| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Godbout, Y Chaput, P Blier, C de Montign. Tandospirone and its metabolite, 1-(2-pyrimidinyl)-piperazine--I. Effects of acute and long-term administration of tandospirone on serotonin neurotransmission. Neuropharmacology. vol 30. issue 7. 1991-11-04. PMID:1681446. |
effects of acute and long-term administration of tandospirone on serotonin neurotransmission. |
1991-11-04 |
2023-08-11 |
rat |
| R Godbout, Y Chaput, P Blier, C de Montign. Tandospirone and its metabolite, 1-(2-pyrimidinyl)-piperazine--I. Effects of acute and long-term administration of tandospirone on serotonin neurotransmission. Neuropharmacology. vol 30. issue 7. 1991-11-04. PMID:1681446. |
the acute and long-term effects of the antidepressant/anxiolytic selective 5-ht1a receptor ligand, tandospirone (sm-3997) on 5-ht neurotransmission were assessed using single-cell extracellular recording in chloral hydrate-anaesthetized rats. |
1991-11-04 |
2023-08-11 |
rat |
| R Godbout, Y Chaput, P Blier, C de Montign. Tandospirone and its metabolite, 1-(2-pyrimidinyl)-piperazine--I. Effects of acute and long-term administration of tandospirone on serotonin neurotransmission. Neuropharmacology. vol 30. issue 7. 1991-11-04. PMID:1681446. |
the acute intravenous administration of tandospirone decreased the firing rate of 5-ht neurones of the dorsal raphe (ed50 = 9.1 +/- 1.1 micrograms/kg). |
1991-11-04 |
2023-08-11 |
rat |
| R Godbout, Y Chaput, P Blier, C de Montign. Tandospirone and its metabolite, 1-(2-pyrimidinyl)-piperazine--I. Effects of acute and long-term administration of tandospirone on serotonin neurotransmission. Neuropharmacology. vol 30. issue 7. 1991-11-04. PMID:1681446. |
a treatment with tandospirone for 2 days (10 mg/kg/day, s.c.), markedly reduced the firing activity of 5-ht neurones of the dorsal raphe; this was followed by a partial recovery after 7 days and by complete recovery after 14 days of administration of tandospirone. |
1991-11-04 |
2023-08-11 |
rat |
| R Godbout, Y Chaput, P Blier, C de Montign. Tandospirone and its metabolite, 1-(2-pyrimidinyl)-piperazine--I. Effects of acute and long-term administration of tandospirone on serotonin neurotransmission. Neuropharmacology. vol 30. issue 7. 1991-11-04. PMID:1681446. |
after treatment with tandospirone for 14 days (10 mg/kg/day, s.c.), the responsiveness of 5-ht neurones to the intravenous administration of lsd was reduced, suggesting that somatodendritic 5-ht autoreceptors had desensitized. |
1991-11-04 |
2023-08-11 |
rat |
| R Godbout, Y Chaput, P Blier, C de Montign. Tandospirone and its metabolite, 1-(2-pyrimidinyl)-piperazine--I. Effects of acute and long-term administration of tandospirone on serotonin neurotransmission. Neuropharmacology. vol 30. issue 7. 1991-11-04. PMID:1681446. |
the depressant effects of microiontophoretically-applied tandospirone and 5-ht, on the firing activity of ca3 pyramidal neurones in the hippocampus were blocked by the intravenous injection of the 5-ht1a receptor antagonist, bmy-7378. |
1991-11-04 |
2023-08-11 |
rat |
| R Godbout, Y Chaput, P Blier, C de Montign. Tandospirone and its metabolite, 1-(2-pyrimidinyl)-piperazine--I. Effects of acute and long-term administration of tandospirone on serotonin neurotransmission. Neuropharmacology. vol 30. issue 7. 1991-11-04. PMID:1681446. |
the depressant effect of microiontophoretically-applied 5-ht onto these same neurones was markedly reduced during concurrent background application of tandospirone, suggesting that the latter acted as a partial agonist at postsynaptic 5-ht1a receptors. |
1991-11-04 |
2023-08-11 |
rat |
| R Godbout, Y Chaput, P Blier, C de Montign. Tandospirone and its metabolite, 1-(2-pyrimidinyl)-piperazine--I. Effects of acute and long-term administration of tandospirone on serotonin neurotransmission. Neuropharmacology. vol 30. issue 7. 1991-11-04. PMID:1681446. |
the sustained administration of tandospirone for 14 days (10 mg/kg/day, s.c.) altered neither the effectiveness of microiontophoretically-applied 5-ht and tandospirone nor that of endogenous 5-ht, released by the electrical simulation of the afferent 5-ht pathway, in suppressing the firing activity of pyramidal neurones in the hippocampus, suggesting that postsynaptic 5-ht1a receptors had not desensitized. |
1991-11-04 |
2023-08-11 |
rat |
| R Godbout, Y Chaput, P Blier, C de Montign. Tandospirone and its metabolite, 1-(2-pyrimidinyl)-piperazine--I. Effects of acute and long-term administration of tandospirone on serotonin neurotransmission. Neuropharmacology. vol 30. issue 7. 1991-11-04. PMID:1681446. |
furthermore, long-term treatment with tandospirone did not alter the sensitivity of the terminal 5-ht autoreceptor. |
1991-11-04 |
2023-08-11 |
rat |
| R Godbout, Y Chaput, P Blier, C de Montign. Tandospirone and its metabolite, 1-(2-pyrimidinyl)-piperazine--I. Effects of acute and long-term administration of tandospirone on serotonin neurotransmission. Neuropharmacology. vol 30. issue 7. 1991-11-04. PMID:1681446. |
it is thus concluded that desensitization of somatodendritic 5-ht autoreceptors permits 5-ht neurones to regain their physiological rate of firing during long-term treatment with tandospirone and, consequently, to release a normal amount of 5-ht into the synaptic cleft. |
1991-11-04 |
2023-08-11 |
rat |
| E Chojnacka-Wójcik, E Tatarczyńska, K Gołembiowska, E Przegalińsk. Involvement of 5-HT1A receptors in the antidepressant-like activity of gepirone in the forced swimming test in rats. Neuropharmacology. vol 30. issue 7. 1991-11-04. PMID:1681449. |
on the other hand, the non-selective 5-ht receptor antagonist, metergoline (2 and 4 mg/kg), the selective 5-ht2 receptor antagonist, ketanserin (1 and 2 mg/kg), the selective alpha 1-adrenoceptor blocker, prazosin (0.25 and 0.5 mg/kg) and the beta-blockers with no affinity for 5-ht receptors, betaxolol (4 and 8 mg/kg) and ici 118,551 (4 and 8 mg/kg), did not affect the anti-immobility effect of gepirone. |
1991-11-04 |
2023-08-11 |
rat |
| A Płaźnik, R Stefański, W Pałejko, W Kostowsk. Serotonergic mechanisms in the nucleus accumbens affected by chronic desipramine treatment. Pharmacology, biochemistry, and behavior. vol 39. issue 1. 1991-11-01. PMID:1833782. |
local microinjections of 5-ht, quipazine as well as 5-ht1a receptor agonist buspirone, 8-oh-dpat and ndo-008, inhibited rat locomotor activity in the open-field test. |
1991-11-01 |
2023-08-11 |
rat |
| A Płaźnik, R Stefański, W Pałejko, W Kostowsk. Serotonergic mechanisms in the nucleus accumbens affected by chronic desipramine treatment. Pharmacology, biochemistry, and behavior. vol 39. issue 1. 1991-11-01. PMID:1833782. |
the effect of 5-ht and buspirone was blocked by serotonergic receptor antagonists methysergide and cyanopindolol, respectively. |
1991-11-01 |
2023-08-11 |
rat |
| A Płaźnik, R Stefański, W Pałejko, W Kostowsk. Serotonergic mechanisms in the nucleus accumbens affected by chronic desipramine treatment. Pharmacology, biochemistry, and behavior. vol 39. issue 1. 1991-11-01. PMID:1833782. |
chronic, but not acute treatment of rats with desipramine (10 mg/kg, po, twice a day for 21 days, tests were performed 24 h after the last dose) significantly attenuated behavioral depression after 5-ht and quipazine microinjections, while the effect of buspirone was left unchanged. |
1991-11-01 |
2023-08-11 |
rat |
| B G Wells, C C Chu, R Johnson, C Nasdahl, M A Ayubi, E Sewell, P Statha. Buspirone in the treatment of posttraumatic stress disorder. Pharmacotherapy. vol 11. issue 4. 1991-10-29. PMID:1923917. |
serotonin partial agonist effects are a possible mechanism underlying buspirone's efficacy. |
1991-10-29 |
2023-08-11 |
Not clear |
| D P Taylor, S L Moo. Buspirone and related compounds as alternative anxiolytics. Neuropeptides. vol 19 Suppl. 1991-09-30. PMID:1679210. |
the azapirones appear to act as serotonin 5-ht1a partial agonists as they all share high affinity for 5-ht1a binding sites in vitro as well as in anatomical studies. |
1991-09-30 |
2023-08-11 |
Not clear |
| A J Lazosky, D R Britto. Effects of 5-HT-1A receptor agonists on CRF-induced behavior. Psychopharmacology. vol 104. issue 1. 1991-09-30. PMID:1831906. |
buspirone (2.0 or 4.0 mg/kg) and 8-hydroxy-2-(di-n-propylamino)-tetralin (8-oh-dpat) (0.25 or 0.5 mg/kg) were used to examine the effects of serotonin 1a receptor agonists on the behavioral response of rats to centrally administered corticotropin-releasing factor (crf). |
1991-09-30 |
2023-08-11 |
rat |
| Y Kataoka, K Shibata, A Miyazaki, Y Inoue, K Tominaga, S Koizumi, S Ueki, M Niw. Involvement of the dorsal hippocampus in mediation of the antianxiety action of tandospirone, a 5-hydroxytryptamine1A agonistic anxiolytic. Neuropharmacology. vol 30. issue 5. 1991-09-11. PMID:1865994. |
the effect of tandospirone, a 5-hydroxytryptamine (5-ht)1a agonist/anxiolytic, injected directly into dorsal hippocampus, on vogel-type conflict behavior in rats was investigated and the findings were compared with the effects of diazepam and zopiclone. |
1991-09-11 |
2023-08-11 |
rat |
| S R Silva, H A Futuro-Neto, J G Pire. Inhibition of chlorpromazine-induced catalepsy by the 5-HT-1A ligands pindolol and buspirone in mice. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 23. issue 9. 1991-09-06. PMID:2101330. |
clomipramine, a 5-ht neuronal uptake blocker, reversed the inhibitory effect of buspirone. |
1991-09-06 |
2023-08-11 |
mouse |
| H Tanaka, H Shimizu, Y Kumasaka, A Hirose, T Tatsuno, M Nakamur. Autoradiographic localization and pharmacological characterization of [3H]tandospirone binding sites in the rat brain. Brain research. vol 546. issue 2. 1991-08-22. PMID:1648988. |
the distribution profiles of [3h]tandospirone binding sites significantly correlated with that of serotonin (5-ht)1a receptors identified using [3h]8-oh-dpat. |
1991-08-22 |
2023-08-11 |
rat |