| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kevin Clayton, Jean Christophe Delpech, Shawn Herron, Naotoshi Iwahara, Maria Ericsson, Takashi Saito, Takaomi C Saido, Seiko Ikezu, Tsuneya Ikez. Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model. Molecular neurodegeneration. vol 16. issue 1. 2021-07-31. PMID:33752701. |
recent studies suggest that microglia contribute to tau pathology progression in alzheimer's disease. |
2021-07-31 |
2023-08-13 |
mouse |
| Kevin Clayton, Jean Christophe Delpech, Shawn Herron, Naotoshi Iwahara, Maria Ericsson, Takashi Saito, Takaomi C Saido, Seiko Ikezu, Tsuneya Ikez. Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model. Molecular neurodegeneration. vol 16. issue 1. 2021-07-31. PMID:33752701. |
amyloid plaque accumulation transforms microglia, the primary innate immune cells in the brain, into neurodegenerative microglia (mgnd), which exhibit enhanced phagocytosis of plaques, apoptotic neurons and dystrophic neurites containing aggregated and phosphorylated tau (p-tau). |
2021-07-31 |
2023-08-13 |
mouse |
| Chunmei Liang, Ting Zou, Miaoping Zhang, Weihao Fan, Tianzhen Zhang, Yuling Jiang, Yujie Cai, Feng Chen, Xiongjin Chen, Yuanhong Sun, Bin Zhao, Yan Wang, Lili Cu. MicroRNA-146a switches microglial phenotypes to resist the pathological processes and cognitive degradation of Alzheimer's disease. Theranostics. vol 11. issue 9. 2021-07-29. PMID:33754051. |
microglia can be neuroprotective by degrading and removing aβ and tau. |
2021-07-29 |
2023-08-13 |
mouse |
| Annerieke Sierksma, Ashley Lu, Renzo Mancuso, Nicola Fattorelli, Nicola Thrupp, Evgenia Salta, Jesus Zoco, David Blum, Luc Buée, Bart De Strooper, Mark Fier. Novel Alzheimer risk genes determine the microglia response to amyloid-β but not to TAU pathology. EMBO molecular medicine. vol 12. issue 3. 2021-07-28. PMID:31951107. |
novel alzheimer risk genes determine the microglia response to amyloid-β but not to tau pathology. |
2021-07-28 |
2023-08-13 |
mouse |
| Lingyun Yue, Pu Liu, Ningtian Ma, Yuxia Xu, Cuiqing Zh. Interaction between extracellular ATP5A1 and LPS alleviates LPS-induced neuroinflammation in mice. Neuroscience letters. vol 758. 2021-07-20. PMID:34098024. |
furthermore, ratp5a1 suppressed the activation of astrocytes and microglia, il-1β accumulation, and tau phosphorylation induced by lps. |
2021-07-20 |
2023-08-13 |
mouse |
| M A Berezutsky, N A Durnova, L E Sigarev. [Neurobiological effects of tenuigenin and the opportunity of it's using in the therapy of Alzheimer's and Parkinson's diseases (literature review).] Advances in gerontology = Uspekhi gerontologii. vol 34. issue 2. 2021-07-13. PMID:34245502. |
it was noted, that the capacities of the tenuigenin to decrease the secretion of beta amyloid and to protect of neurons from damage by already made beta ameloids, to inhibit the processes of the tau proteins` hyperphosphorylation and inflammations in microglia, as well as increase the main synaptic transmission can be used by the development of effective therapeutic drugs aimed to reduce the pathogenesis of alzheimer`s disease. |
2021-07-13 |
2023-08-13 |
Not clear |
| Gai Ayalon, Seung-Hye Lee, Oskar Adolfsson, Corinne Foo-Atkins, Jasvinder K Atwal, Mira Blendstrup, Helen Booler, Joseph Bravo, Robert Brendza, Flavia Brunstein, Ruby Chan, Priya Chandra, Jessica A Couch, Akash Datwani, Barthélemy Demeule, Danielle DiCara, Rich Erickson, James A Ernst, Oded Foreman, Dongping He, Isidro Hötzel, Michael Keeley, Michael C M Kwok, Julien Lafrance-Vanasse, Han Lin, Yanmei Lu, Wilman Luk, Paul Manser, Andreas Muhs, Hai Ngu, Andrea Pfeifer, Maria Pihlgren, Gautham K Rao, Kimberly Scearce-Levie, Stephen P Schauer, William B Smith, Hilda Solanoy, Edmond Teng, Kristin R Wildsmith, Daniela Bumbaca Yadav, Yong Ying, Reina N Fuji, Geoffrey A Kerchne. Antibody semorinemab reduces tau pathology in a transgenic mouse model and engages tau in patients with Alzheimer's disease. Science translational medicine. vol 13. issue 593. 2021-07-12. PMID:33980574. |
semorinemab binds all six human tau isoforms and protects neurons against tau oligomer neurotoxicity in cocultures of neurons and microglia. |
2021-07-12 |
2023-08-13 |
mouse |
| Chritica Lodder, Isabelle Scheyltjens, Ilie Cosmin Stancu, Pablo Botella Lucena, Manuel Gutiérrez de Ravé, Sarah Vanherle, Tim Vanmierlo, Niels Cremers, Hannah Vanrusselt, Bert Brône, Bernard Hanseeuw, Jean-Noël Octave, Astrid Bottelbergs, Kiavash Movahedi, Ilse Dewachte. CSF1R inhibition rescues tau pathology and neurodegeneration in an A/T/N model with combined AD pathologies, while preserving plaque associated microglia. Acta neuropathologica communications. vol 9. issue 1. 2021-07-12. PMID:34103079. |
csf1r inhibition rescues tau pathology and neurodegeneration in an a/t/n model with combined ad pathologies, while preserving plaque associated microglia. |
2021-07-12 |
2023-08-13 |
Not clear |
| Chritica Lodder, Isabelle Scheyltjens, Ilie Cosmin Stancu, Pablo Botella Lucena, Manuel Gutiérrez de Ravé, Sarah Vanherle, Tim Vanmierlo, Niels Cremers, Hannah Vanrusselt, Bert Brône, Bernard Hanseeuw, Jean-Noël Octave, Astrid Bottelbergs, Kiavash Movahedi, Ilse Dewachte. CSF1R inhibition rescues tau pathology and neurodegeneration in an A/T/N model with combined AD pathologies, while preserving plaque associated microglia. Acta neuropathologica communications. vol 9. issue 1. 2021-07-12. PMID:34103079. |
the preferential depletion of non-plaque-associated microglia significantly attenuated tau pathology and neuronal atrophy, indicating their detrimental role during atn progression. |
2021-07-12 |
2023-08-13 |
Not clear |
| Mariko Taga, Vladislav A Petyuk, Charles White, Galina Marsh, Yiyi Ma, Hans-Ulrich Klein, Sarah M Connor, Alexandra Kroshilina, Christina J Yung, Anthony Khairallah, Marta Olah, Julie Schneider, Kyle Karhohs, Anne E Carpenter, Richard Ransohoff, David A Bennett, Andrea Crotti, Elizabeth M Bradshaw, Philip L De Jage. BIN1 protein isoforms are differentially expressed in astrocytes, neurons, and microglia: neuronal and astrocyte BIN1 are implicated in tau pathology. Molecular neurodegeneration. vol 15. issue 1. 2021-07-01. PMID:32727516. |
bin1 protein isoforms are differentially expressed in astrocytes, neurons, and microglia: neuronal and astrocyte bin1 are implicated in tau pathology. |
2021-07-01 |
2023-08-13 |
Not clear |
| John Hardy, Dervis Sali. TREM2-mediated activation of microglia breaks link between amyloid and tau. The Lancet. Neurology. vol 20. issue 6. 2021-06-25. PMID:34022161. |
trem2-mediated activation of microglia breaks link between amyloid and tau. |
2021-06-25 |
2023-08-13 |
Not clear |
| Shun-Fat Lau, Amy K Y Fu, Nancy Y I. Cytokine signaling convergence regulates the microglial state transition in Alzheimer's disease. Cellular and molecular life sciences : CMLS. vol 78. issue 10. 2021-06-22. PMID:33847763. |
along ad progression, the accumulation of danger-associated molecular patterns (damps) including beta-amyloid and hyperphosphorylated tau continuously stimulates microglia, which results in their chronic activation. |
2021-06-22 |
2023-08-13 |
Not clear |
| Ellis Patrick, Marta Olah, Mariko Taga, Hans-Ulrich Klein, Jishu Xu, Charles C White, Daniel Felsky, Sonal Agrawal, Chris Gaiteri, Lori B Chibnik, Sara Mostafavi, Julie A Schneider, David A Bennett, Elizabeth M Bradshaw, Philip L De Jage. A cortical immune network map identifies distinct microglial transcriptional programs associated with β-amyloid and Tau pathologies. Translational psychiatry. vol 11. issue 1. 2021-06-18. PMID:33446646. |
in terms of tau, we propose that module 5, a marker of activated microglia, may lead to tau accumulation and subsequent cognitive decline. |
2021-06-18 |
2023-08-13 |
human |
| David H Allendorf, Mar Puigdellívol, Guy C Brow. Activated microglia desialylate their surface, stimulating complement receptor 3-mediated phagocytosis of neurons. Glia. vol 68. issue 5. 2021-06-10. PMID:31774586. |
we found that activation of microglia with lipopolysaccharide (lps), fibrillar amyloid beta (aβ), tau or phorbol myristate acetate resulted in increased surface sialidase activity and desialylation of the microglial surface. |
2021-06-10 |
2023-08-13 |
Not clear |
| Monika Zilkova, Anna Nolle, Branislav Kovacech, Eva Kontsekova, Petronela Weisova, Peter Filipcik, Rostislav Skrabana, Michal Prcina, Tomas Hromadka, Ondrej Cehlar, Gabriela Paulikova Rolkova, Denisa Maderova, Michal Novak, Norbert Zilka, Jeroen J M Hoozeman. Humanized tau antibodies promote tau uptake by human microglia without any increase of inflammation. Acta neuropathologica communications. vol 8. issue 1. 2021-05-28. PMID:32471486. |
humanized tau antibodies promote tau uptake by human microglia without any increase of inflammation. |
2021-05-28 |
2023-08-13 |
mouse |
| Monika Zilkova, Anna Nolle, Branislav Kovacech, Eva Kontsekova, Petronela Weisova, Peter Filipcik, Rostislav Skrabana, Michal Prcina, Tomas Hromadka, Ondrej Cehlar, Gabriela Paulikova Rolkova, Denisa Maderova, Michal Novak, Norbert Zilka, Jeroen J M Hoozeman. Humanized tau antibodies promote tau uptake by human microglia without any increase of inflammation. Acta neuropathologica communications. vol 8. issue 1. 2021-05-28. PMID:32471486. |
we have previously showed that the mouse antibody dc8e8 discriminates between healthy and pathological tau, reduces tau pathology in murine tauopathy models and inhibits neuronal internalization of ad tau species in vitro.here we show, that dc8e8 and antibodies elicited against the first-in-man tau vaccine, aadvac1, which is based on the dc8e8 epitope peptide, both promote uptake of pathological tau by mouse primary microglia. |
2021-05-28 |
2023-08-13 |
mouse |
| Monika Zilkova, Anna Nolle, Branislav Kovacech, Eva Kontsekova, Petronela Weisova, Peter Filipcik, Rostislav Skrabana, Michal Prcina, Tomas Hromadka, Ondrej Cehlar, Gabriela Paulikova Rolkova, Denisa Maderova, Michal Novak, Norbert Zilka, Jeroen J M Hoozeman. Humanized tau antibodies promote tau uptake by human microglia without any increase of inflammation. Acta neuropathologica communications. vol 8. issue 1. 2021-05-28. PMID:32471486. |
igg1 and igg4 isotypes of ax004, the humanized versions of dc8e8, accelerate tau uptake by human primary microglia isolated from post-mortem aged and diseased brains. |
2021-05-28 |
2023-08-13 |
mouse |
| Monika Zilkova, Anna Nolle, Branislav Kovacech, Eva Kontsekova, Petronela Weisova, Peter Filipcik, Rostislav Skrabana, Michal Prcina, Tomas Hromadka, Ondrej Cehlar, Gabriela Paulikova Rolkova, Denisa Maderova, Michal Novak, Norbert Zilka, Jeroen J M Hoozeman. Humanized tau antibodies promote tau uptake by human microglia without any increase of inflammation. Acta neuropathologica communications. vol 8. issue 1. 2021-05-28. PMID:32471486. |
this promoting activity requires the presence of the fc-domain of the antibodies.the igg1 isotype of ax004 showed greater ability to promote tau uptake compared to the igg4 isotype, while none of the antibody-tau complexes provoked increased pro-inflammatory activity of microglia. |
2021-05-28 |
2023-08-13 |
mouse |
| Peng Yang, Dongyu Sheng, Qian Guo, Pengzhen Wang, Shuting Xu, Kang Qian, Yixian Li, Yunlong Cheng, Liuchang Wang, Wei Lu, Qizhi Zhan. Neuronal mitochondria-targeted micelles relieving oxidative stress for delayed progression of Alzheimer's disease. Biomaterials. vol 238. 2021-05-19. PMID:32062148. |
the targeted micelles restore the cognitive performance in app/ps1 transgenic mice to the level of wild-type mice characterized by up-regulation of sirtuin 1 expression, reduction of amyloid deposition and tau hyperphosphorylation, protection of synapses and inhibition of microglia proliferation. |
2021-05-19 |
2023-08-13 |
mouse |
| Xiaoliang Wang, Lihai Chen, Yajie Xu, Wanling Wang, Youran Wang, Zhiyuan Zhang, Jing Zheng, Hongguang Ba. Gastrodin alleviates perioperative neurocognitive dysfunction of aged mice by suppressing neuroinflammation. European journal of pharmacology. vol 892. 2021-05-18. PMID:33220272. |
furthermore, surgery induced more serious cognitive dysfunction, inflammatory factors, activation of microglia, and phosphorylation of gsk-3β and tau in gsk-3β overexpressing aged mice. |
2021-05-18 |
2023-08-13 |
mouse |