| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mahima Kapoor, Subashchandrabose Chinnathamb. TGF-β1 signalling in Alzheimer's pathology and cytoskeletal reorganization: a specialized Tau perspective. Journal of neuroinflammation. vol 20. issue 1. 2023-03-14. PMID:36915196. |
channelizing microglia to target extracellular tau could be a good strategy to combat the prion-like transmission and seeding problem in alzheimer's disease. |
2023-03-14 |
2023-08-14 |
Not clear |
| Cuicui Wang, Shuai Zong, Xiaolin Cui, Xueying Wang, Shuang Wu, Le Wang, Yingchao Liu, Zhiming L. The effects of microglia-associated neuroinflammation on Alzheimer's disease. Frontiers in immunology. vol 14. 2023-03-13. PMID:36911732. |
here, we summarize the effects of microglia-mediated neuroinflammation on ad, focusing on the temporal and spatial changes in microglial phenotype, the interactions among microglia, aβ, tau, and neurons, and the prospects and recent advances in neuroinflammation as a diagnostic and therapeutic target of ad. |
2023-03-13 |
2023-08-14 |
human |
| Miguel Moutinho, Israel Coronel, Andy P Tsai, Gonzalo Viana Di Prisco, Taylor Pennington, Brady K Atwood, Shweta S Puntambekar, Daniel C Smith, Pablo Martinez, Seonggyun Han, Younghee Lee, Cristian A Lasagna-Reeves, Bruce T Lamb, Stephanie J Bissel, Kwangsik Nho, Gary E Landret. TREM2 splice isoforms generate soluble TREM2 species that disrupt long-term potentiation. Genome medicine. vol 15. issue 1. 2023-02-22. PMID:36805764. |
trem2 governs the response of microglia to amyloid and tau pathologies in the alzheimer's disease (ad) brain. |
2023-02-22 |
2023-08-14 |
mouse |
| Baiping Wang, Heidi Martini-Stoica, Chuangye Qi, Tzu-Chiao Lu, Shuo Wang, Wen Xiong, Yanyan Qi, Yin Xu, Marco Sardiello, Hongjie Li, Hui Zhen. TFEB-vacuolar ATPase signaling regulates lysosomal function and microglial activation in tauopathy. bioRxiv : the preprint server for biology. 2023-02-17. PMID:36798205. |
single nucleus rna-sequencing (snrna-seq) of wild-type and ps19 (tau) transgenic mice identified three unique microglia subclusters in tau mice that were associated with heightened lysosome and immune pathway genes. |
2023-02-17 |
2023-08-14 |
mouse |
| Gao Rong, Wu Hongrong, Li Qingqi, Zhao Jianfen. Roles of Microglia in AD Pathology. Current Alzheimer research. 2023-02-06. PMID:36740796. |
as cerebral resident phagocytes, microglia have different roles in aβ pathology and tau pathology. |
2023-02-06 |
2023-08-14 |
Not clear |
| Xiaoqian Peng, Hongsong Guo, Xiao Zhang, Zikang Yang, John Bosco Ruganzu, Zhuoyuan Yang, Xiangyuan Wu, Wei Bi, Shengfeng Ji, Weina Yan. TREM2 Inhibits Tau Hyperphosphorylation and Neuronal Apoptosis via the PI3K/Akt/GSK-3β Signaling Pathway In vivo and In vitro. Molecular neurobiology. 2023-01-20. PMID:36662361. |
in line with in vivo findings, trem2-overexpressing bv2 microglia following β-amyloid (aβ) stimulation led to a significant increase in the phosphorylation of pi3k, akt, and gsk-3β, accompanied by a decrease in tau hyperphosphorylation and apoptosis in co-cultured sh-sy5y cells. |
2023-01-20 |
2023-08-14 |
mouse |
| Birsu Bac, Cheima Hicheri, Craig Weiss, Amelia Buell, Natalia Vilcek, Claudia Spaeni, Changiz Geula, Jeffrey N Savas, John F Disterhof. The TgF344-AD rat: behavioral and proteomic changes associated with aging and protein expression in a transgenic rat model of Alzheimer's disease. Neurobiology of aging. vol 123. 2023-01-19. PMID:36657371. |
levels of phosphorylated tau, reactive astrocytes and microglia were significantly increased in aged tg rats and correlated with the wmz learning index (li); in contrast, no significant correlation was present between amyloid plaques or insoluble aβ levels and li. |
2023-01-19 |
2023-08-14 |
rat |
| Melissa K Edler, Emily L Munger, Hannah Maycon, William D Hopkins, Patrick R Hof, Chet C Sherwood, Mary Ann Raghant. The association of astrogliosis and microglial activation with aging and Alzheimer's disease pathology in the chimpanzee brain. Journal of neuroscience research. 2023-01-17. PMID:36647571. |
vascular amyloid correlated with decreased astrocyte and microglia densities, while tau lesions were associated with morphological changes in microglia and greater total glia density and glia: neuron ratio. |
2023-01-17 |
2023-08-14 |
human |
| Gunel Ayyubov. TREM2-signaling as a multifaceted player in brain homeostasis and a potential target for Alzheimer's Disease treatment. The European journal of neuroscience. 2023-01-13. PMID:36637116. |
trem2 also ameliorates the pathological effects of activated microglia on neuronal tau pathology, demonstrating its protective anti-inflammatory effects. |
2023-01-13 |
2023-08-14 |
mouse |
| Mengmeng Jin, Ziyuan Ma, Peng Jian. Generation of iPSC-based human-mouse microglial brain chimeras to study senescence of human microglia. STAR protocols. vol 3. issue 4. 2023-01-03. PMID:36595906. |
in addition, we detail steps for intracerebral injection of pathological tau and magnetic cell isolation of human microglia from chimeric mouse brains for single-cell rna sequencing. |
2023-01-03 |
2023-08-14 |
mouse |
| Teresa H Evering, Jez L Marston, Li Gan, Douglas F Nixo. Transposable elements and Alzheimer's disease pathogenesis. Trends in neurosciences. 2023-01-01. PMID:36588011. |
microglia and astrocytes respond to the abnormal presence of tau protein with induced transposable element (te) transcription. |
2023-01-01 |
2023-08-14 |
Not clear |
| Guanying You, Jinyi Yao, Qiong Liu, Nan L. The Strategies for Treating "Alzheimer's Disease": Insulin Signaling May Be a Feasible Target. Current issues in molecular biology. vol 44. issue 12. 2022-12-22. PMID:36547082. |
interestingly, recent studies revealed that in ad brains the microglia transformed into a disease-associated microglia (dam) status in a trem2-dependent manner to restrain the toxicity of aβ and propagation of tau. |
2022-12-22 |
2023-08-14 |
Not clear |
| Guanying You, Jinyi Yao, Qiong Liu, Nan L. The Strategies for Treating "Alzheimer's Disease": Insulin Signaling May Be a Feasible Target. Current issues in molecular biology. vol 44. issue 12. 2022-12-22. PMID:36547082. |
in this review, we summarize the main strategies for curing ad, including lowering the level of aβ, suppressing the phosphorylation of tau, the ablation and/or repopulation of microglia, and especially the supply of insulin. |
2022-12-22 |
2023-08-14 |
Not clear |
| Catalina Novoa, Paulina Salazar, Pedro Cisternas, Camila Gherardelli, Roberto Vera-Salazar, Juan M Zolezzi, Nibaldo C Inestros. Inflammation context in Alzheimer's disease, a relationship intricate to define. Biological research. vol 55. issue 1. 2022-12-22. PMID:36550479. |
importantly, aβ and tau species are able to activate astrocytes and microglia, which release several proinflammatory cytokines, such as tumor necrosis factor α (tnf-α) and interleukin 1β (il-1β), together with reactive oxygen (ros) and nitrogen species (rns), triggering neuroinflammation. |
2022-12-22 |
2023-08-14 |
Not clear |
| Dong Won Kim, Kevin J Tu, Alice Wei, Ashley J Lau, Anabel Gonzalez-Gil, Tianyu Cao, Kerstin Braunstein, Jonathan P Ling, Juan C Troncoso, Philip C Wong, Seth Blackshaw, Ronald L Schnaar, Tong L. Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes. Molecular neurodegeneration. vol 17. issue 1. 2022-12-19. PMID:36536457. |
amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes. |
2022-12-19 |
2023-08-14 |
Not clear |
| Dong Won Kim, Kevin J Tu, Alice Wei, Ashley J Lau, Anabel Gonzalez-Gil, Tianyu Cao, Kerstin Braunstein, Jonathan P Ling, Juan C Troncoso, Philip C Wong, Seth Blackshaw, Ronald L Schnaar, Tong L. Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes. Molecular neurodegeneration. vol 17. issue 1. 2022-12-19. PMID:36536457. |
yet, how canonical amyloid-β (aβ) and tau pathologies regulate microglia subtypes during the progression of ad remains poorly understood. |
2022-12-19 |
2023-08-14 |
Not clear |
| Kseniya B Varshavskaya, Vladimir A Mitkevich, Alexander A Makarov, Evgeny P Baryki. Synthetic, Cell-Derived, Brain-Derived, and Recombinant β-Amyloid: Modelling Alzheimer's Disease for Research and Drug Development. International journal of molecular sciences. vol 23. issue 23. 2022-12-11. PMID:36499362. |
the development of ad is a pathological cascade starting according to the amyloid hypothesis with the accumulation and aggregation of the β-amyloid peptide (aβ), which induces hyperphosphorylation of tau and promotes the pro-inflammatory activation of microglia leading to synaptic loss and, ultimately, neuronal death. |
2022-12-11 |
2023-08-14 |
Not clear |
| Ruxin Zhang, Yanrong Song, Xuefeng S. Necroptosis and Alzheimer's Disease: Pathogenic Mechanisms and Therapeutic Opportunities. Journal of Alzheimer's disease : JAD. 2022-12-04. PMID:36463451. |
the keywords in the search included: "necroptosis", "alzheimer's disease", "signaling pathways", "aβ", aβo", "tau", "p-tau", "neuronal death", "bbb damage", "neuroinflammation", "microglia", "mitochondrial dysfunction", "granulovacuolar degeneration", "synaptic loss", "axonal degeneration", "nec-1", "nec-1s", "gsk872", "nsa", "oga", "ripk1", "ripk3", and "mlkl". |
2022-12-04 |
2023-08-14 |
Not clear |
| Na Li, Mingru Deng, Gonghui Hu, Nan Li, Haicheng Yuan, Yu Zho. New Insights into Microglial Mechanisms of Memory Impairment in Alzheimer's Disease. Biomolecules. vol 12. issue 11. 2022-11-24. PMID:36421736. |
activated microglia not only directly mediate the central immune response, but also participate in the pathological changes of ad, including amyloid-beta (aβ) aggregation, tau protein phosphorylation, synaptic dissection, neuron loss, memory function decline, etc. |
2022-11-24 |
2023-08-14 |
Not clear |
| Nimansha Jain, Jason D Ulric. TREM2 and microglia exosomes: a potential highway for pathological tau. Molecular neurodegeneration. vol 17. issue 1. 2022-11-18. PMID:36397070. |
trem2 and microglia exosomes: a potential highway for pathological tau. |
2022-11-18 |
2023-08-14 |
Not clear |