| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jianfeng Wu, Yi Su, Yanxi Chen, Wenhui Zhu, Eric M Reiman, Richard J Caselli, Kewei Chen, Paul M Thompson, Junwen Wang, Yalin Wan. A Surface-Based Federated Chow Test Model for Integrating APOE Status, Tau Deposition Measure, and Hippocampal Surface Morphometry. Journal of Alzheimer's disease : JAD. 2023-05-14. PMID:37182882. |
tau neurofibrillary tangles are the primary driver of downstream neurodegeneration and subsequent cognitive impairment in ad, resulting in structural deformations such as hippocampal atrophy that can be observed in magnetic resonance imaging (mri) scans. |
2023-05-14 |
2023-08-14 |
Not clear |
| Qiyao Wang, Chenglong Xia, An Zhu, Yongjie Bao, Jiani Lu, Yuan Chen, Jiayi Xu, Binbin Wang, C Benjamin Naman, Liping Li, Qinwen Wang, Hao Liu, Hongze Liang, Wei Cu. Discrepancy of synaptic and microtubular protein phosphorylation in the hippocampus of APP/PS1 and MAPT×P301S transgenic mice at the early stage of Alzheimer's disease. Metabolic brain disease. 2023-05-09. PMID:37160613. |
thus in this study, a quantitative phosphoproteomics analysis was performed to evaluate global protein phosphorylation in the hippocampus of aβ overexpressing app/ps1 transgenic mice and tau overexpressing mapt×p301s transgenic mice, two in vivo ad model systems. |
2023-05-09 |
2023-08-14 |
mouse |
| Jessica Brown, Elena Camporesi, Juan Lantero-Rodriguez, Maria Olsson, Alice Wang, Blanca Medem, Henrik Zetterberg, Kaj Blennow, Thomas K Karikari, Mark Wall, Emily Hil. Tau in cerebrospinal fluid induces neuronal hyperexcitability and alters hippocampal theta oscillations. Acta neuropathologica communications. vol 11. issue 1. 2023-04-24. PMID:37095572. |
tau in cerebrospinal fluid induces neuronal hyperexcitability and alters hippocampal theta oscillations. |
2023-04-24 |
2023-08-14 |
mouse |
| Lydia Reinhardt, Fabrizio Musacchio, Maria Bichmann, Annika Behrendt, Ebru Ercan-Herbst, Juliane Stein, Isabelle Becher, Per Haberkant, Julia Mader, David C Schöndorf, Melanie Schmitt, Jürgen Korffmann, Peter Reinhardt, Christian Pohl, Mikhail Savitski, Corinna Klein, Laura Gasparini, Martin Fuhrmann, Dagmar E Ehrnhoefe. Dual truncation of tau by caspase-2 accelerates its CHIP-mediated degradation. Neurobiology of disease. 2023-04-22. PMID:37086756. |
caspase-2-generated tau fragments show increased aggregation potential in vitro, but do not accumulate in vivo after aav-mediated overexpression in mouse hippocampus. |
2023-04-22 |
2023-08-14 |
mouse |
| Christopher Daniel Morrone, Radha Raghuraman, S Abid Hussaini, Wai Haung Y. Proteostasis failure exacerbates neuronal circuit dysfunction and sleep impairments in Alzheimer's disease. Molecular neurodegeneration. vol 18. issue 1. 2023-04-21. PMID:37085942. |
canonical pathological hallmarks, β-amyloid, and tau, directly disrupt sleep, and neurodegeneration of locus coeruleus, hippocampal and hypothalamic neurons from tau proteinopathy causes disruption of the neuronal circuitry of sleep. |
2023-04-21 |
2023-08-14 |
Not clear |
| Fang Du, Qing Yu, Russell H Swerdlow, Clarissa L Waite. Glucocorticoid-driven mitochondrial damage stimulates Tau pathology. Brain : a journal of neurology. 2023-04-18. PMID:37070763. |
using cultured murine hippocampal neurons and 4-5-month-old mice treated with the synthetic glucocorticoid dexamethasone, we investigate the mechanisms underlying glucocorticoid-induced mitochondrial damage and tau pathology. |
2023-04-18 |
2023-08-14 |
mouse |
| Jianqiao Tian, Sheela Kumari Raghavan Pillai, Robert I Reid, Scott A Przybelski, Timothy G Lesnick, Robel K Gebre, Jonathan Graff-Radford, Christopher G Schwarz, Val J Lowe, Kejal Kantarci, David S Knopman, Ronald C Petersen, Clifford R Jack, Prashanthi Vemur. White Matter Degeneration Pathways Associated With Tau Deposition in Alzheimer Disease. Neurology. 2023-04-17. PMID:37068958. |
of all the significant wm tracts, the uncinate fasciculus ([formula: see text]-0.274 for braak i, -0.311 for braak iii/iv, and -0.292 for braak v/vi, [formula: see text] 0.05) and cingulum adjoining hippocampus ([formula: see text] -0.274, -0.288, -0.233, [formula: see text] 0.05), both tracts anatomically connected to areas of early tau deposition, were consistently found to be within the top five distinguishing wm tracts associated with flortaucipir suvrs. |
2023-04-17 |
2023-08-14 |
human |
| Anastasie Mate de Gerando, Lindsay A Welikovitch, Anita Khasnavis, Caitlin Commins, Calina Glynn, Romain Perbet, Bradley T Hyma. Tau seeding and spreading in vivo is supported by both fibrillar and oligomeric tau. bioRxiv : the preprint server for biology. 2023-04-10. PMID:37034629. |
injection of sonicated fibrils or native hmw tau reveals similar local uptake into hippocampal neurons in ps19 tau transgenic mice. |
2023-04-10 |
2023-08-14 |
mouse |
| Chiara Panzi, Sunaina Surana, Samantha De La-Rocque, Edoardo Moretto, Oscar Marcelo Lazo, Giampietro Schiav. Botulinum neurotoxin A modulates the axonal release of pathological tau in hippocampal neurons. Toxicon : official journal of the International Society on Toxinology. 2023-04-10. PMID:37037273. |
botulinum neurotoxin a modulates the axonal release of pathological tau in hippocampal neurons. |
2023-04-10 |
2023-08-14 |
mouse |
| Chiara Panzi, Sunaina Surana, Samantha De La-Rocque, Edoardo Moretto, Oscar Marcelo Lazo, Giampietro Schiav. Botulinum neurotoxin A modulates the axonal release of pathological tau in hippocampal neurons. Toxicon : official journal of the International Society on Toxinology. 2023-04-10. PMID:37037273. |
hippocampal neurons were grown in microfluidic chambers and transduced with lentiviruses expressing human tau (htau). |
2023-04-10 |
2023-08-14 |
mouse |
| Michael Malek-Ahmadi, Yi Su, Valentina Ghisays, Ji Luo, Vivek Devadas, Yinghua Chen, Wendy Lee, Hillary Protas, Kewei Chen, Henrik Zetterberg, Kaj Blennow, Richard J Caselli, Eric M Reima. Plasma NfL is associated with the APOE ε4 allele, brain imaging measurements of neurodegeneration, and lower recall memory scores in cognitively unimpaired late-middle-aged and older adults. Alzheimer's research & therapy. vol 15. issue 1. 2023-04-10. PMID:37038190. |
we then assessed plasma nfl associations with brain imaging measurements of ad-related neurodegeneration (hippocampal atrophy and a hypometabolic convergence index [hci]), brain imaging measurements of amyloid-β plaque burden, tau tangle burden and white matter hyperintensity volume (wmhv), and delayed and total recall memory scores. |
2023-04-10 |
2023-08-14 |
Not clear |
| Mingqi Liu, Jinhao Huang, Tao Liu, Jiangyuan Yuan, Chuanxiang Lv, Zhuang Sha, Chenrui Wu, Weiwei Jiang, Xuanhui Liu, Meng Nie, Yupeng Chen, Shiying Dong, Yu Qian, Chuang Gao, Yibing Fan, Di Wu, Rongcai Jian. Exogenous interleukin 33 enhances the brain's lymphatic drainage and toxic protein clearance in acute traumatic brain injury mice. Acta neuropathologica communications. vol 11. issue 1. 2023-04-06. PMID:37024941. |
we verified that exogenous il-33 could improve the motor and memory skills of tbi mice and demonstrated that in the acute phase, it increased the exchange of cerebrospinal and interstitial fluid, reversed the dysregulation and depolarization of aquaporin-4 in the cortex and hippocampus, improved the drainage of mlvs to deep cervical lymph nodes, and reduced tau accumulation and glial activation. |
2023-04-06 |
2023-08-14 |
mouse |
| Laura J Mahady, Sylvia E Perez, Michael Malek-Ahmadi, Elliott J Mufso. Oligomeric, phosphorylated, and truncated tau and spliceosome pathology within the entorhinal-hippocampal connectome across stages of Alzheimer's disease. The Journal of comparative neurology. 2023-03-29. PMID:36989381. |
here, we used quantitative immunohistochemistry to determine the density of posttranslational oligomeric (toc1 and tnt1), phosphorylated (at8), and late truncated (tauc3) tau epitopes within the mtl subfields including entorhinal cortex (ec) layer ii, subiculum, cornu ammonis (ca) subfields, and dentate gyrus (dg) in subjects who died with a clinical diagnosis of no cognitive impairment (nci), mild cognitive impairment (mci), and ad. |
2023-03-29 |
2023-08-14 |
human |
| Laura J Mahady, Sylvia E Perez, Michael Malek-Ahmadi, Elliott J Mufso. Oligomeric, phosphorylated, and truncated tau and spliceosome pathology within the entorhinal-hippocampal connectome across stages of Alzheimer's disease. The Journal of comparative neurology. 2023-03-29. PMID:36989381. |
decreased nuclear srsf2 in the presence of cytoplasmic phosphorylated tau suggests a dual-hit process in nft formation within the entorhinal hippocampal connectome during the onset of ad. |
2023-03-29 |
2023-08-14 |
human |
| Kangshuai Du, Yunxiao Dou, Kui Chen, Yanxin Zha. Activation of TRPV4 induces intraneuronal tau hyperphosphorylation via cholesterol accumulation. Experimental neurology. 2023-03-29. PMID:36990137. |
our data indicated that trpv4 activation increased tau phosphorylation in the cortex and hippocampus of p301s tauopathy mouse model and aggravated its cognitive decline. |
2023-03-29 |
2023-08-14 |
mouse |
| Ferre. The unique neuropathological vulnerability of the human brain to aging. Ageing research reviews. 2023-03-29. PMID:36990284. |
alzheimer's disease (ad)-related neurofibrillary tangles (nft), argyrophilic grain disease (agd), aging-related tau astrogliopathy (artag), limbic predominant tdp-43 proteinopathy (late), and amygdala-predominant lewy body disease (lbd) are proteinopathies that, together with hippocampal sclerosis, progressively appear in the elderly affecting from 50% to 99% of individuals aged 80 years, depending on the disease. |
2023-03-29 |
2023-08-14 |
human |
| Yusong Wu, Xiaohui Niu, Peifan Li, Tong Tong, Qinger Wang, Michael Zhang, Yongli Li, Jia Liu, Zuming L. Lactobacillaceae improve cognitive dysfunction via regulating gut microbiota and suppressing Aβ deposits and neuroinflammation in APP/PS1 mice. Archives of microbiology. vol 205. issue 4. 2023-03-17. PMID:36928985. |
furthermore, the expression of aβ plaques, tau phosphorylation and neuroinflammation were markedly reduced in the hippocampus. |
2023-03-17 |
2023-08-14 |
mouse |
| Benjamin B Tournier, Christophe Snoeijs, Stergios Tsartsalis, Quentin Amossé, Ramzi Farchoukh, Eniko Kövari, Kelly Ceyzériat, Philippe Mille. The 18 kDa translocator protein is associated with microglia in the hippocampus of non-demented elderly subjects. Aging brain. vol 2. 2023-03-13. PMID:36908874. |
to determine if tspo is associated with the presence of amyloid β plaques and/or phosphorylated tau accumulation, we analyzed hippocampal sections using immunohistochemistry of 14 non-demented subjects with positive staining for aβ and/or phosphorylated tau. |
2023-03-13 |
2023-08-14 |
human |
| Emma M Coomans, Jori Tomassen, Rik Ossenkoppele, Betty M Tijms, Luigi Lorenzini, Mara Ten Kate, Lyduine E Collij, Fiona Heeman, Roos M Rikken, Sophie M van der Landen, Marijke E den Hollander, Sandeep S V Golla, Maqsood Yaqub, Albert D Windhorst, Frederik Barkhof, Philip Scheltens, Eco J C de Geus, Pieter Jelle Visser, Bart N M van Berckel, Anouk den Brabe. Genetically identical twin-pair difference models support the amyloid cascade hypothesis. Brain : a journal of neurology. 2023-03-09. PMID:36892415. |
we included 78 cognitively unimpaired identical twins with [18f]flutemetamol (amyloid-β)-pet, [18f]flortaucipir (tau)-pet, mri (hippocampal volume), and cognitive data (composite memory). |
2023-03-09 |
2023-08-14 |
Not clear |
| Emma M Coomans, Jori Tomassen, Rik Ossenkoppele, Betty M Tijms, Luigi Lorenzini, Mara Ten Kate, Lyduine E Collij, Fiona Heeman, Roos M Rikken, Sophie M van der Landen, Marijke E den Hollander, Sandeep S V Golla, Maqsood Yaqub, Albert D Windhorst, Frederik Barkhof, Philip Scheltens, Eco J C de Geus, Pieter Jelle Visser, Bart N M van Berckel, Anouk den Brabe. Genetically identical twin-pair difference models support the amyloid cascade hypothesis. Brain : a journal of neurology. 2023-03-09. PMID:36892415. |
within-pair differences in amyloid-β were strongly associated with within-pair differences in tau (β=0.68, p < 0.001), and moderately associated with within-pair differences in hippocampal volume (β=-0.37, p = 0.03) and memory functioning (β=-0.57, p < 0.001). |
2023-03-09 |
2023-08-14 |
Not clear |