| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sha Sha, Xiao-Na Xing, Tao Wang, Ying Li, Rong-Wei Zhang, Xue-Li Shen, Yun-Peng Cao, Le Q. DNA vaccines targeting amyloid-\\xce\\xb2 oligomer ameliorate cognitive deficits of aged APP/PS1/tau triple-transgenic mouse models of Alzheimer's disease. Neural regeneration research vol 17 issue 10 2022 35259854 |
our results showed that the p(a\xce\xb23-10)10-mt vaccine effectively reduced a\xce\xb2 oligomer levels and plaque deposition in the cerebral cortex and hippocampus, decreased the levels tau protein variants, reduced synaptic loss, protected synaptic function, reduced neuron loss, and ameliorated memory impairment without causing any cerebral hemorrhaging. |
2022-03-09 |
2023-01-27 |
mouse |
| Qing Wang, Gengsheng Chen, Suzanne E Schindler, Jon Christensen, Nicole S McKay, Jingxia Liu, Sicheng Wang, Zhexian Sun, Jason Hassenstab, Yi Su, Shaney Flores, Russ Hornbeck, Lisa Cash, Carlos Cruchaga, Anne M Fagan, Zhude Tu, John C Morris, Mark A Mintun, Yong Wang, Tammie L S Benzinge. Baseline Microglial Activation Correlates With Brain Amyloidosis and Longitudinal Cognitive Decline in Alzheimer Disease. Neurology(R) neuroimmunology & neuroinflammation vol 9 issue 3 2022 35260470 |
this study aims to quantify microglial activation in individuals with alzheimer disease (ad) using the 18-kda translocator protein (tspo) pet imaging in the hippocampus and precuneus, the 2 ad-vulnerable regions, and to evaluate the association of baseline neuroinflammation with amyloidosis, tau, and longitudinal cognitive decline. |
2022-03-09 |
2023-01-27 |
Not clear |
| Reza Yekta, Leila Sadeghi, Gholamreza Dehgha. The role of non-enzymatic glycation on Tau-DNA interactions: Kinetic and mechanistic approaches. International journal of biological macromolecules vol issue 2022 35257729 |
the study of hippocampal cells under hyperglycemic conditions showed that near to 70% of tau proteins glycated in these cells, although the expression of tau remained unaffected. |
2022-03-08 |
2023-01-27 |
Not clear |
| Gabriel Boer Grigoletti-Lima, Marcelo Gustavo Lopes, Ana Tereza Barufi Franco, Aparecida Marcela Damico, Patr\\xc3\\xaccia Aline Boer, Jos\\xc3\\xa9 Antonio Rocha Gontij. Severe Gestational Low-Protein Intake Impacts Hippocampal Cellularity, Tau, and Amyloid-\\xce\\xb2 Levels, and Memory Performance in Male Adult Offspring: An Alzheimer-Simile Disease Model? Journal of Alzheimer's disease reports vol 6 issue 1 2022 35243209 |
severe gestational low-protein intake impacts hippocampal cellularity, tau, and amyloid-\xce\xb2 levels, and memory performance in male adult offspring: an alzheimer-simile disease model? |
2022-03-04 |
2023-01-27 |
Not clear |
| Bin Qiu, Zhaohui Zhong, Shawn Righter, Yuxue Xu, Jun Wang, Ran Deng, Chao Wang, Kent E Williams, Yao-Ying Ma, Gavriil Tsechpenakis, Tiebing Liang, Weidong Yon. FKBP51 modulates hippocampal size and function in post-translational regulation of Parkin. Cellular and molecular life sciences : CMLS vol 79 issue 3 2022 35244772 |
ko has more flattened hippocampus using ai-assisted measurement both pyramidal cell layer (pcl) of ca and granular cell layer (gcl) of dg distinguishable as two layers: deep cell layer and superficial layer.\xc2\xa0distinct map2 expression between deep and superficial layer between ko and wt, higher parkin expression in ko brain mechanism of fkbp51 inhibition resulting in parkin, map2, tau, and tubulin expression differences between ko and wt mice, and resulting neurite outgrowth differences. |
2022-03-04 |
2023-01-27 |
mouse |
| Ping Xu, Liang Xu, Shuyun Huang, Danfeng Li, Yanping Liu, Hongmin Guo, Niuniu Dai, Zongyuan Hong, Shuzhi Zhon. Analysis of the Molecular Mechanism of Punicalagin in the Treatment of Alzheimer's Disease by Computer-Aided Drug Research Technology. ACS omega vol 7 issue 7 2022 35224375 |
the amyloid \xce\xb2 protein (a\xce\xb2) in the hippocampus was examined by immunohistochemistry, and the phosphorylation of serine at position 404 of the tau protein (tau-ps404) was examined by western blot in the mouse brain. |
2022-02-28 |
2023-01-27 |
mouse |
| Li-Fan Lin, Yun-Ting Jhao, Chuang-Hsin Chiu, Lu-Han Sun, Ta-Kai Chou, Chyng-Yann Shiue, Cheng-Yi Cheng, Kuo-Hsing M. Bezafibrate Exerts Neuroprotective Effects in a Rat Model of Sporadic Alzheimer's Disease. Pharmaceuticals (Basel, Switzerland) vol 15 issue 2 2022 35215222 |
stz-icv administration induced significant cognitive impairment and substantial neuronal loss, tau pathology, glucose hypometabolism, and microgliosis in the cortex and hippocampus, while bezafibrate effectively attenuated these abnormalities. |
2022-02-26 |
2023-01-27 |
rat |
| Tomohiro Umeda, Rumi Uekado, Keiko Shigemori, Hiroshi Eguchi, Takami Tomiyam. Nasal Rifampicin Halts the Progression of Tauopathy by Inhibiting Tau Oligomer Propagation in Alzheimer Brain Extract-Injected Mice. Biomedicines vol 10 issue 2 2022 35203506 |
a tau oligomer-rich fraction prepared from the brain of an ad patient was injected into a unilateral hippocampus of tau264 mice that express both 3-repeat and 4-repeat wild-type human tau. |
2022-02-25 |
2023-01-27 |
mouse |
| Sang-Seo Park, Hye-Sang Park, Chang-Ju Kim, Seung-Soo Baek, Song-Young Park, Cody Philip Anderson, Myung-Ki Kim, Ik-Ryeul Park, Tae-Woon Ki. Combined effects of Aerobic exercise and 40Hz light flicker exposure on early cognitive impairments in Alzheimer's disease of 3xTg mice. Journal of applied physiology (Bethesda, Md. : 1985) vol issue 2022 35201933 |
spatial learning and memory, long-term memory, hippocampal a\xce\xb2, tau, neuroinflammation, pro-inflammatory cytokine expression, mitochondrial function, and neuroplasticity, were analyzed. |
2022-02-24 |
2023-01-27 |
mouse |
| Noorul Hasan, Saima Zameer, Abul Kalam Najmi, Suhel Parvez, Mohd Akhta. Roflumilast Reduces Pathological Symptoms of Sporadic Alzheimer's Disease in Rats Produced by Intracerebroventricular Streptozotocin by Inhibiting NF-\\xce\\xbaB/BACE-1 Mediated A\\xce\\xb2 Production in the Hippocampus and Activating the cAMP/BDNF Signalling Pathway. Neurotoxicity research vol issue 2022 35192144 |
rfm was found to significantly reduce icv-stz-induced neuroinflammation, amyloidogenesis, oxidative stress cholinergic impairments, gsk-3\xce\xb2, and phosphorylated tau levels in the rat hippocampus. |
2022-02-22 |
2023-01-27 |
rat |
| Ilie Cosmin Stancu, Chritica Lodder, Pablo Botella Lucena, Sarah Vanherle, Manuel Guti\\xc3\\xa9rrez de Rav\\xc3\\xa9, Dick Terwel, Astrid Bottelbergs, Ilse Dewachte. The NLRP3 inflammasome modulates tau pathology and neurodegeneration in a tauopathy model. Glia vol issue 2022 35174546 |
in this model we studied non-seeded tau pathology and hippocampal atrophy, reminiscent characteristics of tauopathies. |
2022-02-17 |
2023-01-27 |
mouse |
| Ilie Cosmin Stancu, Chritica Lodder, Pablo Botella Lucena, Sarah Vanherle, Manuel Guti\\xc3\\xa9rrez de Rav\\xc3\\xa9, Dick Terwel, Astrid Bottelbergs, Ilse Dewachte. The NLRP3 inflammasome modulates tau pathology and neurodegeneration in a tauopathy model. Glia vol issue 2022 35174546 |
tau pathology in hippocampus and cortex was significantly decreased in tau.nlrp3-/- versus tau.nlrp3+/+ mice. |
2022-02-17 |
2023-01-27 |
mouse |
| Ilie Cosmin Stancu, Chritica Lodder, Pablo Botella Lucena, Sarah Vanherle, Manuel Guti\\xc3\\xa9rrez de Rav\\xc3\\xa9, Dick Terwel, Astrid Bottelbergs, Ilse Dewachte. The NLRP3 inflammasome modulates tau pathology and neurodegeneration in a tauopathy model. Glia vol issue 2022 35174546 |
we furthermore assessed the effect of nlrp3 deficiency on tau propagation and associated hippocampal atrophy. |
2022-02-17 |
2023-01-27 |
mouse |
| Ilie Cosmin Stancu, Chritica Lodder, Pablo Botella Lucena, Sarah Vanherle, Manuel Guti\\xc3\\xa9rrez de Rav\\xc3\\xa9, Dick Terwel, Astrid Bottelbergs, Ilse Dewachte. The NLRP3 inflammasome modulates tau pathology and neurodegeneration in a tauopathy model. Glia vol issue 2022 35174546 |
nlrp3 deficiency significantly decreased prion-like seeding and propagation of tau pathology, reflected in decreased tau pathology in ipsi- and contralateral hippocampus and cortex in tau.nlrp3-/- following tau seeding. |
2022-02-17 |
2023-01-27 |
mouse |
| Xiao-Bo Yang, Heng-Bing Zu, Yong-Fei Zhao, Kai Ya. Agomelatine Prevents Amyloid Plaque Deposition, Tau Phosphorylation, and Neuroinflammation in APP/PS1 Mice. Frontiers in aging neuroscience vol 13 issue 2022 35153715 |
in this study, we found that agomelatine attenuated spatial memory deficit, amyloid-\xce\xb2 (a\xce\xb2) deposition, tau phosphorylation, and neuroinflammation in the hippocampus of app/ps1 mice. |
2022-02-14 |
2023-01-27 |
mouse |
| Marta Scarioni, Priya Gami-Patel, Carel F W Peeters, Florianne de Koning, Harro Seelaar, Merel O Mol, John C van Swieten, Annemieke J M Rozemuller, Jeroen J M Hoozemans, Yolande A L Pijnenburg, Anke A Dijkstr. Psychiatric symptoms of frontotemporal dementia and subcortical (co-)pathology burden: new insights. Brain : a journal of neurology vol issue 2022 35136978 |
in subcortical regions, the presence of psychiatric symptoms showed positive correlations with increased hippocampal pathology burden: hallucinations with tdp-43 in the granular layer (r\xe2\x80\x89=\xe2\x80\x890.33), mania with tdp-43 in ca1 (r\xe2\x80\x89=\xe2\x80\x890.35), depression with tdp-43 in ca3 and with parahippocampal tau (r\xe2\x80\x89=\xe2\x80\x890.30 and r\xe2\x80\x89=\xe2\x80\x890.23), and delusions with ca3 tau (r\xe2\x80\x89=\xe2\x80\x890.26) and subicular amyloid-beta (r\xe2\x80\x89=\xe2\x80\x890.25). |
2022-02-09 |
2023-01-27 |
Not clear |
| Eduardo R Zimmer, Bruna Bellaver, Wagner Scheeren Brum, Pamela C L Ferreira, Guilherme Povala, Andreia Silva da Rocha, D\\xc3\\xa9bora Guerini de Souza, Marco Ant\\xc3\\xb4nio De Bastian. Tau pathology reshapes GFAP-positive astrocytes phenotype. Alzheimer's & dementia : the journal of the Alzheimer's Association vol 17 Suppl 3 issue 2022 35109062 |
here, we aimed at evaluating hippocampal astrocyte phenotypes in the presence of tau pathology in a transgenic human tau mouse model. |
2022-02-03 |
2023-01-27 |
human |
| Eduardo R Zimmer, Bruna Bellaver, Wagner Scheeren Brum, Pamela C L Ferreira, Guilherme Povala, Andreia Silva da Rocha, D\\xc3\\xa9bora Guerini de Souza, Marco Ant\\xc3\\xb4nio De Bastian. Tau pathology reshapes GFAP-positive astrocytes phenotype. Alzheimer's & dementia : the journal of the Alzheimer's Association vol 17 Suppl 3 issue 2022 35109062 |
we hypothesize that hippocampal astrocytes will respond to tau pathology by assuming a reactive phenotype. |
2022-02-03 |
2023-01-27 |
human |
| Sanaz Arezoumandan, Katheryn A Q Cousins, Jeffrey S Phillips, Daniel T Ohm, Claire Peterson, Ranjit Ittyerah, Corey T McMillan, David A Wolk, Paul A Yushkevich, John Q Trojanowski, Eddie B Lee, Murray Grossman, David J Irwi. Regional distribution of tau pathology in subfields of hippocampus among phenotypic variants of AD and FTLD-tau. Alzheimer's & dementia : the journal of the Alzheimer's Association vol 17 Suppl 3 issue 2022 35109105 |
regional distribution of tau pathology in subfields of hippocampus among phenotypic variants of ad and ftld-tau. |
2022-02-03 |
2023-01-27 |
Not clear |
| Sanaz Arezoumandan, Katheryn A Q Cousins, Jeffrey S Phillips, Daniel T Ohm, Claire Peterson, Ranjit Ittyerah, Corey T McMillan, David A Wolk, Paul A Yushkevich, John Q Trojanowski, Eddie B Lee, Murray Grossman, David J Irwi. Regional distribution of tau pathology in subfields of hippocampus among phenotypic variants of AD and FTLD-tau. Alzheimer's & dementia : the journal of the Alzheimer's Association vol 17 Suppl 3 issue 2022 35109105 |
moreover, previous work finds relative sparing of the hippocampal formation compared to typical amnestic ad (aad); however, there is limited data on the regional patterns of tau pathology across subfields of the hippocampus in naad or comparisons with clinically-similar non-amnestic forms of frontotemporal lobar degeneration tauopathies (ftld-tau). |
2022-02-03 |
2023-01-27 |
Not clear |