-blocking drug hexamethonium and by vagotomy. |
2005-02-22 |
2023-08-12 |
cat |
| Geoffrey Andrew Lambert, Cathy Donaldson, Karen Lisa Hoskin, Peter Michael Boers, Alessandro Stefano Zagam. Dilatation induced by 5-HT in the middle meningeal artery of the anaesthetised cat. Naunyn-Schmiedeberg's archives of pharmacology. vol 369. issue 6. 2005-02-22. PMID:15197536. |
we conclude that intravenously-administered 5-ht is a vasodilator in vivo in the cat dural circulation, and that the dilation is not mediated by 5-ht1, 5-ht2, 5-ht4 or 5-ht7 receptors, but is primarily mediated by a vagal reflex, initiated via 5-ht3 receptor activation and brought about by an increase in parasympathetic tone to the middle meningeal artery as part of the von bezold-jarisch reflex. |
2005-02-22 |
2023-08-12 |
cat |
| Trond Brattelid, Eirik Qvigstad, James A Lynham, Peter Molenaar, Halfdan Aass, Odd Geiran, Tor Skomedal, Jan-Bjørn Osnes, Finn Olav Levy, Alberto J Kauman. Functional serotonin 5-HT4 receptors in porcine and human ventricular myocardium with increased 5-HT4 mRNA in heart failure. Naunyn-Schmiedeberg's archives of pharmacology. vol 370. issue 3. 2005-02-01. PMID:15365689. |
functional serotonin 5-ht4 receptors in porcine and human ventricular myocardium with increased 5-ht4 mrna in heart failure. |
2005-02-01 |
2023-08-12 |
human |
| Michael Camilleri, Sanna McKinzie, Jean Fox, Amy Foxx-Orenstein, Duane Burton, George Thomforde, Kari Baxter, Alan R Zinsmeiste. Effect of renzapride on transit in constipation-predominant irritable bowel syndrome. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. vol 2. issue 10. 2005-01-27. PMID:15476153. |
the aim of this study was to evaluate the dose-ranging pharmacodynamic effects of renzapride, a 5-hydroxytryptamine 4 (5-ht4) receptor full agonist/5-ht3 receptor antagonist, on gastrointestinal transit and symptoms in patients with constipation-predominant irritable bowel syndrome (c-ibs). |
2005-01-27 |
2023-08-12 |
Not clear |
| Yang Ning, Jin Xia Zhu, Hsiao Chang Cha. Regulation of ion transport by 5-hydroxytryptamine in rat colon. Clinical and experimental pharmacology & physiology. vol 31. issue 7. 2005-01-24. PMID:15236628. |
in conclusion, the present study has demonstrated that 5-ht can elicit cl(-)- and hco3- anion secretion and na+ absorption by acting directly on colonic epithelial cells via 5-ht4 receptors. |
2005-01-24 |
2023-08-12 |
rat |
| A E Lychkova, V I Savchuk, V M Smirnov, I E Trubitsyn. [Probable mechanisms of the regulation in the jejunum motility]. Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology. issue 6. 2004-11-15. PMID:15065541. |
carcinoid cells containing 5ht have 5ht3 and 5ht4 receptors on their superficial membranes. |
2004-11-15 |
2023-08-12 |
Not clear |
| A S Pivovarov, V L Nistratov. Modulatory serotonin receptors on the soma of command neurons in edible snail. Bulletin of experimental biology and medicine. vol 136. issue 2. 2004-10-22. PMID:14631485. |
by contrast, ly-53.857, ics-205.930, and sdz-205.557, antagonists of 5-ht2, 5-ht3, and 5-ht4 serotonin receptors, respectively, produced no effect on the modulatory effect of serotonin. |
2004-10-22 |
2023-08-12 |
Not clear |