| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chiara Prinzi, Anna Kostenko, Gioacchino de Leo, Rosario Gulino, Giampiero Leanza, Antonella Caccam. Selective Noradrenaline Depletion in the Neocortex and Hippocampus Induces Working Memory Deficits and Regional Occurrence of Pathological Proteins. Biology. vol 12. issue 9. 2023-09-28. PMID:37759663. |
at about 12 weeks post-lesion, dose-dependent working memory deficits were detected in these animals, associated with a marked increase in cortical and hippocampal levels of tdp-43 phosphorylated at ser 409/410 and tau phosphorylated at thr 217. |
2023-09-28 |
2023-10-07 |
rat |
| Aida Muntsant, Maria Del Mar Castillo-Ruiz, Lydia Giménez-Llor. Survival Bias, Non-Lineal Behavioral and Cortico-Limbic Neuropathological Signatures in 3xTg-AD Mice for Alzheimer's Disease from Premorbid to Advanced Stages and Compared to Normal Aging. International journal of molecular sciences. vol 24. issue 18. 2023-09-28. PMID:37762098. |
the underlying temporal and spatial progression of aβ and tau pathologies pointed to a relevant cortico-limbic substrate roadmap: premorbid intracellular aβ immunoreactivity and pser202/pthr205 tau phosphorylation in the amygdala and ventral hippocampus, and the entorhinal cortex and ventral hippocampus as the areas most affected by aβ plaques. |
2023-09-28 |
2023-10-07 |
mouse |
| Meixiang Huang, Carolyn Tallon, Xiaolei Zhu, Kaitlyn D J Huizar, Silvia Picciolini, Ajit G Thomas, Lukas Tenora, Wathsala Liyanage, Francesca Rodà, Alice Gualerzi, Rangaramanujam M Kannan, Marzia Bedoni, Rana Rais, Barbara S Slushe. Microglial-Targeted nSMase2 Inhibitor Fails to Reduce Tau Propagation in PS19 Mice. Pharmaceutics. vol 15. issue 9. 2023-09-28. PMID:37765332. |
the progression of alzheimer's disease (ad) correlates with the propagation of hyperphosphorylated tau (ptau) from the entorhinal cortex to the hippocampus and neocortex. |
2023-09-28 |
2023-10-07 |
mouse |
| Mohammad Amin Rajizadeh, Amirhossein Moslemizadeh, Mahdieh Sadat Hosseini, Forouzan Rafiei, Zahra Soltani, Kayvan Khoramipou. Adiponectin receptor 1 could explain the sex differences in molecular basis of cognitive improvements induced by exercise training in type 2 diabetic rats. Scientific reports. vol 13. issue 1. 2023-09-27. PMID:37758935. |
leptin and adiponectin levels in serum were measured along with hippocampal expression of leptin and adiponectin receptors, amp-activated protein kinase (ampk), dephosphorylated glycogen synthase kinase-3 beta (dep-gsk3β), tau, and beta-amyloid (aβ). |
2023-09-27 |
2023-10-07 |
rat |
| Mohammad Amin Rajizadeh, Amirhossein Moslemizadeh, Mahdieh Sadat Hosseini, Forouzan Rafiei, Zahra Soltani, Kayvan Khoramipou. Adiponectin receptor 1 could explain the sex differences in molecular basis of cognitive improvements induced by exercise training in type 2 diabetic rats. Scientific reports. vol 13. issue 1. 2023-09-27. PMID:37758935. |
however, after 8 weeks of hiit, hippocampal levels of apnr1 and ampk as well as quicki were lower and hippocampal levels of gsk, tau, and aβ were higher in females compared to male rats (p < 0.05). |
2023-09-27 |
2023-10-07 |
rat |
| Genevieve L Stein-O'Brien, Ryan Palaganas, Ernest M Meyer, Javier Redding-Ochoa, Olga Pletnikova, Haidan Guo, William R Bell, Juan C Troncoso, Richard L Huganir, Meaghan Morri. Transcriptional Signatures of Hippocampal Tau Pathology in Primary Age-Related Tauopathy and Alzheimer's Disease. medRxiv : the preprint server for health sciences. 2023-09-25. PMID:37745408. |
transcriptional signatures of hippocampal tau pathology in primary age-related tauopathy and alzheimer's disease. |
2023-09-25 |
2023-10-07 |
Not clear |
| Feng Han, JiaQie Lee, Xi Chen, Jacob Ziontz, Tyler Ward, Susan M Landau, Suzanne L Baker, Theresa M Harrison, William J Jagus. Global brain activity and its coupling with cerebrospinal fluid flow is related to tau pathology. bioRxiv : the preprint server for biology. 2023-09-25. PMID:37745434. |
cortical tau deposits first in the entorhinal cortex and hippocampus and then propagates to neocortex in an aβ-dependent manner. |
2023-09-25 |
2023-10-07 |
human |
| Suzanne D Lanooij, W H I M Drinkenburg, U L M Eisel, E A van der Zee, Martien J H Ka. The effects of social environment on AD-related pathology in hAPP-J20 mice and tau-P301L mice. Neurobiology of disease. 2023-09-25. PMID:37748620. |
in 12-week-old p301l mice, tau pathology was induced through seeding by injecting k18 into the dorsal hippocampus (p301l |
2023-09-25 |
2023-10-07 |
mouse |
| Lovedeep Singh, Harpreet Kaur, Girish Chandra Arya, Rajbir Bhatt. Neuroprotective potential of formononetin, a naturally occurring isoflavone phytoestrogen. Chemical biology & drug design. 2023-09-18. PMID:37722967. |
furthermore, formononetin also increases the expression of adam-10, which affects the pathology of neurodegenerative disease by lowering tau phosphorylation, maintaining synaptic plasticity, and boosting hippocampus neurogenesis. |
2023-09-18 |
2023-10-07 |
Not clear |
| Khadga Raj Aran, G D Gupta, Shamsher Sing. Cladribine Induces Apoptosis, Neuroinflammation, Mitochondrial Oxidative Stress, Tau Phosphorylation and Aβ (1-42) Pathway in the Hippocampus: An In vivo Approach. Journal of chemical neuroanatomy. 2023-09-14. PMID:37708945. |
cladribine induces apoptosis, neuroinflammation, mitochondrial oxidative stress, tau phosphorylation and aβ (1-42) pathway in the hippocampus: an in vivo approach. |
2023-09-14 |
2023-10-07 |
rat |
| Christopher G Schwarz, Walter K Kremers, Stephen D Weigand, Carl M Prakaashana, Matthew L Senjem, Scott A Przybelski, Val J Lowe, Jeffrey L Gunter, Kejal Kantarci, Prashanthi Vemuri, Jonathan Graff-Radford, Ronald C Petersen, David S Knopman, Clifford R Jac. Effects of de-facing software mri_reface on utility of imaging biomarkers used in Alzheimer's disease research. NeuroImage. Clinical. vol 40. 2023-09-13. PMID:37703605. |
we created a retrospective sample of participants from three age- and sex-matched clinical groups (cognitively unimpaired, mild cognitive impairment, and ad dementia, and we performed region- and voxel-wise analyses of: hippocampal volume (n), white matter hyperintensity volume (v), amyloid pet (a), and tau pet (t) measures, each from multiple software pipelines, on their ability to separate cognitively defined groups and their degrees of correlation with age and clinical dementia rating (cdr)-sum of boxes (cdr-sb). |
2023-09-13 |
2023-10-07 |
human |
| Li Gao, Dongqing Wang, Jia Ren, Xue Tan, Jiayuan Chen, Zheng Kong, Yunan Nie, Ming Ya. Acteoside ameliorates learning and memory impairment in APP/PS1 transgenic mice by increasing Aβ degradation and inhibiting tau hyperphosphorylation. Phytotherapy research : PTR. 2023-09-04. PMID:37661763. |
we evaluated the levels of aβ40 and aβ42 in serum, cortex, and hippocampus, and aβ-related scavenging enzymes, phosphorylated gsk3β and hyperphosphorylated tau in the cortex and hippocampus of app/ps1 mice by western blotting. |
2023-09-04 |
2023-09-07 |
mouse |
| Giulia Arenare, Riccardo Manca, Paolo Caffarra, Annalena Venneri, On Behalf Of The Alzheimer's Disease Neuroimaging Initiativ. Associations between Neuropsychiatric Symptoms and Alzheimer's Disease Biomarkers in People with Mild Cognitive Impairment. Brain sciences. vol 13. issue 8. 2023-08-26. PMID:37626552. |
this study aimed to investigate the association between nps severity and alzheimer's disease (ad) biomarkers, i.e., amyloid-β (aβ), phosphorylated tau protein (p-tau) and hippocampal volume ratio (hr), to characterise in more detail mci patients with a poor prognosis. |
2023-08-26 |
2023-09-07 |
Not clear |
| Meaghan Morris, Gabrielle I Coste, Javier Redding-Ochoa, Haidan Guo, Austin R Graves, Juan C Troncoso, Richard L Hugani. Hippocampal synaptic alterations associated with tau pathology in primary age-related tauopathy. Journal of neuropathology and experimental neurology. 2023-08-23. PMID:37595576. |
hippocampal synaptic alterations associated with tau pathology in primary age-related tauopathy. |
2023-08-23 |
2023-09-07 |
Not clear |
| Meaghan Morris, Gabrielle I Coste, Javier Redding-Ochoa, Haidan Guo, Austin R Graves, Juan C Troncoso, Richard L Hugani. Hippocampal synaptic alterations associated with tau pathology in primary age-related tauopathy. Journal of neuropathology and experimental neurology. 2023-08-23. PMID:37595576. |
high pathologic tau stage (braak stage) or a high burden of hippocampal tau pathology has been associated with cognitive impairment in part. |
2023-08-23 |
2023-09-07 |
Not clear |
| Meaghan Morris, Gabrielle I Coste, Javier Redding-Ochoa, Haidan Guo, Austin R Graves, Juan C Troncoso, Richard L Hugani. Hippocampal synaptic alterations associated with tau pathology in primary age-related tauopathy. Journal of neuropathology and experimental neurology. 2023-08-23. PMID:37595576. |
in this study, the hippocampal ca2 region showed loss of synaptophysin puncta and intensity in cases of part with either a high stage (braak iv) or a high burden of neuritic tau pathology. |
2023-08-23 |
2023-09-07 |
Not clear |
| Meaghan Morris, Gabrielle I Coste, Javier Redding-Ochoa, Haidan Guo, Austin R Graves, Juan C Troncoso, Richard L Hugani. Hippocampal synaptic alterations associated with tau pathology in primary age-related tauopathy. Journal of neuropathology and experimental neurology. 2023-08-23. PMID:37595576. |
these novel findings suggest the presence of synaptic loss associated with either a high hippocampal tau burden or a braak stage iv in part. |
2023-08-23 |
2023-09-07 |
Not clear |
| Hamed Alizadeh Pahlavan. Exercise therapy to prevent and treat Alzheimer's disease. Frontiers in aging neuroscience. vol 15. 2023-08-21. PMID:37600508. |
while in animals moderate-intensity exercise restores hippocampal and amygdala memory through increased levels of p-akt, p-trkb, and p-pkc and decreased levels of aβ, tau phosphorylation, and amyloid precursor proteins (app) in ad. |
2023-08-21 |
2023-09-07 |
human |
| Grace Minogue, Allegra Kawles, Antonia Zouridakis, Rachel Keszycki, Alyssa Macomber, Vivienne Lubbat, Nathan Gill, Qinwen Mao, Margaret E Flanagan, Hui Zhang, Rudolph Castellani, Eileen H Bigio, M-Marsel Mesulam, Changiz Geula, Tamar Gefe. Distinct Patterns of Hippocampal Pathology in Alzheimer's Disease with TDP-43. Annals of neurology. 2023-08-18. PMID:37592884. |
here, we investigated neuronal integrity and pathologic burden of tdp-43 and tau along the well-charted trisynaptic hippocampal circuit [dentate gyrus (dg), ca3, and ca1] in participants with amnestic dementia due to ad/tdp, amnestic dementia due to ad alone, or non-amnestic dementia due to tdp-43 proteinopathy associated with frontotemporal lobar degeneration (ftld-tdp). |
2023-08-18 |
2023-09-07 |
human |
| Rebecca L Noel, Samantha L Gorman, Alec J Batts, Elisa E Konofago. Getting ahead of Alzheimer's disease: early intervention with focused ultrasound. Frontiers in neuroscience. vol 17. 2023-08-14. PMID:37575309. |
finally, fus-bbbo reduced hippocampal accumulation of aβ40, aβ42, and total tau in females by 12.54, 13.05, and 3.57%, respectively, and reduced total tau in males by 18.98%. |
2023-08-14 |
2023-08-16 |
mouse |