| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Van den Hooff, M Galva. Actions of 5-hydroxytryptamine and 5-HT1A receptor ligands on rat dorso-lateral septal neurones in vitro. British journal of pharmacology. vol 106. issue 4. 1992-11-20. PMID:1393288. |
the estimated ec50s were: dp-5-ct 15 nm, 8-oh-dpat 110 nm, 5-ht 3 microm and buspirone 110 nm. |
1992-11-20 |
2023-08-11 |
rat |
| D Hoyer, H Lery, C Waeber, A T Bruinvels, J Nozulak, J M Palacio. "5-HT1R" or 5-HT1D sites? Evidence for 5-HT1D binding sites in rabbit brain. Naunyn-Schmiedeberg's archives of pharmacology. vol 346. issue 3. 1992-11-19. PMID:1407010. |
the pharmacological profile of [125i]gti binding was fully comparable to that reported previously in human and other brain preparations known to possess 5-ht1d sites (using either [3h]5-ht or [125i]gti) and displayed a characteristic rank order of affinity: 5-carboxamido-tryptamine greater than 5-ht = dihydroergotamine greater than or equal to ergotamine greater than or equal to sumatriptan greater than or equal to cgs 12066 greater than or equal to metergoline greater than yohimbine greater than or equal to methysergide greater than icyp greater than 8-oh-dpat greater than or equal to cp 93129 greater than (-)pindolol greater than ketanserin greater than isamoltane greater than mesulergine greater than corynanthine greater than buspirone greater than mdl 72222. |
1992-11-19 |
2023-08-11 |
human |
| G D Tollefso. Anxiety and alcoholism: a serotonin link. The British journal of psychiatry. Supplement. issue 12. 1992-11-18. PMID:1840761. |
novel serotonin drugs, such as the azapirones, may usefully supplement conventional treatment strategies for substance abuse. |
1992-11-18 |
2023-08-11 |
Not clear |
| V Conde López, M Martínez Roi. [Azaspirodecanodiones in clinical psychiatry]. Actas luso-espanolas de neurologia, psiquiatria y ciencias afines. vol 20. issue 4. 1992-10-22. PMID:1356293. |
buspirone--the only one available--is a novel nonbenzodiazepine anxiolytic that shows affinity for the serotonin 1a receptor subtype, acting as a partial agonist in the serotonergic system. |
1992-10-22 |
2023-08-11 |
Not clear |
| K Bohmaker, F Bordi, E Melle. The effects of pertussis toxin on dopamine D2 and serotonin 5-HT1A autoreceptor-mediated inhibition of neurotransmitter synthesis: relationship to receptor reserve. Neuropharmacology. vol 31. issue 5. 1992-10-20. PMID:1356248. |
completely analogous effects were found at the somatodendritic 5-ht1a autoreceptor in the raphe nuclei, mediating inhibition of the synthesis of serotonin (5-ht); the full agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) and the partial agonist, buspirone were utilized to inhibit the synthesis of 5-ht, as measured by changes in levels of l-5-hydroxytryptophan (5-htp). |
1992-10-20 |
2023-08-11 |
Not clear |
| P M Grasby, K J Friston, C Bench, P J Cowen, C D Frith, P F Liddle, R S Frackowiak, R J Dola. Effect of the 5-HT1A partial agonist buspirone on regional cerebral blood flow in man. Psychopharmacology. vol 108. issue 3. 1992-10-15. PMID:1523287. |
it is concluded that buspirone-induced alterations in regional cerebral blood flow are better understood, not in relation to the known distribution of monoamine neurotransmitter systems (particularly ascending 5-ht projections), but rather in relation to putative neuronal circuits possibly many synapses "downstream" of buspirone's pharmacological site of action. |
1992-10-15 |
2023-08-11 |
human |
| H Shimizu, T Tatsuno, H Tanaka, A Hirose, Y Araki, M Nakamur. Serotonergic mechanisms in anxiolytic effect of tandospirone in the Vogel conflict test. Japanese journal of pharmacology. vol 59. issue 1. 1992-09-22. PMID:1354771. |
to clarify which 5-ht1a receptors, autoreceptors located in the raphe nuclei or post-synaptic receptors in the forebrain areas receiving a 5-ht input, mediate the anticonflict action of tandospirone (a 5-ht1a receptor-related anxiolytics), the behavioral effects of tandospirone were studied in 5,7-dihydroxytryptamine (5,7-dht) treated rats. |
1992-09-22 |
2023-08-11 |
rat |
| H Shimizu, T Tatsuno, H Tanaka, A Hirose, Y Araki, M Nakamur. Serotonergic mechanisms in anxiolytic effect of tandospirone in the Vogel conflict test. Japanese journal of pharmacology. vol 59. issue 1. 1992-09-22. PMID:1354771. |
furthermore, this destruction altered neither the effect of tandospirone on punished responding in this procedure nor the potency of tandospirone to induce a flat body posture in rats, which is known as the "serotonin behavioral syndrome". |
1992-09-22 |
2023-08-11 |
rat |
| H Shimizu, T Tatsuno, H Tanaka, A Hirose, Y Araki, M Nakamur. Serotonergic mechanisms in anxiolytic effect of tandospirone in the Vogel conflict test. Japanese journal of pharmacology. vol 59. issue 1. 1992-09-22. PMID:1354771. |
these results suggested that the anticonflict action of tandospirone may be produced, at least in part, by binding to postsynaptic 5-ht1a receptors and activating them as agonists, and not to 5-ht1a autoreceptors located on the cell bodies of 5-ht neurons. |
1992-09-22 |
2023-08-11 |
rat |
| M J Millan, J M Rivet, H Canton, F Lejeune, K Bervoets, M Brocco, A Gobert, B Lefebvre de Ladonchamps, S Le Marouille-Girardon, L Verriel. S 14671: a naphtylpiperazine 5-hydroxytryptamine1A agonist of exceptional potency and high efficacy possessing antagonist activity at 5-hydroxytryptamine1C/2 receptors. The Journal of pharmacology and experimental therapeutics. vol 262. issue 2. 1992-09-11. PMID:1323650. |
the interaction at 5-hydroxytryptamine (5-ht) receptors of the novel naphtylpiperazine, s 14671 (1-[2-(2-thenoylamino)ethyl]-4[1-(7- methoxynaphtyl)]piperazine), was compared to that of the 5-ht1a ligands, 8-hydroxy-2-(di-n-propylamino)tetralin hydrobromide (8-oh-dpat), wy 50,324 [n-(29(4-(2-pyrimidinyl)-1-piperazinyl)ethyl)tricyclo(3.3.1.1(3,7) )- decane-1-carboxamide], (+)-flesinoxan, buspirone and bmy 7378 [(8-[2-[4-(2-methoxyphenyl)- 1-piperazinyl]ethyl]-8-azaspirol[-4-]-decane-7,9-dione 2hcl]. |
1992-09-11 |
2023-08-11 |
rat |
| M G De Simoni, A De Luigi, A Clavenna, A Manfrid. In vivo studies on the enhancement of serotonin reuptake by tianeptine. Brain research. vol 574. issue 1-2. 1992-08-28. PMID:1379111. |
the interaction between tianeptine and drugs known to interfere with the uptake or release of serotonin (sertraline, buspirone, d-norfenfluramine) was then studied and, to ascertain the in vivo pharmacological relevance of tianeptine's effects, its ability to reduce the serotoninergic syndrome was evaluated. |
1992-08-28 |
2023-08-11 |
rat |
| S J Peroutka, A J Sleight, B G McCarthy, P A Pierce, A W Schmidt, C R Hekmatpana. The clinical utility of pharmacological agents that act at serotonin receptors. The Journal of neuropsychiatry and clinical neurosciences. vol 1. issue 3. 1992-08-18. PMID:2562495. |
the putative novel anxiolytic effects of 5-ht1a partial agonists such as buspirone, the antidepressant effects of selective serotonin (5-ht) uptake blockers such as fluoxetine, and the unique and potent antiemetic effects of 5-ht3 antagonists in cancer chemotherapy are excellent examples of the clinical relevance of selective 5-ht receptor agents. |
1992-08-18 |
2023-08-11 |
human |
| A Lecci, S Giuliani, P Santicioli, C A Magg. Involvement of 5-hydroxytryptamine1A receptors in the modulation of micturition reflexes in the anesthetized rat. The Journal of pharmacology and experimental therapeutics. vol 262. issue 1. 1992-08-11. PMID:1352548. |
intravenous administration of the selective 5-hydroxytryptamine (5-ht)1a receptor agonist 8-hydroxy-2-(di-n-propylaminotetralin (8-oh-dpat) and of a low doses of buspirone elicited the supraspinal micturition reflex (smr) in urethane-anesthetized rats when the urinary bladder was filled with just a subthreshold volume of saline (threshold conditions). |
1992-08-11 |
2023-08-11 |
rat |
| J V Lucey, G Butcher, A W Clare, T G Dina. Buspirone induced prolactin responses in obsessive-compulsive disorder (OCD): is OCD a 5-HT2 receptor disorder? International clinical psychopharmacology. vol 7. issue 1. 1992-08-07. PMID:1624756. |
buspirone (busp) is a serotonergic (5-ht) agonist with activity at the 5-ht1a receptor. |
1992-08-07 |
2023-08-11 |
Not clear |
| N R Newberr. 5-HT1A receptors activate a potassium conductance in rat ventromedial hypothalamic neurones. European journal of pharmacology. vol 210. issue 2. 1992-07-10. PMID:1601058. |
the extracellularly recorded firing rate of rat ventromedial hypothalamic neurones in vitro was inhibited by 5-hydroxytryptamine (5-ht), 5-carboxamidotryptamine (5-ct), 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) and buspirone, 2-methyl-5-ht was relatively ineffective. |
1992-07-10 |
2023-08-11 |
rat |
| C F Coop, N McNaughton, D J Scot. Pindolol antagonizes the effects on hippocampal rhythmical slow activity of clonidine, baclofen and 8-OH-DPAT, but not chlordiazepoxide and sodium amylobarbitone. Neuroscience. vol 46. issue 1. 1992-06-30. PMID:1350666. |
buspirone, clonidine, baclofen and 8-oh-dpat act via a system dependent on 5-hydroxytryptamine 1a receptor activation. |
1992-06-30 |
2023-08-11 |
Not clear |
| J D Amsterda. Gepirone, a selective serotonin (5HT1A) partial agonist in the treatment of major depression. Progress in neuro-psychopharmacology & biological psychiatry. vol 16. issue 3. 1992-06-24. PMID:1350353. |
gepirone, a selective serotonin (5ht1a) partial agonist in the treatment of major depression. |
1992-06-24 |
2023-08-11 |
human |
| J D Amsterda. Gepirone, a selective serotonin (5HT1A) partial agonist in the treatment of major depression. Progress in neuro-psychopharmacology & biological psychiatry. vol 16. issue 3. 1992-06-24. PMID:1350353. |
the present study assessed the potential antidepressant action of gepirone hydrochloride, an azapirone serotonin (5-ht1a) partial agonist in patients with major depression. |
1992-06-24 |
2023-08-11 |
human |
| I M Anderson, P J Cowe. Effect of pindolol on endocrine and temperature responses to buspirone in healthy volunteers. Psychopharmacology. vol 106. issue 3. 1992-05-22. PMID:1570392. |
both this latter possibility and the lack of selectivity of pindolol for 5-ht receptors indicate the need for the further neuroendocrine studies of the mode of action of buspirone, preferably with more selective 5-ht1a receptor antagonists. |
1992-05-22 |
2023-08-11 |
human |
| R J Goldberg, M Hu. Serotonin syndrome from trazodone and buspirone. Psychosomatics. vol 33. issue 2. 1992-05-07. PMID:1557493. |
serotonin syndrome from trazodone and buspirone. |
1992-05-07 |
2023-08-11 |
Not clear |